UniProtKB - O95644 (NFAC1_HUMAN)
Nuclear factor of activated T-cells, cytoplasmic 1
NFATC1
Functioni
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178).
Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity).
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 439 – 446 | 8 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: BHF-UCL
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
- FK506 binding Source: ProtInc
- mitogen-activated protein kinase p38 binding Source: BHF-UCL
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: BHF-UCL
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription coactivator binding Source: Ensembl
GO - Biological processi
- aortic valve morphogenesis Source: BHF-UCL
- calcineurin-NFAT signaling cascade Source: UniProtKB
- intracellular signal transduction Source: MGI
- negative regulation of vascular associated smooth muscle cell differentiation Source: BHF-UCL
- negative regulation of Wnt signaling pathway Source: ParkinsonsUK-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- pulmonary valve morphogenesis Source: BHF-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | O95644 |
Reactomei | R-HSA-2025928, Calcineurin activates NFAT R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-4086398, Ca2+ pathway R-HSA-5607763, CLEC7A (Dectin-1) induces NFAT activation |
SignaLinki | O95644 |
SIGNORi | O95644 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear factor of activated T-cells, cytoplasmic 1Short name: NF-ATc1 Short name: NFATc1 Alternative name(s): NFAT transcription complex cytosolic component Short name: NF-ATc Short name: NFATc |
Gene namesi | Name:NFATC1 Synonyms:NFAT2, NFATC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7775, NFATC1 |
MIMi | 600489, gene |
neXtProti | NX_O95644 |
VEuPathDBi | HostDB:ENSG00000131196 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus 1 Publication
Note: Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription (PubMed:16511445). Nuclear translocation of NFATC1 is enhanced in the presence of TNFSF11. Nuclear translocation is decreased in the presence of FBN1 which can bind and sequester TNFSF11 (By similarity).By similarity1 Publication
Cytosol
- cytosol Source: Reactome
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: MGI
Other locations
- chromatin Source: BHF-UCL
- cytoplasm Source: BHF-UCL
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 169 | S → A: No effect on subcellular localization. | 1 | |
Mutagenesisi | 172 | S → A: Partial nuclear translocation. 1 Publication | 1 | |
Mutagenesisi | 187 | S → A: No effect on subcellular localization. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 4772 |
OpenTargetsi | ENSG00000131196 |
PharmGKBi | PA31582 |
Miscellaneous databases
Pharosi | O95644, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3876 |
DrugBanki | DB00852, Pseudoephedrine |
Genetic variation databases
BioMutai | NFATC1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000030329 | 1 – 943 | Nuclear factor of activated T-cells, cytoplasmic 1Add BLAST | 943 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 233 | PhosphoserineCombined sources | 1 | |
Modified residuei | 237 | PhosphoserineBy similarity | 1 | |
Modified residuei | 245 | Phosphoserine; by PKA1 Publication | 1 | |
Modified residuei | 269 | Phosphoserine; by PKA1 Publication | 1 | |
Modified residuei | 294 | Phosphoserine; by PKA1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | CPTAC-983 |
jPOSTi | O95644 |
MassIVEi | O95644 |
MaxQBi | O95644 |
PaxDbi | O95644 |
PeptideAtlasi | O95644 |
PRIDEi | O95644 |
ProteomicsDBi | 50973 [O95644-1] 50974 [O95644-2] 50975 [O95644-3] 50976 [O95644-4] 50977 [O95644-5] 50978 [O95644-6] 50979 [O95644-8] 5935 |
PTM databases
GlyGeni | O95644, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O95644 |
PhosphoSitePlusi | O95644 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000131196, Expressed in muscle organ and 213 other tissues |
ExpressionAtlasi | O95644, baseline and differential |
Genevisiblei | O95644, HS |
Organism-specific databases
HPAi | ENSG00000131196, Low tissue specificity |
Interactioni
Subunit structurei
Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers (PubMed:9506523).
Interacts with HOMER2 and HOMER3; this interaction may compete with calcineurin/PPP3CA-binding and hence prevent NFATC1 dephosphorylation and activation (PubMed:18218901).
Interacts with TLE6/GRG6 (By similarity).
By similarity2 PublicationsBinary interactionsi
O95644
GO - Molecular functioni
- mitogen-activated protein kinase p38 binding Source: BHF-UCL
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- transcription coactivator binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 110845, 149 interactors |
DIPi | DIP-44311N |
IntActi | O95644, 58 interactors |
MINTi | O95644 |
STRINGi | 9606.ENSP00000389377 |
Chemistry databases
BindingDBi | O95644 |
Miscellaneous databases
RNActi | O95644, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O95644 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O95644 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 203 – 219 | 1Add BLAST | 17 | |
Repeati | 233 – 249 | 2Add BLAST | 17 | |
Repeati | 282 – 298 | 3Add BLAST | 17 | |
Domaini | 410 – 592 | RHDPROSITE-ProRule annotationAdd BLAST | 183 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 22 – 48 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 118 – 123 | Calcineurin-binding | 6 | |
Regioni | 126 – 218 | Trans-activation domain A (TAD-A)Add BLAST | 93 | |
Regioni | 200 – 298 | DisorderedSequence analysisAdd BLAST | 99 | |
Regioni | 203 – 298 | 3 X SP repeatsAdd BLAST | 96 | |
Regioni | 703 – 943 | Trans-activation domain B (TAD-B)Add BLAST | 241 | |
Regioni | 787 – 912 | DisorderedSequence analysisAdd BLAST | 126 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 265 – 267 | Nuclear localization signal | 3 | |
Motifi | 310 – 321 | Nuclear export signalAdd BLAST | 12 | |
Motifi | 682 – 684 | Nuclear localization signal | 3 | |
Motifi | 924 – 933 | Nuclear export signal | 10 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 233 – 254 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 810 – 825 | Pro residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 842 – 873 | Pro residuesSequence analysisAdd BLAST | 32 |
Domaini
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QTX8, Eukaryota |
GeneTreei | ENSGT00940000157616 |
HOGENOMi | CLU_010185_1_0_1 |
InParanoidi | O95644 |
OMAi | RGLGACN |
OrthoDBi | 277998at2759 |
PhylomeDBi | O95644 |
TreeFami | TF326480 |
Family and domain databases
DisProti | DP01724 |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
IDEALi | IID00435 |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR008366, NFAT IPR015647, NFAT1 IPR008967, p53-like_TF_DNA-bd IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR12533, PTHR12533, 1 hit PTHR12533:SF5, PTHR12533:SF5, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01789, NUCFACTORATC |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
s (10+)i Sequence
Sequence statusi: Complete.
This entry describes 10 produced by isoformsialternative splicing and alternative initiation. AlignAdd to basketThis entry has 10 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPSTSFPVPS KFPLGPAAAV FGRGETLGPA PRAGGTMKSA EEEHYGYASS
60 70 80 90 100
NVSPALPLPT AHSTLPAPCH NLQTSTPGII PPADHPSGYG AALDGGPAGY
110 120 130 140 150
FLSSGHTRPD GAPALESPRI EITSCLGLYH NNNQFFHDVE VEDVLPSSKR
160 170 180 190 200
SPSTATLSLP SLEAYRDPSC LSPASSLSSR SCNSEASSYE SNYSYPYASP
210 220 230 240 250
QTSPWQSPCV SPKTTDPEEG FPRGLGACTL LGSPRHSPST SPRASVTEES
260 270 280 290 300
WLGARSSRPA SPCNKRKYSL NGRQPPYSPH HSPTPSPHGS PRVSVTDDSW
310 320 330 340 350
LGNTTQYTSS AIVAAINALT TDSSLDLGDG VPVKSRKTTL EQPPSVALKV
360 370 380 390 400
EPVGEDLGSP PPPADFAPED YSSFQHIRKG GFCDQYLAVP QHPYQWAKPK
410 420 430 440 450
