UniProtKB - O95718 (ERR2_HUMAN)
Steroid hormone receptor ERR2
ESRRB
Functioni
Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (PubMed:17920186, PubMed:19755138).
Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity).
Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:23836911).
Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (PubMed:17920186, PubMed:19755138).
During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity).
By similarity3 PublicationsTranscription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Positively regulates ESR1 transcriptional activity upon E2 stimulation.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 185 | Important for stabilizing DNA-binding | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 100 – 186 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 87 | |
Zinc fingeri | 103 – 123 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 139 – 163 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
- nuclear receptor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- RNA polymerase II complex binding Source: UniProtKB
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- steroid binding Source: InterPro
- steroid hormone receptor activity Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- cell dedifferentiation Source: UniProtKB
- cell population proliferation Source: UniProtKB
- inner ear development Source: UniProtKB
- negative regulation of stem cell differentiation Source: UniProtKB
- photoreceptor cell maintenance Source: UniProtKB
- positive regulation of stem cell population maintenance Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKB
- positive regulation of transcription involved in G2/M transition of mitotic cell cycle Source: UniProtKB
- regulation of stem cell division Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- stem cell division Source: UniProtKB
- stem cell population maintenance Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O95718 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway |
SignaLinki | O95718 |
SIGNORi | O95718 |
Names & Taxonomyi
Protein namesi | Recommended name: Steroid hormone receptor ERR2CuratedAlternative name(s): ERR beta-2 Estrogen receptor-like 2 Estrogen-related receptor beta1 Publication Short name: ERR-beta Nuclear receptor subfamily 3 group B member 2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3473, ESRRB |
MIMi | 602167, gene |
neXtProti | NX_O95718 |
VEuPathDBi | HostDB:ENSG00000119715 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- Nucleus 1 Publication
Other locations
- Chromosome By similarity
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
Other locations
- chromatin Source: NTNU_SB
- condensed chromosome Source: UniProtKB
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Chromosome, Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Deafness, autosomal recessive, 35 (DFNB35)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043503 | 110 | A → V in DFNB35. 1 PublicationCorresponds to variant dbSNP:rs121909110Ensembl. | 1 | |
Natural variantiVAR_043504 | 320 | L → P in DFNB35. 1 Publication | 1 | |
Natural variantiVAR_043505 | 342 | V → L in DFNB35. 1 PublicationCorresponds to variant dbSNP:rs121909111Ensembl. | 1 | |
Natural variantiVAR_043506 | 347 | L → P in DFNB35. 1 Publication | 1 | |
Natural variantiVAR_043508 | 389 | T → M in DFNB35; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201714970Ensembl. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 185 | Y → A: 6-fold decrease in DNA-binding affinity. 1 Publication | 1 |
Keywords - Diseasei
Deafness, Disease variant, Non-syndromic deafnessOrganism-specific databases
DisGeNETi | 2103 |
GeneReviewsi | ESRRB |
MalaCardsi | ESRRB |
MIMi | 608565, phenotype |
OpenTargetsi | ENSG00000119715 |
Orphaneti | 90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB |
PharmGKBi | PA27889 |
Miscellaneous databases
Pharosi | O95718, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3751 |
DrugBanki | DB00255, Diethylstilbestrol DB07776, Flavone DB01645, Genistein |
DrugCentrali | O95718 |
GuidetoPHARMACOLOGYi | 623 |
Genetic variation databases
BioMutai | ESRRB |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053662 | 1 – 433 | Steroid hormone receptor ERR2Add BLAST | 433 |
Post-translational modificationi
Keywords - PTMi
AcetylationProteomic databases
MassIVEi | O95718 |
MaxQBi | O95718 |
PaxDbi | O95718 |
PeptideAtlasi | O95718 |
PRIDEi | O95718 |
ProteomicsDBi | 51011 [O95718-1] 51012 [O95718-2] 51013 [O95718-3] |
PTM databases
iPTMneti | O95718 |
PhosphoSitePlusi | O95718 |
Expressioni
Gene expression databases
Bgeei | ENSG00000119715, Expressed in cortex of kidney and 104 other tissues |
ExpressionAtlasi | O95718, baseline and differential |
Genevisiblei | O95718, HS |
Organism-specific databases
HPAi | ENSG00000119715, Tissue enriched (retina) |
Interactioni
Subunit structurei
Binds DNA as a monomer (PubMed:12654265).
