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Protein

Fibroblast growth factor 19

Gene

FGF19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.4 Publications

Miscellaneous

Contrarily to other members of the family that can bind several FGF receptors FGF19 is specific for FGFR4.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1307965 betaKlotho-mediated ligand binding
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SIGNORiO95750

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 19
Short name:
FGF-19
Gene namesi
Name:FGF19
ORF Names:UNQ334/PRO533
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000162344.3
HGNCiHGNC:3675 FGF19
MIMi603891 gene
neXtProtiNX_O95750

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9965
OpenTargetsiENSG00000162344
PharmGKBiPA28114

Polymorphism and mutation databases

BioMutaiFGF19

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000000899325 – 216Fibroblast growth factor 19Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 701 Publication
Disulfide bondi102 ↔ 1201 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO95750
PeptideAtlasiO95750
PRIDEiO95750
ProteomicsDBi51021

PTM databases

iPTMnetiO95750
PhosphoSitePlusiO95750

Expressioni

Tissue specificityi

Expressed in fetal brain, cartilage, retina, and adult gall bladder.1 Publication

Inductioni

Induced by the bile acids receptor NR1H4 that binds and activates a NR1H4-responsive element within intron 2.1 Publication

Gene expression databases

BgeeiENSG00000162344 Expressed in 14 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_FGF19
GenevisibleiO95750 HS

Organism-specific databases

HPAiHPA036082

Interactioni

Subunit structurei

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with KL; this interaction is direct. Interacts with KLB; this interaction is direct. Interacts with FGFR4 in the presence of heparin, KL or KLB. Interacts with MALRD1 (PubMed:23747249).6 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115290, 1 interactor
CORUMiO95750
DIPiDIP-6039N
IntActiO95750, 2 interactors
STRINGi9606.ENSP00000294312

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95750
SMRiO95750
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95750

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00530000063469
HOGENOMiHOG000112572
HOVERGENiHBG051611
InParanoidiO95750
KOiK22603
OMAiHSLMEIR
OrthoDBiEOG091G0NAY
PhylomeDBiO95750
TreeFamiTF335872

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR035444 FGF15/19/21
IPR028303 FGF15/FGF19
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF74 PTHR11486:SF74, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PIRSFiPIRSF037961 FGF-19_FGF-21, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95750-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSGCVVVHV WILAGLWLAV AGRPLAFSDA GPHVHYGWGD PIRLRHLYTS
60 70 80 90 100
GPHGLSSCFL RIRADGVVDC ARGQSAHSLL EIKAVALRTV AIKGVHSVRY
110 120 130 140 150
LCMGADGKMQ GLLQYSEEDC AFEEEIRPDG YNVYRSEKHR LPVSLSSAKQ
160 170 180 190 200
RQLYKNRGFL PLSHFLPMLP MVPEEPEDLR GHLESDMFSS PLETDSMDPF
210
GLVTGLEAVR SPSFEK
Length:216
Mass (Da):24,003
Last modified:May 1, 1999 - v1
Checksum:iE0BCBC9C220F9832
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018122 mRNA Translation: BAA75500.1
AF110400 mRNA Translation: AAD45973.1
AY358302 mRNA Translation: AAQ88669.1
BT006729 mRNA Translation: AAP35375.1
BC017664 mRNA Translation: AAH17664.1
CCDSiCCDS8193.1
RefSeqiNP_005108.1, NM_005117.2
UniGeneiHs.249200

Genome annotation databases

EnsembliENST00000294312; ENSP00000294312; ENSG00000162344
GeneIDi9965
KEGGihsa:9965
UCSCiuc001opf.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018122 mRNA Translation: BAA75500.1
AF110400 mRNA Translation: AAD45973.1
AY358302 mRNA Translation: AAQ88669.1
BT006729 mRNA Translation: AAP35375.1
BC017664 mRNA Translation: AAH17664.1
CCDSiCCDS8193.1
RefSeqiNP_005108.1, NM_005117.2
UniGeneiHs.249200

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PWAX-ray1.30A39-196[»]
2P23X-ray1.80A/B23-216[»]
ProteinModelPortaliO95750
SMRiO95750
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115290, 1 interactor
CORUMiO95750
DIPiDIP-6039N
IntActiO95750, 2 interactors
STRINGi9606.ENSP00000294312

PTM databases

iPTMnetiO95750
PhosphoSitePlusiO95750

Polymorphism and mutation databases

BioMutaiFGF19

Proteomic databases

PaxDbiO95750
PeptideAtlasiO95750
PRIDEiO95750
ProteomicsDBi51021

Protocols and materials databases

DNASUi9965
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294312; ENSP00000294312; ENSG00000162344
GeneIDi9965
KEGGihsa:9965
UCSCiuc001opf.4 human

Organism-specific databases

CTDi9965
DisGeNETi9965
EuPathDBiHostDB:ENSG00000162344.3
GeneCardsiFGF19
HGNCiHGNC:3675 FGF19
HPAiHPA036082
MIMi603891 gene
neXtProtiNX_O95750
OpenTargetsiENSG00000162344
PharmGKBiPA28114
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00530000063469
HOGENOMiHOG000112572
HOVERGENiHBG051611
InParanoidiO95750
KOiK22603
OMAiHSLMEIR
OrthoDBiEOG091G0NAY
PhylomeDBiO95750
TreeFamiTF335872

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1307965 betaKlotho-mediated ligand binding
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SIGNORiO95750

Miscellaneous databases

EvolutionaryTraceiO95750
GeneWikiiFGF19
GenomeRNAii9965
PROiPR:O95750
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162344 Expressed in 14 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_FGF19
GenevisibleiO95750 HS

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR035444 FGF15/19/21
IPR028303 FGF15/FGF19
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF74 PTHR11486:SF74, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PIRSFiPIRSF037961 FGF-19_FGF-21, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGF19_HUMAN
AccessioniPrimary (citable) accession number: O95750
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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