PLSPTSYMSP TLPALDWQLP SHSGPYELRI EVQPKSHHRA HYETEGSRGA
460 470 480 490 500
VKASAGGHPI VQLHGYLENE PLMLQLFIGT ADDRLLRPHA FYQVHRITGK
510 520 530 540 550
TVSTTSHEAI LSNTKVLEIP LLPENSMRAV IDCAGILKLR NSDIELRKGE
560 570 580 590 600
TDIGRKNTRV RLVFRVHVPQ PSGRTLSLQV ASNPIECSQR SAQELPLVEK
610 620 630 640 650
QSTDSYPVVG GKKMVLSGHN FLQDSKVIFV EKAPDGHHVW EMEAKTDRDL
660 670 680 690 700
CKPNSLVVEI PPFRNQRITS PVHVSFYVCN GKRKRSQYQR FTYLPANVPI
710 720 730 740 750
IKTEPTDDYE PAPTCGPVSQ GLSPLPRPYY SQQLAMPPDP SSCLVAGFPP
760 770 780 790 800
CPQRSTLMPA APGVSPKLHD LSPAAYTKGV ASPGHCHLGL PQPAGEAPAV
810 820 830 840 850
QDVPRPVATH PGSPGQPPPA LLPQQVSAPP SSSCPPGLEH SLCPSSPSPP
860 870 880 890 900
LPPATQEPTC LQPCSPACPP ATGRPQHLPS TVRRDESPTA GPRLLPEVHE
910 920 930 940
DGSPNLAPIP VTVKREPEEL DQLYLDDVNE IIRNDLSSTS THS
The sequence of this isoform differs from the canonical sequence as follows:
698-716: VPIIKTEPTDDYEPAPTCG → GNAIFLTVSREHERVGCFF
717-943: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-42: MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEE → MTGLEDQEFDFEFLFEFNQRDEGAAAAAP
698-716: VPIIKTEPTDDYEPAPTCG → GNAIFLTVSREHERVGCFF
717-943: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
826-943: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-42: MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEE → MTGLEDQEFDFEFLFEFNQRDEGAAAAAP
826-943: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-42: MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEE → MTGLEDQEFDFEFLFEFNQRDEGAAAAAP
The sequence of this isoform differs from the canonical sequence as follows:
1-36: Missing.
698-716: VPIIKTEPTDDYEPAPTCG → GNAIFLTVSREHERVGCFF
717-943: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
698-927: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-42: MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEE → MTGLEDQEFDFEFLFEFNQRDEGAAAAAP
698-927: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-472: Missing.
826-943: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ER53 | K7ER53_HUMAN | Nuclear factor of-activated T-cells... | NFATC1 | 639 | Annotation score: | ||
F5H4S8 | F5H4S8_HUMAN | Nuclear factor of-activated T-cells... | NFATC1 | 471 | Annotation score: | ||
K7EQ04 | K7EQ04_HUMAN | Nuclear factor of-activated T-cells... | NFATC1 | 71 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 232 | G → S in AAC50869 (PubMed:8702849).Curated | 1 | |
Sequence conflicti | 235 | R → Q in AAA19601 (PubMed:8202141).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057145 | 68 | P → T. Corresponds to variant dbSNP:rs1051978Ensembl. | 1 | |
Natural variantiVAR_036529 | 315 | A → T in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs779866756Ensembl. | 1 | |
Natural variantiVAR_057146 | 751 | C → G. Corresponds to variant dbSNP:rs754093Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053806 | 1 – 472 | Missing in isoform 10. CuratedAdd BLAST | 472 | |
Alternative sequenceiVSP_005590 | 1 – 42 | MPSTS…KSAEE → MTGLEDQEFDFEFLFEFNQR DEGAAAAAP in isoform A-beta, isoform B-beta, isoform C-beta and isoform IB-deltaIX. 3 PublicationsAdd BLAST | 42 | |
Alternative sequenceiVSP_018978 | 1 – 36 | Missing in isoform A-alpha'. CuratedAdd BLAST | 36 | |
Alternative sequenceiVSP_047820 | 698 – 927 | Missing in isoform IA-deltaIX and isoform IB-deltaIX. 1 PublicationAdd BLAST | 230 | |
Alternative sequenceiVSP_005591 | 698 – 716 | VPIIK…APTCG → GNAIFLTVSREHERVGCFF in isoform A-alpha, isoform A-alpha' and isoform A-beta. 3 PublicationsAdd BLAST | 19 | |
