APBB3

Functionⁱ

May modulate the internalization of amyloid-beta precursor protein.

GO - Molecular functionⁱ

amyloid-beta binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

SignaLinkⁱ	O95704

SignaLinkⁱ

O95704

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Amyloid-beta A4 precursor protein-binding family B member 3 Alternative name(s): Protein Fe65-like 2 Short name: Fe65L2
Gene namesⁱ	Name:APBB3 Synonyms:FE65L2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000113108.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20708 APBB3
MIMⁱ	602711 gene
neXtProtⁱ	NX_O95704

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10307
Open Targets More...OpenTargetsⁱ	ENSG00000113108
PharmGKBⁱ	PA134958636

Polymorphism and mutation databases

BioMutaⁱ	APBB3

BioMutaⁱ

APBB3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076054	1 – 486	Amyloid-beta A4 precursor protein-binding family B member 3Add BLAST		486

Proteomic databases

PaxDbⁱ	O95704
PeptideAtlas More...PeptideAtlasⁱ	O95704
PRIDEⁱ	O95704
ProteomicsDBⁱ	51002 51003 [O95704-2] 51004 [O95704-3] 51005 [O95704-4]

PTM databases

iPTMnetⁱ	O95704
PhosphoSitePlusⁱ	O95704

Expressionⁱ

Tissue specificityⁱ

Expressed in various tissues, highest expression in brain.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000113108 Expressed in 91 organ(s), highest expression level in right ovary
CleanExⁱ	HS_APBB3
ExpressionAtlasⁱ	O95704 baseline and differential
Genevisibleⁱ	O95704 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA005571

HPAⁱ

HPA005571

Interactionⁱ

Subunit structureⁱ

Binds to the intracellular domain of the amyloid-beta precursor protein. Also binds to APP-like proteins.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DAPP1	Q9UN19	2	EBI-286427,EBI-3918199
EGFR	P00533	2	EBI-286427,EBI-297353

GO - Molecular functionⁱ

transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115593, 25 interactors
IntActⁱ	O95704, 7 interactors
Molecular INTeraction database More...MINTⁱ	O95704
STRINGⁱ	9606.ENSP00000346378

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	35 – 40	Combined sources	6
Beta strandⁱ	43 – 51	Combined sources	9
Beta strandⁱ	54 – 57	Combined sources	4
Beta strandⁱ	292 – 304	Combined sources	13
Helixⁱ	307 – 318	Combined sources	12
Beta strandⁱ	327 – 333	Combined sources	7
Beta strandⁱ	335 – 342	Combined sources	8
Beta strandⁱ	354 – 358	Combined sources	5
Helixⁱ	359 – 361	Combined sources	3
Beta strandⁱ	362 – 367	Combined sources	6
Beta strandⁱ	373 – 379	Combined sources	7
Beta strandⁱ	381 – 383	Combined sources	3
Beta strandⁱ	385 – 391	Combined sources	7
Helixⁱ	397 – 415	Combined sources	19

Show more details

3D structure databases

ProteinModelPortalⁱ	O95704
SMRⁱ	O95704
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O95704

EvolutionaryTraceⁱ

O95704

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	29 – 61	WWPROSITE-ProRule annotationAdd BLAST	33
Domainⁱ	113 – 280	PID 1PROSITE-ProRule annotationAdd BLAST	168
Domainⁱ	285 – 440	PID 2PROSITE-ProRule annotationAdd BLAST	156

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IEKA Eukaryota ENOG410YEVS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000002
HOGENOMⁱ	HOG000033983
HOVERGENⁱ	HBG075162
InParanoidⁱ	O95704
OMAⁱ	TWVPAML
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04HV
PhylomeDBⁱ	O95704
TreeFamⁱ	TF314331

