UniProtKB - O95704 (APBB3_HUMAN)
Amyloid-beta A4 precursor protein-binding family B member 3
APBB3
Functioni
May modulate the internalization of amyloid-beta precursor protein.
GO - Molecular functioni
- amyloid-beta binding Source: GO_Central
- low-density lipoprotein particle receptor binding Source: ARUK-UCL
GO - Biological processi
- positive regulation of protein secretion Source: ARUK-UCL
- regulation of transcription, DNA-templated Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | O95704 |
SignaLinki | O95704 |
Names & Taxonomyi
Protein namesi | Recommended name: Amyloid-beta A4 precursor protein-binding family B member 3Alternative name(s): Protein Fe65-like 2 Short name: Fe65L2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20708, APBB3 |
MIMi | 602711, gene |
neXtProti | NX_O95704 |
VEuPathDBi | HostDB:ENSG00000113108 |
Subcellular locationi
Nucleus
Nucleus
Cytoskeleton
- actin cytoskeleton Source: HPA
Cytosol
- cytosol Source: ARUK-UCL
Nucleus
- nucleus Source: ARUK-UCL
Other locations
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10307 |
OpenTargetsi | ENSG00000113108 |
PharmGKBi | PA134958636 |
Miscellaneous databases
Pharosi | O95704, Tbio |
Genetic variation databases
BioMutai | APBB3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076054 | 1 – 486 | Amyloid-beta A4 precursor protein-binding family B member 3Add BLAST | 486 |
Proteomic databases
MassIVEi | O95704 |
PaxDbi | O95704 |
PeptideAtlasi | O95704 |
PRIDEi | O95704 |
ProteomicsDBi | 51002 [O95704-1] 51003 [O95704-2] 51004 [O95704-3] 51005 [O95704-4] 77814 79619 |
PTM databases
iPTMneti | O95704 |
PhosphoSitePlusi | O95704 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000113108, Expressed in right ovary and 116 other tissues |
ExpressionAtlasi | O95704, baseline and differential |
Genevisiblei | O95704, HS |
Organism-specific databases
HPAi | ENSG00000113108, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Binary interactionsi
O95704
With | #Exp. | IntAct |
---|---|---|
APP [P05067] | 5 | EBI-286427,EBI-77613 |
DAPP1 [Q9UN19] | 2 | EBI-286427,EBI-3918199 |
EGFR [P00533] | 2 | EBI-286427,EBI-297353 |
PIK3R1 - isoform 2 [P27986-2] | 3 | EBI-286427,EBI-9090282 |
GO - Molecular functioni
- low-density lipoprotein particle receptor binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 115593, 26 interactors |
IntActi | O95704, 24 interactors |
MINTi | O95704 |
STRINGi | 9606.ENSP00000346378 |
Miscellaneous databases
RNActi | O95704, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | O95704 |
SMRi | O95704 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O95704 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 61 | WWPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 113 – 280 | PID 1PROSITE-ProRule annotationAdd BLAST | 168 | |
Domaini | 285 – 440 | PID 2PROSITE-ProRule annotationAdd BLAST | 156 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QR5N, Eukaryota |
GeneTreei | ENSGT00390000000002 |
HOGENOMi | CLU_093354_0_0_1 |
InParanoidi | O95704 |
OMAi | LYMGILP |
PhylomeDBi | O95704 |
TreeFami | TF314331 |
Family and domain databases
CDDi | cd00201, WW, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR039576, APBB1/2/3 IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom IPR001202, WW_dom IPR036020, WW_dom_sf |
PANTHERi | PTHR14058, PTHR14058, 1 hit |
Pfami | View protein in Pfam PF00640, PID, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 2 hits SM00456, WW, 1 hit |
SUPFAMi | SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 2 hits PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLGKDYMLAI ILVNCDDDLW GDHSLEVEAG LPPGWRKIHD AAGTYYWHVP
60 70 80 90 100
