UniProtKB - O95670 (VATG2_HUMAN)
Protein
V-type proton ATPase subunit G 2
Gene
ATP6V1G2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
GO - Molecular functioni
- ATPase-coupled transmembrane transporter activity Source: InterPro
GO - Biological processi
- cellular response to amino acid starvation Source: Reactome
- insulin receptor signaling pathway Source: Reactome
- ion transmembrane transport Source: Reactome
- phagosome acidification Source: Reactome
- proton transmembrane transport Source: InterPro
- regulation of macroautophagy Source: ParkinsonsUK-UCL
- transferrin transport Source: Reactome
Keywordsi
Biological process | Hydrogen ion transport, Ion transport, Transport |
Enzyme and pathway databases
BioCyci | MetaCyc:HS10685-MONOMER |
PathwayCommonsi | O95670 |
Reactomei | R-HSA-1222556, ROS and RNS production in phagocytes R-HSA-77387, Insulin receptor recycling R-HSA-917977, Transferrin endocytosis and recycling R-HSA-9639288, Amino acids regulate mTORC1 R-HSA-983712, Ion channel transport |
Names & Taxonomyi
Protein namesi | Recommended name: V-type proton ATPase subunit G 2Short name: V-ATPase subunit G 2 Alternative name(s): V-ATPase 13 kDa subunit 2 Vacuolar proton pump subunit G 2 |
Gene namesi | Name:ATP6V1G2 Synonyms:ATP6G, ATP6G2, NG38 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:862, ATP6V1G2 |
MIMi | 606853, gene |
neXtProti | NX_O95670 |
VEuPathDBi | HostDB:ENSG00000213760.10 |
Subcellular locationi
Other locations
- Melanosome 1 Publication
Note: Highly enriched in late-stage melanosomes.
Cytosol
- cytosol Source: Reactome
Other locations
- melanosome Source: UniProtKB-SubCell
- vacuolar proton-transporting V-type ATPase complex Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 534 |
OpenTargetsi | ENSG00000213760 |
PharmGKBi | PA25164 |
Miscellaneous databases
Pharosi | O95670, Tbio |
Chemistry databases
DrugBanki | DB01133, Tiludronic acid |
Genetic variation databases
BioMutai | ATP6V1G2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000192900 | 1 – 118 | V-type proton ATPase subunit G 2Add BLAST | 118 |
Proteomic databases
jPOSTi | O95670 |
MassIVEi | O95670 |
PaxDbi | O95670 |
PeptideAtlasi | O95670 |
PRIDEi | O95670 |
ProteomicsDBi | 50983 [O95670-1] 6232 62960 |
PTM databases
iPTMneti | O95670 |
PhosphoSitePlusi | O95670 |
Expressioni
Tissue specificityi
Brain.1 Publication
Gene expression databases
Bgeei | ENSG00000213760, Expressed in cerebellar hemisphere and 157 other tissues |
ExpressionAtlasi | O95670, baseline and differential |
Genevisiblei | O95670, HS |
Organism-specific databases
HPAi | ENSG00000213760, Tissue enriched (brain) |
Interactioni
Subunit structurei
V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).
By similarityBinary interactionsi
Hide detailsO95670
With | #Exp. | IntAct |
---|---|---|
ATP6V1E2 [Q96A05] | 6 | EBI-348290,EBI-8650380 |
USP20 [A0A024R8A9] | 3 | EBI-348290,EBI-14096082 |
Protein-protein interaction databases
BioGRIDi | 107017, 11 interactors |
IntActi | O95670, 9 interactors |
STRINGi | 9606.ENSP00000302194 |
Miscellaneous databases
RNActi | O95670, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the V-ATPase G subunit family.Curated
Phylogenomic databases
eggNOGi | KOG1772, Eukaryota |
GeneTreei | ENSGT00940000161280 |
HOGENOMi | CLU_125101_1_1_1 |
InParanoidi | O95670 |
OMAi | HPNYRIT |
PhylomeDBi | O95670 |
TreeFami | TF313777 |
Family and domain databases
InterProi | View protein in InterPro IPR005124, V-ATPase_G |
PANTHERi | PTHR12713, PTHR12713, 1 hit |
Pfami | View protein in Pfam PF03179, V-ATPase_G, 1 hit |
TIGRFAMsi | TIGR01147, V_ATP_synt_G, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: O95670-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASQSQGIQQ LLQAEKRAAE KVADARKRKA RRLKQAKEEA QMEVEQYRRE
60 70 80 90 100
REHEFQSKQQ AAMGSQGNLS AEVEQATRRQ VQGMQSSQQR NRERVLAQLL
110
GMVCDVRPQV HPNYRISA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0Y474 | H0Y474_HUMAN | V-type proton ATPase subunit G | ATP6V1G2 | 158 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 52 | E → D in AA401769 (Ref. 10) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047411 | 1 – 41 | Missing in isoform 3. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_045909 | 35 – 74 | Missing in isoform 2. 