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Protein

Bromodomain-containing protein 1

Gene

BRD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri214 – 264PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri268 – 301C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri325 – 389PHD-type 2PROSITE-ProRule annotationAdd BLAST65

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • histone binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214847 HATs acetylate histones
R-HSA-6804758 Regulation of TP53 Activity through Acetylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain-containing protein 1
Alternative name(s):
BR140-like protein
Bromodomain and PHD finger-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRD1
Synonyms:BRL, BRPF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100425.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1102 BRD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604589 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95696

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23774

Open Targets

More...
OpenTargetsi
ENSG00000100425

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25413

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2176774

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2724

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BRD1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002111771 – 1058Bromodomain-containing protein 1Add BLAST1058

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei128PhosphoserineCombined sources1
Modified residuei368N6-acetyllysineCombined sources1
Modified residuei516N6-acetyllysineCombined sources1
Modified residuei519N6-acetyllysineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki554Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki594Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei803PhosphoserineCombined sources1
Modified residuei903N6-acetyllysineCombined sources1
Modified residuei1052PhosphoserineCombined sources1
Modified residuei1055PhosphoserineCombined sources1
Isoform 2 (identifier: O95696-2)
Modified residuei906PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O95696

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95696

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95696

PeptideAtlas

More...
PeptideAtlasi
O95696

PRoteomics IDEntifications database

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PRIDEi
O95696

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51000
51001 [O95696-2]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
O95696

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95696

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O95696

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
O95696

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100425 Expressed in 231 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_BRD1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95696 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O95696 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA000807
HPA001063

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts (via PHD-type zinc finger domain) with unmodified histone H3. Interacts (via PWWP domain) with dimethylated and trimethylated 'Lys-79' on histone H3.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PBRM1Q86U862EBI-11700916,EBI-637807

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117273, 55 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-733 MOZ2 histone acetyltransferase complex
CPX-739 MORF2 histone acetyltransferase complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O95696

Protein interaction database and analysis system

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IntActi
O95696, 49 interactors

Molecular INTeraction database

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MINTi
O95696

STRING: functional protein association networks

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STRINGi
9606.ENSP00000216267

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
O95696

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11058
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O95696

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95696

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O95696

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini579 – 649BromoPROSITE-ProRule annotationAdd BLAST71
Domaini929 – 1012PWWPPROSITE-ProRule annotationAdd BLAST84

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 264PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri268 – 301C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri325 – 389PHD-type 2PROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

Bromodomain, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0955 Eukaryota
COG5076 LUCA
COG5141 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157236

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000000705

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004895

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95696

KEGG Orthology (KO)

