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Entry version 174 (26 Feb 2020)
Sequence version 3 (03 Oct 2006)
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Protein

Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein

Gene

ASMTL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m5UTP) and 5-methyl-CTP (m5CTP). Has weak activity with dCTP, 8-oxo-GTP and N4-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable).Curated1 Publication

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It represents a unique fusion product of 2 different genes of different evolutionary origin and function. The N-terminus is homologous to the bacterial maf/orfE genes and the C-terminus is homologous to ASMT. Exon duplication, exon shuffling and gene fusion seem to be common characteristics of the PAR1 region.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cation1 PublicationNote: Pyrophosphatase activity requires a divalent metal cation.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.7 sec(-1) with dTTP as substrate. kcat is 0.7 sec(-1) with UTP as substrate. kcat is 0.8 sec(-1) with CTP as substrate. kcat is 0.3 sec(-1) with dCTP as substrate. kcat is 1.5 sec(-1) with m5UTP as substrate. kcat is 3.7 sec(-1) with m5CTP as substrate. kcat is 2.5 sec(-1) with pseudo-UTP as substrate. kcat is 0.2 sec(-1) with 8-oxo-GTP as substrate. kcat is 0.3 sec(-1) with N4-methyl-dCTP as substrate.1 Publication
  1. KM=32.7 µM for dTTP1 Publication
  2. KM=41.2 µM for UTP1 Publication
  3. KM=17.4 µM for CTP1 Publication
  4. KM=22.8 µM for dCTP1 Publication
  5. KM=16.1 µM for m5UTP1 Publication
  6. KM=39.4 µM for m5CTP1 Publication
  7. KM=18.7 µM for pseudo-UTP1 Publication
  8. KM=10.7 µM for 8-oxo-GTP1 Publication
  9. KM=10.3 µM for N4-methyl-dCTP1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei23Important for substrate specificity; for pyrophosphatase activity1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei88Proton acceptor; for pyrophosphatase activity1 Publication1
    Sitei89Important for substrate specificity; for pyrophosphatase activity1 Publication1
    Sitei179Important for substrate specificity; for pyrophosphatase activity1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei482S-adenosyl-L-methionineBy similarity1
    Binding sitei525S-adenosyl-L-methionineBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Methyltransferase, Transferase
    Biological processNucleotide metabolism
    LigandS-adenosyl-L-methionine

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase proteinCurated
    Including the following 2 domains:
    dTTP/UTP pyrophosphataseCurated (EC:3.6.1.91 Publication)
    Short name:
    dTTPase/UTPaseCurated
    Alternative name(s):
    Nucleoside triphosphate pyrophosphatase1 Publication
    Nucleotide pyrophosphatase1 Publication
    Short name:
    Nucleotide PPaseCurated
    N-acetylserotonin O-methyltransferase-like protein (EC:2.1.1.-)
    Short name:
    ASMTL
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ASMTL
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:751 ASMTL

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    300162 gene
    400011 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_O95671

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi19S → A: Loss of pyrophosphatase activity. 1 Publication1
    Mutagenesisi21S → A: Loss of pyrophosphatase activity. 1 Publication1
    Mutagenesisi23R → A: Decrease in pyrophosphatase activity. 1 Publication1
    Mutagenesisi24R → A: Loss of pyrophosphatase activity. 1 Publication1
    Mutagenesisi44E → A: Loss of pyrophosphatase activity. 1 Publication1
    Mutagenesisi57Y → A: Loss of pyrophosphatase activity. 1 Publication1
    Mutagenesisi65K → A: Loss of pyrophosphatase activity. 1 Publication1
    Mutagenesisi88D → A or N: Loss of pyrophosphatase activity. 1 Publication1
    Mutagenesisi99E → A: Loss of pyrophosphatase activity. 1 Publication1
    Mutagenesisi179Q → A: Loss of pyrophosphatase activity. 1 Publication1
    Mutagenesisi179Q → E: Strong decrease in pyrophosphatase activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    8623

