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Protein

Ras-related protein Rab-36

Gene

RAB36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi130 – 137GTPBy similarity8
Nucleotide bindingi178 – 182GTPBy similarity5
Nucleotide bindingi237 – 240GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic
R-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-36
Gene namesi
Name:RAB36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100228.12
HGNCiHGNC:9775 RAB36
MIMi605662 gene
neXtProtiNX_O95755

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100228
PharmGKBiPA34128

Polymorphism and mutation databases

BioMutaiRAB36

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212481 – 333Ras-related protein Rab-36Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi332S-geranylgeranyl cysteineSequence analysis1
Lipidationi333S-geranylgeranyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiO95755
MaxQBiO95755
PaxDbiO95755
PeptideAtlasiO95755
PRIDEiO95755
ProteomicsDBi51025
51026 [O95755-2]
TopDownProteomicsiO95755-1 [O95755-1]

2D gel databases

REPRODUCTION-2DPAGEiO95755

PTM databases

iPTMnetiO95755
PhosphoSitePlusiO95755

Expressioni

Tissue specificityi

Ubiquitously present in all tissues examined.

Gene expression databases

BgeeiENSG00000100228 Expressed in 143 organ(s), highest expression level in right uterine tube
CleanExiHS_RAB36
ExpressionAtlasiO95755 baseline and differential
GenevisibleiO95755 HS

Organism-specific databases

HPAiHPA059631

Interactioni

Protein-protein interaction databases

BioGridi114971, 2 interactors
IntActiO95755, 1 interactor
STRINGi9606.ENSP00000263116

Structurei

3D structure databases

ProteinModelPortaliO95755
SMRiO95755
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi152 – 160Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094 Eukaryota
ENOG410XPBI LUCA
GeneTreeiENSGT00910000144073
HOGENOMiHOG000233970
HOVERGENiHBG106693
InParanoidiO95755
KOiK07922
OMAiNEPASCF
OrthoDBiEOG091G0EPX
PhylomeDBiO95755
TreeFamiTF326626

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O95755-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVIAGASWML GRAAASPTQT PPTTSTIRVA RRSRVALVAM VIAAAGSGGP
60 70 80 90 100
GRAEPQLSQP SLDCGRMRSS LTPLGPPVSR DRVIASFPKW YTPEACLQLR
110 120 130 140 150
EHFHGQVSAA CQRRNTGTVG LKLSKVVVVG DLYVGKTSLI HRFCKNVFDR
160 170 180 190 200
DYKATIGVDF EIERFEIAGI PYSLQIWDTA GQEKFKCIAS AYYRGAQVII
210 220 230 240 250
TAFDLTDVQT LEHTRQWLED ALRENEAGSC FIFLVGTKKD LLSGAACEQA
260 270 280 290 300
EADAVHLARE MQAEYWSVSA KTGENVKAFF SRVAALAFEQ SVLQDLERQS
310 320 330
SARLQVGNGD LIQMEGSPPE TQESKRPSSL GCC
Length:333
Mass (Da):36,322
Last modified:April 26, 2004 - v2
Checksum:iFFDD522F6DE40A2D
GO
Isoform 2 (identifier: O95755-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-142: Missing.

Note: No experimental confirmation available.
Show »
Length:311
Mass (Da):33,915
Checksum:i03099737E46D6D13
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0Z1H7C0Z1_HUMAN
Ras-related protein Rab-36
RAB36
132Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42I → N in AAQ16115 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03443350P → L. Corresponds to variant dbSNP:rs9624036Ensembl.1
Natural variantiVAR_024189308N → D1 PublicationCorresponds to variant dbSNP:rs5759612Ensembl.1
Natural variantiVAR_051715320E → K. Corresponds to variant dbSNP:rs9624038Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010143121 – 142Missing in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023061 mRNA Translation: BAA75195.1
AF133588 mRNA Translation: AAF02485.1
AY336745 mRNA Translation: AAQ16115.1
CR456553 mRNA Translation: CAG30439.1
BC104989 mRNA Translation: AAI04990.1
BC104991 mRNA Translation: AAI04992.1
CCDSiCCDS13805.1 [O95755-1]
RefSeqiNP_004905.2, NM_004914.3 [O95755-1]
UniGeneiHs.353024
Hs.369557

Genome annotation databases

EnsembliENST00000263116; ENSP00000263116; ENSG00000100228 [O95755-1]
ENST00000341989; ENSP00000343494; ENSG00000100228 [O95755-2]
GeneIDi9609
KEGGihsa:9609
UCSCiuc002zwv.2 human [O95755-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023061 mRNA Translation: BAA75195.1
AF133588 mRNA Translation: AAF02485.1
AY336745 mRNA Translation: AAQ16115.1
CR456553 mRNA Translation: CAG30439.1
BC104989 mRNA Translation: AAI04990.1
BC104991 mRNA Translation: AAI04992.1
CCDSiCCDS13805.1 [O95755-1]
RefSeqiNP_004905.2, NM_004914.3 [O95755-1]
UniGeneiHs.353024
Hs.369557

3D structure databases

ProteinModelPortaliO95755
SMRiO95755
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114971, 2 interactors
IntActiO95755, 1 interactor
STRINGi9606.ENSP00000263116

PTM databases

iPTMnetiO95755
PhosphoSitePlusiO95755

Polymorphism and mutation databases

BioMutaiRAB36

2D gel databases

REPRODUCTION-2DPAGEiO95755

Proteomic databases

EPDiO95755
MaxQBiO95755
PaxDbiO95755
PeptideAtlasiO95755
PRIDEiO95755
ProteomicsDBi51025
51026 [O95755-2]
TopDownProteomicsiO95755-1 [O95755-1]

Protocols and materials databases

DNASUi9609
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263116; ENSP00000263116; ENSG00000100228 [O95755-1]
ENST00000341989; ENSP00000343494; ENSG00000100228 [O95755-2]
GeneIDi9609
KEGGihsa:9609
UCSCiuc002zwv.2 human [O95755-1]

Organism-specific databases

CTDi9609
EuPathDBiHostDB:ENSG00000100228.12
GeneCardsiRAB36
H-InvDBiHIX0027922
HGNCiHGNC:9775 RAB36
HPAiHPA059631
MIMi605662 gene
neXtProtiNX_O95755
OpenTargetsiENSG00000100228
PharmGKBiPA34128
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0094 Eukaryota
ENOG410XPBI LUCA
GeneTreeiENSGT00910000144073
HOGENOMiHOG000233970
HOVERGENiHBG106693
InParanoidiO95755
KOiK07922
OMAiNEPASCF
OrthoDBiEOG091G0EPX
PhylomeDBiO95755
TreeFamiTF326626

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic
R-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

ChiTaRSiRAB36 human
GeneWikiiRAB36
GenomeRNAii9609
PROiPR:O95755
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100228 Expressed in 143 organ(s), highest expression level in right uterine tube
CleanExiHS_RAB36
ExpressionAtlasiO95755 baseline and differential
GenevisibleiO95755 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB36_HUMAN
AccessioniPrimary (citable) accession number: O95755
Secondary accession number(s): Q2M390, Q7Z4A9, Q9UHP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 26, 2004
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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