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KOi
K11349

Identification of Orthologs from Complete Genome Data

More...
OMAi
NESHSTC

Database for complete collections of gene phylogenies

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PhylomeDBi
O95696

TreeFam database of animal gene trees

More...
TreeFami
TF316118

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05839 BR140_related, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035502 BR140-rel_PWWD
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR000313 PWWP_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 1 hit
PF10513 EPL1, 1 hit
PF00855 PWWP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SM00293 PWWP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS50812 PWWP, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O95696-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRKGRCHRG SAARHPSSPC SVKHSPTRET LTYAQAQRMV EIEIEGRLHR
60 70 80 90 100
ISIFDPLEII LEDDLTAQEM SECNSNKENS ERPPVCLRTK RHKNNRVKKK
110 120 130 140 150
NEALPSAHGT PASASALPEP KVRIVEYSPP SAPRRPPVYY KFIEKSAEEL
160 170 180 190 200
DNEVEYDMDE EDYAWLEIVN EKRKGDCVPA VSQSMFEFLM DRFEKESHCE
210 220 230 240 250
NQKQGEQQSL IDEDAVCCIC MDGECQNSNV ILFCDMCNLA VHQECYGVPY
260 270 280 290 300
IPEGQWLCRH CLQSRARPAD CVLCPNKGGA FKKTDDDRWG HVVCALWIPE
310 320 330 340 350
VGFANTVFIE PIDGVRNIPP ARWKLTCYLC KQKGVGACIQ CHKANCYTAF
360 370 380 390 400
HVTCAQKAGL YMKMEPVKEL TGGGTTFSVR KTAYCDVHTP PGCTRRPLNI
410 420 430 440 450
YGDVEMKNGV CRKESSVKTV RSTSKVRKKA KKAKKALAEP CAVLPTVCAP
460 470 480 490 500
YIPPQRLNRI ANQVAIQRKK QFVERAHSYW LLKRLSRNGA PLLRRLQSSL
510 520 530 540 550
QSQRSSQQRE NDEEMKAAKE KLKYWQRLRH DLERARLLIE LLRKREKLKR
560 570 580 590 600
EQVKVEQVAM ELRLTPLTVL LRSVLDQLQD KDPARIFAQP VSLKEVPDYL
610 620 630 640 650
DHIKHPMDFA TMRKRLEAQG YKNLHEFEED FDLIIDNCMK YNARDTVFYR
660 670 680 690 700
AAVRLRDQGG VVLRQARREV DSIGLEEASG MHLPERPAAA PRRPFSWEDV
710 720 730 740 750
DRLLDPANRA HLGLEEQLRE LLDMLDLTCA MKSSGSRSKR AKLLKKEIAL
760 770 780 790 800
LRNKLSQQHS QPLPTGPGLE GFEEDGAALG PEAGEEVLPR LETLLQPRKR
810 820 830 840 850
SRSTCGDSEV EEESPGKRLD AGLTNGFGGA RSEQEPGGGL GRKATPRRRC
860 870 880 890 900
ASESSISSSN SPLCDSSFNA PKCGRGKPAL VRRHTLEDRS ELISCIENGN
910 920 930 940 950
YAKAARIAAE VGQSSMWIST DAAASVLEPL KVVWAKCSGY PSYPALIIDP
960 970 980 990 1000
KMPRVPGHHN GVTIPAPPLD VLKIGEHMQT KSDEKLFLVL FFDNKRSWQW
1010 1020 1030 1040 1050
LPKSKMVPLG IDETIDKLKM MEGRNSSIRK AVRIAFDRAM NHLSRVHGEP

TSDLSDID
Length:1,058
Mass (Da):119,520
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E7B07E8A030E104
GO
Isoform 2 (identifier: O95696-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     786-786: E → EGDKSPPKLE...QLGTKTFLSV

Show »
Length:1,189
Mass (Da):133,243
Checksum:i770DB2F610CB5052
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQ61J3KQ61_HUMAN
Bromodomain-containing protein 1
BRD1
509Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04842438R → G. Corresponds to variant dbSNP:rs11549978Ensembl.1
Natural variantiVAR_079184230V → L Polymorphism. 1 Publication1
Natural variantiVAR_048425321A → S. Corresponds to variant dbSNP:rs12157714Ensembl.1
Natural variantiVAR_048426730A → T. Corresponds to variant dbSNP:rs35331092Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040262786E → EGDKSPPKLEPSDALPLPSN SETNSEPPTLKPVELNPEQS KLFKRVTFDNESHSACTQSA LVSGRPPEPTRASSGDVPAA AASAVAEPASDVNRRTSVLF CKSKSVSPPKSAKNTETQPT SPQLGTKTFLSV in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF005067 mRNA Translation: AAF34320.1
CR456408 mRNA Translation: CAG30294.1
AK292428 mRNA Translation: BAF85117.1
Z98885 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73473.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14080.1 [O95696-1]
CCDS77686.1 [O95696-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001291737.1, NM_001304808.1 [O95696-2]
NP_001291738.1, NM_001304809.1 [O95696-1]
XP_016884204.1, XM_017028715.1 [O95696-2]
XP_016884205.1, XM_017028716.1 [O95696-2]
XP_016884206.1, XM_017028717.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.127950

