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Entry version 175 (12 Aug 2020)
Sequence version 1 (01 May 1999)
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Protein

Cleavage and polyadenylation specificity factor subunit 4

Gene

CPSF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri35 – 61C3H1-type 1PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri62 – 89C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri90 – 117C3H1-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri118 – 142C3H1-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri143 – 169C3H1-type 5PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri243 – 260CCHC-typePROSITE-ProRule annotationAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction, mRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O95639

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-168315, Inhibition of Host mRNA Processing and RNA Silencing
R-HSA-6784531, tRNA processing in the nucleus
R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72187, mRNA 3'-end processing
R-HSA-73856, RNA Polymerase II Transcription Termination
R-HSA-77595, Processing of Intronless Pre-mRNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cleavage and polyadenylation specificity factor subunit 4
Alternative name(s):
Cleavage and polyadenylation specificity factor 30 kDa subunit
Short name:
CPSF 30 kDa subunit
NS1 effector domain-binding protein 1
Short name:
Neb-1
No arches homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CPSF4
Synonyms:CPSF30, NAR, NEB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160917.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2327, CPSF4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603052, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95639

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10898

Open Targets

More...
OpenTargetsi
ENSG00000160917

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26844

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O95639, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CPSF4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000744021 – 269Cleavage and polyadenylation specificity factor subunit 4Add BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei200PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei212PhosphoserineCombined sources1
Modified residuei267PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95639

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O95639

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O95639

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95639

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95639

PeptideAtlas

More...
PeptideAtlasi
O95639

PRoteomics IDEntifications database

More...
PRIDEi
O95639

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50970 [O95639-1]
50971 [O95639-2]
50972 [O95639-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O95639

MetOSite database of methionine sulfoxide sites

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MetOSitei
O95639

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95639

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O95639

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000160917, Expressed in secondary oocyte and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95639, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95639, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000160917, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1.

Interacts with FIP1L1.

2 Publications

(Microbial infection) Interacts with influenza A virus NS1 blocks processing of pre-mRNAs, thereby preventing nuclear export of host cell mRNAs.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116104, 46 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O95639

Database of interacting proteins

More...
DIPi
DIP-48675N

Protein interaction database and analysis system

More...
IntActi
O95639, 43 interactors

Molecular INTeraction database

More...
MINTi
O95639

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000292476

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O95639, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1269
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95639

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O95639

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CPSF4/YTH1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri35 – 61C3H1-type 1PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri62 – 89C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri90 – 117C3H1-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri118 – 142C3H1-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri143 – 169C3H1-type 5PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri243 – 260CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1040, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155520

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024513_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95639

KEGG Orthology (KO)

More...
KOi
K14404

Identification of Orthologs from Complete Genome Data

More...
OMAi
HKANSCK

Database of Orthologous Groups

More...
OrthoDBi
1472764at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95639

TreeFam database of animal gene trees

More...
TreeFami
TF314871

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041686, Znf-CCCH_3
IPR000571, Znf_CCCH
IPR036855, Znf_CCCH_sf
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00642, zf-CCCH, 1 hit
PF15663, zf-CCCH_3, 1 hit
PF00098, zf-CCHC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00343, ZnF_C2HC, 1 hit
SM00356, ZnF_C3H1, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57756, SSF57756, 1 hit
SSF90229, SSF90229, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50103, ZF_C3H1, 5 hits
PS50158, ZF_CCHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95639-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQEIIASVDH IKFDLEIAVE QQLGAQPLPF PGMDKSGAAV CEFFLKAACG
60 70 80 90 100
KGGMCPFRHI SGEKTVVCKH WLRGLCKKGD QCEFLHEYDM TKMPECYFYS
110 120 130 140 150
KFGECSNKEC PFLHIDPESK IKDCPWYDRG FCKHGPLCRH RHTRRVICVN
160 170 180 190 200
YLVGFCPEGP SCKFMHPRFE LPMGTTEQPP LPQQTQPPAK QSNNPPLQRS
210 220 230 240 250
SSLIQLTSQN SSPNQQRTPQ VIGVMQSQNS SAGNRGPRPL EQVTCYKCGE
260
KGHYANRCTK GHLAFLSGQ
Length:269
Mass (Da):30,255
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49444E3EB840464A
GO
Isoform 2 (identifier: O95639-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     191-215: Missing.

Show »
Length:244
Mass (Da):27,547
Checksum:i0DF72BE36CF97106
GO
Isoform 3 (identifier: O95639-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     191-216: Missing.

Note: May be due to a competing acceptor splice site.Curated
Show »
Length:243
Mass (Da):27,419
Checksum:i3535FE5A0D525C8F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C419H7C419_HUMAN
Cleavage and polyadenylation-specif...
CPSF4
193Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JEV9C9JEV9_HUMAN
Cleavage and polyadenylation specif...
CPSF4
211Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z7B0B7Z7B0_HUMAN
Cleavage and polyadenylation specif...
CPSF4
191Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C016H7C016_HUMAN
Cleavage and polyadenylation-specif...
CPSF4
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0K2C9K0K2_HUMAN
Cleavage and polyadenylation-specif...
CPSF4
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEL7F8WEL7_HUMAN
Cleavage and polyadenylation-specif...
CPSF4
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008602191 – 216Missing in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_008601191 – 215Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U79569 mRNA Translation: AAD00321.1
CR542161 mRNA Translation: CAG46958.1
EF191081 Genomic DNA Translation: ABN05292.1
CH236956 Genomic DNA Translation: EAL23878.1
CH471091 Genomic DNA Translation: EAW76667.1
CH471091 Genomic DNA Translation: EAW76668.1
BC003101 mRNA Translation: AAH03101.1
BC050738 mRNA Translation: AAH50738.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47652.1 [O95639-2]
CCDS5664.1 [O95639-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001075028.1, NM_001081559.2 [O95639-2]
NP_001305089.1, NM_001318160.1 [O95639-3]
NP_001305090.1, NM_001318161.1
NP_001305091.1, NM_001318162.1
NP_006684.1, NM_006693.3 [O95639-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000292476; ENSP00000292476; ENSG00000160917 [O95639-1]
ENST00000436336; ENSP00000395311; ENSG00000160917 [O95639-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10898