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00201 WW, 1 hit
Gene3Dⁱ	2.30.29.30, 2 hits
InterProⁱ	View protein in InterPro IPR039576 Fe65 IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom IPR001202 WW_dom IPR036020 WW_dom_sf
PANTHERⁱ	PTHR14058 PTHR14058, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00640 PID, 1 hit
SMARTⁱ	View protein in SMART SM00462 PTB, 2 hits SM00456 WW, 1 hit
SUPFAMⁱ	SSF51045 SSF51045, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179 PID, 2 hits PS01159 WW_DOMAIN_1, 1 hit PS50020 WW_DOMAIN_2, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform II (identifier: O95704-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGKDYMLAI ILVNCDDDLW GDHSLEVEAG LPPGWRKIHD AAGTYYWHVP 
        60         70         80         90        100
SGSTQWQRPT WELGDAEDPG TGTEGIWGLR PPKGRSFSSL ESSLDRSNSL 
       110        120        130        140        150
SWYGGESYIQ SMEPGAKCFA VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL 
       160        170        180        190        200
AQTRSRSQPP DGAWGEGQNM LMILKKDAMS LVNPLDHSLI HCQPLVHIRV 
       210        220        230        240        250
WGVGSSKGRD RDFAFVASDK DSCMLKCHVF CCDVPAKAIA SALHGLCAQI 
       260        270        280        290        300
LSERVEVSGD ASCCSPDPIS PEDLPRQVEL LDAVSQAAQK YEALYMGTLP 
       310        320        330        340        350
VTKAMGMDVL NEAIGTLTAR GDRNAWVPTM LSVSDSLMTA HPIQAEASTE 
       360        370        380        390        400
EEPLWQCPVR LVTFIGVGRD PHTFGLIADL GRQSFQCAAF WCQPHAGGLS 
       410        420        430        440        450
EAVQAACMVQ YQKCLVASAA RGKAWGAQAR ARLRLKRTSS MDSPGGPLPL 
       460        470        480 
PLLKGGVGGA GATPRKRGVF SFLDAFRLKP SLLHMP

Length:486

Mass (Da):52,585

Last modified:November 30, 2010 - v2

Checksum:ⁱ553DFB4D8655EFA1

GO

Isoform I (identifier: O95704-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
210-211: Missing.

« Hide

        10         20         30         40         50
MLGKDYMLAI ILVNCDDDLW GDHSLEVEAG LPPGWRKIHD AAGTYYWHVP 
        60         70         80         90        100
SGSTQWQRPT WELGDAEDPG TGTEGIWGLR PPKGRSFSSL ESSLDRSNSL 
       110        120        130        140        150
SWYGGESYIQ SMEPGAKCFA VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL 
       160        170        180        190        200
AQTRSRSQPP DGAWGEGQNM LMILKKDAMS LVNPLDHSLI HCQPLVHIRV 
       210        220        230        240        250
WGVGSSKGRD FAFVASDKDS CMLKCHVFCC DVPAKAIASA LHGLCAQILS 
       260        270        280        290        300
ERVEVSGDAS CCSPDPISPE DLPRQVELLD AVSQAAQKYE ALYMGTLPVT 
       310        320        330        340        350
KAMGMDVLNE AIGTLTARGD RNAWVPTMLS VSDSLMTAHP IQAEASTEEE 
       360        370        380        390        400
PLWQCPVRLV TFIGVGRDPH TFGLIADLGR QSFQCAAFWC QPHAGGLSEA 
       410        420        430        440        450
VQAACMVQYQ KCLVASAARG KAWGAQARAR LRLKRTSSMD SPGGPLPLPL 
       460        470        480 
LKGGVGGAGA TPRKRGVFSF LDAFRLKPSL LHMP

Show »

Length:484

Mass (Da):52,314

Checksum:ⁱ2A57615AAA0CF980

GO

Isoform III (identifier: O95704-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
210-210: D → PISAPA

« Hide

        10         20         30         40         50
MLGKDYMLAI ILVNCDDDLW GDHSLEVEAG LPPGWRKIHD AAGTYYWHVP 
        60         70         80         90        100
SGSTQWQRPT WELGDAEDPG TGTEGIWGLR PPKGRSFSSL ESSLDRSNSL 
       110        120        130        140        150
SWYGGESYIQ SMEPGAKCFA VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL 
       160        170        180        190        200
AQTRSRSQPP DGAWGEGQNM LMILKKDAMS LVNPLDHSLI HCQPLVHIRV 
       210        220        230        240        250
WGVGSSKGRP ISAPARDFAF VASDKDSCML KCHVFCCDVP AKAIASALHG 
       260        270        280        290        300
LCAQILSERV EVSGDASCCS PDPISPEDLP RQVELLDAVS QAAQKYEALY 
       310        320        330        340        350
MGTLPVTKAM GMDVLNEAIG TLTARGDRNA WVPTMLSVSD SLMTAHPIQA 
       360        370        380        390        400
EASTEEEPLW QCPVRLVTFI GVGRDPHTFG LIADLGRQSF QCAAFWCQPH 
       410        420        430        440        450
AGGLSEAVQA ACMVQYQKCL VASAARGKAW GAQARARLRL KRTSSMDSPG 
       460        470        480        490 
GPLPLPLLKG GVGGAGATPR KRGVFSFLDA FRLKPSLLHM P