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000216267; ENSP00000216267; ENSG00000100425 [O95696-1]
ENST00000404034; ENSP00000384076; ENSG00000100425 [O95696-1]
ENST00000404760; ENSP00000385858; ENSG00000100425 [O95696-2]
ENST00000457780; ENSP00000410042; ENSG00000100425 [O95696-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23774

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23774

UCSC genome browser

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UCSCi
uc003biu.6 human [O95696-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005067 mRNA Translation: AAF34320.1
CR456408 mRNA Translation: CAG30294.1
AK292428 mRNA Translation: BAF85117.1
Z98885 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73473.1
CCDSiCCDS14080.1 [O95696-1]
CCDS77686.1 [O95696-2]
RefSeqiNP_001291737.1, NM_001304808.1 [O95696-2]
NP_001291738.1, NM_001304809.1 [O95696-1]
XP_016884204.1, XM_017028715.1 [O95696-2]
XP_016884205.1, XM_017028716.1 [O95696-2]
XP_016884206.1, XM_017028717.1
UniGeneiHs.127950

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KU3NMR-A208-269[»]
2L43NMR-A205-269[»]
2LQ6NMR-A317-392[»]
3LYIX-ray2.10A/B925-1049[»]
3RCWX-ray2.21A/B/C/D/E/F/G/H556-688[»]
4Z02X-ray1.87A/B925-1049[»]
5AMEX-ray1.58A/B556-688[»]
5AMFX-ray1.75A/B556-688[»]
5FG6X-ray1.10A563-688[»]
5GK9X-ray2.40B31-80[»]
5N49X-ray1.94A/B555-688[»]
5PNXX-ray1.47A/B555-688[»]
5PNYX-ray1.48A/B555-688[»]
5PNZX-ray1.56A/B555-688[»]
5PO0X-ray1.46A/B555-688[»]
5PO1X-ray1.52A/B555-688[»]
5PO2X-ray1.67A/B555-688[»]
5PO3X-ray1.70A/B555-688[»]
5PO4X-ray1.49A/B555-688[»]
5PO5X-ray1.44A/B555-688[»]
5PO6X-ray1.61A/B555-688[»]
5PO7X-ray1.50A/B555-688[»]
5PO8X-ray1.50A/B555-688[»]
5PO9X-ray2.12A/B555-688[»]
5POAX-ray1.62A/B555-688[»]
5POBX-ray1.78A/B555-688[»]
5POCX-ray1.48A/B555-688[»]
5PODX-ray1.56A/B555-688[»]
5POEX-ray1.52A/B555-688[»]
5POFX-ray2.27A/B555-688[»]
5POGX-ray1.77A/B555-688[»]
5POHX-ray1.61A/B555-688[»]
5POIX-ray2.37A/B555-688[»]
5POJX-ray1.62A/B555-688[»]
5POKX-ray1.56A/B555-688[»]
5POLX-ray1.62A/B555-688[»]
5POMX-ray1.54A/B555-688[»]
5PONX-ray1.52A/B555-688[»]
5POOX-ray1.50A/B555-688[»]
5POPX-ray1.58A/B555-688[»]
5POQX-ray1.97A/B555-688[»]
5PORX-ray1.58A/B555-688[»]
5POSX-ray1.75A/B555-688[»]
5POTX-ray1.63A/B555-688[»]
5POUX-ray1.43A/B555-688[»]
5POVX-ray1.57A/B555-688[»]
5POWX-ray1.77A/B555-688[»]
5POXX-ray1.75A/B555-688[»]
5POYX-ray1.76A/B555-688[»]
5POZX-ray1.50A/B555-688[»]
