Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O95665 (NTR2_HUMAN)

Entry version 158 (02 Dec 2020)
Sequence version 2 (02 Nov 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Neurotensin receptor type 2

Gene

NTSR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95665

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-375276, Peptide ligand-binding receptors
R-HSA-416476, G alpha (q) signalling events

SIGNOR Signaling Network Open Resource

More...SIGNORi		O95665

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurotensin receptor type 2
Short name:
NT-R-2
Short name:
NTR2
Alternative name(s):
Levocabastine-sensitive neurotensin receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NTSR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000169006.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:8040, NTSR2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605538, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95665

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 55Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini56 – 64CytoplasmicSequence analysis9
Transmembranei65 – 87Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini88 – 109ExtracellularSequence analysisAdd BLAST22
Transmembranei110 – 131Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini132 – 154CytoplasmicSequence analysisAdd BLAST23
Transmembranei155 – 176Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini177 – 217ExtracellularSequence analysisAdd BLAST41
Transmembranei218 – 237Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini238 – 297CytoplasmicSequence analysisAdd BLAST60
Transmembranei298 – 318Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini319 – 337ExtracellularSequence analysisAdd BLAST19
Transmembranei338 – 358Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini359 – 410CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23620

Open Targets

More...OpenTargetsi		ENSG00000169006

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31822

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95665, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2514

Drug and drug target database

More...DrugBanki		DB01106, Levocabastine

DrugCentral

More...DrugCentrali		O95665

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		310

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NTSR2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000699491 – 410Neurotensin receptor type 2Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi108 ↔ 194PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi377S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95665

PeptideAtlas

More...PeptideAtlasi		O95665

PRoteomics IDEntifications database

More...PRIDEi		O95665

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50982

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95665

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95665

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in prostate (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000169006, Expressed in nucleus accumbens and 88 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95665, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000169006, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000303686

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O95665

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95665, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01010000222466

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_6_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95665

Identification of Orthologs from Complete Genome Data

More...OMAi		YSFRLWG

Database of Orthologous Groups

More...OrthoDBi		890529at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95665

TreeFam database of animal gene trees

More...TreeFami		TF337167

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR003986, NT2_rcpt
IPR003984, NT_rcpt

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN
PR01479, NEUROTENSINR
PR01481, NEUROTENSN2R

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O95665-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METSSPRPPR PSSNPGLSLD ARLGVDTRLW AKVLFTALYA LIWALGAAGN 
        60         70         80         90        100
ALSAHVVLKA RAGRAGRLRH HVLSLALAGL LLLLVGVPVE LYSFVWFHYP 
       110        120        130        140        150
WVFGDLGCRG YYFVHELCAY ATVLSVAGLS AERCLAVCQP LRARSLLTPR 
       160        170        180        190        200
RTRWLVALSW AASLGLALPM AVIMGQKHEL ETADGEPEPA SRVCTVLVSR 
       210        220        230        240        250
TALQVFIQVN VLVSFVLPLA LTAFLNGVTV SHLLALCSQV PSTSTPGSST 
       260        270        280        290        300
PSRLELLSEE GLLSFIVWKK TFIQGGQVSL VRHKDVRRIR SLQRSVQVLR 
       310        320        330        340        350
AIVVMYVICW LPYHARRLMY CYVPDDAWTD PLYNFYHYFY MVTNTLFYVS 
       360        370        380        390        400
SAVTPLLYNA VSSSFRKLFL EAVSSLCGEH HPMKRLPPKP QSPTLMDTAS 
       410
GFGDPPETRT
Length:410
Mass (Da):45,385
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B87DFD6923CBD42
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EAX00924 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti109 – 134Missing in AAH37776 (PubMed:15489334).CuratedAdd BLAST26
Sequence conflicti142R → C in AAH37776 (PubMed:15489334).Curated1
Sequence conflicti168L → M in AAH22501 (PubMed:15489334).Curated1
Sequence conflicti367K → R in AAH22501 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04942554A → V3 PublicationsCorresponds to variant dbSNP:rs6432225Ensembl.1
Natural variantiVAR_061225282R → K. Corresponds to variant dbSNP:rs34764121EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y10148 mRNA Translation: CAA71233.1
AY429107 mRNA Translation: AAR07902.1
AC106875 Genomic DNA Translation: AAY14691.1
AC110754 Genomic DNA Translation: AAX82018.1
CH471053 Genomic DNA Translation: EAX00924.1 Sequence problems.
BC022501 mRNA Translation: AAH22501.1
BC037776 mRNA Translation: AAH37776.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1681.1

NCBI Reference Sequences

More...RefSeqi		NP_036476.1, NM_012344.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000306928; ENSP00000303686; ENSG00000169006

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23620

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23620

UCSC genome browser

More...UCSCi		uc002rbq.5, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Neurotensin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10148 mRNA Translation: CAA71233.1
AY429107 mRNA Translation: AAR07902.1
AC106875 Genomic DNA Translation: AAY14691.1
AC110754 Genomic DNA Translation: AAX82018.1
CH471053 Genomic DNA Translation: EAX00924.1 Sequence problems.
BC022501 mRNA Translation: AAH22501.1
BC037776 mRNA Translation: AAH37776.1
CCDSiCCDS1681.1
RefSeqiNP_036476.1, NM_012344.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000303686

Chemistry databases

BindingDBiO95665
ChEMBLiCHEMBL2514
DrugBankiDB01106, Levocabastine
DrugCentraliO95665
GuidetoPHARMACOLOGYi310

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiO95665
PhosphoSitePlusiO95665

Polymorphism and mutation databases

BioMutaiNTSR2

Proteomic databases

PaxDbiO95665
PeptideAtlasiO95665
PRIDEiO95665
ProteomicsDBi50982

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12728, 288 antibodies

The DNASU plasmid repository

More...DNASUi		23620

Genome annotation databases

EnsembliENST00000306928; ENSP00000303686; ENSG00000169006
GeneIDi23620
KEGGihsa:23620
UCSCiuc002rbq.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23620
DisGeNETi23620
EuPathDBiHostDB:ENSG00000169006.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		NTSR2
HGNCiHGNC:8040, NTSR2
HPAiENSG00000169006, Tissue enriched (brain)
MIMi605538, gene
neXtProtiNX_O95665
OpenTargetsiENSG00000169006
PharmGKBiPA31822

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT01010000222466
HOGENOMiCLU_009579_6_5_1
InParanoidiO95665
OMAiYSFRLWG
OrthoDBi890529at2759
PhylomeDBiO95665
TreeFamiTF337167

Enzyme and pathway databases

PathwayCommonsiO95665
ReactomeiR-HSA-375276, Peptide ligand-binding receptors
R-HSA-416476, G alpha (q) signalling events
SIGNORiO95665

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23620, 7 hits in 841 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Neurotensin_receptor_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23620
PharosiO95665, Tchem

Protein Ontology

More...PROi		PR:O95665
RNActiO95665, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000169006, Expressed in nucleus accumbens and 88 other tissues
GenevisibleiO95665, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR003986, NT2_rcpt
IPR003984, NT_rcpt
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR01479, NEUROTENSINR
PR01481, NEUROTENSN2R
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTR2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95665
Secondary accession number(s): Q53QQ5
, Q57Z87, Q8IY58, Q8TBH6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2010
Last modified: December 2, 2020
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again