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Protein

V-type proton ATPase subunit G 2

Gene

ATP6V1G2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS10685-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G 2
Short name:
V-ATPase subunit G 2
Alternative name(s):
V-ATPase 13 kDa subunit 2
Vacuolar proton pump subunit G 2
Gene namesi
Name:ATP6V1G2
Synonyms:ATP6G, ATP6G2, NG38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000213760.10
HGNCiHGNC:862 ATP6V1G2
MIMi606853 gene
neXtProtiNX_O95670

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi534
OpenTargetsiENSG00000213760
PharmGKBiPA25164

Polymorphism and mutation databases

BioMutaiATP6V1G2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001929001 – 118V-type proton ATPase subunit G 2Add BLAST118

Proteomic databases

EPDiO95670
PaxDbiO95670
PeptideAtlasiO95670
PRIDEiO95670
ProteomicsDBi50983

PTM databases

iPTMnetiO95670
PhosphoSitePlusiO95670

Expressioni

Tissue specificityi

Brain.1 Publication

Gene expression databases

BgeeiENSG00000213760 Expressed in 133 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_ATP6V1G2
ExpressionAtlasiO95670 baseline and differential
GenevisibleiO95670 HS

Organism-specific databases

HPAiCAB004616

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ATP6V1E2Q96A054EBI-348290,EBI-8650380

Protein-protein interaction databases

BioGridi107017, 8 interactors
IntActiO95670, 5 interactors
STRINGi9606.ENSP00000302194

Structurei

3D structure databases

ProteinModelPortaliO95670
SMRiO95670
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase G subunit family.Curated

Phylogenomic databases

eggNOGiKOG1772 Eukaryota
ENOG4111XX0 LUCA
GeneTreeiENSGT00390000011172
HOGENOMiHOG000186416
HOVERGENiHBG057827
InParanoidiO95670
KOiK02152
OMAiHPNYRIT
OrthoDBiEOG091G0XIZ
PhylomeDBiO95670
TreeFamiTF313777

Family and domain databases

InterProiView protein in InterPro
IPR005124 V-ATPase_G
PANTHERiPTHR12713 PTHR12713, 1 hit
PfamiView protein in Pfam
PF03179 V-ATPase_G, 1 hit
TIGRFAMsiTIGR01147 V_ATP_synt_G, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O95670-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASQSQGIQQ LLQAEKRAAE KVADARKRKA RRLKQAKEEA QMEVEQYRRE
60 70 80 90 100
REHEFQSKQQ AAMGSQGNLS AEVEQATRRQ VQGMQSSQQR NRERVLAQLL
110
GMVCDVRPQV HPNYRISA
Length:118
Mass (Da):13,604
Last modified:May 1, 1999 - v1
Checksum:i5D46EEE0C8D7657D
GO
Isoform 2 (identifier: O95670-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-74: Missing.

Note: No experimental confirmation available.
Show »
Length:78
Mass (Da):8,954
Checksum:iC58F9F6252E8076A
GO
Isoform 3 (identifier: O95670-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Note: No experimental confirmation available.
Show »
Length:77
Mass (Da):8,972
Checksum:iA22322E87147DFE7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y474H0Y474_HUMAN
V-type proton ATPase subunit G
ATP6V1G2
158Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52E → D in AA401769 (Ref. 10) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0474111 – 41Missing in isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_04590935 – 74Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14768 Genomic DNA Translation: CAA75073.1
AB063177 Genomic DNA Translation: BAC00863.1
AB102692 Genomic DNA Translation: BAD74058.1
AB097672 Genomic DNA Translation: BAD74057.1
BA000025 Genomic DNA Translation: BAB63399.1
AB088115 Genomic DNA Translation: BAC54952.1
AL662801 Genomic DNA No translation available.
AL662847 Genomic DNA No translation available.
BX001040 Genomic DNA No translation available.
BX248516 Genomic DNA No translation available.
CR753892 Genomic DNA No translation available.
BX927320 Genomic DNA No translation available.
CR753864 Genomic DNA No translation available.
CR753820 Genomic DNA No translation available.
CR942185 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03414.1
CH471081 Genomic DNA Translation: EAX03416.1
AB202112 Genomic DNA Translation: BAE78636.1
AB103621 Genomic DNA Translation: BAF31286.1
BC047791 mRNA No translation available.
BC119726 mRNA Translation: AAI19727.1
BC119727 mRNA Translation: AAI19728.1
AA401769 mRNA No translation available.
CCDSiCCDS4698.1 [O95670-1]
CCDS4699.1 [O95670-3]
CCDS56413.1 [O95670-2]
RefSeqiNP_001191007.1, NM_001204078.1 [O95670-2]
NP_569730.1, NM_130463.3 [O95670-1]
NP_612139.1, NM_138282.2 [O95670-3]
UniGeneiHs.249227