5PP0X-ray1.61A/B555-688[»]
5PP1X-ray2.35A/B555-688[»]
5PP2X-ray1.61A/B555-688[»]
5PP3X-ray2.58A/B555-688[»]
5PP4X-ray1.92A/B555-688[»]
5PP5X-ray1.87A/B555-688[»]
5PP6X-ray1.52A/B555-688[»]
5PP7X-ray1.52A/B555-688[»]
5PP8X-ray1.74A/B555-688[»]
5PP9X-ray1.82A/B555-688[»]
5PPAX-ray1.91A/B555-688[»]
5PPBX-ray1.48A/B555-688[»]
5PPCX-ray1.61A/B555-688[»]
5PPDX-ray1.67A/B555-688[»]
5PPEX-ray1.46A/B555-688[»]
5PPFX-ray1.64A/B555-688[»]
5PPGX-ray1.55A/B555-688[»]
5PPHX-ray1.89A/B555-688[»]
5PPIX-ray1.56A/B555-688[»]
5PPJX-ray1.61A/B555-688[»]
5PPKX-ray1.87A/B555-688[»]
5PPLX-ray1.63A/B555-688[»]
5PPMX-ray1.87A/B555-688[»]
5PPNX-ray1.80A/B555-688[»]
5PPOX-ray1.84A/B555-688[»]
5PPPX-ray1.68A/B555-688[»]
5PPQX-ray1.70A/B555-688[»]
5PPRX-ray2.69A/B555-688[»]
5PPSX-ray1.53A/B555-688[»]
5PPTX-ray1.61A/B555-688[»]
5PPUX-ray1.63A/B555-688[»]
5PPVX-ray1.70A/B555-688[»]
5PPWX-ray1.45A/B555-688[»]
5PPXX-ray1.44A/B555-688[»]
5PPYX-ray1.45A/B555-688[»]
5PPZX-ray1.55A/B555-688[»]
5PQ0X-ray1.81A/B555-688[»]
5PQ1X-ray1.55A/B555-688[»]
5PQ2X-ray1.47A/B555-688[»]
5PQ3X-ray1.72A/B555-688[»]
5PQ4X-ray1.63A/B555-688[»]
5PQ5X-ray1.60A/B555-688[»]
5PQ6X-ray1.64A/B555-688[»]
5PQ7X-ray1.56A/B555-688[»]
5PQ8X-ray1.65A/B555-688[»]
5PQ9X-ray1.60A/B555-688[»]
5PQAX-ray1.78A/B555-688[»]
5PQBX-ray1.58A/B555-688[»]
5PQCX-ray1.45A/B555-688[»]
5PQDX-ray1.65A/B555-688[»]
5PQEX-ray1.53A/B555-688[»]
5PQFX-ray1.65A/B555-688[»]
5PQGX-ray1.82A/B555-688[»]
5PQHX-ray1.52A/B555-688[»]
5PQIX-ray1.33A/B555-688[»]
5PQJX-ray1.59A/B555-688[»]
5PQKX-ray1.58A/B555-688[»]
5PQLX-ray1.52A/B555-688[»]
5PQMX-ray2.56A/B555-688[»]
5PQNX-ray2.00A/B555-688[»]
5PQOX-ray1.75A/B555-688[»]
5PQPX-ray1.97A/B555-688[»]
5PQQX-ray2.30A/B555-688[»]
5PQRX-ray2.43A/B555-688[»]
5PQSX-ray1.82A/B555-688[»]
5PQTX-ray1.89A/B555-688[»]
5PQUX-ray2.00A/B555-688[»]
5PQVX-ray1.97A/B555-688[»]
5PQWX-ray2.00A/B555-688[»]
5PQXX-ray1.95A/B555-688[»]
5PQYX-ray1.89A/B555-688[»]
5PQZX-ray2.58A/B555-688[»]
5PR0X-ray2.23A/B555-688[»]
5PR1X-ray2.10A/B555-688[»]
5PR2X-ray2.10A/B555-688[»]
5PR4X-ray1.82A/B555-688[»]
5PR5X-ray1.95A/B555-688[»]
5PR6X-ray1.80A/B555-688[»]
5PR7X-ray1.80A/B555-688[»]
5PR8X-ray1.92A/B555-688[»]
5PR9X-ray1.82A/B555-688[»]
5PRAX-ray1.87A/B555-688[»]
5PRBX-ray2.23A/B555-688[»]
5PRDX-ray1.90A/B555-688[»]
5PREX-ray1.73A/B555-688[»]
5PRFX-ray1.82A/B555-688[»]
5PRGX-ray2.68A/B555-688[»]
5PRHX-ray1.95A/B555-688[»]
5PRIX-ray1.90A/B555-688[»]
5PRJX-ray2.17A/B555-688[»]
