UniProtKB - O95665 (NTR2_HUMAN)
Protein
Neurotensin receptor type 2
Gene
NTSR2
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
GO - Molecular functioni
- G protein-coupled neurotensin receptor activity Source: Ensembl
- G protein-coupled receptor activity Source: ProtInc
GO - Biological processi
- cell surface receptor signaling pathway Source: ProtInc
- G protein-coupled receptor signaling pathway Source: Reactome
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
- regulation of membrane potential Source: Ensembl
- sensory perception Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | O95665 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | O95665 |
Names & Taxonomyi
Protein namesi | Recommended name: Neurotensin receptor type 2Short name: NT-R-2 Short name: NTR2 Alternative name(s): Levocabastine-sensitive neurotensin receptor |
Gene namesi | Name:NTSR2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000169006.6 |
HGNCi | HGNC:8040, NTSR2 |
MIMi | 605538, gene |
neXtProti | NX_O95665 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 32 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 33 – 55 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 56 – 64 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 65 – 87 | Helical; Name=2Sequence analysisAdd BLAST | 23 | |
Topological domaini | 88 – 109 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 110 – 131 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 132 – 154 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 155 – 176 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 177 – 217 | ExtracellularSequence analysisAdd BLAST | 41 | |
Transmembranei | 218 – 237 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 238 – 297 | CytoplasmicSequence analysisAdd BLAST | 60 | |
Transmembranei | 298 – 318 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 319 – 337 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 338 – 358 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 359 – 410 | CytoplasmicSequence analysisAdd BLAST | 52 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 23620 |
OpenTargetsi | ENSG00000169006 |
PharmGKBi | PA31822 |
Miscellaneous databases
Pharosi | O95665, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2514 |
DrugBanki | DB01106, Levocabastine |
DrugCentrali | O95665 |
GuidetoPHARMACOLOGYi | 310 |
Polymorphism and mutation databases
BioMutai | NTSR2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069949 | 1 – 410 | Neurotensin receptor type 2Add BLAST | 410 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 108 ↔ 194 | PROSITE-ProRule annotation | ||
Lipidationi | 377 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Lipoprotein, PalmitateProteomic databases
PaxDbi | O95665 |
PeptideAtlasi | O95665 |
PRIDEi | O95665 |
ProteomicsDBi | 50982 |
PTM databases
iPTMneti | O95665 |
PhosphoSitePlusi | O95665 |
Expressioni
Tissue specificityi
Expressed in prostate (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000169006, Expressed in nucleus accumbens and 88 other tissues |
Genevisiblei | O95665, HS |
Organism-specific databases
HPAi | ENSG00000169006, Tissue enriched (brain) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000303686 |
Chemistry databases
BindingDBi | O95665 |
Miscellaneous databases
RNActi | O95665, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222466 |
HOGENOMi | CLU_009579_6_5_1 |
InParanoidi | O95665 |
OMAi | YSFRLWG |
OrthoDBi | 890529at2759 |
PhylomeDBi | O95665 |
TreeFami | TF337167 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR003986, NT2_rcpt IPR003984, NT_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01479, NEUROTENSINR PR01481, NEUROTENSN2R |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O95665-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METSSPRPPR PSSNPGLSLD ARLGVDTRLW AKVLFTALYA LIWALGAAGN
60 70 80 90 100
ALSAHVVLKA RAGRAGRLRH HVLSLALAGL LLLLVGVPVE LYSFVWFHYP
110 120 130 140 150
WVFGDLGCRG YYFVHELCAY ATVLSVAGLS AERCLAVCQP LRARSLLTPR
160 170 180 190 200
RTRWLVALSW AASLGLALPM AVIMGQKHEL ETADGEPEPA SRVCTVLVSR
210 220 230 240 250
