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Protein

Heat shock 70 kDa protein 4L

Gene

HSPA4L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 4L
Alternative name(s):
Heat shock 70-related protein APG-1
Osmotic stress protein 94
Gene namesi
Name:HSPA4L
Synonyms:APG1, OSP94
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000164070.11
HGNCiHGNC:17041 HSPA4L
neXtProtiNX_O95757

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22824
OpenTargetsiENSG00000164070
PharmGKBiPA134905749

Polymorphism and mutation databases

BioMutaiHSPA4L

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000782801 – 839Heat shock 70 kDa protein 4LAdd BLAST839

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74PhosphoserineCombined sources1
Modified residuei508PhosphoserineCombined sources1
Modified residuei545PhosphothreonineBy similarity1
Modified residuei579PhosphoserineCombined sources1
Modified residuei761PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95757
MaxQBiO95757
PaxDbiO95757
PeptideAtlasiO95757
PRIDEiO95757
ProteomicsDBi51027

2D gel databases

REPRODUCTION-2DPAGEiIPI00295485

PTM databases

iPTMnetiO95757
PhosphoSitePlusiO95757

Expressioni

Inductioni

By heat shock and osmotic imbalance.1 Publication

Gene expression databases

BgeeiENSG00000164070 Expressed in 191 organ(s), highest expression level in sperm
CleanExiHS_HSPA4L
ExpressionAtlasiO95757 baseline and differential
GenevisibleiO95757 HS

Organism-specific databases

HPAiCAB034450
HPA039149
HPA061446

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi116500, 68 interactors
IntActiO95757, 22 interactors
MINTiO95757
STRINGi9606.ENSP00000296464

Structurei

3D structure databases

ProteinModelPortaliO95757
SMRiO95757
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0103 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00390000016919
HOGENOMiHOG000228138
HOVERGENiHBG047955
InParanoidiO95757
KOiK09485
OMAiDYFCEEF
OrthoDBiEOG091G04Y6
PhylomeDBiO95757
TreeFamiTF105043

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 2 hits
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 2 hits
PROSITEiView protein in PROSITE
PS01036 HSP70_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O95757-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVVGIDLGF LNCYIAVARS GGIETIANEY SDRCTPACIS LGSRTRAIGN
60 70 80 90 100
AAKSQIVTNV RNTIHGFKKL HGRSFDDPIV QTERIRLPYE LQKMPNGSAG
110 120 130 140 150
VKVRYLEEER PFAIEQVTGM LLAKLKETSE NALKKPVADC VISIPSFFTD
160 170 180 190 200
AERRSVMAAA QVAGLNCLRL MNETTAVALA YGIYKQDLPP LDEKPRNVVF
210 220 230 240 250
IDMGHSAYQV LVCAFNKGKL KVLATTFDPY LGGRNFDEAL VDYFCDEFKT
260 270 280 290 300
KYKINVKENS RALLRLYQEC EKLKKLMSAN ASDLPLNIEC FMNDLDVSSK
310 320 330 340 350
MNRAQFEQLC ASLLARVEPP LKAVMEQANL QREDISSIEI VGGATRIPAV
360 370 380 390 400
KEQITKFFLK DISTTLNADE AVARGCALQC AILSPAFKVR EFSITDLVPY
410 420 430 440 450
SITLRWKTSF EDGSGECEVF CKNHPAPFSK VITFHKKEPF ELEAFYTNLH
460 470 480 490 500
EVPYPDARIG SFTIQNVFPQ SDGDSSKVKV KVRVNIHGIF SVASASVIEK
510 520 530 540 550
QNLEGDHSDA PMETETSFKN ENKDNMDKMQ VDQEEGHQKC HAEHTPEEEI
560 570 580 590 600
DHTGAKTKSA VSDKQDRLNQ TLKKGKVKSI DLPIQSSLCR QLGQDLLNSY
610 620 630 640 650
IENEGKMIMQ DKLEKERNDA KNAVEEYVYD FRDRLGTVYE KFITPEDLSK
660 670 680 690 700
LSAVLEDTEN WLYEDGEDQP KQVYVDKLQE LKKYGQPIQM KYMEHEERPK
710 720 730 740 750
ALNDLGKKIQ LVMKVIEAYR NKDERYDHLD PTEMEKVEKC ISDAMSWLNS
760 770 780 790 800
KMNAQNKLSL TQDPVVKVSE IVAKSKELDN FCNPIIYKPK PKAEVPEDKP
810 820 830
KANSEHNGPM DGQSGTETKS DSTKDSSQHT KSSGEMEVD
Length:839
Mass (Da):94,512
Last modified:November 2, 2010 - v3
Checksum:i549933AECFF4369A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PDE8E9PDE8_HUMAN
Heat shock 70 kDa protein 4L
HSPA4L
813Annotation score:
D6RJ96D6RJ96_HUMAN
Heat shock 70 kDa protein 4L
HSPA4L
531Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti806H → R in BAA75063 (PubMed:10524232).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025405211L → S1 PublicationCorresponds to variant dbSNP:rs1380154Ensembl.1
Natural variantiVAR_031214216N → T. Corresponds to variant dbSNP:rs12507229Ensembl.1
Natural variantiVAR_055966601I → T. Corresponds to variant dbSNP:rs35518193Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023421 mRNA Translation: BAA75063.1
EF197155 mRNA Translation: ABM69040.1
AC093591 Genomic DNA Translation: AAY40975.1
CH471056 Genomic DNA Translation: EAX05198.1
BC040560 mRNA Translation: AAH40560.1
CCDSiCCDS3734.1
RefSeqiNP_001304310.1, NM_001317381.1
NP_001304311.1, NM_001317382.1
NP_001304312.1, NM_001317383.1
NP_055093.2, NM_014278.3
UniGeneiHs.135554