5PRKX-ray2.23A/B555-688[»]
5PRLX-ray1.75A/B555-688[»]
5PRMX-ray3.58A/B555-688[»]
5PROX-ray1.55A/B555-688[»]
5PRPX-ray1.45A/B555-688[»]
5PRQX-ray1.68A/B555-688[»]
5PRRX-ray1.63A/B555-688[»]
5PRSX-ray1.72A/B555-688[»]
5PRTX-ray1.89A/B555-688[»]
5PRUX-ray1.58A/B555-688[»]
5PRVX-ray1.62A/B555-688[»]
5PRWX-ray1.65A/B555-688[»]
5PRXX-ray1.87A/B555-688[»]
5PRYX-ray1.80A/B555-688[»]
5PRZX-ray1.62A/B555-688[»]
5PS0X-ray1.68A/B555-688[»]
5PS1X-ray1.71A/B555-688[»]
5PS2X-ray1.55A/B555-688[»]
5PS3X-ray1.93A/B555-688[»]
5PS4X-ray1.70A/B555-688[»]
5PS5X-ray2.15A/B555-688[»]
5PS6X-ray1.52A/B555-688[»]
5PS7X-ray2.21A/B555-688[»]
5PS8X-ray1.93A/B555-688[»]
5PS9X-ray1.71A/B555-688[»]
5PSAX-ray1.64A/B555-688[»]
5PSBX-ray1.62A/B555-688[»]
5PSCX-ray1.68A/B555-688[»]
5PSDX-ray1.63A/B555-688[»]
5PSEX-ray2.19A/B555-688[»]
5PSFX-ray2.31A/B555-688[»]
5PSGX-ray1.55A/B555-688[»]
5PSHX-ray3.43A/B555-688[»]
5PSIX-ray1.62A/B555-688[»]
5PSJX-ray1.38A/B555-688[»]
5PSKX-ray1.38A/B555-688[»]
5PSLX-ray1.39A/B555-688[»]
5PSMX-ray1.53A/B555-688[»]
5PSNX-ray1.48A/B555-688[»]
5PSOX-ray1.55A/B555-688[»]
5PSPX-ray1.58A/B555-688[»]
5PSQX-ray1.43A/B555-688[»]
5PSRX-ray1.59A/B555-688[»]
5PSSX-ray1.59A/B555-688[»]
5PSTX-ray1.39A/B555-688[»]
5PSUX-ray1.56A/B555-688[»]
5PSVX-ray1.53A/B555-688[»]
5PSWX-ray1.53A/B555-688[»]
5PSXX-ray1.59A/B555-688[»]
5PSYX-ray1.82A/B555-688[»]
5PSZX-ray1.53A/B555-688[»]
5PT0X-ray1.43A/B555-688[»]
5PT1X-ray1.54A/B555-688[»]
5PT2X-ray1.52A/B555-688[»]
5PT3X-ray1.70A/B555-688[»]
5PT4X-ray1.54A/B555-688[»]
5PT5X-ray1.76A/B555-688[»]
5PT6X-ray1.53A/B555-688[»]
5PT7X-ray1.55A/B555-688[»]
5PT8X-ray1.66A/B555-688[»]
5PT9X-ray1.47A/B555-688[»]
5PTAX-ray2.19A/B555-688[»]
5PTBX-ray1.88A/B555-688[»]
5PTCX-ray1.78A/B555-688[»]
5PTEX-ray1.63A/B555-688[»]
5PTFX-ray1.49A/B555-688[»]
5PTGX-ray1.46A/B555-688[»]
5PTHX-ray1.56A/B555-688[»]
5PTJX-ray1.69A/B555-688[»]
5PTKX-ray1.48A/B555-688[»]
5PTLX-ray1.53A/B555-688[»]
5PTMX-ray1.41A/B555-688[»]
5PTNX-ray1.47A/B555-688[»]
5PTOX-ray1.67A/B555-688[»]
5PTQX-ray1.49A/B555-688[»]
5PTRX-ray1.52A/B555-688[»]
5PTSX-ray1.45A/B555-688[»]
5PTTX-ray1.47A/B555-688[»]
5PTUX-ray1.69A/B555-688[»]
5PTVX-ray1.70A/B555-688[»]
5PTWX-ray1.82A/B555-688[»]
5PTXX-ray1.60A/B555-688[»]
5PTYX-ray2.10A/B555-688[»]
5PTZX-ray1.51A/B555-688[»]
5PU0X-ray1.89A/B555-688[»]
5PU1X-ray1.73A/B555-688[»]
5PU2X-ray1.59A/B555-688[»]
5PU3X-ray2.37A/B555-688[»]
5PU4X-ray1.55A/B555-688[»]
5PU5X-ray1.55A/B555-688[»]