Interacts with NR0B1; represses ESRRB activity at the GATA6 promoter.
Interacts with NANOG; reciprocally modulates their transcriptional activities and activates POU5F1 expression.
Interacts with NCOA3; mediates the interaction between ESRRB and RNA polymerase II complexes and allows NCOA3 corecruitment to ESRRB, KLF4, NANOG, and SOX2 enhancer regions to trigger ESRRB-dependent gene activation involved in self-renewal and pluripotency.
Interacts with KDM1A; co-occupes the core set of ESRRB targets including ELF5 and EOMES.
Interacts with the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12; ESRRB is probably not a core component of the integrator complex and associates to integrator via its interaction with INTS1 and INTS9; attracts the transcriptional machinery.
Interacts with JARID2.
Interacts with POU5F1; recruits ESRRB near the POU5F1-SOX2 element in the NANOG proximal promoter leading to activation of NANOG expression; the interaction is DNA independent (By similarity).
Interacts with NFE2L2; represses NFE2L2 transcriptional activity (PubMed:17920186).
Isoform 1 interacts with ESR1 (PubMed:19755138).
By similarity3 PublicationsBinary interactionsi
GO - Molecular functioni
- RNA polymerase II complex binding Source: UniProtKB
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 108406, 104 interactors |
IntActi | O95718, 3 interactors |
STRINGi | 9606.ENSP00000422488 |
Chemistry databases
BindingDBi | O95718 |
Miscellaneous databases
RNActi | O95718, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | O95718 |
BMRBi | O95718 |
SMRi | O95718 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O95718 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 208 – 432 | NR LBDPROSITE-ProRule annotationAdd BLAST | 225 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 38 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 93 – 211 | Interaction with NANOGBy similarityAdd BLAST | 119 | |
Regioni | 203 – 433 | Essential for ESRRB transcriptional activity and interaction with NCOA3By similarityAdd BLAST | 231 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 103 – 123 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 139 – 163 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000153433 |
HOGENOMi | CLU_007368_11_0_1 |
InParanoidi | O95718 |
OrthoDBi | 669799at2759 |
TreeFami | TF323751 |
Family and domain databases
DisProti | DP01764 |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00011 |
InterProi | View protein in InterPro IPR024178, Est_rcpt/est-rel_rcp IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR027289, Oest-rel_rcp IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF002527, ER-like_NR, 1 hit PIRSF500939, ERR1-2-3, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSDDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGLALG
60 70 80 90 100
THANGLDSPP MFAGAGLGGT PCRKSYEDCA SGIMEDSAIK CEYMLNAIPK
110 120 130 140 150
RLCLVCGDIA SGYHYGVASC EACKAFFKRT IQGNIEYSCP ATNECEITKR
160 170 180 190 200
RRKSCQACRF MKCLKVGMLK EGVRLDRVRG GRQKYKRRLD SESSPYLSLQ
210 220 230 240 250
ISPPAKKPLT KIVSYLLVAE PDKLYAMPPP GMPEGDIKAL TTLCDLADRE
260 270 280 290 300
LVVIIGWAKH IPGFSSLSLG DQMSLLQSAW MEILILGIVY RSLPYDDKLV
