NTSR2

Functionⁱ

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functionⁱ

G protein-coupled neurotensin receptor activity Source: Ensembl
G protein-coupled receptor activity
Source: ProtInc
Traceable author statementⁱ
- 9851594

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 9851594
G protein-coupled receptor signaling pathway Source: Reactome
phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
regulation of membrane potential Source: Ensembl
sensory perception
Source: ProtInc
Traceable author statementⁱ
- 8795617

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events
SIGNORⁱ	O95665

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neurotensin receptor type 2 Short name: NT-R-2 Short name: NTR2 Alternative name(s): Levocabastine-sensitive neurotensin receptor
Gene namesⁱ	Name:NTSR2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000169006.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8040 NTSR2
MIMⁱ	605538 gene
neXtProtⁱ	NX_O95665

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 32	ExtracellularSequence analysisAdd BLAST	32
Transmembraneⁱ	33 – 55	Helical; Name=1Sequence analysisAdd BLAST	23
Topological domainⁱ	56 – 64	CytoplasmicSequence analysis	9
Transmembraneⁱ	65 – 87	Helical; Name=2Sequence analysisAdd BLAST	23
Topological domainⁱ	88 – 109	ExtracellularSequence analysisAdd BLAST	22
Transmembraneⁱ	110 – 131	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	132 – 154	CytoplasmicSequence analysisAdd BLAST	23
Transmembraneⁱ	155 – 176	Helical; Name=4Sequence analysisAdd BLAST	22
Topological domainⁱ	177 – 217	ExtracellularSequence analysisAdd BLAST	41
Transmembraneⁱ	218 – 237	Helical; Name=5Sequence analysisAdd BLAST	20
Topological domainⁱ	238 – 297	CytoplasmicSequence analysisAdd BLAST	60
Transmembraneⁱ	298 – 318	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	319 – 337	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	338 – 358	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	359 – 410	CytoplasmicSequence analysisAdd BLAST	52

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23620
Open Targets More...OpenTargetsⁱ	ENSG00000169006
PharmGKBⁱ	PA31822

Chemistry databases

ChEMBLⁱ	CHEMBL2514
Drug and drug target database More...DrugBankⁱ	DB01106 Levocabastine
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	310

Polymorphism and mutation databases

BioMutaⁱ	NTSR2

BioMutaⁱ

NTSR2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069949	1 – 410	Neurotensin receptor type 2Add BLAST		410

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	108 ↔ 194	PROSITE-ProRule annotation
Lipidationⁱ	377	S-palmitoyl cysteineSequence analysis		1

Keywords - PTMⁱ

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	O95665
PeptideAtlas More...PeptideAtlasⁱ	O95665
PRIDEⁱ	O95665
ProteomicsDBⁱ	50982

PTM databases

iPTMnetⁱ	O95665
PhosphoSitePlusⁱ	O95665

Expressionⁱ

Tissue specificityⁱ

Expressed in prostate (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000169006 Expressed in 76 organ(s), highest expression level in nucleus accumbens
CleanExⁱ	HS_NTSR2
Genevisibleⁱ	O95665 HS

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000303686

STRINGⁱ

9606.ENSP00000303686

Chemistry databases

BindingDBⁱ

O95665

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95665
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104070
HOGENOMⁱ	HOG000231271
HOVERGENⁱ	HBG098285
InParanoidⁱ	O95665
KEGG Orthology (KO) More...KOⁱ	K04212
OMAⁱ	ELYSFVW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ACG
PhylomeDBⁱ	O95665
TreeFamⁱ	TF337167

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR003986 NT2_rcpt IPR003984 NT_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR01479 NEUROTENSINR PR01481 NEUROTENSN2R
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O95665-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
METSSPRPPR PSSNPGLSLD ARLGVDTRLW AKVLFTALYA LIWALGAAGN 
        60         70         80         90        100
ALSAHVVLKA RAGRAGRLRH HVLSLALAGL LLLLVGVPVE LYSFVWFHYP 
       110        120        130        140        150
WVFGDLGCRG YYFVHELCAY ATVLSVAGLS AERCLAVCQP LRARSLLTPR 
       160        170        180        190        200
RTRWLVALSW AASLGLALPM AVIMGQKHEL ETADGEPEPA SRVCTVLVSR 
       210        220        230        240        250
TALQVFIQVN VLVSFVLPLA LTAFLNGVTV SHLLALCSQV PSTSTPGSST 
       260        270        280        290        300
PSRLELLSEE GLLSFIVWKK TFIQGGQVSL VRHKDVRRIR SLQRSVQVLR 
       310        320        330        340        350
AIVVMYVICW LPYHARRLMY CYVPDDAWTD PLYNFYHYFY MVTNTLFYVS 
       360        370        380        390        400
SAVTPLLYNA VSSSFRKLFL EAVSSLCGEH HPMKRLPPKP QSPTLMDTAS 
       410
GFGDPPETRT

