SNAP29

Functionⁱ

SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions.3 Publications

GO - Molecular functionⁱ

SNAP receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagosome maturation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23217709
autophagosome membrane docking
Source: GO_Central
Inferred from direct assayⁱ
- 25686604
cilium assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25686250
exocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
membrane fusion
Source: ProtInc
Traceable author statementⁱ
- 10839363
neutrophil degranulation Source: Reactome
protein transport Source: UniProtKB-KW
synaptic vesicle fusion to presynaptic active zone membrane
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
synaptic vesicle priming
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vesicle fusion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vesicle targeting
Source: ProtInc
Traceable author statementⁱ
- 9852078

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Autophagy, Cilium biogenesis/degradation, Protein transport, Transport

Biological process

Autophagy, Cilium biogenesis/degradation, Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation R-HSA-6811438 Intra-Golgi traffic

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation
R-HSA-6811438 Intra-Golgi traffic

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Synaptosomal-associated protein 29Imported Short name: SNAP-29Imported Alternative name(s): Soluble 29 kDa NSF attachment proteinImported Vesicle-membrane fusion protein SNAP-29
Gene namesⁱ	Name:SNAP29Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000099940.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11133 SNAP29
MIMⁱ	604202 gene
neXtProtⁱ	NX_O95721

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome (CEDNIK)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis and palmoplantar keratoderma.

Keywords - Diseaseⁱ

Ichthyosis, Neuropathy, Palmoplantar keratoderma

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9342
MalaCards human disease database More...MalaCardsⁱ	SNAP29
MIMⁱ	609528 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000099940
Orphanetⁱ	66631 CEDNIK syndrome
PharmGKBⁱ	PA35981

Polymorphism and mutation databases

BioMutaⁱ	SNAP29

BioMutaⁱ

SNAP29

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000213601	1 – 258	Synaptosomal-associated protein 29Add BLAST		258

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	77	PhosphoserineCombined sources	1
Modified residueⁱ	78	PhosphoserineCombined sources	1
Modified residueⁱ	114	PhosphoserineCombined sources	1
Modified residueⁱ	130	PhosphothreonineCombined sources	1
Modified residueⁱ	137	PhosphothreonineCombined sources	1
Modified residueⁱ	163	PhosphoserineCombined sources	1
Modified residueⁱ	182	PhosphoserineCombined sources	1
Modified residueⁱ	185	PhosphoserineCombined sources	1
Modified residueⁱ	204	PhosphoserineCombined sources	1
Modified residueⁱ	210	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O95721
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95721
PaxDbⁱ	O95721
PeptideAtlas More...PeptideAtlasⁱ	O95721
PRIDEⁱ	O95721
ProteomicsDBⁱ	51014

PTM databases

iPTMnetⁱ	O95721
PhosphoSitePlusⁱ	O95721

Expressionⁱ

Tissue specificityⁱ

Found in brain, heart, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000099940 Expressed in 229 organ(s), highest expression level in testis
CleanExⁱ	HS_SNAP29
ExpressionAtlasⁱ	O95721 baseline and differential
Genevisibleⁱ	O95721 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB037092 HPA031823 HPA056492

HPAⁱ

CAB037092
HPA031823
HPA056492

Interactionⁱ

Subunit structureⁱ

Forms a SNARE complex, composed of VAMP8, SNAP29 and STX17, involved in fusion of autophagosome with lysosome (PubMed:23217709, PubMed:25686604). Interacts with multiple syntaxins including STX6 (By similarity). Interacts with EIPR1 (PubMed:27440922).By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
FAM9B	Q8IZU0	3	EBI-490676,EBI-10175124
NAPB	Q9H115	4	EBI-490676,EBI-3921185
OGT	O15294	2	EBI-490676,EBI-539828
STX12	Q86Y82	4	EBI-490676,EBI-2691717
STX17	P56962	9	EBI-490676,EBI-2797775
STX1A	Q16623	3	EBI-490676,EBI-712466
STX6	O43752	2	EBI-490676,EBI-2695795
VAMP1	P23763	3	EBI-490676,EBI-10201335
VAMP2	P63027	5	EBI-490676,EBI-520113
VAMP4	O75379-2	3	EBI-490676,EBI-10187996
VAMP5	O95183	5	EBI-490676,EBI-10191195
VAMP8	Q9BV40	5	EBI-490676,EBI-727028