310 320 330 340 350
YAEDYIMDEE HSRLAGLLEL YRAILQLVRR YKKLKVEKEE FVTLKALALA
360 370 380 390 400
NSDSMYIEDL EAVQKLQDLL HEALQDYELS QRHEEPWRTG KLLLTLPLLR
410 420 430
QTAAKAVQHF YSVKLQGKVP MHKLFLEMLE AKV
The sequence of this isoform differs from the canonical sequence as follows:
433-433: V → AWARADSLQEWRPLEQVPSPLHRATKRQHVHFLTPLPPPPSVAWVGTAQAGYHLEVFLPQRAGWPRAA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EWD9 | E7EWD9_HUMAN | Steroid hormone receptor ERR2 | ESRRB | 438 | Annotation score: | ||
A0A2R8Y491 | A0A2R8Y491_HUMAN | Steroid hormone receptor ERR2 | ESRRB | 454 | Annotation score: | ||
A0A2R8Y509 | A0A2R8Y509_HUMAN | Steroid hormone receptor ERR2 | ESRRB | 99 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 248 | D → E in BAH02305 (Ref. 3) Curated | 1 | |
Sequence conflicti | 429 | L → V in AAI31518 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043503 | 110 | A → V in DFNB35. 1 PublicationCorresponds to variant dbSNP:rs121909110Ensembl. | 1 | |
Natural variantiVAR_043504 | 320 | L → P in DFNB35. 1 Publication | 1 | |
Natural variantiVAR_043505 | 342 | V → L in DFNB35. 1 PublicationCorresponds to variant dbSNP:rs121909111Ensembl. | 1 | |
Natural variantiVAR_043506 | 347 | L → P in DFNB35. 1 Publication | 1 | |
Natural variantiVAR_043507 | 386 | P → S1 PublicationCorresponds to variant dbSNP:rs61742642Ensembl. | 1 | |
Natural variantiVAR_043508 | 389 | T → M in DFNB35; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201714970Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_058967 | 433 | V → VGQEQLRGSPKDERMSSHDG KCPFQSAAFTSRDQSNSPGI PNPRPSSPTPLNERGRQISP STRTPGGQGKHLWLTM in isoform 1. | 1 | |
Alternative sequenceiVSP_058968 | 433 | V → AWARADSLQEWRPLEQVPSP LHRATKRQHVHFLTPLPPPP SVAWVGTAQAGYHLEVFLPQ RAGWPRAA in isoform 2. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF094517 mRNA Translation: AAC99409.1 AY451389 mRNA Translation: AAS15571.1 AY451390 mRNA Translation: AAS15572.1 AB307714 mRNA Translation: BAH02305.1 HQ692852 mRNA Translation: ADZ17363.1 AC008050 Genomic DNA Translation: AAG17472.1 AC016543 Genomic DNA No translation available. BC131517 mRNA Translation: AAI31518.1 |
CCDSi | CCDS9850.2 [O95718-1] |
RefSeqi | NP_004443.3, NM_004452.3 [O95718-1] XP_016876575.1, XM_017021086.1 |
Genome annotation databases
Ensembli | ENST00000380887.7; ENSP00000370270.2; ENSG00000119715.15 [O95718-1] ENST00000505752.6; ENSP00000423004.1; ENSG00000119715.15 [O95718-2] ENST00000509242.5; ENSP00000422488.1; ENSG00000119715.15 [O95718-1] |
GeneIDi | 2103 |
KEGGi | hsa:2103 |
UCSCi | uc001xsq.2, human [O95718-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF094517 mRNA Translation: AAC99409.1 AY451389 mRNA Translation: AAS15571.1 AY451390 mRNA Translation: AAS15572.1 AB307714 mRNA Translation: BAH02305.1 HQ692852 mRNA Translation: ADZ17363.1 AC008050 Genomic DNA Translation: AAG17472.1 AC016543 Genomic DNA No translation available. BC131517 mRNA Translation: AAI31518.1 |
CCDSi | CCDS9850.2 [O95718-1] |
RefSeqi | NP_004443.3, NM_004452.3 [O95718-1] XP_016876575.1, XM_017021086.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LO1 | NMR | - | A | 97-192 | [»] | |
