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Protein

Synaptosomal-associated protein 29

Gene

SNAP29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions.3 Publications

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: GO_Central

GO - Biological processi

  • autophagosome maturation Source: UniProtKB
  • autophagosome membrane docking Source: GO_Central
  • cilium assembly Source: UniProtKB
  • exocytosis Source: GO_Central
  • membrane fusion Source: ProtInc
  • neutrophil degranulation Source: Reactome
  • protein transport Source: UniProtKB-KW
  • synaptic vesicle fusion to presynaptic active zone membrane Source: GO_Central
  • synaptic vesicle priming Source: GO_Central
  • vesicle fusion Source: GO_Central
  • vesicle targeting Source: ProtInc

Keywordsi

Biological processAutophagy, Cilium biogenesis/degradation, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptosomal-associated protein 29Imported
Short name:
SNAP-29Imported
Alternative name(s):
Soluble 29 kDa NSF attachment proteinImported
Vesicle-membrane fusion protein SNAP-29
Gene namesi
Name:SNAP29Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000099940.11
HGNCiHGNC:11133 SNAP29
MIMi604202 gene
neXtProtiNX_O95721

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome (CEDNIK)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis and palmoplantar keratoderma.
See also OMIM:609528

Keywords - Diseasei

Ichthyosis, Neuropathy, Palmoplantar keratoderma

Organism-specific databases

DisGeNETi9342
MalaCardsiSNAP29
MIMi609528 phenotype
OpenTargetsiENSG00000099940
Orphaneti66631 CEDNIK syndrome
PharmGKBiPA35981

Polymorphism and mutation databases

BioMutaiSNAP29

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002136011 – 258Synaptosomal-associated protein 29Add BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei114PhosphoserineCombined sources1
Modified residuei130PhosphothreonineCombined sources1
Modified residuei137PhosphothreonineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei185PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95721
MaxQBiO95721
PaxDbiO95721
PeptideAtlasiO95721
PRIDEiO95721
ProteomicsDBi51014

PTM databases

iPTMnetiO95721
PhosphoSitePlusiO95721

Expressioni

Tissue specificityi

Found in brain, heart, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000099940 Expressed in 229 organ(s), highest expression level in testis
CleanExiHS_SNAP29
ExpressionAtlasiO95721 baseline and differential
GenevisibleiO95721 HS

Organism-specific databases

HPAiCAB037092
HPA031823
HPA056492

Interactioni

Subunit structurei

Forms a SNARE complex, composed of VAMP8, SNAP29 and STX17, involved in fusion of autophagosome with lysosome (PubMed:23217709, PubMed:25686604). Interacts with multiple syntaxins including STX6 (By similarity). Interacts with EIPR1 (PubMed:27440922).By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114748, 85 interactors
CORUMiO95721
DIPiDIP-56475N
IntActiO95721, 59 interactors
MINTiO95721
STRINGi9606.ENSP00000215730

Structurei

Secondary structure

1258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95721
SMRiO95721
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 258t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili76 – 107Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the SNAP-25 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3065 Eukaryota
ENOG410Y3Y0 LUCA
GeneTreeiENSGT00510000048053
HOGENOMiHOG000046806
HOVERGENiHBG057045
InParanoidiO95721
KOiK08509
OMAiPRSYNPF
OrthoDBiEOG091G0GKH
PhylomeDBiO95721
TreeFamiTF320226

Family and domain databases

InterProiView protein in InterPro
IPR000727 T_SNARE_dom
SMARTiView protein in SMART
SM00397 t_SNARE, 2 hits
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O95721-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAYPKSYNP FDDDGEDEGA RPAPWRDARD LPDGPDAPAD RQQYLRQEVL
60 70 80 90 100
RRAEATAAST SRSLALMYES EKVGVASSEE LARQRGVLER TEKMVDKMDQ
110 120 130 140 150
DLKISQKHIN SIKSVFGGLV NYFKSKPVET PPEQNGTLTS QPNNRLKEAI
160 170 180 190 200
STSKEQEAKY QASHPNLRKL DDTDPVPRGA GSAMSTDAYP KNPHLRAYHQ
210 220 230 240 250
KIDSNLDELS MGLGRLKDIA LGMQTEIEEQ DDILDRLTTK VDKLDVNIKS