Show »

Length:491

Mass (Da):53,007

Checksum:ⁱ054A8696C11578E2

GO

Isoform IV (identifier: O95704-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
210-210: D → DSPISAPA

« Hide

        10         20         30         40         50
MLGKDYMLAI ILVNCDDDLW GDHSLEVEAG LPPGWRKIHD AAGTYYWHVP 
        60         70         80         90        100
SGSTQWQRPT WELGDAEDPG TGTEGIWGLR PPKGRSFSSL ESSLDRSNSL 
       110        120        130        140        150
SWYGGESYIQ SMEPGAKCFA VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL 
       160        170        180        190        200
AQTRSRSQPP DGAWGEGQNM LMILKKDAMS LVNPLDHSLI HCQPLVHIRV 
       210        220        230        240        250
WGVGSSKGRD SPISAPARDF AFVASDKDSC MLKCHVFCCD VPAKAIASAL 
       260        270        280        290        300
HGLCAQILSE RVEVSGDASC CSPDPISPED LPRQVELLDA VSQAAQKYEA 
       310        320        330        340        350
LYMGTLPVTK AMGMDVLNEA IGTLTARGDR NAWVPTMLSV SDSLMTAHPI 
       360        370        380        390        400
QAEASTEEEP LWQCPVRLVT FIGVGRDPHT FGLIADLGRQ SFQCAAFWCQ 
       410        420        430        440        450
PHAGGLSEAV QAACMVQYQK CLVASAARGK AWGAQARARL RLKRTSSMDS 
       460        470        480        490 
PGGPLPLPLL KGGVGGAGAT PRKRGVFSFL DAFRLKPSLL HMP

Show »

Length:493

Mass (Da):53,209

Checksum:ⁱ5EC279FAAE2EEF96

GO

Isoform I-214 (identifier: O95704-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
196-214: VHIRVWGVGSSKGRDRDFA → AVIPTDADPQYLNPWTQIL
215-486: Missing.

« Hide

        10         20         30         40         50
MLGKDYMLAI ILVNCDDDLW GDHSLEVEAG LPPGWRKIHD AAGTYYWHVP 
        60         70         80         90        100
SGSTQWQRPT WELGDAEDPG TGTEGIWGLR PPKGRSFSSL ESSLDRSNSL 
       110        120        130        140        150
SWYGGESYIQ SMEPGAKCFA VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL 
       160        170        180        190        200
AQTRSRSQPP DGAWGEGQNM LMILKKDAMS LVNPLDHSLI HCQPLAVIPT 
       210 
DADPQYLNPW TQIL

Note: Increased expression upon apoptotic stimuli.

Show »

Length:214

Mass (Da):23,634

Checksum:ⁱFD469DC121C73E6C

GO

Isoform I-245 (identifier: O95704-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
210-245: DRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHG → SSDVDPGLLPLPGPALVGEGGPSSAGTVWGESERLG
246-486: Missing.

« Hide

        10         20         30         40         50
MLGKDYMLAI ILVNCDDDLW GDHSLEVEAG LPPGWRKIHD AAGTYYWHVP 
        60         70         80         90        100
SGSTQWQRPT WELGDAEDPG TGTEGIWGLR PPKGRSFSSL ESSLDRSNSL 
       110        120        130        140        150
SWYGGESYIQ SMEPGAKCFA VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL 
       160        170        180        190        200
AQTRSRSQPP DGAWGEGQNM LMILKKDAMS LVNPLDHSLI HCQPLVHIRV 
       210        220        230        240 
WGVGSSKGRS SDVDPGLLPL PGPALVGEGG PSSAGTVWGE SERLG

Show »