    Open Targets

    More...
    OpenTargetsi
    ENSG00000169093

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA25050

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    O95671 Tdark

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ASMTL

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000647021 – 621Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase proteinAdd BLAST621

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21PhosphoserineCombined sources1
    Modified residuei228PhosphoserineCombined sources1
    Modified residuei234PhosphothreonineCombined sources1
    Modified residuei239PhosphoserineCombined sources1
    Modified residuei421PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    O95671

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    O95671

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    O95671

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    O95671

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O95671

    PeptideAtlas

    More...
    PeptideAtlasi
    O95671

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O95671

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    24424
    50984 [O95671-1]
    50985 [O95671-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O95671

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    O95671

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000169093 Expressed in prostate gland and 237 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O95671 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA003630
    HPA021865

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Show more details

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    114178, 17 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    O95671, 16 interactors

    Molecular INTeraction database

    More...
    MINTi
    O95671

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000370718

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    O95671 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1621
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O95671

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    O95671

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni11 – 223MAF-likeAdd BLAST213
    Regioni277 – 621ASMT-likeAdd BLAST345
    Regioni508 – 510S-adenosyl-L-methionine bindingBy similarity3

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    In the N-terminal section; belongs to the Maf family. YhdE subfamily.1 Publication

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1509 Eukaryota
    KOG3178 Eukaryota
    COG0424 LUCA
    ENOG410XS7T LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000162413

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_032774_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O95671

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    VLCHEKD

    Database of Orthologous Groups

    More...
    OrthoDBi
    817726at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O95671

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314574

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00555 Maf, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.10.10, 1 hit
    3.90.950.10, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00528 Maf, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR031725 ASMT_dimerisation
    IPR029001 ITPase-like_fam
    IPR003697 Maf-like
    IPR016461 O-MeTrfase_COMT
    IPR001077 O_MeTrfase_dom
    IPR029063 SAM-dependent_MTases
    IPR036388 WH-like_DNA-bd_sf
    IPR036390 WH_DNA-bd_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR43213 PTHR43213, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF16864 Dimerisation2, 1 hit
    PF02545 Maf, 1 hit
    PF00891 Methyltransf_2, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF46785 SSF46785, 1 hit
    SSF52972 SSF52972, 1 hit
    SSF53335 SSF53335, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00172 maf, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51683 SAM_OMT_II, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform 1 (identifier: O95671-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS KFKEKLDKAS
    60 70 80 90 100
    FATPYGYAME TAKQKALEVA NRLYQKDLRA PDVVIGADTI VTVGGLILEK
    110 120 130 140 150
    PVDKQDAYRM LSRLSGREHS VFTGVAIVHC SSKDHQLDTR VSEFYEETKV
    160 170 180 190 200
    KFSELSEELL WEYVHSGEPM DKAGGYGIQA LGGMLVESVH GDFLNVVGFP
    210 220 230 240 250
    LNHFCKQLVK LYYPPRPEDL RRSVKHDSIP AADTFEDLSD VEGGGSEPTQ
    260 270 280 290 300
    RDAGSRDEKA EAGEAGQATA EAECHRTRET LPPFPTRLLE LIEGFMLSKG
    310 320 330 340 350
    LLTACKLKVF DLLKDEAPQK AADIASKVDA SACGMERLLD ICAAMGLLEK
    360 370 380 390 400
    TEQGYSNTET ANVYLASDGE YSLHGFIMHN NDLTWNLFTY LEFAIREGTN
    410 420 430 440 450
    QHHRALGKKA EDLFQDAYYQ SPETRLRFMR AMHGMTKLTA CQVATAFNLS
    460 470 480 490 500
    RFSSACDVGG CTGALARELA REYPRMQVTV FDLPDIIELA AHFQPPGPQA
    510 520 530 540 550
    VQIHFAAGDF FRDPLPSAEL YVLCRILHDW PDDKVHKLLS RVAESCKPGA
    560 570 580 590 600
    GLLLVETLLD EEKRVAQRAL MQSLNMLVQT EGKERSLGEY QCLLELHGFH
    610 620
    QVQVVHLGGV LDAILATKVA P
    Length:621
    Mass (Da):68,857
    Last modified:October 3, 2006 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i564C2D538F4919EC
    GO
    Isoform 2 (identifier: O95671-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         76-91: Missing.

