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Protein

Neurotensin receptor type 2

Gene

NTSR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • G protein-coupled neurotensin receptor activity Source: Ensembl
  • G protein-coupled receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiO95665

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin receptor type 2
Short name:
NT-R-2
Short name:
NTR2
Alternative name(s):
Levocabastine-sensitive neurotensin receptor
Gene namesi
Name:NTSR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000169006.6
HGNCiHGNC:8040 NTSR2
MIMi605538 gene
neXtProtiNX_O95665

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 55Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini56 – 64CytoplasmicSequence analysis9
Transmembranei65 – 87Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini88 – 109ExtracellularSequence analysisAdd BLAST22
Transmembranei110 – 131Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini132 – 154CytoplasmicSequence analysisAdd BLAST23
Transmembranei155 – 176Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini177 – 217ExtracellularSequence analysisAdd BLAST41
Transmembranei218 – 237Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini238 – 297CytoplasmicSequence analysisAdd BLAST60
Transmembranei298 – 318Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini319 – 337ExtracellularSequence analysisAdd BLAST19
Transmembranei338 – 358Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini359 – 410CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23620
OpenTargetsiENSG00000169006
PharmGKBiPA31822

Chemistry databases

ChEMBLiCHEMBL2514
DrugBankiDB01106 Levocabastine
GuidetoPHARMACOLOGYi310

Polymorphism and mutation databases

BioMutaiNTSR2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699491 – 410Neurotensin receptor type 2Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi108 ↔ 194PROSITE-ProRule annotation
Lipidationi377S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO95665
PeptideAtlasiO95665
PRIDEiO95665
ProteomicsDBi50982

PTM databases

iPTMnetiO95665
PhosphoSitePlusiO95665

Expressioni

Tissue specificityi

Expressed in prostate (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000169006 Expressed in 76 organ(s), highest expression level in nucleus accumbens
CleanExiHS_NTSR2
GenevisibleiO95665 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303686

Chemistry databases

BindingDBiO95665

Structurei

3D structure databases

ProteinModelPortaliO95665
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000231271
HOVERGENiHBG098285
InParanoidiO95665
KOiK04212
OMAiELYSFVW
OrthoDBiEOG091G0ACG
PhylomeDBiO95665
TreeFamiTF337167

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003986 NT2_rcpt
IPR003984 NT_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01479 NEUROTENSINR
PR01481 NEUROTENSN2R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O95665-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METSSPRPPR PSSNPGLSLD ARLGVDTRLW AKVLFTALYA LIWALGAAGN
60 70 80 90 100
ALSAHVVLKA RAGRAGRLRH HVLSLALAGL LLLLVGVPVE LYSFVWFHYP
110 120 130 140 150
WVFGDLGCRG YYFVHELCAY ATVLSVAGLS AERCLAVCQP LRARSLLTPR
160 170 180 190 200
RTRWLVALSW AASLGLALPM AVIMGQKHEL ETADGEPEPA SRVCTVLVSR
210 220 230 240 250
TALQVFIQVN VLVSFVLPLA LTAFLNGVTV SHLLALCSQV PSTSTPGSST
260 270 280 290 300
PSRLELLSEE GLLSFIVWKK TFIQGGQVSL VRHKDVRRIR SLQRSVQVLR
310 320 330 340 350
AIVVMYVICW LPYHARRLMY CYVPDDAWTD PLYNFYHYFY MVTNTLFYVS
360 370 380 390 400
SAVTPLLYNA VSSSFRKLFL EAVSSLCGEH HPMKRLPPKP QSPTLMDTAS
410
GFGDPPETRT
Length:410
Mass (Da):45,385
Last modified:November 2, 2010 - v2
Checksum:i8B87DFD6923CBD42
GO

Sequence cautioni

The sequence EAX00924 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109 – 134Missing in AAH37776 (PubMed:15489334).CuratedAdd BLAST26
Sequence conflicti142R → C in AAH37776 (PubMed:15489334).Curated1
Sequence conflicti168L → M in AAH22501 (PubMed:15489334).Curated1
Sequence conflicti367K → R in AAH22501 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04942554A → V3 PublicationsCorresponds to variant dbSNP:rs6432225Ensembl.1
Natural variantiVAR_061225282R → K. Corresponds to variant dbSNP:rs34764121Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10148 mRNA Translation: CAA71233.1
AY429107 mRNA Translation: AAR07902.1
AC106875 Genomic DNA Translation: AAY14691.1
AC110754 Genomic DNA Translation: AAX82018.1
CH471053 Genomic DNA Translation: EAX00924.1 Sequence problems.
BC022501 mRNA Translation: AAH22501.1
BC037776 mRNA Translation: AAH37776.1
CCDSiCCDS1681.1
RefSeqiNP_036476.1, NM_012344.3
UniGeneiHs.131138

Genome annotation databases

EnsembliENST00000306928; ENSP00000303686; ENSG00000169006
GeneIDi23620
KEGGihsa:23620
UCSCiuc002rbq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Neurotensin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10148 mRNA Translation: CAA71233.1
AY429107 mRNA Translation: AAR07902.1
AC106875 Genomic DNA Translation: AAY14691.1
AC110754 Genomic DNA Translation: AAX82018.1
CH471053 Genomic DNA Translation: EAX00924.1 Sequence problems.
BC022501 mRNA Translation: AAH22501.1
BC037776 mRNA Translation: AAH37776.1
CCDSiCCDS1681.1
RefSeqiNP_036476.1, NM_012344.3
UniGeneiHs.131138

3D structure databases

ProteinModelPortaliO95665
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303686

Chemistry databases

BindingDBiO95665
ChEMBLiCHEMBL2514
DrugBankiDB01106 Levocabastine
GuidetoPHARMACOLOGYi310

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95665
PhosphoSitePlusiO95665

Polymorphism and mutation databases

BioMutaiNTSR2

Proteomic databases

PaxDbiO95665
PeptideAtlasiO95665
PRIDEiO95665
ProteomicsDBi50982

Protocols and materials databases

DNASUi23620
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306928; ENSP00000303686; ENSG00000169006
GeneIDi23620
KEGGihsa:23620
UCSCiuc002rbq.5 human

Organism-specific databases

CTDi23620
DisGeNETi23620
EuPathDBiHostDB:ENSG00000169006.6
GeneCardsiNTSR2
HGNCiHGNC:8040 NTSR2
MIMi605538 gene
neXtProtiNX_O95665
OpenTargetsiENSG00000169006
PharmGKBiPA31822
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000231271
HOVERGENiHBG098285
InParanoidiO95665
KOiK04212
OMAiELYSFVW
OrthoDBiEOG091G0ACG
PhylomeDBiO95665
TreeFamiTF337167

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiO95665

Miscellaneous databases

GeneWikiiNeurotensin_receptor_2
GenomeRNAii23620
PROiPR:O95665
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169006 Expressed in 76 organ(s), highest expression level in nucleus accumbens
CleanExiHS_NTSR2
GenevisibleiO95665 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003986 NT2_rcpt
IPR003984 NT_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01479 NEUROTENSINR
PR01481 NEUROTENSN2R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNTR2_HUMAN
AccessioniPrimary (citable) accession number: O95665
Secondary accession number(s): Q53QQ5
, Q57Z87, Q8IY58, Q8TBH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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