Length:245

Mass (Da):26,460

Checksum:ⁱ7F460206E4157F6C

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RBA1	D6RBA1_HUMAN	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 3	APBB3	337	Annotation score:
E7EX91	E7EX91_HUMAN	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 3	APBB3	339	Annotation score:
D6RJB2	D6RJB2_HUMAN	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 3	APBB3	163	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_029518	165	G → R. Corresponds to variant dbSNP:rs7715021Ensembl.		1
Natural variantⁱVAR_024702	231	C → R5 PublicationsCorresponds to variant dbSNP:rs250430Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_047811	196 – 214	VHIRV…DRDFA → AVIPTDADPQYLNPWTQIL in isoform I-214. 1 PublicationAdd BLAST	19
Alternative sequenceⁱVSP_047812	210 – 245	DRDFA…SALHG → SSDVDPGLLPLPGPALVGEG GPSSAGTVWGESERLG in isoform I-245. 1 PublicationAdd BLAST	36
Alternative sequenceⁱVSP_006799	210 – 211	Missing in isoform I. 2 Publications	2
Alternative sequenceⁱVSP_006800	210	D → PISAPA in isoform III. 1 Publication	1
Alternative sequenceⁱVSP_006801	210	D → DSPISAPA in isoform IV. 1 Publication	1
Alternative sequenceⁱVSP_047813	215 – 486	Missing in isoform I-214. 1 PublicationAdd BLAST	272
Alternative sequenceⁱVSP_047814	246 – 486	Missing in isoform I-245. 1 PublicationAdd BLAST	241

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB018247 mRNA Translation: BAA35188.1 AB024745 Genomic DNA Translation: BAA78674.1 AB049618 mRNA Translation: BAB40806.1 AB061224 mRNA Translation: BAB71767.1 AF224708 mRNA Translation: AAF65172.1 AF224709 mRNA Translation: AAF65173.1 AF224710 mRNA Translation: AAF65174.1 AF224711 mRNA Translation: AAF65175.1 AK075280 mRNA Translation: BAG52101.1 AC011399 Genomic DNA No translation available. AC116353 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW62041.1 BC125187 mRNA Translation: AAI25188.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4227.1 [O95704-4] CCDS4228.1 [O95704-3] CCDS4229.1 [O95704-1] CCDS47279.1 [O95704-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_006042.3, NM_006051.3 [O95704-4] NP_573418.2, NM_133172.2 [O95704-3] NP_573419.2, NM_133173.2 [O95704-1] NP_573420.2, NM_133174.2 [O95704-2]
UniGeneⁱ	Hs.529449

Genome annotation databases

Ensemblⁱ	ENST00000354402; ENSP00000346378; ENSG00000113108 [O95704-4] ENST00000356738; ENSP00000349177; ENSG00000113108 [O95704-3] ENST00000357560; ENSP00000350171; ENSG00000113108 [O95704-1] ENST00000412920; ENSP00000402591; ENSG00000113108 [O95704-2] ENST00000467078; ENSP00000422718; ENSG00000113108 [O95704-6] ENST00000509914; ENSP00000426107; ENSG00000113108 [O95704-5]
GeneIDⁱ	10307
KEGGⁱ	hsa:10307
UCSC genome browser More...UCSCⁱ	uc003lgd.2 human [O95704-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95704	Amyloid beta protein-binding, family B, member 3 isoform b variant (Fragment)		HUMAN		515	UniRef100_O95704

Protein	Similar proteins		Species	Score	Length	Source
O95704	Amyloid beta protein-binding, family B, member 3 isoform b variant (Fragment)		HUMAN		515	UniRef90_O95704
Amyloid beta precursor protein binding family B member 3		PANTR		601
Uncharacterized protein		PANPA		484
Amyloid beta precursor protein binding family B member 3		CHLSB		585
Amyloid beta A4 protein-binding family B member 3 isoform c		MACMU		209
+43
O95704-2	Uncharacterized protein		PIG		488	UniRef90_O95704-2
amyloid beta A4 precursor protein-binding family B member 3 isoform X2		DIPOR		484
Alzheimer's beta-amyloid interaction protein		HUMAN		484
amyloid-beta A4 precursor protein-binding family B member 3 isoform X6		Yangtze finless porpoise		484
Amyloid beta A4 protein-binding family B member 3		CASCN		484
+58
O95704-3	Isoform IV of Amyloid-beta A4 precursor protein-binding family B member 3		HUMAN		493	UniRef90_O95704-4
amyloid-beta A4 precursor protein-binding family B member 3 isoform X3		Yangtze finless porpoise		497
amyloid beta A4 precursor protein-binding family B member 3 isoform X3		ODORO		495
amyloid beta A4 precursor protein-binding family B member 3 isoform X1		LEPWE		495
amyloid beta A4 precursor protein-binding family B member 3 isoform X3		Enhydra lutris kenyoni		495
+81
O95704-4	amyloid-beta A4 precursor protein-binding family B member 3 isoform X3		Yangtze finless porpoise		497	UniRef90_O95704-4
amyloid beta A4 precursor protein-binding family B member 3 isoform X3		ODORO		495
amyloid beta A4 precursor protein-binding family B member 3 isoform X1		LEPWE		495
amyloid beta A4 precursor protein-binding family B member 3 isoform X3		Enhydra lutris kenyoni		495
amyloid beta A4 precursor protein-binding family B member 3 isoform X6		URSMA		495
+81
O95704-5	Isoform I-245 of Amyloid-beta A4 precursor protein-binding family B member 3		HUMAN		245	UniRef90_O95704-6
APBB3 isoform 16		PONAB		245
APBB3 isoform 7		PANTR		245
Amyloid beta (A4) protein-binding, family B, member 3 (Fragment)		NEOVI		210
APBB3 isoform 11		PONAB		217
+1
O95704-6	APBB3 isoform 16		PONAB		245	UniRef90_O95704-6
APBB3 isoform 7		PANTR		245
Isoform I-214 of Amyloid-beta A4 precursor protein-binding family B member 3		HUMAN		214
Amyloid beta (A4) protein-binding, family B, member 3 (Fragment)		NEOVI		210
APBB3 isoform 11		PONAB		217
+1

