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Protein

N-acetylserotonin O-methyltransferase-like protein

Gene

ASMTL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity.

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It represents a unique fusion product of 2 different genes of different evolutionary origin and function. The N-terminus is homologous to the bacterial maf/orfE genes and the C-terminus is homologous to ASMT. Exon duplication, exon shuffling and gene fusion seem to be common characteristics of the PAR1 region.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei44Sequence analysis1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei482S-adenosyl-L-methionineBy similarity1
Binding sitei525S-adenosyl-L-methionineBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-acetylserotonin O-methyltransferase-like protein (EC:2.1.1.-)
Short name:
ASMTL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASMTL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000169093.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:751 ASMTL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300162 gene
400011 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95671

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8623

Open Targets

More...
OpenTargetsi
ENSG00000169093

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25050

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ASMTL

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000647021 – 621N-acetylserotonin O-methyltransferase-like proteinAdd BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21PhosphoserineCombined sources1
Modified residuei228PhosphoserineCombined sources1
Modified residuei234PhosphothreonineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O95671

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95671

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95671

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95671

PeptideAtlas

More...
PeptideAtlasi
O95671

PRoteomics IDEntifications database

More...
PRIDEi
O95671

ProteomicsDB human proteome resource

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ProteomicsDBi
50984
50985 [O95671-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95671

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95671

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169093 Expressed in 238 organ(s), highest expression level in prostate gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_ASMTL

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95671 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003630
HPA021865

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114178, 17 interactors

Protein interaction database and analysis system

More...
IntActi
O95671, 12 interactors

Molecular INTeraction database

More...
MINTi
O95671

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000370718

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1621
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P5XX-ray2.00A/B10-239[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95671

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95671

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O95671

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni11 – 223MAF-likeAdd BLAST213
Regioni277 – 621ASMT-likeAdd BLAST345
Regioni508 – 510S-adenosyl-L-methionine bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the maf family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1509 Eukaryota
KOG3178 Eukaryota
COG0424 LUCA
ENOG410XS7T LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162413

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000034104

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG036737

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O95671

Identification of Orthologs from Complete Genome Data

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OMAi
KHLKTPD

Database of Orthologous Groups

More...
OrthoDBi
817726at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95671

TreeFam database of animal gene trees

More...
TreeFami
TF314574

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00555 Maf, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
3.90.950.10, 1 hit

HAMAP database of protein families

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HAMAPi
MF_00528 Maf, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR031725 ASMT_dimerisation
IPR029001 ITPase-like_fam
IPR003697 Maf
IPR016461 O-MeTrfase_COMT
IPR001077 O_MeTrfase_dom
IPR029063 SAM-dependent_MTases
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR43213 PTHR43213, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16864 Dimerisation2, 1 hit
PF02545 Maf, 1 hit
PF00891 Methyltransf_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF52972 SSF52972, 1 hit
SSF53335 SSF53335, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00172 maf, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51683 SAM_OMT_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O95671-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS KFKEKLDKAS
60 70 80 90 100
FATPYGYAME TAKQKALEVA NRLYQKDLRA PDVVIGADTI VTVGGLILEK
110 120 130 140 150
PVDKQDAYRM LSRLSGREHS VFTGVAIVHC SSKDHQLDTR VSEFYEETKV
160 170 180 190 200
KFSELSEELL WEYVHSGEPM DKAGGYGIQA LGGMLVESVH GDFLNVVGFP
210 220 230 240 250
LNHFCKQLVK LYYPPRPEDL RRSVKHDSIP AADTFEDLSD VEGGGSEPTQ
260 270 280 290 300
RDAGSRDEKA EAGEAGQATA EAECHRTRET LPPFPTRLLE LIEGFMLSKG
310 320 330 340 350
LLTACKLKVF DLLKDEAPQK AADIASKVDA SACGMERLLD ICAAMGLLEK
360 370 380 390 400
TEQGYSNTET ANVYLASDGE YSLHGFIMHN NDLTWNLFTY LEFAIREGTN
410 420 430 440 450
QHHRALGKKA EDLFQDAYYQ SPETRLRFMR AMHGMTKLTA CQVATAFNLS
460 470 480 490 500
RFSSACDVGG CTGALARELA REYPRMQVTV FDLPDIIELA AHFQPPGPQA
510 520 530 540 550
VQIHFAAGDF FRDPLPSAEL YVLCRILHDW PDDKVHKLLS RVAESCKPGA
560 570 580 590 600
GLLLVETLLD EEKRVAQRAL MQSLNMLVQT EGKERSLGEY QCLLELHGFH
610 620
QVQVVHLGGV LDAILATKVA P
Length:621
Mass (Da):68,857
Last modified:October 3, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i564C2D538F4919EC
GO
Isoform 2 (identifier: O95671-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-91: Missing.