5PU6X-ray1.74A/B555-688[»]
5PU7X-ray1.62A/B555-688[»]
5PU8X-ray1.55A/B555-688[»]
5PU9X-ray1.56A/B555-688[»]
5PUAX-ray1.63A/B555-688[»]
5PUBX-ray2.23A/B555-688[»]
5PUCX-ray1.64A/B555-688[»]
5PUDX-ray2.01A/B555-688[»]
5PUEX-ray1.70A/B555-688[»]
5PUFX-ray1.82A/B555-688[»]
5PUGX-ray2.00A/B555-688[»]
5PUHX-ray1.92A/B555-688[»]
5PUIX-ray1.51A/B555-688[»]
5PUJX-ray1.90A/B555-688[»]
5PUKX-ray1.64A/B555-688[»]
5PULX-ray1.95A/B555-688[»]
5PUMX-ray2.15A/B555-688[»]
5PUNX-ray1.84A/B555-688[»]
5PUOX-ray2.06A/B555-688[»]
5PUPX-ray1.60A/B555-688[»]
5PUQX-ray1.70A/B555-688[»]
5PURX-ray1.73A/B555-688[»]
5PUSX-ray1.67A/B555-688[»]
5PUTX-ray2.32A/B555-688[»]
5PUUX-ray1.69A/B555-688[»]
5PUVX-ray1.69A/B555-688[»]
5PUWX-ray1.82A/B555-688[»]
5PUXX-ray1.51A/B555-688[»]
5PUYX-ray2.01A/B555-688[»]
5PUZX-ray1.49A/B555-688[»]
5PV0X-ray1.76A/B555-688[»]
5PV1X-ray1.73A/B555-688[»]
5PV2X-ray1.63A/B555-688[»]
5PV3X-ray1.48A/B555-688[»]
5PV4X-ray1.58A/B555-688[»]
5PV5X-ray1.68A/B555-688[»]
5PV6X-ray1.62A/B555-688[»]
5PV7X-ray1.58A/B555-688[»]
5PV8X-ray1.49A/B555-688[»]
5PV9X-ray1.67A/B555-688[»]
5PVAX-ray1.98A/B555-688[»]
5PVBX-ray1.53A/B555-688[»]
5PVCX-ray1.56A/B555-688[»]
5PVDX-ray1.53A/B555-688[»]
5PVEX-ray2.29A/B555-688[»]
5PVFX-ray1.71A/B555-688[»]
5PVGX-ray1.69A/B555-688[»]
5PVHX-ray1.69A/B555-688[»]
5PVIX-ray2.19A/B555-688[»]
5PVJX-ray1.57A/B555-688[»]
5PVKX-ray1.58A/B555-688[»]
5PVLX-ray1.53A/B555-688[»]
5PVMX-ray1.65A/B555-688[»]
5PVNX-ray1.63A/B555-688[»]
5PVOX-ray1.96A/B555-688[»]
5PVPX-ray1.69A/B555-688[»]
5PVQX-ray1.61A/B555-688[»]
5PVRX-ray1.57A/B555-688[»]
5PVSX-ray1.55A/B555-688[»]
5PVTX-ray1.48A/B555-688[»]
5PVUX-ray3.01A/B555-688[»]
5PVVX-ray1.80A/B555-688[»]
5PVWX-ray2.18A/B555-688[»]
5PVXX-ray1.74A/B555-688[»]
5PVYX-ray2.49A/B555-688[»]
5PVZX-ray1.64A/B555-688[»]
5PW0X-ray2.13A/B555-688[»]
5PW1X-ray1.57A/B555-688[»]
5PW2X-ray2.32A/B555-688[»]
5PW3X-ray2.21A/B555-688[»]
5PW4X-ray1.91A/B555-688[»]
5PW5X-ray2.09A/B555-688[»]
5PW6X-ray2.75A/B555-688[»]
5PW7X-ray1.85A/B555-688[»]
5PW8X-ray2.08A/B555-688[»]
5PW9X-ray3.44A/B555-688[»]
5PWAX-ray1.86A/B555-688[»]
5PWBX-ray2.09A/B555-688[»]
ProteinModelPortaliO95696
SMRiO95696
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117273, 55 interactors
ComplexPortaliCPX-733 MOZ2 histone acetyltransferase complex
CPX-739 MORF2 histone acetyltransferase complex
CORUMiO95696
IntActiO95696, 49 interactors
MINTiO95696
STRINGi9606.ENSP00000216267