Genome annotation databases

EnsembliENST00000296464; ENSP00000296464; ENSG00000164070
ENST00000508776; ENSP00000422482; ENSG00000164070
GeneIDi22824
KEGGihsa:22824
UCSCiuc003ifm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023421 mRNA Translation: BAA75063.1
EF197155 mRNA Translation: ABM69040.1
AC093591 Genomic DNA Translation: AAY40975.1
CH471056 Genomic DNA Translation: EAX05198.1
BC040560 mRNA Translation: AAH40560.1
CCDSiCCDS3734.1
RefSeqiNP_001304310.1, NM_001317381.1
NP_001304311.1, NM_001317382.1
NP_001304312.1, NM_001317383.1
NP_055093.2, NM_014278.3
UniGeneiHs.135554

3D structure databases

ProteinModelPortaliO95757
SMRiO95757
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116500, 68 interactors
IntActiO95757, 22 interactors
MINTiO95757
STRINGi9606.ENSP00000296464

PTM databases

iPTMnetiO95757
PhosphoSitePlusiO95757

Polymorphism and mutation databases

BioMutaiHSPA4L

2D gel databases

REPRODUCTION-2DPAGEiIPI00295485

Proteomic databases

EPDiO95757
MaxQBiO95757
PaxDbiO95757
PeptideAtlasiO95757
PRIDEiO95757
ProteomicsDBi51027

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296464; ENSP00000296464; ENSG00000164070
ENST00000508776; ENSP00000422482; ENSG00000164070
GeneIDi22824
KEGGihsa:22824
UCSCiuc003ifm.4 human

Organism-specific databases

CTDi22824
DisGeNETi22824
EuPathDBiHostDB:ENSG00000164070.11
GeneCardsiHSPA4L
HGNCiHGNC:17041 HSPA4L
HPAiCAB034450
HPA039149
HPA061446
neXtProtiNX_O95757
OpenTargetsiENSG00000164070
PharmGKBiPA134905749
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0103 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00390000016919
HOGENOMiHOG000228138
HOVERGENiHBG047955
InParanoidiO95757
KOiK09485
OMAiDYFCEEF
OrthoDBiEOG091G04Y6
PhylomeDBiO95757
TreeFamiTF105043

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response

Miscellaneous databases

ChiTaRSiHSPA4L human
GeneWikiiHSPA4L
GenomeRNAii22824
PROiPR:O95757

Gene expression databases

BgeeiENSG00000164070 Expressed in 191 organ(s), highest expression level in sperm
CleanExiHS_HSPA4L
ExpressionAtlasiO95757 baseline and differential
GenevisibleiO95757 HS

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 2 hits
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 2 hits
PROSITEiView protein in PROSITE
PS01036 HSP70_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHS74L_HUMAN
AccessioniPrimary (citable) accession number: O95757
Secondary accession number(s): A2ICT2, Q4W5M5, Q8IWA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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