1 PublicationAdd BLAST | 40 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y14768 Genomic DNA Translation: CAA75073.1 AB063177 Genomic DNA Translation: BAC00863.1 AB102692 Genomic DNA Translation: BAD74058.1 AB097672 Genomic DNA Translation: BAD74057.1 BA000025 Genomic DNA Translation: BAB63399.1 AB088115 Genomic DNA Translation: BAC54952.1 AL662801 Genomic DNA No translation available. AL662847 Genomic DNA No translation available. BX001040 Genomic DNA No translation available. BX248516 Genomic DNA No translation available. CR753892 Genomic DNA No translation available. BX927320 Genomic DNA No translation available. CR753864 Genomic DNA No translation available. CR753820 Genomic DNA No translation available. CR942185 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03414.1 CH471081 Genomic DNA Translation: EAX03416.1 AB202112 Genomic DNA Translation: BAE78636.1 AB103621 Genomic DNA Translation: BAF31286.1 BC047791 mRNA No translation available. BC119726 mRNA Translation: AAI19727.1 BC119727 mRNA Translation: AAI19728.1 AA401769 mRNA No translation available. |
CCDSi | CCDS4698.1 [O95670-1] CCDS4699.1 [O95670-3] CCDS56413.1 [O95670-2] |
RefSeqi | NP_001191007.1, NM_001204078.1 [O95670-2] NP_569730.1, NM_130463.3 [O95670-1] NP_612139.1, NM_138282.2 [O95670-3] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y14768 Genomic DNA Translation: CAA75073.1 AB063177 Genomic DNA Translation: BAC00863.1 AB102692 Genomic DNA Translation: BAD74058.1 AB097672 Genomic DNA Translation: BAD74057.1 BA000025 Genomic DNA Translation: BAB63399.1 AB088115 Genomic DNA Translation: BAC54952.1 AL662801 Genomic DNA No translation available. AL662847 Genomic DNA No translation available. BX001040 Genomic DNA No translation available. BX248516 Genomic DNA No translation available. CR753892 Genomic DNA No translation available. BX927320 Genomic DNA No translation available. CR753864 Genomic DNA No translation available. CR753820 Genomic DNA No translation available. CR942185 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03414.1 CH471081 Genomic DNA Translation: EAX03416.1 AB202112 Genomic DNA Translation: BAE78636.1 AB103621 Genomic DNA Translation: BAF31286.1 BC047791 mRNA No translation available. BC119726 mRNA Translation: AAI19727.1 BC119727 mRNA Translation: AAI19728.1 AA401769 mRNA No translation available. |
CCDSi | CCDS4698.1 [O95670-1] CCDS4699.1 [O95670-3] CCDS56413.1 [O95670-2] |
RefSeqi | NP_001191007.1, NM_001204078.1 [O95670-2] NP_569730.1, NM_130463.3 [O95670-1] NP_612139.1, NM_138282.2 [O95670-3] |
3D structure databases
SMRi | O95670 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107017, 11 interactors |
IntActi | O95670, 9 interactors |
STRINGi | 9606.ENSP00000302194 |
Chemistry databases
DrugBanki | DB01133, Tiludronic acid |
PTM databases
iPTMneti | O95670 |
PhosphoSitePlusi | O95670 |
Genetic variation databases
BioMutai | ATP6V1G2 |
Proteomic databases
jPOSTi | O95670 |
MassIVEi | O95670 |
PaxDbi | O95670 |
PeptideAtlasi | O95670 |
PRIDEi | O95670 |
ProteomicsDBi | 50983 [O95670-1] 6232 62960 |
Protocols and materials databases
Antibodypediai | 48928, 96 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 534 |
DisGeNETi | 534 |
GeneCardsi | ATP6V1G2 |
HGNCi | HGNC:862, ATP6V1G2 |
HPAi | ENSG00000213760, Tissue enriched (brain) |
MIMi | 606853, gene |
neXtProti | NX_O95670 |
OpenTargetsi | ENSG00000213760 |
PharmGKBi | PA25164 |
VEuPathDBi | HostDB:ENSG00000213760.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1772, Eukaryota |
GeneTreei | ENSGT00940000161280 |
HOGENOMi | CLU_125101_1_1_1 |
InParanoidi | O95670 |
OMAi | HPNYRIT |
PhylomeDBi | O95670 |
TreeFami | TF313777 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS10685-MONOMER |
PathwayCommonsi | O95670 |
Reactomei | R-HSA-1222556, ROS and RNS production in phagocytes R-HSA-77387, Insulin receptor recycling R-HSA-917977, Transferrin endocytosis and recycling R-HSA-9639288, Amino acids regulate mTORC1 R-HSA-983712, Ion channel transport |
Miscellaneous databases
BioGRID-ORCSi | 534, 6 hits in 985 CRISPR screens |
GeneWikii | ATP6V1G2 |
GenomeRNAii | 534 |
Pharosi | O95670, Tbio |
PROi | PR:O95670 |
RNActi | O95670, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213760, Expressed in cerebellar hemisphere and 157 other tissues |
ExpressionAtlasi | O95670, baseline and differential |
Genevisiblei | O95670, HS |
Family and domain databases
InterProi | View protein in InterPro IPR005124, V-ATPase_G |
PANTHERi | PTHR12713, PTHR12713, 1 hit |
Pfami | View protein in Pfam PF03179, V-ATPase_G, 1 hit |
TIGRFAMsi | TIGR01147, V_ATP_synt_G, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VATG2_HUMAN | |
Accessioni | O95670Primary (citable) accession number: O95670 Secondary accession number(s): B5MEF0 Q5RJ63 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families