6LIT | X-ray | 2.00 | A/B | 204-433 | [»] | |
6LN4 | X-ray | 2.61 | A | 204-432 | [»] | |
AlphaFoldDBi | O95718 | |||||
BMRBi | O95718 | |||||
SMRi | O95718 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108406, 104 interactors |
IntActi | O95718, 3 interactors |
STRINGi | 9606.ENSP00000422488 |
Chemistry databases
BindingDBi | O95718 |
ChEMBLi | CHEMBL3751 |
DrugBanki | DB00255, Diethylstilbestrol DB07776, Flavone DB01645, Genistein |
DrugCentrali | O95718 |
GuidetoPHARMACOLOGYi | 623 |
PTM databases
iPTMneti | O95718 |
PhosphoSitePlusi | O95718 |
Genetic variation databases
BioMutai | ESRRB |
Proteomic databases
MassIVEi | O95718 |
MaxQBi | O95718 |
PaxDbi | O95718 |
PeptideAtlasi | O95718 |
PRIDEi | O95718 |
ProteomicsDBi | 51011 [O95718-1] 51012 [O95718-2] 51013 [O95718-3] |
Protocols and materials databases
Antibodypediai | 13059, 311 antibodies from 35 providers |
DNASUi | 2103 |
Genome annotation databases
Ensembli | ENST00000380887.7; ENSP00000370270.2; ENSG00000119715.15 [O95718-1] ENST00000505752.6; ENSP00000423004.1; ENSG00000119715.15 [O95718-2] ENST00000509242.5; ENSP00000422488.1; ENSG00000119715.15 [O95718-1] |
GeneIDi | 2103 |
KEGGi | hsa:2103 |
UCSCi | uc001xsq.2, human [O95718-3] |
Organism-specific databases
CTDi | 2103 |
DisGeNETi | 2103 |
GeneCardsi | ESRRB |
GeneReviewsi | ESRRB |
HGNCi | HGNC:3473, ESRRB |
HPAi | ENSG00000119715, Tissue enriched (retina) |
MalaCardsi | ESRRB |
MIMi | 602167, gene 608565, phenotype |
neXtProti | NX_O95718 |
OpenTargetsi | ENSG00000119715 |
Orphaneti | 90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB |
PharmGKBi | PA27889 |
VEuPathDBi | HostDB:ENSG00000119715 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000153433 |
HOGENOMi | CLU_007368_11_0_1 |
InParanoidi | O95718 |
OrthoDBi | 669799at2759 |
TreeFami | TF323751 |
Enzyme and pathway databases
PathwayCommonsi | O95718 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway |
SignaLinki | O95718 |
SIGNORi | O95718 |
Miscellaneous databases
BioGRID-ORCSi | 2103, 13 hits in 1100 CRISPR screens |
ChiTaRSi | ESRRB, human |
EvolutionaryTracei | O95718 |
GeneWikii | Estrogen-related_receptor_beta |
GenomeRNAii | 2103 |
Pharosi | O95718, Tchem |
PROi | PR:O95718 |
RNActi | O95718, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000119715, Expressed in cortex of kidney and 104 other tissues |
ExpressionAtlasi | O95718, baseline and differential |
Genevisiblei | O95718, HS |
Family and domain databases
DisProti | DP01764 |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00011 |
InterProi | View protein in InterPro IPR024178, Est_rcpt/est-rel_rcp IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR027289, Oest-rel_rcp IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF002527, ER-like_NR, 1 hit PIRSF500939, ERR1-2-3, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ERR2_HUMAN | |
Accessioni | O95718Primary (citable) accession number: O95718 Secondary accession number(s): A2VDJ2 Q9HCB4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | June 7, 2017 | |
Last modified: | May 25, 2022 | |
This is version 209 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families