TERKVRQL
Length:258
Mass (Da):28,970
Last modified:May 1, 1999 - v1
Checksum:i7E1CDBA22D6F5A3C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JAF7C9JAF7_HUMAN
Synaptosomal-associated protein 29
SNAP29
160Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115436 mRNA Translation: AAD11436.1
AF278704 Genomic DNA Translation: AAF91421.1
CR456582 mRNA Translation: CAG30468.1
BT007357 mRNA Translation: AAP36021.1
BC009715 mRNA Translation: AAH09715.1
CCDSiCCDS13784.1
RefSeqiNP_004773.1, NM_004782.3
UniGeneiHs.108002

Genome annotation databases

EnsembliENST00000215730; ENSP00000215730; ENSG00000099940
GeneIDi9342
KEGGihsa:9342
UCSCiuc011ahw.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115436 mRNA Translation: AAD11436.1
AF278704 Genomic DNA Translation: AAF91421.1
CR456582 mRNA Translation: CAG30468.1
BT007357 mRNA Translation: AAP36021.1
BC009715 mRNA Translation: AAH09715.1
CCDSiCCDS13784.1
RefSeqiNP_004773.1, NM_004782.3
UniGeneiHs.108002

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WY4X-ray1.40C39-116[»]
D194-258[»]
ProteinModelPortaliO95721
SMRiO95721
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114748, 85 interactors
CORUMiO95721
DIPiDIP-56475N
IntActiO95721, 59 interactors
MINTiO95721
STRINGi9606.ENSP00000215730

PTM databases

iPTMnetiO95721
PhosphoSitePlusiO95721

Polymorphism and mutation databases

BioMutaiSNAP29

Proteomic databases

EPDiO95721
MaxQBiO95721
PaxDbiO95721
PeptideAtlasiO95721
PRIDEiO95721
ProteomicsDBi51014

Protocols and materials databases

DNASUi9342
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215730; ENSP00000215730; ENSG00000099940
GeneIDi9342
KEGGihsa:9342
UCSCiuc011ahw.3 human

Organism-specific databases

CTDi9342
DisGeNETi9342
EuPathDBiHostDB:ENSG00000099940.11
GeneCardsiSNAP29
HGNCiHGNC:11133 SNAP29
HPAiCAB037092
HPA031823
HPA056492
MalaCardsiSNAP29
MIMi604202 gene
609528 phenotype
neXtProtiNX_O95721
OpenTargetsiENSG00000099940
Orphaneti66631 CEDNIK syndrome
PharmGKBiPA35981
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3065 Eukaryota
ENOG410Y3Y0 LUCA
GeneTreeiENSGT00510000048053
HOGENOMiHOG000046806
HOVERGENiHBG057045
InParanoidiO95721
KOiK08509
OMAiPRSYNPF
OrthoDBiEOG091G0GKH
PhylomeDBiO95721
TreeFamiTF320226

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-6811438 Intra-Golgi traffic

Miscellaneous databases

ChiTaRSiSNAP29 human
GeneWikiiSNAP29
GenomeRNAii9342
PROiPR:O95721
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099940 Expressed in 229 organ(s), highest expression level in testis
CleanExiHS_SNAP29
ExpressionAtlasiO95721 baseline and differential
GenevisibleiO95721 HS

Family and domain databases

InterProiView protein in InterPro
IPR000727 T_SNARE_dom
SMARTiView protein in SMART
SM00397 t_SNARE, 2 hits
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNP29_HUMAN
AccessioniPrimary (citable) accession number: O95721
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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