SGSTQWQRPT WELGDAEDPG TGTEGIWGLR PPKGRSFSSL ESSLDRSNSL
110 120 130 140 150
SWYGGESYIQ SMEPGAKCFA VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL
160 170 180 190 200
AQTRSRSQPP DGAWGEGQNM LMILKKDAMS LVNPLDHSLI HCQPLVHIRV
210 220 230 240 250
WGVGSSKGRD RDFAFVASDK DSCMLKCHVF CCDVPAKAIA SALHGLCAQI
260 270 280 290 300
LSERVEVSGD ASCCSPDPIS PEDLPRQVEL LDAVSQAAQK YEALYMGTLP
310 320 330 340 350
VTKAMGMDVL NEAIGTLTAR GDRNAWVPTM LSVSDSLMTA HPIQAEASTE
360 370 380 390 400
EEPLWQCPVR LVTFIGVGRD PHTFGLIADL GRQSFQCAAF WCQPHAGGLS
410 420 430 440 450
EAVQAACMVQ YQKCLVASAA RGKAWGAQAR ARLRLKRTSS MDSPGGPLPL
460 470 480
PLLKGGVGGA GATPRKRGVF SFLDAFRLKP SLLHMP
The sequence of this isoform differs from the canonical sequence as follows:
210-210: D → PISAPA
The sequence of this isoform differs from the canonical sequence as follows:
210-210: D → DSPISAPA
The sequence of this isoform differs from the canonical sequence as follows:
196-214: VHIRVWGVGSSKGRDRDFA → AVIPTDADPQYLNPWTQIL
215-486: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
210-245: DRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHG → SSDVDPGLLPLPGPALVGEGGPSSAGTVWGESERLG
246-486: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RBA1 | D6RBA1_HUMAN | Amyloid-beta A4 precursor protein-b... | APBB3 | 337 | Annotation score: | ||
E7EX91 | E7EX91_HUMAN | Amyloid-beta A4 precursor protein-b... | APBB3 | 339 | Annotation score: | ||
D6RJB2 | D6RJB2_HUMAN | Amyloid-beta A4 precursor protein-b... | APBB3 | 163 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029518 | 165 | G → R. Corresponds to variant dbSNP:rs7715021Ensembl. | 1 | |
Natural variantiVAR_024702 | 231 | C → R5 PublicationsCorresponds to variant dbSNP:rs250430Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047811 | 196 – 214 | VHIRV…DRDFA → AVIPTDADPQYLNPWTQIL in isoform I-214. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_047812 | 210 – 245 | DRDFA…SALHG → SSDVDPGLLPLPGPALVGEG GPSSAGTVWGESERLG in isoform I-245. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_006799 | 210 – 211 | Missing in isoform I. 2 Publications | 2 | |
Alternative sequenceiVSP_006800 | 210 | D → PISAPA in isoform III. 1 Publication | 1 | |
Alternative sequenceiVSP_006801 | 210 | D → DSPISAPA in isoform IV. 1 Publication | 1 | |
Alternative sequenceiVSP_047813 | 215 – 486 | Missing in isoform I-214. 1 PublicationAdd BLAST | 272 | |
Alternative sequenceiVSP_047814 | 246 – 486 | Missing in isoform I-245. 1 PublicationAdd BLAST | 241 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB018247 mRNA Translation: BAA35188.1 AB024745 Genomic DNA Translation: BAA78674.1 AB049618 mRNA Translation: BAB40806.1 AB061224 mRNA Translation: BAB71767.1 AF224708 mRNA Translation: AAF65172.1 AF224709 mRNA Translation: AAF65173.1 AF224710 mRNA Translation: AAF65174.1 AF224711 mRNA Translation: AAF65175.1 AK075280 mRNA Translation: BAG52101.1 AC011399 Genomic DNA No translation available. AC116353 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW62041.1 BC125187 mRNA Translation: AAI25188.1 |
CCDSi | CCDS4227.1 [O95704-4] CCDS4228.1 [O95704-3] CCDS4229.1 [O95704-1] CCDS47279.1 [O95704-2] |
RefSeqi | NP_006042.3, NM_006051.3 [O95704-4] NP_573418.2, NM_133172.2 [O95704-3] NP_573419.2, NM_133173.2 [O95704-1] NP_573420.2, NM_133174.2 [O95704-2] |
Genome annotation databases
Ensembli | ENST00000354402.9; ENSP00000346378.5; ENSG00000113108.20 [O95704-4] ENST00000356738.6; ENSP00000349177.2; ENSG00000113108.20 [O95704-3] ENST00000357560.9; ENSP00000350171.4; ENSG00000113108.20 ENST00000412920.7; ENSP00000402591.3; ENSG00000113108.20 [O95704-2] ENST00000467078.5; ENSP00000422718.1; ENSG00000113108.20 [O95704-6] ENST00000509914.5; ENSP00000426107.1; ENSG00000113108.20 [O95704-5] |