TALQVFIQVN VLVSFVLPLA LTAFLNGVTV SHLLALCSQV PSTSTPGSST
260 270 280 290 300
PSRLELLSEE GLLSFIVWKK TFIQGGQVSL VRHKDVRRIR SLQRSVQVLR
310 320 330 340 350
AIVVMYVICW LPYHARRLMY CYVPDDAWTD PLYNFYHYFY MVTNTLFYVS
360 370 380 390 400
SAVTPLLYNA VSSSFRKLFL EAVSSLCGEH HPMKRLPPKP QSPTLMDTAS
410
GFGDPPETRT
Sequence cautioni
The sequence EAX00924 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 109 – 134 | Missing in AAH37776 (PubMed:15489334).CuratedAdd BLAST | 26 | |
Sequence conflicti | 142 | R → C in AAH37776 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 168 | L → M in AAH22501 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 367 | K → R in AAH22501 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049425 | 54 | A → V3 PublicationsCorresponds to variant dbSNP:rs6432225Ensembl. | 1 | |
Natural variantiVAR_061225 | 282 | R → K. Corresponds to variant dbSNP:rs34764121EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y10148 mRNA Translation: CAA71233.1 AY429107 mRNA Translation: AAR07902.1 AC106875 Genomic DNA Translation: AAY14691.1 AC110754 Genomic DNA Translation: AAX82018.1 CH471053 Genomic DNA Translation: EAX00924.1 Sequence problems. BC022501 mRNA Translation: AAH22501.1 BC037776 mRNA Translation: AAH37776.1 |
CCDSi | CCDS1681.1 |
RefSeqi | NP_036476.1, NM_012344.3 |
Genome annotation databases
Ensembli | ENST00000306928; ENSP00000303686; ENSG00000169006 |
GeneIDi | 23620 |
KEGGi | hsa:23620 |
UCSCi | uc002rbq.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Neurotensin receptor entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y10148 mRNA Translation: CAA71233.1 AY429107 mRNA Translation: AAR07902.1 AC106875 Genomic DNA Translation: AAY14691.1 AC110754 Genomic DNA Translation: AAX82018.1 CH471053 Genomic DNA Translation: EAX00924.1 Sequence problems. BC022501 mRNA Translation: AAH22501.1 BC037776 mRNA Translation: AAH37776.1 |
CCDSi | CCDS1681.1 |
RefSeqi | NP_036476.1, NM_012344.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000303686 |
Chemistry databases
BindingDBi | O95665 |
ChEMBLi | CHEMBL2514 |
DrugBanki | DB01106, Levocabastine |
DrugCentrali | O95665 |
GuidetoPHARMACOLOGYi | 310 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | O95665 |
PhosphoSitePlusi | O95665 |
Polymorphism and mutation databases
BioMutai | NTSR2 |
Proteomic databases
PaxDbi | O95665 |
PeptideAtlasi | O95665 |
PRIDEi | O95665 |
ProteomicsDBi | 50982 |
Protocols and materials databases
Antibodypediai | 12728, 288 antibodies |
DNASUi | 23620 |
Genome annotation databases
Ensembli | ENST00000306928; ENSP00000303686; ENSG00000169006 |
GeneIDi | 23620 |
KEGGi | hsa:23620 |
UCSCi | uc002rbq.5, human |
Organism-specific databases
CTDi | 23620 |
DisGeNETi | 23620 |
EuPathDBi | HostDB:ENSG00000169006.6 |
GeneCardsi | NTSR2 |
HGNCi | HGNC:8040, NTSR2 |
HPAi | ENSG00000169006, Tissue enriched (brain) |
MIMi | 605538, gene |
neXtProti | NX_O95665 |
OpenTargetsi | ENSG00000169006 |
PharmGKBi | PA31822 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222466 |
HOGENOMi | CLU_009579_6_5_1 |
InParanoidi | O95665 |
OMAi | YSFRLWG |
OrthoDBi | 890529at2759 |
PhylomeDBi | O95665 |
TreeFami | TF337167 |
Enzyme and pathway databases
PathwayCommonsi | O95665 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | O95665 |
Miscellaneous databases
BioGRID-ORCSi | 23620, 7 hits in 841 CRISPR screens |
GeneWikii | Neurotensin_receptor_2 |
GenomeRNAii | 23620 |
Pharosi | O95665, Tchem |
PROi | PR:O95665 |
RNActi | O95665, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169006, Expressed in nucleus accumbens and 88 other tissues |
Genevisiblei | O95665, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR003986, NT2_rcpt IPR003984, NT_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01479, NEUROTENSINR PR01481, NEUROTENSN2R |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NTR2_HUMAN | |
Accessioni | O95665Primary (citable) accession number: O95665 Secondary accession number(s): Q53QQ5 Q8TBH6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 2, 2010 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries