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Protein

N-acetylserotonin O-methyltransferase-like protein

Gene

ASMTL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity.

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It represents a unique fusion product of 2 different genes of different evolutionary origin and function. The N-terminus is homologous to the bacterial maf/orfE genes and the C-terminus is homologous to ASMT. Exon duplication, exon shuffling and gene fusion seem to be common characteristics of the PAR1 region.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44Sequence analysis1
Binding sitei482S-adenosyl-L-methionineBy similarity1
Binding sitei525S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylserotonin O-methyltransferase-like protein (EC:2.1.1.-)
Short name:
ASMTL
Gene namesi
Name:ASMTL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000169093.15
HGNCiHGNC:751 ASMTL
MIMi300162 gene
400011 gene
neXtProtiNX_O95671

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi8623
OpenTargetsiENSG00000169093
PharmGKBiPA25050

Polymorphism and mutation databases

BioMutaiASMTL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000647021 – 621N-acetylserotonin O-methyltransferase-like proteinAdd BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei228PhosphoserineCombined sources1
Modified residuei234PhosphothreonineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95671
MaxQBiO95671
PaxDbiO95671
PeptideAtlasiO95671
PRIDEiO95671
ProteomicsDBi50984
50985 [O95671-2]

PTM databases

iPTMnetiO95671
PhosphoSitePlusiO95671

Expressioni

Tissue specificityi

Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver.

Gene expression databases

BgeeiENSG00000169093 Expressed in 238 organ(s), highest expression level in prostate gland
CleanExiHS_ASMTL
GenevisibleiO95671 HS

Organism-specific databases

HPAiHPA003630
HPA021865

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi114178, 17 interactors
IntActiO95671, 12 interactors
MINTiO95671
STRINGi9606.ENSP00000370718

Structurei

Secondary structure

1621
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95671
SMRiO95671
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95671

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 223MAF-likeAdd BLAST213
Regioni277 – 621ASMT-likeAdd BLAST345
Regioni508 – 510S-adenosyl-L-methionine bindingBy similarity3

Sequence similaritiesi

In the N-terminal section; belongs to the maf family.Curated

Phylogenomic databases

eggNOGiKOG1509 Eukaryota
KOG3178 Eukaryota
COG0424 LUCA
ENOG410XS7T LUCA
GeneTreeiENSGT00530000064032
HOGENOMiHOG000034104
HOVERGENiHBG036737
InParanoidiO95671
OMAiKHLKTPD
OrthoDBiEOG091G0PPM
PhylomeDBiO95671
TreeFamiTF314574