Length:410

Mass (Da):45,385

Last modified:November 2, 2010 - v2

Checksum:ⁱ8B87DFD6923CBD42

GO

Sequence cautionⁱ

The sequence EAX00924 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	109 – 134	Missing in AAH37776 (PubMed:15489334).CuratedAdd BLAST	26
Sequence conflictⁱ	142	R → C in AAH37776 (PubMed:15489334).Curated	1
Sequence conflictⁱ	168	L → M in AAH22501 (PubMed:15489334).Curated	1
Sequence conflictⁱ	367	K → R in AAH22501 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049425	54	A → V3 PublicationsCorresponds to variant dbSNP:rs6432225Ensembl.		1
Natural variantⁱVAR_061225	282	R → K. Corresponds to variant dbSNP:rs34764121Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y10148 mRNA Translation: CAA71233.1 AY429107 mRNA Translation: AAR07902.1 AC106875 Genomic DNA Translation: AAY14691.1 AC110754 Genomic DNA Translation: AAX82018.1 CH471053 Genomic DNA Translation: EAX00924.1 Sequence problems. BC022501 mRNA Translation: AAH22501.1 BC037776 mRNA Translation: AAH37776.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1681.1
NCBI Reference Sequences More...RefSeqⁱ	NP_036476.1, NM_012344.3
UniGeneⁱ	Hs.131138

Genome annotation databases

Ensemblⁱ	ENST00000306928; ENSP00000303686; ENSG00000169006
GeneIDⁱ	23620
KEGGⁱ	hsa:23620
UCSC genome browser More...UCSCⁱ	uc002rbq.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95665	NTSR2 isoform 1		PONAB		426	UniRef90_O95665
Neurotensin receptor 2		CHLSB		417
NTSR2 isoform 1		PANTR		416
Uncharacterized protein		MACFA		388
Uncharacterized protein		MACMU		388
+13

Protein	Similar proteins		Species	Score	Length	Source
O95665	Neurotensin receptor type 2		RAT		416	UniRef50_Q63384
Neurotensin receptor type 2		MOUSE		416
neurotensin receptor type 2		TURTR		408
LOW QUALITY PROTEIN: neurotensin receptor type 2		DELLE		427
LOW QUALITY PROTEIN: neurotensin receptor type 2		PHYCD		417
+122

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Neurotensin receptor entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y10148 mRNA Translation: CAA71233.1 AY429107 mRNA Translation: AAR07902.1 AC106875 Genomic DNA Translation: AAY14691.1 AC110754 Genomic DNA Translation: AAX82018.1 CH471053 Genomic DNA Translation: EAX00924.1 Sequence problems. BC022501 mRNA Translation: AAH22501.1 BC037776 mRNA Translation: AAH37776.1
CCDSⁱ	CCDS1681.1
RefSeqⁱ	NP_036476.1, NM_012344.3
UniGeneⁱ	Hs.131138

3D structure databases

ProteinModelPortalⁱ	O95665
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000303686

STRINGⁱ

9606.ENSP00000303686

Chemistry databases

BindingDBⁱ	O95665
ChEMBLⁱ	CHEMBL2514
DrugBankⁱ	DB01106 Levocabastine
GuidetoPHARMACOLOGYⁱ	310

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	O95665
PhosphoSitePlusⁱ	O95665

Polymorphism and mutation databases

BioMutaⁱ	NTSR2

BioMutaⁱ

NTSR2

Proteomic databases

PaxDbⁱ	O95665
PeptideAtlasⁱ	O95665
PRIDEⁱ	O95665
ProteomicsDBⁱ	50982

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23620
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000306928; ENSP00000303686; ENSG00000169006
GeneIDⁱ	23620
KEGGⁱ	hsa:23620
UCSCⁱ	uc002rbq.5 human

Organism-specific databases

CTDⁱ	23620
DisGeNETⁱ	23620
EuPathDBⁱ	HostDB:ENSG00000169006.6
GeneCardsⁱ	NTSR2
HGNCⁱ	HGNC:8040 NTSR2
MIMⁱ	605538 gene
neXtProtⁱ	NX_O95665
OpenTargetsⁱ	ENSG00000169006
PharmGKBⁱ	PA31822
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00700000104070
HOGENOMⁱ	HOG000231271
HOVERGENⁱ	HBG098285
InParanoidⁱ	O95665
KOⁱ	K04212
OMAⁱ	ELYSFVW
OrthoDBⁱ	EOG091G0ACG
PhylomeDBⁱ	O95665
TreeFamⁱ	TF337167

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events
SIGNORⁱ	O95665

Miscellaneous databases

GeneWikiⁱ	Neurotensin_receptor_2
GenomeRNAiⁱ	23620
Protein Ontology More...PROⁱ	PR:O95665
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000169006 Expressed in 76 organ(s), highest expression level in nucleus accumbens
CleanExⁱ	HS_NTSR2
Genevisibleⁱ	O95665 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR003986 NT2_rcpt IPR003984 NT_rcpt
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR01479 NEUROTENSINR PR01481 NEUROTENSN2R
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NTR2_HUMAN
Accessionⁱ	O95665Primary (citable) accession number: O95665 Secondary accession number(s): Q53QQ5 , Q57Z87, Q8IY58, Q8TBH6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	November 2, 2010
	Last modified:	November 7, 2018
	This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - O95665 (NTR2_HUMAN)

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Neurotensin receptor type 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