Protein	Similar proteins		Species	Score	Length	Source
O95704	Amyloid beta protein-binding, family B, member 3 isoform b variant (Fragment)		HUMAN		515	UniRef50_O95704
Amyloid beta precursor protein binding family B member 3		PANTR		601
Uncharacterized protein		PANPA		484
Amyloid beta precursor protein binding family B member 3		CHLSB		585
Amyloid beta A4 protein-binding family B member 3 isoform c		MACMU		209
+54
O95704-2	Isoform IV of Amyloid-beta A4 precursor protein-binding family B member 3		HUMAN		493	UniRef50_O95704-4
Amyloid-beta A4 precursor protein-binding family B member 3		MOUSE		486
amyloid-beta A4 precursor protein-binding family B member 3 isoform X3		Yangtze finless porpoise		497
amyloid beta A4 precursor protein-binding family B member 3 isoform X3		ODORO		495
amyloid beta A4 precursor protein-binding family B member 3 isoform X6		URSMA		495
+280
O95704-3	Isoform IV of Amyloid-beta A4 precursor protein-binding family B member 3		HUMAN		493	UniRef50_O95704-4
Amyloid-beta A4 precursor protein-binding family B member 3		MOUSE		486
amyloid-beta A4 precursor protein-binding family B member 3 isoform X3		Yangtze finless porpoise		497
amyloid beta A4 precursor protein-binding family B member 3 isoform X3		ODORO		495
amyloid beta A4 precursor protein-binding family B member 3 isoform X6		URSMA		495
+280
O95704-4	Amyloid-beta A4 precursor protein-binding family B member 3		MOUSE		486	UniRef50_O95704-4
amyloid-beta A4 precursor protein-binding family B member 3 isoform X3		Yangtze finless porpoise		497
amyloid beta A4 precursor protein-binding family B member 3 isoform X3		ODORO		495
amyloid beta A4 precursor protein-binding family B member 3 isoform X6		URSMA		495
Amyloid beta precursor protein binding family B member 3		AILME		495
+280
O95704-5	Isoform I-245 of Amyloid-beta A4 precursor protein-binding family B member 3		HUMAN		245	UniRef50_O95704-6
APBB3 isoform 7		PANTR		245
APBB3 isoform 16		PONAB		245
Amyloid beta (A4) protein-binding, family B, member 3 (Fragment)		NEOVI		210
Uncharacterized protein		NEOLE		242
+3
O95704-6	APBB3 isoform 7		PANTR		245	UniRef50_O95704-6
APBB3 isoform 16		PONAB		245
Isoform I-214 of Amyloid-beta A4 precursor protein-binding family B member 3		HUMAN		214
Amyloid beta (A4) protein-binding, family B, member 3 (Fragment)		NEOVI		210
Uncharacterized protein		NEOLE		242
+3

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB018247 mRNA Translation: BAA35188.1 AB024745 Genomic DNA Translation: BAA78674.1 AB049618 mRNA Translation: BAB40806.1 AB061224 mRNA Translation: BAB71767.1 AF224708 mRNA Translation: AAF65172.1 AF224709 mRNA Translation: AAF65173.1 AF224710 mRNA Translation: AAF65174.1 AF224711 mRNA Translation: AAF65175.1 AK075280 mRNA Translation: BAG52101.1 AC011399 Genomic DNA No translation available. AC116353 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW62041.1 BC125187 mRNA Translation: AAI25188.1
CCDSⁱ	CCDS4227.1 [O95704-4] CCDS4228.1 [O95704-3] CCDS4229.1 [O95704-1] CCDS47279.1 [O95704-2]
RefSeqⁱ	NP_006042.3, NM_006051.3 [O95704-4] NP_573418.2, NM_133172.2 [O95704-3] NP_573419.2, NM_133173.2 [O95704-1] NP_573420.2, NM_133174.2 [O95704-2]
UniGeneⁱ	Hs.529449