GeneIDi | 10307 |
KEGGi | hsa:10307 |
MANE-Selecti | ENST00000357560.9; ENSP00000350171.4; NM_133173.3; NP_573419.2 |
UCSCi | uc003lgd.2, human [O95704-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB018247 mRNA Translation: BAA35188.1 AB024745 Genomic DNA Translation: BAA78674.1 AB049618 mRNA Translation: BAB40806.1 AB061224 mRNA Translation: BAB71767.1 AF224708 mRNA Translation: AAF65172.1 AF224709 mRNA Translation: AAF65173.1 AF224710 mRNA Translation: AAF65174.1 AF224711 mRNA Translation: AAF65175.1 AK075280 mRNA Translation: BAG52101.1 AC011399 Genomic DNA No translation available. AC116353 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW62041.1 BC125187 mRNA Translation: AAI25188.1 |
CCDSi | CCDS4227.1 [O95704-4] CCDS4228.1 [O95704-3] CCDS4229.1 [O95704-1] CCDS47279.1 [O95704-2] |
RefSeqi | NP_006042.3, NM_006051.3 [O95704-4] NP_573418.2, NM_133172.2 [O95704-3] NP_573419.2, NM_133173.2 [O95704-1] NP_573420.2, NM_133174.2 [O95704-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DYQ | X-ray | 3.10 | A | 281-417 | [»] | |
2YSC | NMR | - | A | 30-61 | [»] | |
AlphaFoldDBi | O95704 | |||||
SMRi | O95704 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115593, 26 interactors |
IntActi | O95704, 24 interactors |
MINTi | O95704 |
STRINGi | 9606.ENSP00000346378 |
PTM databases
iPTMneti | O95704 |
PhosphoSitePlusi | O95704 |
Genetic variation databases
BioMutai | APBB3 |
Proteomic databases
MassIVEi | O95704 |
PaxDbi | O95704 |
PeptideAtlasi | O95704 |
PRIDEi | O95704 |
ProteomicsDBi | 51002 [O95704-1] 51003 [O95704-2] 51004 [O95704-3] 51005 [O95704-4] 77814 79619 |
Protocols and materials databases
Antibodypediai | 1613, 184 antibodies from 22 providers |
DNASUi | 10307 |
Genome annotation databases
Organism-specific databases
CTDi | 10307 |
DisGeNETi | 10307 |
GeneCardsi | APBB3 |
HGNCi | HGNC:20708, APBB3 |
HPAi | ENSG00000113108, Tissue enhanced (brain) |
MIMi | 602711, gene |
neXtProti | NX_O95704 |
OpenTargetsi | ENSG00000113108 |
PharmGKBi | PA134958636 |
VEuPathDBi | HostDB:ENSG00000113108 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QR5N, Eukaryota |
GeneTreei | ENSGT00390000000002 |
HOGENOMi | CLU_093354_0_0_1 |
InParanoidi | O95704 |
OMAi | LYMGILP |
PhylomeDBi | O95704 |
TreeFami | TF314331 |
Enzyme and pathway databases
PathwayCommonsi | O95704 |
SignaLinki | O95704 |
Miscellaneous databases
BioGRID-ORCSi | 10307, 10 hits in 1075 CRISPR screens |
ChiTaRSi | APBB3, human |
EvolutionaryTracei | O95704 |
GeneWikii | APBB3 |
GenomeRNAii | 10307 |
Pharosi | O95704, Tbio |
PROi | PR:O95704 |
RNActi | O95704, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000113108, Expressed in right ovary and 116 other tissues |
ExpressionAtlasi | O95704, baseline and differential |
Genevisiblei | O95704, HS |
Family and domain databases
CDDi | cd00201, WW, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR039576, APBB1/2/3 IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom IPR001202, WW_dom IPR036020, WW_dom_sf |
PANTHERi | PTHR14058, PTHR14058, 1 hit |
Pfami | View protein in Pfam PF00640, PID, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 2 hits SM00456, WW, 1 hit |
SUPFAMi | SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 2 hits PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | APBB3_HUMAN | |
Accessioni | O95704Primary (citable) accession number: O95704 Secondary accession number(s): B3KQN9 Q9NYX8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | November 30, 2010 | |
Last modified: | May 25, 2022 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references