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Protein

Serine/threonine-protein kinase OSR1

Gene

OXSR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202).4 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Activity regulationi

By autophosphorylation on threonine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46ATPPROSITE-ProRule annotation1 Publication1
Active sitei146Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 31ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • magnesium ion binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiO95747
SIGNORiO95747

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase OSR1 (EC:2.7.11.1)
Alternative name(s):
Oxidative stress-responsive 1 protein
Gene namesi
Name:OXSR1Imported
Synonyms:KIAA1101Imported, OSR1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000172939.8
HGNCiHGNC:8508 OXSR1
MIMi604046 gene
neXtProtiNX_O95747

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi46K → A: Loss of autophosphorylation and kinase activity. 2 Publications1
Mutagenesisi46K → M: Loss of RELT, RELL1 and RELL2 phosphorylation. Retention of some autophosphorylation activity may be due to complex formation with other endogenous kinases in the assay. 2 Publications1

Organism-specific databases

DisGeNETi9943
OpenTargetsiENSG00000172939
PharmGKBiPA134973207

Chemistry databases

ChEMBLiCHEMBL1163104

Polymorphism and mutation databases

BioMutaiOXSR1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000864562 – 527Serine/threonine-protein kinase OSR1Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei310PhosphothreonineCombined sources1
Modified residuei324PhosphoserineCombined sources1
Modified residuei325PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1
Modified residuei427PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95747
MaxQBiO95747
PaxDbiO95747
PeptideAtlasiO95747
PRIDEiO95747
ProteomicsDBi51019

PTM databases

iPTMnetiO95747
PhosphoSitePlusiO95747
SwissPalmiO95747

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissue examined.1 Publication

Gene expression databases

BgeeiENSG00000172939 Expressed in 229 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_OSR1
HS_OXSR1
ExpressionAtlasiO95747 baseline and differential
GenevisibleiO95747 HS

Organism-specific databases

HPAiCAB017181
HPA008237

Interactioni

Subunit structurei

Interacts with PAK1 (PubMed:14707132). Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress (By similarity). Interacts with RELL1, RELL2 and RELT (PubMed:16389068). Interacts with PLSCR1 in the presence of RELT (PubMed:22052202).By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115269, 34 interactors
CORUMiO95747
DIPiDIP-34977N
ELMiO95747
IntActiO95747, 13 interactors
MINTiO95747
STRINGi9606.ENSP00000311713

Chemistry databases

BindingDBiO95747

Structurei

Secondary structure

1527
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95747
SMRiO95747
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95747

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 291Protein kinasePROSITE-ProRule annotationAdd BLAST275

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0582 Eukaryota
ENOG410XSWS LUCA
GeneTreeiENSGT00930000150829
HOGENOMiHOG000234204
HOVERGENiHBG108518
InParanoidiO95747
KOiK08835
OMAiEPQANRS
OrthoDBiEOG091G0AKO
PhylomeDBiO95747
TreeFamiTF105339

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR024678 Kinase_OSR1/WNK_CCT
IPR028749 Oxsr1
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PANTHERiPTHR24361:SF435 PTHR24361:SF435, 1 hit
PfamiView protein in Pfam
PF12202 OSR1_C, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O95747-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEDSSALPW SINRDDYELQ EVIGSGATAV VQAAYCAPKK EKVAIKRINL
60 70 80 90 100
EKCQTSMDEL LKEIQAMSQC HHPNIVSYYT SFVVKDELWL VMKLLSGGSV
110 120 130 140 150
LDIIKHIVAK GEHKSGVLDE STIATILREV LEGLEYLHKN GQIHRDVKAG
160 170 180 190 200
NILLGEDGSV QIADFGVSAF LATGGDITRN KVRKTFVGTP CWMAPEVMEQ
210 220 230 240 250
VRGYDFKADI WSFGITAIEL ATGAAPYHKY PPMKVLMLTL QNDPPSLETG
260 270 280 290 300
VQDKEMLKKY GKSFRKMISL CLQKDPEKRP TAAELLRHKF FQKAKNKEFL
310 320 330 340 350
QEKTLQRAPT ISERAKKVRR VPGSSGRLHK TEDGGWEWSD DEFDEESEEG
360 370 380 390 400
KAAISQLRSP RVKESISNSE LFPTTDPVGT LLQVPEQISA HLPQPAGQIA
410 420 430 440 450
TQPTQVSLPP TAEPAKTAQA LSSGSGSQET KIPISLVLRL RNSKKELNDI
460 470 480 490 500
RFEFTPGRDT AEGVSQELIS AGLVDGRDLV IVAANLQKIV EEPQSNRSVT
510 520
FKLASGVEGS DIPDDGKLIG FAQLSIS
Length:527
Mass (Da):58,022
Last modified:May 1, 1999 - v1
Checksum:iB46EC934E95A3A1F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JIG9C9JIG9_HUMAN
Serine/threonine-protein kinase OSR...
OXSR1
468Annotation score:
F8WBK9F8WBK9_HUMAN
Serine/threonine-protein kinase OSR...
OXSR1
113Annotation score:

Sequence cautioni

The sequence AAP97192 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA83053 differs from that shown. Reason: Frameshift at position 63.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti316K → R in AAP97192 (Ref. 5) Curated1
Sequence conflicti325S → G in AAP97192 (Ref. 5) Curated1
Sequence conflicti363K → R in AAP97192 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023232304T → I3 PublicationsCorresponds to variant dbSNP:rs6599079Ensembl.1
Natural variantiVAR_025181425S → T1 PublicationCorresponds to variant dbSNP:rs35295772Ensembl.1
Natural variantiVAR_040969433P → S in a metastatic melanoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017642 mRNA Translation: BAA75674.1
AB029024 mRNA Translation: BAA83053.2 Frameshift.
DQ201638 Genomic DNA Translation: ABA27097.1
BC008726 mRNA Translation: AAH08726.1
AF087893 mRNA Translation: AAP97192.1 Different initiation.
CCDSiCCDS2675.1
RefSeqiNP_005100.1, NM_005109.2
UniGeneiHs.475970

Genome annotation databases

EnsembliENST00000311806; ENSP00000311713; ENSG00000172939
GeneIDi9943
KEGGihsa:9943
UCSCiuc003chy.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017642 mRNA Translation: BAA75674.1
AB029024 mRNA Translation: BAA83053.2 Frameshift.
DQ201638 Genomic DNA Translation: ABA27097.1
BC008726 mRNA Translation: AAH08726.1
AF087893 mRNA Translation: AAP97192.1 Different initiation.
CCDSiCCDS2675.1
RefSeqiNP_005100.1, NM_005109.2
UniGeneiHs.475970

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V3SX-ray1.70A/B433-527[»]
2VWIX-ray2.15A/B/C/D1-303[»]
3DAKX-ray2.25A/B/C/D6-295[»]
ProteinModelPortaliO95747
SMRiO95747
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115269, 34 interactors
CORUMiO95747
DIPiDIP-34977N
ELMiO95747
IntActiO95747, 13 interactors
MINTiO95747
STRINGi9606.ENSP00000311713

Chemistry databases

BindingDBiO95747
ChEMBLiCHEMBL1163104

PTM databases

iPTMnetiO95747
PhosphoSitePlusiO95747
SwissPalmiO95747

Polymorphism and mutation databases

BioMutaiOXSR1

Proteomic databases

EPDiO95747
MaxQBiO95747
PaxDbiO95747
PeptideAtlasiO95747
PRIDEiO95747
ProteomicsDBi51019

Protocols and materials databases

DNASUi9943
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311806; ENSP00000311713; ENSG00000172939
GeneIDi9943
KEGGihsa:9943
UCSCiuc003chy.4 human

Organism-specific databases

CTDi9943
DisGeNETi9943
EuPathDBiHostDB:ENSG00000172939.8
GeneCardsiOXSR1
HGNCiHGNC:8508 OXSR1
HPAiCAB017181
HPA008237
MIMi604046 gene
neXtProtiNX_O95747
OpenTargetsiENSG00000172939
PharmGKBiPA134973207
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0582 Eukaryota
ENOG410XSWS LUCA
GeneTreeiENSGT00930000150829
HOGENOMiHOG000234204
HOVERGENiHBG108518
InParanoidiO95747
KOiK08835
OMAiEPQANRS
OrthoDBiEOG091G0AKO
PhylomeDBiO95747
TreeFamiTF105339

Enzyme and pathway databases

SignaLinkiO95747
SIGNORiO95747

Miscellaneous databases

ChiTaRSiOXSR1 human
EvolutionaryTraceiO95747
GeneWikiiOXSR1
GenomeRNAii9943
PROiPR:O95747
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172939 Expressed in 229 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_OSR1
HS_OXSR1
ExpressionAtlasiO95747 baseline and differential
GenevisibleiO95747 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR024678 Kinase_OSR1/WNK_CCT
IPR028749 Oxsr1
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PANTHERiPTHR24361:SF435 PTHR24361:SF435, 1 hit
PfamiView protein in Pfam
PF12202 OSR1_C, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOXSR1_HUMAN
AccessioniPrimary (citable) accession number: O95747
Secondary accession number(s): Q3LR53, Q7Z501, Q9UPQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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