    Show »
    Length:605
    Mass (Da):67,193
    Checksum:i68D9C963275E9A36
    GO
    Isoform 3 (identifier: O95671-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-58: Missing.

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    Length:563
    Mass (Da):62,443
    Checksum:i5AC40CB68911EF40
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence CAA75675 differs from that shown. Reason: Frameshift.Curated
    The sequence CAA75676 differs from that shown. Reason: Frameshift.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti228S → P in BAG63287 (PubMed:14702039).Curated1
    Sequence conflicti364Y → H in BAG63287 (PubMed:14702039).Curated1
    Sequence conflicti434G → S in BAG63287 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054802458V → M1 PublicationCorresponds to variant dbSNP:rs4503285Ensembl.1
    Natural variantiVAR_054803541R → K2 PublicationsCorresponds to variant dbSNP:rs1127297Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0474121 – 58Missing in isoform 3. 1 PublicationAdd BLAST58
    Alternative sequenceiVSP_00721376 – 91Missing in isoform 2. 1 PublicationAdd BLAST16

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

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    EMBLi

    GenBank nucleotide sequence database

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    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

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    DDBJi
    Links Updated
    Y15521 Genomic DNA Translation: CAA75675.1 Frameshift.
    Y15521 Genomic DNA Translation: CAA75676.1 Frameshift.
    AK090498 mRNA Translation: BAC03468.1
    AK301844 mRNA Translation: BAG63287.1
    AL683870 Genomic DNA No translation available.
    BC002508 mRNA Translation: AAH02508.1
    BC010089 mRNA Translation: AAH10089.1

    The Consensus CDS (CCDS) project

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    CCDSi
    CCDS43917.1 [O95671-1]
    CCDS55362.1 [O95671-3]
    CCDS55363.1 [O95671-2]

    NCBI Reference Sequences

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    RefSeqi
    NP_001166944.1, NM_001173473.1 [O95671-3]
    NP_001166945.1, NM_001173474.1 [O95671-2]
    NP_004183.2, NM_004192.3 [O95671-1]
    XP_005274491.1, XM_005274434.3 [O95671-1]
    XP_005274840.1, XM_005274783.3 [O95671-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

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    Ensembli
    ENST00000381317; ENSP00000370718; ENSG00000169093 [O95671-1]
    ENST00000381333; ENSP00000370734; ENSG00000169093 [O95671-2]
    ENST00000534940; ENSP00000446410; ENSG00000169093 [O95671-3]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    8623

    KEGG: Kyoto Encyclopedia of Genes and Genomes

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    KEGGi
    hsa:8623

    UCSC genome browser

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    UCSCi
    uc004cpx.3 human [O95671-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    Y15521 Genomic DNA Translation: CAA75675.1 Frameshift.
    Y15521 Genomic DNA Translation: CAA75676.1 Frameshift.
    AK090498 mRNA Translation: BAC03468.1
    AK301844 mRNA Translation: BAG63287.1
    AL683870 Genomic DNA No translation available.
    BC002508 mRNA Translation: AAH02508.1
    BC010089 mRNA Translation: AAH10089.1
    CCDSiCCDS43917.1 [O95671-1]
    CCDS55362.1 [O95671-3]
    CCDS55363.1 [O95671-2]
    RefSeqiNP_001166944.1, NM_001173473.1 [O95671-3]
    NP_001166945.1, NM_001173474.1 [O95671-2]
    NP_004183.2, NM_004192.3 [O95671-1]
    XP_005274491.1, XM_005274434.3 [O95671-1]
    XP_005274840.1, XM_005274783.3 [O95671-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