GO - Molecular functionⁱ

SNAP receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114748, 85 interactors
CORUMⁱ	O95721
Database of interacting proteins More...DIPⁱ	DIP-56475N
IntActⁱ	O95721, 59 interactors
Molecular INTeraction database More...MINTⁱ	O95721
STRINGⁱ	9606.ENSP00000215730

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	40 – 113	Combined sources		74
Helixⁱ	195 – 255	Combined sources		61

Show more details

3D structure databases

ProteinModelPortalⁱ	O95721
SMRⁱ	O95721
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	196 – 258	t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST		63

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	76 – 107	Sequence analysisAdd BLAST		32

Sequence similaritiesⁱ

Belongs to the SNAP-25 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG3065 Eukaryota ENOG410Y3Y0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048053
HOGENOMⁱ	HOG000046806
HOVERGENⁱ	HBG057045
InParanoidⁱ	O95721
KEGG Orthology (KO) More...KOⁱ	K08509
OMAⁱ	PRSYNPF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GKH
PhylomeDBⁱ	O95721
TreeFamⁱ	TF320226

Family and domain databases

InterProⁱ	View protein in InterPro IPR000727 T_SNARE_dom
SMARTⁱ	View protein in SMART SM00397 t_SNARE, 2 hits
PROSITEⁱ	View protein in PROSITE PS50192 T_SNARE, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O95721-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSAYPKSYNP FDDDGEDEGA RPAPWRDARD LPDGPDAPAD RQQYLRQEVL 
        60         70         80         90        100
RRAEATAAST SRSLALMYES EKVGVASSEE LARQRGVLER TEKMVDKMDQ 
       110        120        130        140        150
DLKISQKHIN SIKSVFGGLV NYFKSKPVET PPEQNGTLTS QPNNRLKEAI 
       160        170        180        190        200
STSKEQEAKY QASHPNLRKL DDTDPVPRGA GSAMSTDAYP KNPHLRAYHQ 
       210        220        230        240        250
KIDSNLDELS MGLGRLKDIA LGMQTEIEEQ DDILDRLTTK VDKLDVNIKS 

TERKVRQL

Length:258

Mass (Da):28,970

Last modified:May 1, 1999 - v1

Checksum:ⁱ7E1CDBA22D6F5A3C

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9JAF7	C9JAF7_HUMAN		Synaptosomal-associated protein 29 Synaptosomal-associated protein 29	SNAP29	160	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF115436 mRNA Translation: AAD11436.1 AF278704 Genomic DNA Translation: AAF91421.1 CR456582 mRNA Translation: CAG30468.1 BT007357 mRNA Translation: AAP36021.1 BC009715 mRNA Translation: AAH09715.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13784.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004773.1, NM_004782.3
UniGeneⁱ	Hs.108002

Genome annotation databases

Ensemblⁱ	ENST00000215730; ENSP00000215730; ENSG00000099940
GeneIDⁱ	9342
KEGGⁱ	hsa:9342
UCSC genome browser More...UCSCⁱ	uc011ahw.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95721	Synaptosomal-associated protein 29 (Fragment)		HUMAN		160	UniRef100_O95721

Protein	Similar proteins		Species	Score	Length	Source
O95721	Synaptosomal-associated protein 29		PONAB		258	UniRef90_O95721
Synaptosomal-associated protein 29 (Fragment)		HUMAN		160
Uncharacterized protein		PANPA		318
SNAP29 isoform 1		PANTR		258
Uncharacterized protein		NOMLE		258
+22