Chemistry databases

BindingDBiO95696
ChEMBLiCHEMBL2176774
GuidetoPHARMACOLOGYi2724

PTM databases

iPTMnetiO95696
PhosphoSitePlusiO95696

Polymorphism and mutation databases

BioMutaiBRD1

2D gel databases

OGPiO95696

Proteomic databases

EPDiO95696
MaxQBiO95696
PaxDbiO95696
PeptideAtlasiO95696
PRIDEiO95696
ProteomicsDBi51000
51001 [O95696-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23774
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216267; ENSP00000216267; ENSG00000100425 [O95696-1]
ENST00000404034; ENSP00000384076; ENSG00000100425 [O95696-1]
ENST00000404760; ENSP00000385858; ENSG00000100425 [O95696-2]
ENST00000457780; ENSP00000410042; ENSG00000100425 [O95696-2]
GeneIDi23774
KEGGihsa:23774
UCSCiuc003biu.6 human [O95696-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23774
DisGeNETi23774
EuPathDBiHostDB:ENSG00000100425.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BRD1
HGNCiHGNC:1102 BRD1
HPAiHPA000807
HPA001063
MIMi604589 gene
neXtProtiNX_O95696
OpenTargetsiENSG00000100425
PharmGKBiPA25413

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0955 Eukaryota
COG5076 LUCA
COG5141 LUCA
GeneTreeiENSGT00940000157236
HOGENOMiHOG000000705
HOVERGENiHBG004895
InParanoidiO95696
KOiK11349
OMAiNESHSTC
PhylomeDBiO95696
TreeFamiTF316118

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones
R-HSA-6804758 Regulation of TP53 Activity through Acetylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BRD1 human
EvolutionaryTraceiO95696

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23774
PMAP-CutDBiO95696

Protein Ontology

More...
PROi
PR:O95696

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100425 Expressed in 231 organ(s), highest expression level in testis
CleanExiHS_BRD1
ExpressionAtlasiO95696 baseline and differential
GenevisibleiO95696 HS

Family and domain databases

CDDicd05839 BR140_related, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR035502 BR140-rel_PWWD
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR000313 PWWP_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF10513 EPL1, 1 hit
PF00855 PWWP, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SM00293 PWWP, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS50812 PWWP, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95696
Secondary accession number(s): A6ZJA4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: December 5, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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