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    PDBei

    Protein Data Bank RCSB

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    RCSB PDBi

    Protein Data Bank Japan

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    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2P5XX-ray2.00A/B10-239[»]
    SMRiO95671
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi114178, 17 interactors
    IntActiO95671, 16 interactors
    MINTiO95671
    STRINGi9606.ENSP00000370718

    PTM databases

    iPTMnetiO95671
    PhosphoSitePlusiO95671

    Polymorphism and mutation databases

    BioMutaiASMTL

    Proteomic databases

    EPDiO95671
    jPOSTiO95671
    MassIVEiO95671
    MaxQBiO95671
    PaxDbiO95671
    PeptideAtlasiO95671
    PRIDEiO95671
    ProteomicsDBi24424
    50984 [O95671-1]
    50985 [O95671-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    8623

    Genome annotation databases

    EnsembliENST00000381317; ENSP00000370718; ENSG00000169093 [O95671-1]
    ENST00000381333; ENSP00000370734; ENSG00000169093 [O95671-2]
    ENST00000534940; ENSP00000446410; ENSG00000169093 [O95671-3]
    GeneIDi8623
    KEGGihsa:8623
    UCSCiuc004cpx.3 human [O95671-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    8623
    DisGeNETi8623

    GeneCards: human genes, protein and diseases

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    GeneCardsi
    ASMTL
    HGNCiHGNC:751 ASMTL
    HPAiHPA003630
    HPA021865
    MIMi300162 gene
    400011 gene
    neXtProtiNX_O95671
    OpenTargetsiENSG00000169093
    PharmGKBiPA25050

    GenAtlas: human gene database

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    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1509 Eukaryota
    KOG3178 Eukaryota
    COG0424 LUCA
    ENOG410XS7T LUCA
    GeneTreeiENSGT00940000162413
    HOGENOMiCLU_032774_0_0_1
    InParanoidiO95671
    OMAiVLCHEKD
    OrthoDBi817726at2759
    PhylomeDBiO95671
    TreeFamiTF314574

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ASMTL human
    EvolutionaryTraceiO95671

    The Gene Wiki collection of pages on human genes and proteins

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    GeneWikii
    ASMTL

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    8623
    PharosiO95671 Tdark

    Protein Ontology

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    PROi
    PR:O95671
    RNActiO95671 protein

    The Stanford Online Universal Resource for Clones and ESTs

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    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000169093 Expressed in prostate gland and 237 other tissues
    GenevisibleiO95671 HS

    Family and domain databases

    CDDicd00555 Maf, 1 hit
    Gene3Di1.10.10.10, 1 hit
    3.90.950.10, 1 hit
    HAMAPiMF_00528 Maf, 1 hit
    InterProiView protein in InterPro
    IPR031725 ASMT_dimerisation
    IPR029001 ITPase-like_fam
    IPR003697 Maf-like
    IPR016461 O-MeTrfase_COMT
    IPR001077 O_MeTrfase_dom
    IPR029063 SAM-dependent_MTases
    IPR036388 WH-like_DNA-bd_sf
    IPR036390 WH_DNA-bd_sf
    PANTHERiPTHR43213 PTHR43213, 1 hit
    PfamiView protein in Pfam
    PF16864 Dimerisation2, 1 hit
    PF02545 Maf, 1 hit
    PF00891 Methyltransf_2, 1 hit
    SUPFAMiSSF46785 SSF46785, 1 hit
    SSF52972 SSF52972, 1 hit
    SSF53335 SSF53335, 1 hit
    TIGRFAMsiTIGR00172 maf, 1 hit
    PROSITEiView protein in PROSITE
    PS51683 SAM_OMT_II, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASML_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95671
    Secondary accession number(s): B4DX75
    , F5GXH4, J3JS33, Q5JQ53, Q8NBH5, Q96G02, Q9BUL6
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: October 3, 2006
    Last modified: February 26, 2020
    This is version 174 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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