UniProtKB - O95747 (OXSR1_HUMAN)
Serine/threonine-protein kinase OSR1
OXSR1
Functioni
Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764).
Phosphorylates PAK1 (PubMed:14707132).
Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202).
4 PublicationsCatalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 46 | ATPPROSITE-ProRule annotation1 Publication | 1 | |
Active sitei | 146 | Proton acceptorPROSITE-ProRule annotationBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 23 – 31 | ATPPROSITE-ProRule annotationBy similarity | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- identical protein binding Source: IntAct
- magnesium ion binding Source: UniProtKB
- protein kinase binding Source: ParkinsonsUK-UCL
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
GO - Biological processi
- cellular hypotonic response Source: Ensembl
- cellular response to chemokine Source: BHF-UCL
- chemokine (C-C motif) ligand 21 signaling pathway Source: BHF-UCL
- chemokine (C-X-C motif) ligand 12 signaling pathway Source: BHF-UCL
- intracellular signal transduction Source: UniProtKB
- negative regulation of potassium ion transmembrane transporter activity Source: Ensembl
- osmosensory signaling pathway Source: ParkinsonsUK-UCL
- peptidyl-threonine phosphorylation Source: ParkinsonsUK-UCL
- positive regulation of T cell chemotaxis Source: BHF-UCL
- protein autophosphorylation Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- response to oxidative stress Source: ProtInc
- signal transduction Source: ParkinsonsUK-UCL
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O95747 |
SignaLinki | O95747 |
SIGNORi | O95747 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase OSR1 (EC:2.7.11.1)Alternative name(s): Oxidative stress-responsive 1 protein |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8508, OXSR1 |
MIMi | 604046, gene |
neXtProti | NX_O95747 |
VEuPathDBi | HostDB:ENSG00000172939 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 46 | K → A: Loss of autophosphorylation and kinase activity. 2 Publications | 1 | |
Mutagenesisi | 46 | K → M: Loss of RELT, RELL1 and RELL2 phosphorylation. Retention of some autophosphorylation activity may be due to complex formation with other endogenous kinases in the assay. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 9943 |
OpenTargetsi | ENSG00000172939 |
PharmGKBi | PA134973207 |
Miscellaneous databases
Pharosi | O95747, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1163104 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | O95747 |
Genetic variation databases
BioMutai | OXSR1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000086456 | 2 – 527 | Serine/threonine-protein kinase OSR1Add BLAST | 526 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 310 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 324 | PhosphoserineCombined sources | 1 | |
Modified residuei | 325 | PhosphoserineCombined sources | 1 | |
Modified residuei | 339 | PhosphoserineCombined sources | 1 | |
Modified residuei | 347 | PhosphoserineCombined sources | 1 | |
Modified residuei | 359 | PhosphoserineCombined sources | 1 | |
Modified residuei | 427 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O95747 |
jPOSTi | O95747 |
MassIVEi | O95747 |
MaxQBi | O95747 |
PaxDbi | O95747 |
PeptideAtlasi | O95747 |
PRIDEi | O95747 |
ProteomicsDBi | 51019 |
PTM databases
iPTMneti | O95747 |
PhosphoSitePlusi | O95747 |
SwissPalmi | O95747 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000172939, Expressed in buccal mucosa cell and 243 other tissues |
ExpressionAtlasi | O95747, baseline and differential |
Genevisiblei | O95747, HS |
Organism-specific databases
HPAi | ENSG00000172939, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PAK1 (PubMed:14707132).
Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress (By similarity).
Interacts with RELL1, RELL2 and RELT (PubMed:16389068).
Interacts with PLSCR1 in the presence of RELT (PubMed:22052202).