Family and domain databases

CDDicd00555 Maf, 1 hit
Gene3Di1.10.10.10, 1 hit
3.90.950.10, 1 hit
HAMAPiMF_00528 Maf, 1 hit
InterProiView protein in InterPro
IPR031725 ASMT_dimerisation
IPR029001 ITPase-like_fam
IPR003697 Maf
IPR016461 O-MeTrfase_COMT
IPR001077 O_MeTrfase_2
IPR029063 SAM-dependent_MTases
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR43213 PTHR43213, 1 hit
PfamiView protein in Pfam
PF16864 Dimerisation2, 1 hit
PF02545 Maf, 1 hit
PF00891 Methyltransf_2, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52972 SSF52972, 1 hit
SSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00172 maf, 1 hit
PROSITEiView protein in PROSITE
PS51683 SAM_OMT_II, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O95671-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS KFKEKLDKAS
60 70 80 90 100
FATPYGYAME TAKQKALEVA NRLYQKDLRA PDVVIGADTI VTVGGLILEK
110 120 130 140 150
PVDKQDAYRM LSRLSGREHS VFTGVAIVHC SSKDHQLDTR VSEFYEETKV
160 170 180 190 200
KFSELSEELL WEYVHSGEPM DKAGGYGIQA LGGMLVESVH GDFLNVVGFP
210 220 230 240 250
LNHFCKQLVK LYYPPRPEDL RRSVKHDSIP AADTFEDLSD VEGGGSEPTQ
260 270 280 290 300
RDAGSRDEKA EAGEAGQATA EAECHRTRET LPPFPTRLLE LIEGFMLSKG
310 320 330 340 350
LLTACKLKVF DLLKDEAPQK AADIASKVDA SACGMERLLD ICAAMGLLEK
360 370 380 390 400
TEQGYSNTET ANVYLASDGE YSLHGFIMHN NDLTWNLFTY LEFAIREGTN
410 420 430 440 450
QHHRALGKKA EDLFQDAYYQ SPETRLRFMR AMHGMTKLTA CQVATAFNLS
460 470 480 490 500
RFSSACDVGG CTGALARELA REYPRMQVTV FDLPDIIELA AHFQPPGPQA
510 520 530 540 550
VQIHFAAGDF FRDPLPSAEL YVLCRILHDW PDDKVHKLLS RVAESCKPGA
560 570 580 590 600
GLLLVETLLD EEKRVAQRAL MQSLNMLVQT EGKERSLGEY QCLLELHGFH
610 620
QVQVVHLGGV LDAILATKVA P
Length:621
Mass (Da):68,857
Last modified:October 3, 2006 - v3
Checksum:i564C2D538F4919EC
GO
Isoform 2 (identifier: O95671-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-91: Missing.

Note: No experimental confirmation available.
Show »
Length:605
Mass (Da):67,193
Checksum:i68D9C963275E9A36
GO
Isoform 3 (identifier: O95671-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Note: No experimental confirmation available.
Show »
Length:563
Mass (Da):62,443
Checksum:i5AC40CB68911EF40
GO

Sequence cautioni

The sequence CAA75675 differs from that shown. Reason: Frameshift at position 616.Curated
The sequence CAA75676 differs from that shown. Reason: Frameshift at position 616.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228S → P in BAG63287 (PubMed:14702039).Curated1
Sequence conflicti364Y → H in BAG63287 (PubMed:14702039).Curated1
Sequence conflicti434G → S in BAG63287 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054802458V → M1 PublicationCorresponds to variant dbSNP:rs4503285Ensembl.1
Natural variantiVAR_054803541R → K2 PublicationsCorresponds to variant dbSNP:rs1127297Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0474121 – 58Missing in isoform 3. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_00721376 – 91Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15521 Genomic DNA Translation: CAA75675.1 Frameshift.
Y15521 Genomic DNA Translation: CAA75676.1 Frameshift.
AK090498 mRNA Translation: BAC03468.1
AK301844 mRNA Translation: BAG63287.1
AL683870 Genomic DNA No translation available.
BC002508 mRNA Translation: AAH02508.1
BC010089 mRNA Translation: AAH10089.1
CCDSiCCDS43917.1 [O95671-1]
CCDS55362.1 [O95671-3]
CCDS55363.1 [O95671-2]
RefSeqiNP_001166944.1, NM_001173473.1 [O95671-3]
NP_001166945.1, NM_001173474.1 [O95671-2]
NP_004183.2, NM_004192.3 [O95671-1]
XP_005274491.1, XM_005274434.3 [O95671-1]
XP_005274840.1, XM_005274783.3 [O95671-1]
UniGeneiHs.533514