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10898

UCSC genome browser

More...
UCSCi
uc003uqi.4, human [O95639-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79569 mRNA Translation: AAD00321.1
CR542161 mRNA Translation: CAG46958.1
EF191081 Genomic DNA Translation: ABN05292.1
CH236956 Genomic DNA Translation: EAL23878.1
CH471091 Genomic DNA Translation: EAW76667.1
CH471091 Genomic DNA Translation: EAW76668.1
BC003101 mRNA Translation: AAH03101.1
BC050738 mRNA Translation: AAH50738.1
CCDSiCCDS47652.1 [O95639-2]
CCDS5664.1 [O95639-1]
RefSeqiNP_001075028.1, NM_001081559.2 [O95639-2]
NP_001305089.1, NM_001318160.1 [O95639-3]
NP_001305090.1, NM_001318161.1
NP_001305091.1, NM_001318162.1
NP_006684.1, NM_006693.3 [O95639-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D9NNMR-A61-126[»]
2RHKX-ray1.95C/D61-121[»]
6DNHelectron microscopy3.40C1-269[»]
6FBSelectron microscopy3.07C1-178[»]
6FUWelectron microscopy3.07C1-178[»]
6URGelectron microscopy3.00C1-269[»]
6UROelectron microscopy3.60C1-269[»]
SMRiO95639
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116104, 46 interactors
CORUMiO95639
DIPiDIP-48675N
IntActiO95639, 43 interactors
MINTiO95639
STRINGi9606.ENSP00000292476

PTM databases

iPTMnetiO95639
MetOSiteiO95639
PhosphoSitePlusiO95639
SwissPalmiO95639

Polymorphism and mutation databases

BioMutaiCPSF4

Proteomic databases

EPDiO95639
jPOSTiO95639
MassIVEiO95639
MaxQBiO95639
PaxDbiO95639
PeptideAtlasiO95639
PRIDEiO95639
ProteomicsDBi50970 [O95639-1]
50971 [O95639-2]
50972 [O95639-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
16165, 207 antibodies

The DNASU plasmid repository

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DNASUi
10898

Genome annotation databases

EnsembliENST00000292476; ENSP00000292476; ENSG00000160917 [O95639-1]
ENST00000436336; ENSP00000395311; ENSG00000160917 [O95639-2]
GeneIDi10898
KEGGihsa:10898
UCSCiuc003uqi.4, human [O95639-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10898
DisGeNETi10898
EuPathDBiHostDB:ENSG00000160917.14

GeneCards: human genes, protein and diseases

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GeneCardsi
CPSF4
HGNCiHGNC:2327, CPSF4
HPAiENSG00000160917, Low tissue specificity
MIMi603052, gene
neXtProtiNX_O95639
OpenTargetsiENSG00000160917
PharmGKBiPA26844

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1040, Eukaryota
GeneTreeiENSGT00940000155520
HOGENOMiCLU_024513_0_1_1
InParanoidiO95639
KOiK14404
OMAiHKANSCK
OrthoDBi1472764at2759
PhylomeDBiO95639
TreeFamiTF314871

Enzyme and pathway databases

PathwayCommonsiO95639
ReactomeiR-HSA-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-168315, Inhibition of Host mRNA Processing and RNA Silencing
R-HSA-6784531, tRNA processing in the nucleus
R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72187, mRNA 3'-end processing
R-HSA-73856, RNA Polymerase II Transcription Termination
R-HSA-77595, Processing of Intronless Pre-mRNAs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
10898, 532 hits in 888 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CPSF4, human
EvolutionaryTraceiO95639

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CPSF4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10898
PharosiO95639, Tbio

Protein Ontology

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PROi
PR:O95639
RNActiO95639, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160917, Expressed in secondary oocyte and 236 other tissues
ExpressionAtlasiO95639, baseline and differential
GenevisibleiO95639, HS

Family and domain databases

InterProiView protein in InterPro
IPR041686, Znf-CCCH_3
IPR000571, Znf_CCCH
IPR036855, Znf_CCCH_sf
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf
PfamiView protein in Pfam
PF00642, zf-CCCH, 1 hit
PF15663, zf-CCCH_3, 1 hit
PF00098, zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343, ZnF_C2HC, 1 hit
SM00356, ZnF_C3H1, 5 hits
SUPFAMiSSF57756, SSF57756, 1 hit
SSF90229, SSF90229, 2 hits
PROSITEiView protein in PROSITE
PS50103, ZF_C3H1, 5 hits
PS50158, ZF_CCHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCPSF4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95639
Secondary accession number(s): D6W5S8
, Q6FGE6, Q86TF8, Q9BTW6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 1, 1999
Last modified: August 12, 2020
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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