By similarity3 PublicationsBinary interactionsi
O95747
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein kinase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 115269, 116 interactors |
CORUMi | O95747 |
DIPi | DIP-34977N |
ELMi | O95747 |
IntActi | O95747, 22 interactors |
MINTi | O95747 |
STRINGi | 9606.ENSP00000311713 |
Chemistry databases
BindingDBi | O95747 |
Miscellaneous databases
RNActi | O95747, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O95747 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O95747 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 291 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 275 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 315 – 360 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 405 – 427 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 315 – 336 | Basic and acidic residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0582, Eukaryota |
GeneTreei | ENSGT00940000162134 |
HOGENOMi | CLU_000288_111_1_1 |
InParanoidi | O95747 |
OMAi | TSNCKQG |
OrthoDBi | 789556at2759 |
PhylomeDBi | O95747 |
TreeFami | TF105339 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR024678, Kinase_OSR1/WNK_CCT IPR028749, Oxsr1 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS |
PANTHERi | PTHR48012:SF1, PTHR48012:SF1, 1 hit |
Pfami | View protein in Pfam PF12202, OSR1_C, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSEDSSALPW SINRDDYELQ EVIGSGATAV VQAAYCAPKK EKVAIKRINL
60 70 80 90 100
EKCQTSMDEL LKEIQAMSQC HHPNIVSYYT SFVVKDELWL VMKLLSGGSV
110 120 130 140 150
LDIIKHIVAK GEHKSGVLDE STIATILREV LEGLEYLHKN GQIHRDVKAG
160 170 180 190 200
NILLGEDGSV QIADFGVSAF LATGGDITRN KVRKTFVGTP CWMAPEVMEQ
210 220 230 240 250
VRGYDFKADI WSFGITAIEL ATGAAPYHKY PPMKVLMLTL QNDPPSLETG
260 270 280 290 300
VQDKEMLKKY GKSFRKMISL CLQKDPEKRP TAAELLRHKF FQKAKNKEFL
310 320 330 340 350
QEKTLQRAPT ISERAKKVRR VPGSSGRLHK TEDGGWEWSD DEFDEESEEG
360 370 380 390 400
KAAISQLRSP RVKESISNSE LFPTTDPVGT LLQVPEQISA HLPQPAGQIA
410 420 430 440 450
TQPTQVSLPP TAEPAKTAQA LSSGSGSQET KIPISLVLRL RNSKKELNDI
460 470 480 490 500
RFEFTPGRDT AEGVSQELIS AGLVDGRDLV IVAANLQKIV EEPQSNRSVT
510 520
FKLASGVEGS DIPDDGKLIG FAQLSIS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JIG9 | C9JIG9_HUMAN | Non-specific serine/threonine prote... | OXSR1 | 468 | Annotation score: | ||
F8WBK9 | F8WBK9_HUMAN | Serine/threonine-protein kinase OSR... | OXSR1 | 113 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 316 | K → R in AAP97192 (Ref. 5) Curated | 1 | |
Sequence conflicti | 325 | S → G in AAP97192 (Ref. 5) Curated | 1 | |
Sequence conflicti | 363 | K → R in AAP97192 (Ref. 5) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023232 | 304 | T → I3 PublicationsCorresponds to variant dbSNP:rs6599079Ensembl. | 1 | |
Natural variantiVAR_025181 | 425 | S → T1 PublicationCorresponds to variant dbSNP:rs35295772Ensembl. | 1 | |
Natural variantiVAR_040969 | 433 | P → S in a metastatic melanoma sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB017642 mRNA Translation: BAA75674.1 AB029024 mRNA Translation: BAA83053.2 Frameshift. DQ201638 Genomic DNA Translation: ABA27097.1 BC008726 mRNA Translation: AAH08726.1 AF087893 mRNA Translation: AAP97192.1 Different initiation. |
CCDSi | CCDS2675.1 |
RefSeqi | NP_005100.1, NM_005109.2 |
Genome annotation databases
Ensembli | ENST00000311806; ENSP00000311713; ENSG00000172939 |
