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Protein

Protein phosphatase 1 regulatory subunit 3D

Gene

PPP1R3D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.

GO - Molecular functioni

  • enzyme binding Source: Ensembl
  • protein serine/threonine phosphatase activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processCarbohydrate metabolism, Glycogen metabolism

Protein family/group databases

CAZyiCBM21 Carbohydrate-Binding Module Family 21

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3D
Alternative name(s):
Protein phosphatase 1 regulatory subunit 6
Short name:
PP1 subunit R6
Protein phosphatase 1-binding subunit R6
Gene namesi
Name:PPP1R3D
Synonyms:PPP1R6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000132825.6
HGNCiHGNC:9294 PPP1R3D
MIMi603326 gene
neXtProtiNX_O95685

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132825
PharmGKBiPA33654

Polymorphism and mutation databases

BioMutaiPPP1R3D

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000715031 – 299Protein phosphatase 1 regulatory subunit 3DAdd BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95685
MaxQBiO95685
PaxDbiO95685
PeptideAtlasiO95685
PRIDEiO95685
ProteomicsDBi50999

PTM databases

iPTMnetiO95685
PhosphoSitePlusiO95685

Expressioni

Tissue specificityi

Expressed in all tissues tested. High expression in skeletal muscle and heart.

Gene expression databases

BgeeiENSG00000132825 Expressed in 214 organ(s), highest expression level in secondary oocyte
CleanExiHS_PPP1R3D
GenevisibleiO95685 HS

Organism-specific databases

HPAiHPA041146

Interactioni

Subunit structurei

Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen. Interacts with EPM2A; in the presence of NHLC1/malin the interaction leads to PPP1R3D ubiquitination and autophagic degradation.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111501, 8 interactors
IntActiO95685, 8 interactors
MINTiO95685
STRINGi9606.ENSP00000360035

Structurei

3D structure databases

ProteinModelPortaliO95685
SMRiO95685
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 278CBM21PROSITE-ProRule annotationAdd BLAST110

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi101 – 104PP1-binding motif4

Domaini

The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.

Phylogenomic databases

eggNOGiKOG3986 Eukaryota
ENOG4111FT1 LUCA
GeneTreeiENSGT00530000062978
HOGENOMiHOG000231580
HOVERGENiHBG053658
InParanoidiO95685
KOiK07189
OMAiRPGCSRQ
OrthoDBiEOG091G0IMS
PhylomeDBiO95685
TreeFamiTF105537

Family and domain databases

Gene3Di2.60.40.2440, 1 hit
InterProiView protein in InterPro
IPR005036 CBM21_dom
IPR038175 CBM21_dom_sf
IPR017434 Pase-1_reg-su_3B/C/D_met
PfamiView protein in Pfam
PF03370 CBM_21, 1 hit
PIRSFiPIRSF038207 PP1_GT_animal, 1 hit
PROSITEiView protein in PROSITE
PS51159 CBM21, 1 hit

Sequencei

Sequence statusi: Complete.

O95685-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRGPSSAVL PSALGSRKLG PRSLSCLSDL DGGVALEPRA CRPPGSPGRA
60 70 80 90 100
PPPTPAPSGC DPRLRPIILR RARSLPSSPE RRQKAAGAPG AACRPGCSQK
110 120 130 140 150
LRVRFADALG LELAQVKVFN AGDDPSVPLH VLSRLAINSD LCCSSQDLEF
160 170 180 190 200
TLHCLVPDFP PPVEAADFGE RLQRQLVCLE RVTCSDLGIS GTVRVCNVAF
210 220 230 240 250
EKQVAVRYTF SGWRSTHEAV ARWRGPAGPE GTEDVFTFGF PVPPFLLELG
260 270 280 290
SRVHFAVRYQ VAGAEYWDNN DHRDYSLTCR NHALHMPRGE CEESWIHFI
Length:299
Mass (Da):32,559
Last modified:May 1, 1999 - v1
Checksum:iDB848FB1CF55E49E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18206 mRNA Translation: CAA77081.1
AL109928 Genomic DNA No translation available.
BC074860 mRNA Translation: AAH74860.2
BC074861 mRNA Translation: AAH74861.2
CCDSiCCDS13483.1
RefSeqiNP_006233.1, NM_006242.3
UniGeneiHs.42215

Genome annotation databases

EnsembliENST00000370996; ENSP00000360035; ENSG00000132825
GeneIDi5509
KEGGihsa:5509
UCSCiuc002ybb.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18206 mRNA Translation: CAA77081.1
AL109928 Genomic DNA No translation available.
BC074860 mRNA Translation: AAH74860.2
BC074861 mRNA Translation: AAH74861.2
CCDSiCCDS13483.1
RefSeqiNP_006233.1, NM_006242.3
UniGeneiHs.42215

3D structure databases

ProteinModelPortaliO95685
SMRiO95685
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111501, 8 interactors
IntActiO95685, 8 interactors
MINTiO95685
STRINGi9606.ENSP00000360035

Protein family/group databases

CAZyiCBM21 Carbohydrate-Binding Module Family 21

PTM databases

iPTMnetiO95685
PhosphoSitePlusiO95685

Polymorphism and mutation databases

BioMutaiPPP1R3D

Proteomic databases

EPDiO95685
MaxQBiO95685
PaxDbiO95685
PeptideAtlasiO95685
PRIDEiO95685
ProteomicsDBi50999

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370996; ENSP00000360035; ENSG00000132825
GeneIDi5509
KEGGihsa:5509
UCSCiuc002ybb.4 human

Organism-specific databases

CTDi5509
EuPathDBiHostDB:ENSG00000132825.6
GeneCardsiPPP1R3D
HGNCiHGNC:9294 PPP1R3D
HPAiHPA041146
MIMi603326 gene
neXtProtiNX_O95685
OpenTargetsiENSG00000132825
PharmGKBiPA33654
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3986 Eukaryota
ENOG4111FT1 LUCA
GeneTreeiENSGT00530000062978
HOGENOMiHOG000231580
HOVERGENiHBG053658
InParanoidiO95685
KOiK07189
OMAiRPGCSRQ
OrthoDBiEOG091G0IMS
PhylomeDBiO95685
TreeFamiTF105537

Miscellaneous databases

GenomeRNAii5509
PROiPR:O95685
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132825 Expressed in 214 organ(s), highest expression level in secondary oocyte
CleanExiHS_PPP1R3D
GenevisibleiO95685 HS

Family and domain databases

Gene3Di2.60.40.2440, 1 hit
InterProiView protein in InterPro
IPR005036 CBM21_dom
IPR038175 CBM21_dom_sf
IPR017434 Pase-1_reg-su_3B/C/D_met
PfamiView protein in Pfam
PF03370 CBM_21, 1 hit
PIRSFiPIRSF038207 PP1_GT_animal, 1 hit
PROSITEiView protein in PROSITE
PS51159 CBM21, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPR3D_HUMAN
AccessioniPrimary (citable) accession number: O95685
Secondary accession number(s): Q6DK02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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