Genome annotation databases

EnsembliENST00000381317; ENSP00000370718; ENSG00000169093 [O95671-1]
ENST00000381333; ENSP00000370734; ENSG00000169093 [O95671-2]
ENST00000534940; ENSP00000446410; ENSG00000169093 [O95671-3]
GeneIDi8623
KEGGihsa:8623
UCSCiuc004cpx.3 human [O95671-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15521 Genomic DNA Translation: CAA75675.1 Frameshift.
Y15521 Genomic DNA Translation: CAA75676.1 Frameshift.
AK090498 mRNA Translation: BAC03468.1
AK301844 mRNA Translation: BAG63287.1
AL683870 Genomic DNA No translation available.
BC002508 mRNA Translation: AAH02508.1
BC010089 mRNA Translation: AAH10089.1
CCDSiCCDS43917.1 [O95671-1]
CCDS55362.1 [O95671-3]
CCDS55363.1 [O95671-2]
RefSeqiNP_001166944.1, NM_001173473.1 [O95671-3]
NP_001166945.1, NM_001173474.1 [O95671-2]
NP_004183.2, NM_004192.3 [O95671-1]
XP_005274491.1, XM_005274434.3 [O95671-1]
XP_005274840.1, XM_005274783.3 [O95671-1]
UniGeneiHs.533514

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P5XX-ray2.00A/B10-239[»]
ProteinModelPortaliO95671
SMRiO95671
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114178, 17 interactors
IntActiO95671, 12 interactors
MINTiO95671
STRINGi9606.ENSP00000370718

PTM databases

iPTMnetiO95671
PhosphoSitePlusiO95671

Polymorphism and mutation databases

BioMutaiASMTL

Proteomic databases

EPDiO95671
MaxQBiO95671
PaxDbiO95671
PeptideAtlasiO95671
PRIDEiO95671
ProteomicsDBi50984
50985 [O95671-2]

Protocols and materials databases

DNASUi8623
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381317; ENSP00000370718; ENSG00000169093 [O95671-1]
ENST00000381333; ENSP00000370734; ENSG00000169093 [O95671-2]
ENST00000534940; ENSP00000446410; ENSG00000169093 [O95671-3]
GeneIDi8623
KEGGihsa:8623
UCSCiuc004cpx.3 human [O95671-1]

Organism-specific databases

CTDi8623
DisGeNETi8623
EuPathDBiHostDB:ENSG00000169093.15
GeneCardsiASMTL
H-InvDBiHIX0176513
HIX0177590
HGNCiHGNC:751 ASMTL
HPAiHPA003630
HPA021865
MIMi300162 gene
400011 gene
neXtProtiNX_O95671
OpenTargetsiENSG00000169093
PharmGKBiPA25050
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1509 Eukaryota
KOG3178 Eukaryota
COG0424 LUCA
ENOG410XS7T LUCA
GeneTreeiENSGT00530000064032
HOGENOMiHOG000034104
HOVERGENiHBG036737
InParanoidiO95671
OMAiKHLKTPD
OrthoDBiEOG091G0PPM
PhylomeDBiO95671
TreeFamiTF314574

Miscellaneous databases

ChiTaRSiASMTL human
EvolutionaryTraceiO95671
GeneWikiiASMTL
GenomeRNAii8623
PROiPR:O95671
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169093 Expressed in 238 organ(s), highest expression level in prostate gland
CleanExiHS_ASMTL
GenevisibleiO95671 HS

Family and domain databases

CDDicd00555 Maf, 1 hit
Gene3Di1.10.10.10, 1 hit
3.90.950.10, 1 hit
HAMAPiMF_00528 Maf, 1 hit
InterProiView protein in InterPro
IPR031725 ASMT_dimerisation
IPR029001 ITPase-like_fam
IPR003697 Maf
IPR016461 O-MeTrfase_COMT
IPR001077 O_MeTrfase_2
IPR029063 SAM-dependent_MTases
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR43213 PTHR43213, 1 hit
PfamiView protein in Pfam
PF16864 Dimerisation2, 1 hit
PF02545 Maf, 1 hit
PF00891 Methyltransf_2, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52972 SSF52972, 1 hit
SSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00172 maf, 1 hit
PROSITEiView protein in PROSITE
PS51683 SAM_OMT_II, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASML_HUMAN
AccessioniPrimary (citable) accession number: O95671
Secondary accession number(s): B4DX75
, F5GXH4, J3JS33, Q5JQ53, Q8NBH5, Q96G02, Q9BUL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 3, 2006
Last modified: September 12, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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