Genome annotation databases

EnsembliENST00000303892; ENSP00000302194; ENSG00000213760 [O95670-1]
ENST00000376151; ENSP00000365321; ENSG00000213760 [O95670-2]
ENST00000383503; ENSP00000372995; ENSG00000206445 [O95670-1]
ENST00000421596; ENSP00000406575; ENSG00000234668 [O95670-2]
ENST00000434217; ENSP00000406668; ENSG00000226850 [O95670-2]
ENST00000441959; ENSP00000395436; ENSG00000227587 [O95670-1]
ENST00000443657; ENSP00000416031; ENSG00000227587 [O95670-2]
ENST00000444088; ENSP00000406389; ENSG00000234920 [O95670-1]
ENST00000447174; ENSP00000403158; ENSG00000230900 [O95670-2]
ENST00000448779; ENSP00000409104; ENSG00000234920 [O95670-2]
ENST00000449748; ENSP00000406372; ENSG00000226850 [O95670-1]
ENST00000452453; ENSP00000402430; ENSG00000206445 [O95670-2]
ENST00000454370; ENSP00000413222; ENSG00000234668 [O95670-1]
ENST00000454889; ENSP00000408670; ENSG00000230900 [O95670-1]
ENST00000483251; ENSP00000419698; ENSG00000213760 [O95670-3]
GeneIDi534
KEGGihsa:534
UCSCiuc003ntz.4 human [O95670-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14768 Genomic DNA Translation: CAA75073.1
AB063177 Genomic DNA Translation: BAC00863.1
AB102692 Genomic DNA Translation: BAD74058.1
AB097672 Genomic DNA Translation: BAD74057.1
BA000025 Genomic DNA Translation: BAB63399.1
AB088115 Genomic DNA Translation: BAC54952.1
AL662801 Genomic DNA No translation available.
AL662847 Genomic DNA No translation available.
BX001040 Genomic DNA No translation available.
BX248516 Genomic DNA No translation available.
CR753892 Genomic DNA No translation available.
BX927320 Genomic DNA No translation available.
CR753864 Genomic DNA No translation available.
CR753820 Genomic DNA No translation available.
CR942185 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03414.1
CH471081 Genomic DNA Translation: EAX03416.1
AB202112 Genomic DNA Translation: BAE78636.1
AB103621 Genomic DNA Translation: BAF31286.1
BC047791 mRNA No translation available.
BC119726 mRNA Translation: AAI19727.1
BC119727 mRNA Translation: AAI19728.1
AA401769 mRNA No translation available.
CCDSiCCDS4698.1 [O95670-1]
CCDS4699.1 [O95670-3]
CCDS56413.1 [O95670-2]
RefSeqiNP_001191007.1, NM_001204078.1 [O95670-2]
NP_569730.1, NM_130463.3 [O95670-1]
NP_612139.1, NM_138282.2 [O95670-3]
UniGeneiHs.249227

3D structure databases

ProteinModelPortaliO95670
SMRiO95670
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107017, 8 interactors
IntActiO95670, 5 interactors
STRINGi9606.ENSP00000302194

PTM databases

iPTMnetiO95670
PhosphoSitePlusiO95670

Polymorphism and mutation databases

BioMutaiATP6V1G2

Proteomic databases

EPDiO95670
PaxDbiO95670
PeptideAtlasiO95670
PRIDEiO95670
ProteomicsDBi50983

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303892; ENSP00000302194; ENSG00000213760 [O95670-1]
ENST00000376151; ENSP00000365321; ENSG00000213760 [O95670-2]
ENST00000383503; ENSP00000372995; ENSG00000206445 [O95670-1]
ENST00000421596; ENSP00000406575; ENSG00000234668 [O95670-2]
ENST00000434217; ENSP00000406668; ENSG00000226850 [O95670-2]
ENST00000441959; ENSP00000395436; ENSG00000227587 [O95670-1]
ENST00000443657; ENSP00000416031; ENSG00000227587 [O95670-2]
ENST00000444088; ENSP00000406389; ENSG00000234920 [O95670-1]
ENST00000447174; ENSP00000403158; ENSG00000230900 [O95670-2]
ENST00000448779; ENSP00000409104; ENSG00000234920 [O95670-2]
ENST00000449748; ENSP00000406372; ENSG00000226850 [O95670-1]
ENST00000452453; ENSP00000402430; ENSG00000206445 [O95670-2]
ENST00000454370; ENSP00000413222; ENSG00000234668 [O95670-1]
ENST00000454889; ENSP00000408670; ENSG00000230900 [O95670-1]
ENST00000483251; ENSP00000419698; ENSG00000213760 [O95670-3]
GeneIDi534
KEGGihsa:534
UCSCiuc003ntz.4 human [O95670-1]

Organism-specific databases

CTDi534
DisGeNETi534
EuPathDBiHostDB:ENSG00000213760.10
GeneCardsiATP6V1G2
HGNCiHGNC:862 ATP6V1G2
HPAiCAB004616
MIMi606853 gene
neXtProtiNX_O95670
OpenTargetsiENSG00000213760
PharmGKBiPA25164
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1772 Eukaryota
ENOG4111XX0 LUCA
GeneTreeiENSGT00390000011172
HOGENOMiHOG000186416
HOVERGENiHBG057827
InParanoidiO95670
KOiK02152
OMAiHPNYRIT
OrthoDBiEOG091G0XIZ
PhylomeDBiO95670
TreeFamiTF313777

Enzyme and pathway databases

BioCyciMetaCyc:HS10685-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport

Miscellaneous databases

GeneWikiiATP6V1G2
GenomeRNAii534
PROiPR:O95670
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213760 Expressed in 133 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_ATP6V1G2
ExpressionAtlasiO95670 baseline and differential
GenevisibleiO95670 HS

Family and domain databases

InterProiView protein in InterPro
IPR005124 V-ATPase_G
PANTHERiPTHR12713 PTHR12713, 1 hit
PfamiView protein in Pfam
PF03179 V-ATPase_G, 1 hit
TIGRFAMsiTIGR01147 V_ATP_synt_G, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVATG2_HUMAN
AccessioniPrimary (citable) accession number: O95670
Secondary accession number(s): B5MEF0
, Q2L6F8, Q5HYU8, Q5RJ63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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