GeneIDi | 9943 |
KEGGi | hsa:9943 |
MANE-Selecti | ENST00000311806.8; ENSP00000311713.3; NM_005109.3; NP_005100.1 |
UCSCi | uc003chy.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB017642 mRNA Translation: BAA75674.1 AB029024 mRNA Translation: BAA83053.2 Frameshift. DQ201638 Genomic DNA Translation: ABA27097.1 BC008726 mRNA Translation: AAH08726.1 AF087893 mRNA Translation: AAP97192.1 Different initiation. |
CCDSi | CCDS2675.1 |
RefSeqi | NP_005100.1, NM_005109.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2V3S | X-ray | 1.70 | A/B | 433-527 | [»] | |
2VWI | X-ray | 2.15 | A/B/C/D | 1-303 | [»] | |
3DAK | X-ray | 2.25 | A/B/C/D | 6-295 | [»] | |
7OKW | X-ray | 1.62 | A/B | 423-527 | [»] | |
SMRi | O95747 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115269, 116 interactors |
CORUMi | O95747 |
DIPi | DIP-34977N |
ELMi | O95747 |
IntActi | O95747, 22 interactors |
MINTi | O95747 |
STRINGi | 9606.ENSP00000311713 |
Chemistry databases
BindingDBi | O95747 |
ChEMBLi | CHEMBL1163104 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | O95747 |
PTM databases
iPTMneti | O95747 |
PhosphoSitePlusi | O95747 |
SwissPalmi | O95747 |
Genetic variation databases
BioMutai | OXSR1 |
Proteomic databases
EPDi | O95747 |
jPOSTi | O95747 |
MassIVEi | O95747 |
MaxQBi | O95747 |
PaxDbi | O95747 |
PeptideAtlasi | O95747 |
PRIDEi | O95747 |
ProteomicsDBi | 51019 |
Protocols and materials databases
Antibodypediai | 2101, 533 antibodies from 37 providers |
DNASUi | 9943 |
Genome annotation databases
Ensembli | ENST00000311806; ENSP00000311713; ENSG00000172939 |
GeneIDi | 9943 |
KEGGi | hsa:9943 |
MANE-Selecti | ENST00000311806.8; ENSP00000311713.3; NM_005109.3; NP_005100.1 |
UCSCi | uc003chy.4, human |
Organism-specific databases
CTDi | 9943 |
DisGeNETi | 9943 |
GeneCardsi | OXSR1 |
HGNCi | HGNC:8508, OXSR1 |
HPAi | ENSG00000172939, Low tissue specificity |
MIMi | 604046, gene |
neXtProti | NX_O95747 |
OpenTargetsi | ENSG00000172939 |
PharmGKBi | PA134973207 |
VEuPathDBi | HostDB:ENSG00000172939 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0582, Eukaryota |
GeneTreei | ENSGT00940000162134 |
HOGENOMi | CLU_000288_111_1_1 |
InParanoidi | O95747 |
OMAi | TSNCKQG |
OrthoDBi | 789556at2759 |
PhylomeDBi | O95747 |
TreeFami | TF105339 |
Enzyme and pathway databases
PathwayCommonsi | O95747 |
SignaLinki | O95747 |
SIGNORi | O95747 |
Miscellaneous databases
BioGRID-ORCSi | 9943, 12 hits in 1081 CRISPR screens |
ChiTaRSi | OXSR1, human |
EvolutionaryTracei | O95747 |
GeneWikii | OXSR1 |
GenomeRNAii | 9943 |
Pharosi | O95747, Tbio |
PROi | PR:O95747 |
RNActi | O95747, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172939, Expressed in buccal mucosa cell and 243 other tissues |
ExpressionAtlasi | O95747, baseline and differential |
Genevisiblei | O95747, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR024678, Kinase_OSR1/WNK_CCT IPR028749, Oxsr1 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS |
PANTHERi | PTHR48012:SF1, PTHR48012:SF1, 1 hit |
Pfami | View protein in Pfam PF12202, OSR1_C, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OXSR1_HUMAN | |
Accessioni | O95747Primary (citable) accession number: O95747 Secondary accession number(s): Q3LR53, Q7Z501, Q9UPQ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 194 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families