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UniProtKB - O95751 (LDOC1_HUMAN)
Protein
Protein LDOC1
Gene
LDOC1
Organism
Homo sapiens (Human)
Status
Functioni
May have an important role in the development and/or progression of some cancers.
GO - Biological processi
- cellular response to lipopolysaccharide Source: UniProtKB
- cellular response to muramyl dipeptide Source: UniProtKB
- maternal placenta development Source: Ensembl
- maternal process involved in parturition Source: Ensembl
- negative regulation of cell population proliferation Source: ProtInc
- regulation of growth hormone activity Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | O95751 |
SignaLinki | O95751 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein LDOC1Alternative name(s): Leucine zipper protein down-regulated in cancer cells |
Gene namesi | Name:LDOC1 Synonyms:BCUR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6548, LDOC1 |
MIMi | 300402, gene |
neXtProti | NX_O95751 |
VEuPathDBi | HostDB:ENSG00000182195 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: ProtInc
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 23641 |
OpenTargetsi | ENSG00000182195 |
PharmGKBi | PA30329 |
Miscellaneous databases
Pharosi | O95751, Tbio |
Genetic variation databases
BioMutai | LDOC1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084391 | 1 – 146 | Protein LDOC1Add BLAST | 146 |
Proteomic databases
EPDi | O95751 |
MassIVEi | O95751 |
MaxQBi | O95751 |
PaxDbi | O95751 |
PeptideAtlasi | O95751 |
PRIDEi | O95751 |
ProteomicsDBi | 51022 |
Expressioni
Tissue specificityi
Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.1 Publication
Inductioni
Down-regulated by muramyl-dipeptide and lipopolysaccharide.1 Publication
Gene expression databases
Bgeei | ENSG00000182195, Expressed in thoracic aorta and 228 other tissues |
Genevisiblei | O95751, HS |
Organism-specific databases
HPAi | ENSG00000182195, Tissue enhanced (pituitary) |
Interactioni
Subunit structurei
Interacts with NOD2.
1 PublicationBinary interactionsi
O95751
Protein-protein interaction databases
BioGRIDi | 117169, 122 interactors |
IntActi | O95751, 117 interactors |
MINTi | O95751 |
STRINGi | 9606.ENSP00000359557 |
Miscellaneous databases
RNActi | O95751, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the LDOC1 family.Curated
Phylogenomic databases
eggNOGi | ENOG502T19P, Eukaryota |
GeneTreei | ENSGT00940000162721 |
HOGENOMi | CLU_154949_0_0_1 |
InParanoidi | O95751 |
OMAi | QTTSYML |
OrthoDBi | 1526235at2759 |
PhylomeDBi | O95751 |
TreeFami | TF337843 |
Family and domain databases
InterProi | View protein in InterPro IPR032549, DUF4939 IPR032567, LDOC1-rel |
PANTHERi | PTHR15503, PTHR15503, 1 hit |
Pfami | View protein in Pfam PF16297, DUF4939, 1 hit |
i Sequence
Sequence statusi: Complete.
O95751-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVDELVLLLH ALLMRHRALS IENSQLMEQL RLLVCERASL LRQVRPPSCP
60 70 80 90 100
VPFPETFNGE SSRLPEFIVQ TASYMLVNEN RFCNDAMKVA FLISLLTGEA
110 120 130 140
EEWVVPYIEM DSPILGDYRA FLDEMKQCFG WDDDEDDDDE EEEDDY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB019527 mRNA Translation: BAA34364.1 CR457088 mRNA Translation: CAG33369.1 AL109799 Genomic DNA Translation: CAC18891.1 BC003104 mRNA Translation: AAH03104.1 |
CCDSi | CCDS14672.1 |
RefSeqi | NP_036449.1, NM_012317.3 |
Genome annotation databases
Ensembli | ENST00000370526; ENSP00000359557; ENSG00000182195 |
GeneIDi | 23641 |
KEGGi | hsa:23641 |
MANE-Selecti | ENST00000370526.5; ENSP00000359557.2; NM_012317.4; NP_036449.1 |
UCSCi | uc004fbj.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB019527 mRNA Translation: BAA34364.1 CR457088 mRNA Translation: CAG33369.1 AL109799 Genomic DNA Translation: CAC18891.1 BC003104 mRNA Translation: AAH03104.1 |
CCDSi | CCDS14672.1 |
RefSeqi | NP_036449.1, NM_012317.3 |
3D structure databases
SMRi | O95751 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117169, 122 interactors |
IntActi | O95751, 117 interactors |
MINTi | O95751 |
STRINGi | 9606.ENSP00000359557 |
Genetic variation databases
BioMutai | LDOC1 |
Proteomic databases
EPDi | O95751 |
MassIVEi | O95751 |
MaxQBi | O95751 |
PaxDbi | O95751 |
PeptideAtlasi | O95751 |
PRIDEi | O95751 |
ProteomicsDBi | 51022 |
Protocols and materials databases
Antibodypediai | 16816, 204 antibodies from 26 providers |
DNASUi | 23641 |
Genome annotation databases
Ensembli | ENST00000370526; ENSP00000359557; ENSG00000182195 |
GeneIDi | 23641 |
KEGGi | hsa:23641 |
MANE-Selecti | ENST00000370526.5; ENSP00000359557.2; NM_012317.4; NP_036449.1 |
UCSCi | uc004fbj.5, human |
Organism-specific databases
CTDi | 23641 |
DisGeNETi | 23641 |
GeneCardsi | LDOC1 |
HGNCi | HGNC:6548, LDOC1 |
HPAi | ENSG00000182195, Tissue enhanced (pituitary) |
MIMi | 300402, gene |
neXtProti | NX_O95751 |
OpenTargetsi | ENSG00000182195 |
PharmGKBi | PA30329 |
VEuPathDBi | HostDB:ENSG00000182195 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502T19P, Eukaryota |
GeneTreei | ENSGT00940000162721 |
HOGENOMi | CLU_154949_0_0_1 |
InParanoidi | O95751 |
OMAi | QTTSYML |
OrthoDBi | 1526235at2759 |
PhylomeDBi | O95751 |
TreeFami | TF337843 |
Enzyme and pathway databases
PathwayCommonsi | O95751 |
SignaLinki | O95751 |
Miscellaneous databases
BioGRID-ORCSi | 23641, 6 hits in 669 CRISPR screens |
ChiTaRSi | LDOC1, human |
GeneWikii | LDOC1 |
GenomeRNAii | 23641 |
Pharosi | O95751, Tbio |
PROi | PR:O95751 |
RNActi | O95751, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182195, Expressed in thoracic aorta and 228 other tissues |
Genevisiblei | O95751, HS |
Family and domain databases
InterProi | View protein in InterPro IPR032549, DUF4939 IPR032567, LDOC1-rel |
PANTHERi | PTHR15503, PTHR15503, 1 hit |
Pfami | View protein in Pfam PF16297, DUF4939, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LDOC1_HUMAN | |
Accessioni | O95751Primary (citable) accession number: O95751 Secondary accession number(s): Q6IAR6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families