Note: No experimental confirmation available.
Show »
Length:605
Mass (Da):67,193
Checksum:i68D9C963275E9A36
GO
Isoform 3 (identifier: O95671-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Note: No experimental confirmation available.
Show »
Length:563
Mass (Da):62,443
Checksum:i5AC40CB68911EF40
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA75675 differs from that shown. Reason: Frameshift at position 616.Curated
The sequence CAA75676 differs from that shown. Reason: Frameshift at position 616.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti228S → P in BAG63287 (PubMed:14702039).Curated1
Sequence conflicti364Y → H in BAG63287 (PubMed:14702039).Curated1
Sequence conflicti434G → S in BAG63287 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054802458V → M1 PublicationCorresponds to variant dbSNP:rs4503285Ensembl.1
Natural variantiVAR_054803541R → K2 PublicationsCorresponds to variant dbSNP:rs1127297Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0474121 – 58Missing in isoform 3. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_00721376 – 91Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y15521 Genomic DNA Translation: CAA75675.1 Frameshift.
Y15521 Genomic DNA Translation: CAA75676.1 Frameshift.
AK090498 mRNA Translation: BAC03468.1
AK301844 mRNA Translation: BAG63287.1
AL683870 Genomic DNA No translation available.
BC002508 mRNA Translation: AAH02508.1
BC010089 mRNA Translation: AAH10089.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43917.1 [O95671-1]
CCDS55362.1 [O95671-3]
CCDS55363.1 [O95671-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001166944.1, NM_001173473.1 [O95671-3]
NP_001166945.1, NM_001173474.1 [O95671-2]
NP_004183.2, NM_004192.3 [O95671-1]
XP_005274491.1, XM_005274434.3 [O95671-1]
XP_005274840.1, XM_005274783.3 [O95671-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.533514

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381317; ENSP00000370718; ENSG00000169093 [O95671-1]
ENST00000381333; ENSP00000370734; ENSG00000169093 [O95671-2]
ENST00000534940; ENSP00000446410; ENSG00000169093 [O95671-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8623

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8623

UCSC genome browser

More...
UCSCi
uc004cpx.3 human [O95671-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15521 Genomic DNA Translation: CAA75675.1 Frameshift.
Y15521 Genomic DNA Translation: CAA75676.1 Frameshift.
AK090498 mRNA Translation: BAC03468.1
AK301844 mRNA Translation: BAG63287.1
AL683870 Genomic DNA No translation available.
BC002508 mRNA Translation: AAH02508.1
BC010089 mRNA Translation: AAH10089.1
CCDSiCCDS43917.1 [O95671-1]
CCDS55362.1 [O95671-3]
CCDS55363.1 [O95671-2]
RefSeqiNP_001166944.1, NM_001173473.1 [O95671-3]
NP_001166945.1, NM_001173474.1 [O95671-2]
NP_004183.2, NM_004192.3 [O95671-1]
XP_005274491.1, XM_005274434.3 [O95671-1]
XP_005274840.1, XM_005274783.3 [O95671-1]
UniGeneiHs.533514

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P5XX-ray2.00A/B10-239[»]
ProteinModelPortaliO95671
SMRiO95671
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114178, 17 interactors
IntActiO95671, 12 interactors
MINTiO95671
STRINGi9606.ENSP00000370718

PTM databases

iPTMnetiO95671
PhosphoSitePlusiO95671

Polymorphism and mutation databases

BioMutaiASMTL

Proteomic databases

EPDiO95671
jPOSTiO95671
MaxQBiO95671
PaxDbiO95671
PeptideAtlasiO95671
PRIDEiO95671
ProteomicsDBi50984
50985 [O95671-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8623
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381317; ENSP00000370718; ENSG00000169093 [O95671-1]
ENST00000381333; ENSP00000370734; ENSG00000169093 [O95671-2]
ENST00000534940; ENSP00000446410; ENSG00000169093 [O95671-3]
GeneIDi8623
KEGGihsa:8623
UCSCiuc004cpx.3 human [O95671-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8623
DisGeNETi8623
EuPathDBiHostDB:ENSG00000169093.15

GeneCards: human genes, protein and diseases

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GeneCardsi
ASMTL

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0176513
HIX0177590
HGNCiHGNC:751 ASMTL
HPAiHPA003630
HPA021865
MIMi300162 gene
400011 gene
neXtProtiNX_O95671
OpenTargetsiENSG00000169093
PharmGKBiPA25050

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1509 Eukaryota
KOG3178 Eukaryota
COG0424 LUCA
ENOG410XS7T LUCA
GeneTreeiENSGT00940000162413
HOGENOMiHOG000034104
HOVERGENiHBG036737
InParanoidiO95671
OMAiKHLKTPD
OrthoDBi817726at2759
PhylomeDBiO95671
TreeFamiTF314574

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ASMTL human
EvolutionaryTraceiO95671

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ASMTL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8623

Protein Ontology

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PROi
PR:O95671

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169093 Expressed in 238 organ(s), highest expression level in prostate gland
CleanExiHS_ASMTL
GenevisibleiO95671 HS

Family and domain databases

CDDicd00555 Maf, 1 hit
Gene3Di1.10.10.10, 1 hit
3.90.950.10, 1 hit
HAMAPiMF_00528 Maf, 1 hit
InterProiView protein in InterPro
IPR031725 ASMT_dimerisation
IPR029001 ITPase-like_fam
IPR003697 Maf
IPR016461 O-MeTrfase_COMT
IPR001077 O_MeTrfase_dom
IPR029063 SAM-dependent_MTases
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR43213 PTHR43213, 1 hit
PfamiView protein in Pfam
PF16864 Dimerisation2, 1 hit
PF02545 Maf, 1 hit
PF00891 Methyltransf_2, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52972 SSF52972, 1 hit
SSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00172 maf, 1 hit
PROSITEiView protein in PROSITE
PS51683 SAM_OMT_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASML_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95671
Secondary accession number(s): B4DX75
, F5GXH4, J3JS33, Q5JQ53, Q8NBH5, Q96G02, Q9BUL6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 3, 2006
Last modified: January 16, 2019
This is version 166 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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