Protein	Similar proteins		Species	Score	Length	Source
O95721	Synaptosomal-associated protein 29		PONAB		258	UniRef50_O95721
Synaptosomal-associated protein 29		MOUSE		260
Synaptosomal-associated protein 29		RAT		257
Synaptosomal-associated protein 29 (Fragment)		HUMAN		160
Uncharacterized protein		PANPA		318
+34

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF115436 mRNA Translation: AAD11436.1 AF278704 Genomic DNA Translation: AAF91421.1 CR456582 mRNA Translation: CAG30468.1 BT007357 mRNA Translation: AAP36021.1 BC009715 mRNA Translation: AAH09715.1
CCDSⁱ	CCDS13784.1
RefSeqⁱ	NP_004773.1, NM_004782.3
UniGeneⁱ	Hs.108002

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4WY4	X-ray	1.40	C	39-116	[»]
				D	194-258	[»]
ProteinModelPortalⁱ	O95721
SMRⁱ	O95721
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114748, 85 interactors
CORUMⁱ	O95721
DIPⁱ	DIP-56475N
IntActⁱ	O95721, 59 interactors
MINTⁱ	O95721
STRINGⁱ	9606.ENSP00000215730

PTM databases

iPTMnetⁱ	O95721
PhosphoSitePlusⁱ	O95721

Polymorphism and mutation databases

BioMutaⁱ	SNAP29

BioMutaⁱ

SNAP29

Proteomic databases

EPDⁱ	O95721
MaxQBⁱ	O95721
PaxDbⁱ	O95721
PeptideAtlasⁱ	O95721
PRIDEⁱ	O95721
ProteomicsDBⁱ	51014

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9342
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000215730; ENSP00000215730; ENSG00000099940
GeneIDⁱ	9342
KEGGⁱ	hsa:9342
UCSCⁱ	uc011ahw.3 human

Organism-specific databases

CTDⁱ	9342
DisGeNETⁱ	9342
EuPathDBⁱ	HostDB:ENSG00000099940.11
GeneCardsⁱ	SNAP29
HGNCⁱ	HGNC:11133 SNAP29
HPAⁱ	CAB037092 HPA031823 HPA056492
MalaCardsⁱ	SNAP29
MIMⁱ	604202 gene 609528 phenotype
neXtProtⁱ	NX_O95721
OpenTargetsⁱ	ENSG00000099940
Orphanetⁱ	66631 CEDNIK syndrome
PharmGKBⁱ	PA35981
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3065 Eukaryota ENOG410Y3Y0 LUCA
GeneTreeⁱ	ENSGT00510000048053
HOGENOMⁱ	HOG000046806
HOVERGENⁱ	HBG057045
InParanoidⁱ	O95721
KOⁱ	K08509
OMAⁱ	PRSYNPF
OrthoDBⁱ	EOG091G0GKH
PhylomeDBⁱ	O95721
TreeFamⁱ	TF320226

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation R-HSA-6811438 Intra-Golgi traffic

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation
R-HSA-6811438 Intra-Golgi traffic

Miscellaneous databases

ChiTaRSⁱ	SNAP29 human
GeneWikiⁱ	SNAP29
GenomeRNAiⁱ	9342
Protein Ontology More...PROⁱ	PR:O95721
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000099940 Expressed in 229 organ(s), highest expression level in testis
CleanExⁱ	HS_SNAP29
ExpressionAtlasⁱ	O95721 baseline and differential
Genevisibleⁱ	O95721 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000727 T_SNARE_dom
SMARTⁱ	View protein in SMART SM00397 t_SNARE, 2 hits
PROSITEⁱ	View protein in PROSITE PS50192 T_SNARE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNP29_HUMAN
Accessionⁱ	O95721Primary (citable) accession number: O95721
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O95721 (SNP29_HUMAN)

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Synaptosomal-associated protein 29

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Plasma membrane

Other locations

Cytoskeleton

Cytosol

Golgi apparatus

Lysosome

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