Alternative sequenceiVSP_005592 | 717 – 943 | Missing in isoform A-alpha, isoform A-alpha' and isoform A-beta. 3 PublicationsAdd BLAST | 227 | |
Alternative sequenceiVSP_005593 | 826 – 943 | Missing in isoform B-alpha, isoform B-beta and isoform 10. 2 PublicationsAdd BLAST | 118 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative initiation, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A66 | NMR | - | A | 414-591 | [»] | |
1NFA | NMR | - | A | 416-591 | [»] | |
5SVE | X-ray | 2.60 | C | 384-400 | [»] | |
SMRi | O95644 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110845, 149 interactors |
DIPi | DIP-44311N |
IntActi | O95644, 58 interactors |
MINTi | O95644 |
STRINGi | 9606.ENSP00000389377 |
Chemistry databases
BindingDBi | O95644 |
ChEMBLi | CHEMBL3876 |
DrugBanki | DB00852, Pseudoephedrine |
PTM databases
GlyGeni | O95644, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O95644 |
PhosphoSitePlusi | O95644 |
Genetic variation databases
BioMutai | NFATC1 |
Proteomic databases
CPTACi | CPTAC-983 |
jPOSTi | O95644 |
MassIVEi | O95644 |
MaxQBi | O95644 |
PaxDbi | O95644 |
PeptideAtlasi | O95644 |
PRIDEi | O95644 |
ProteomicsDBi | 50973 [O95644-1] 50974 [O95644-2] 50975 [O95644-3] 50976 [O95644-4] 50977 [O95644-5] 50978 [O95644-6] 50979 [O95644-8] 5935 |
Protocols and materials databases
Antibodypediai | 3860, 611 antibodies from 41 providers |
DNASUi | 4772 |
Genome annotation databases
Organism-specific databases
CTDi | 4772 |
DisGeNETi | 4772 |
GeneCardsi | NFATC1 |
HGNCi | HGNC:7775, NFATC1 |
HPAi | ENSG00000131196, Low tissue specificity |
MIMi | 600489, gene |
neXtProti | NX_O95644 |
OpenTargetsi | ENSG00000131196 |
PharmGKBi | PA31582 |
VEuPathDBi | HostDB:ENSG00000131196 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTX8, Eukaryota |
GeneTreei | ENSGT00940000157616 |
HOGENOMi | CLU_010185_1_0_1 |
InParanoidi | O95644 |
OMAi | RGLGACN |
OrthoDBi | 277998at2759 |
PhylomeDBi | O95644 |
TreeFami | TF326480 |
Enzyme and pathway databases
PathwayCommonsi | O95644 |
Reactomei | R-HSA-2025928, Calcineurin activates NFAT R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-4086398, Ca2+ pathway R-HSA-5607763, CLEC7A (Dectin-1) induces NFAT activation |
SignaLinki | O95644 |
SIGNORi | O95644 |
Miscellaneous databases
BioGRID-ORCSi | 4772, 7 hits in 1068 CRISPR screens |
ChiTaRSi | NFATC1, human |
EvolutionaryTracei | O95644 |
GeneWikii | NFATC1 |
GenomeRNAii | 4772 |
Pharosi | O95644, Tbio |
PROi | PR:O95644 |
RNActi | O95644, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131196, Expressed in muscle organ and 213 other tissues |
ExpressionAtlasi | O95644, baseline and differential |
Genevisiblei | O95644, HS |
Family and domain databases
DisProti | DP01724 |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
IDEALi | IID00435 |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR008366, NFAT IPR015647, NFAT1 IPR008967, p53-like_TF_DNA-bd IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR12533, PTHR12533, 1 hit PTHR12533:SF5, PTHR12533:SF5, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01789, NUCFACTORATC |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NFAC1_HUMAN | |
Accessioni | O95644Primary (citable) accession number: O95644 Secondary accession number(s): B5B2M4 Q2M1S3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 219 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references