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Protein

Protein LDOC1

Gene

LDOC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have an important role in the development and/or progression of some cancers.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LDOC1
Alternative name(s):
Leucine zipper protein down-regulated in cancer cells
Gene namesi
Name:LDOC1
Synonyms:BCUR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000182195.7
HGNCiHGNC:6548 LDOC1
MIMi300402 gene
neXtProtiNX_O95751

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23641
OpenTargetsiENSG00000182195
PharmGKBiPA30329

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843911 – 146Protein LDOC1Add BLAST146

Proteomic databases

EPDiO95751
MaxQBiO95751
PaxDbiO95751
PeptideAtlasiO95751
PRIDEiO95751
ProteomicsDBi51022

Expressioni

Tissue specificityi

Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.1 Publication

Inductioni

Down-regulated by muramyl-dipeptide and lipopolysaccharide.1 Publication

Gene expression databases

BgeeiENSG00000182195 Expressed in 215 organ(s), highest expression level in thoracic aorta
CleanExiHS_LDOC1
GenevisibleiO95751 HS

Organism-specific databases

HPAiHPA051768
HPA061842

Interactioni

Subunit structurei

Interacts with NOD2.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi117169, 74 interactors
IntActiO95751, 107 interactors
MINTiO95751
STRINGi9606.ENSP00000359557

Structurei

3D structure databases

ProteinModelPortaliO95751
SMRiO95751
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 145Asp/Glu-rich (highly acidic)Add BLAST14

Sequence similaritiesi

Belongs to the LDOC1 family.Curated

Phylogenomic databases

eggNOGiENOG410J3P7 Eukaryota
ENOG410Y6K0 LUCA
GeneTreeiENSGT00510000047956
HOGENOMiHOG000049195
HOVERGENiHBG052318
InParanoidiO95751
OMAiQTTSYML
OrthoDBiEOG091G02TH
PhylomeDBiO95751
TreeFamiTF337843

Family and domain databases

InterProiView protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit

Sequencei

Sequence statusi: Complete.

O95751-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDELVLLLH ALLMRHRALS IENSQLMEQL RLLVCERASL LRQVRPPSCP
60 70 80 90 100
VPFPETFNGE SSRLPEFIVQ TASYMLVNEN RFCNDAMKVA FLISLLTGEA
110 120 130 140
EEWVVPYIEM DSPILGDYRA FLDEMKQCFG WDDDEDDDDE EEEDDY
Length:146
Mass (Da):16,968
Last modified:May 1, 1999 - v1
Checksum:i3D02813B2DE52DBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019527 mRNA Translation: BAA34364.1
CR457088 mRNA Translation: CAG33369.1
AL109799 Genomic DNA Translation: CAC18891.1
BC003104 mRNA Translation: AAH03104.1
CCDSiCCDS14672.1
RefSeqiNP_036449.1, NM_012317.3
UniGeneiHs.45231

Genome annotation databases

EnsembliENST00000370526; ENSP00000359557; ENSG00000182195
GeneIDi23641
KEGGihsa:23641
UCSCiuc004fbj.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019527 mRNA Translation: BAA34364.1
CR457088 mRNA Translation: CAG33369.1
AL109799 Genomic DNA Translation: CAC18891.1
BC003104 mRNA Translation: AAH03104.1
CCDSiCCDS14672.1
RefSeqiNP_036449.1, NM_012317.3
UniGeneiHs.45231

3D structure databases

ProteinModelPortaliO95751
SMRiO95751
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117169, 74 interactors
IntActiO95751, 107 interactors
MINTiO95751
STRINGi9606.ENSP00000359557

Proteomic databases

EPDiO95751
MaxQBiO95751
PaxDbiO95751
PeptideAtlasiO95751
PRIDEiO95751
ProteomicsDBi51022

Protocols and materials databases

DNASUi23641
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370526; ENSP00000359557; ENSG00000182195
GeneIDi23641
KEGGihsa:23641
UCSCiuc004fbj.5 human

Organism-specific databases

CTDi23641
DisGeNETi23641
EuPathDBiHostDB:ENSG00000182195.7
GeneCardsiLDOC1
HGNCiHGNC:6548 LDOC1
HPAiHPA051768
HPA061842
MIMi300402 gene
neXtProtiNX_O95751
OpenTargetsiENSG00000182195
PharmGKBiPA30329
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3P7 Eukaryota
ENOG410Y6K0 LUCA
GeneTreeiENSGT00510000047956
HOGENOMiHOG000049195
HOVERGENiHBG052318
InParanoidiO95751
OMAiQTTSYML
OrthoDBiEOG091G02TH
PhylomeDBiO95751
TreeFamiTF337843

Miscellaneous databases

ChiTaRSiLDOC1 human
GeneWikiiLDOC1
GenomeRNAii23641
PROiPR:O95751
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182195 Expressed in 215 organ(s), highest expression level in thoracic aorta
CleanExiHS_LDOC1
GenevisibleiO95751 HS

Family and domain databases

InterProiView protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLDOC1_HUMAN
AccessioniPrimary (citable) accession number: O95751
Secondary accession number(s): Q6IAR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 10, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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