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DYQ	X-ray	3.10	A	281-417	[»]
	2YSC	NMR	-	A	30-61	[»]
ProteinModelPortalⁱ	O95704
SMRⁱ	O95704
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115593, 25 interactors
IntActⁱ	O95704, 7 interactors
MINTⁱ	O95704
STRINGⁱ	9606.ENSP00000346378

PTM databases

iPTMnetⁱ	O95704
PhosphoSitePlusⁱ	O95704

Polymorphism and mutation databases

BioMutaⁱ	APBB3

BioMutaⁱ

APBB3

Proteomic databases

PaxDbⁱ	O95704
PeptideAtlasⁱ	O95704
PRIDEⁱ	O95704
ProteomicsDBⁱ	51002 51003 [O95704-2] 51004 [O95704-3] 51005 [O95704-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000354402; ENSP00000346378; ENSG00000113108 [O95704-4] ENST00000356738; ENSP00000349177; ENSG00000113108 [O95704-3] ENST00000357560; ENSP00000350171; ENSG00000113108 [O95704-1] ENST00000412920; ENSP00000402591; ENSG00000113108 [O95704-2] ENST00000467078; ENSP00000422718; ENSG00000113108 [O95704-6] ENST00000509914; ENSP00000426107; ENSG00000113108 [O95704-5]
GeneIDⁱ	10307
KEGGⁱ	hsa:10307
UCSCⁱ	uc003lgd.2 human [O95704-1]

Organism-specific databases

CTDⁱ	10307
DisGeNETⁱ	10307
EuPathDBⁱ	HostDB:ENSG00000113108.17
GeneCardsⁱ	APBB3
HGNCⁱ	HGNC:20708 APBB3
HPAⁱ	HPA005571
MIMⁱ	602711 gene
neXtProtⁱ	NX_O95704
OpenTargetsⁱ	ENSG00000113108
PharmGKBⁱ	PA134958636
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEKA Eukaryota ENOG410YEVS LUCA
GeneTreeⁱ	ENSGT00390000000002
HOGENOMⁱ	HOG000033983
HOVERGENⁱ	HBG075162
InParanoidⁱ	O95704
OMAⁱ	TWVPAML
OrthoDBⁱ	EOG091G04HV
PhylomeDBⁱ	O95704
TreeFamⁱ	TF314331

Enzyme and pathway databases

SignaLinkⁱ	O95704

SignaLinkⁱ

O95704

Miscellaneous databases

ChiTaRSⁱ	APBB3 human
EvolutionaryTraceⁱ	O95704
GeneWikiⁱ	APBB3
GenomeRNAiⁱ	10307
Protein Ontology More...PROⁱ	PR:O95704
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000113108 Expressed in 91 organ(s), highest expression level in right ovary
CleanExⁱ	HS_APBB3
ExpressionAtlasⁱ	O95704 baseline and differential
Genevisibleⁱ	O95704 HS

Family and domain databases

CDDⁱ	cd00201 WW, 1 hit
Gene3Dⁱ	2.30.29.30, 2 hits
InterProⁱ	View protein in InterPro IPR039576 Fe65 IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom IPR001202 WW_dom IPR036020 WW_dom_sf
PANTHERⁱ	PTHR14058 PTHR14058, 1 hit
Pfamⁱ	View protein in Pfam PF00640 PID, 1 hit
SMARTⁱ	View protein in SMART SM00462 PTB, 2 hits SM00456 WW, 1 hit
SUPFAMⁱ	SSF51045 SSF51045, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179 PID, 2 hits PS01159 WW_DOMAIN_1, 1 hit PS50020 WW_DOMAIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	APBB3_HUMAN
Accessionⁱ	O95704Primary (citable) accession number: O95704 Secondary accession number(s): B3KQN9 Q9NYX8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	November 30, 2010
	Last modified:	November 7, 2018
	This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniProtKB - O95704 (APBB3_HUMAN)

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Amyloid-beta A4 precursor protein-binding family B member 3

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Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

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GO - Molecular functionⁱ

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Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

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Keywords - Technical termⁱ