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Protein

Follistatin-related protein 3

Gene

FSTL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.6 Publications

GO - Molecular functioni

  • activin binding Source: UniProtKB
  • fibronectin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processOsteogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-2473224 Antagonism of Activin by Follistatin
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiO95633

Protein family/group databases

MEROPSiI01.968

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin-related protein 3
Alternative name(s):
Follistatin-like protein 3
Follistatin-related gene protein
Gene namesi
Name:FSTL3
Synonyms:FLRG
ORF Names:UNQ674/PRO1308
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000070404.9
HGNCiHGNC:3973 FSTL3
MIMi605343 gene
neXtProtiNX_O95633

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Secreted

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi27M → A: Nuclear localization. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi10272
OpenTargetsiENSG00000070404
PharmGKBiPA28390

Polymorphism and mutation databases

BioMutaiFSTL3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000001011527 – 263Follistatin-related protein 3Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 61PROSITE-ProRule annotation
Disulfide bondi48 ↔ 92PROSITE-ProRule annotation
Disulfide bondi62 ↔ 95PROSITE-ProRule annotation
Glycosylationi73N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi99 ↔ 110
Disulfide bondi104 ↔ 119
Disulfide bondi121 ↔ 153
Disulfide bondi125 ↔ 146
Disulfide bondi135 ↔ 167
Disulfide bondi171 ↔ 182
Disulfide bondi176 ↔ 192
Disulfide bondi195 ↔ 229
Disulfide bondi200 ↔ 222
Disulfide bondi211 ↔ 243
Glycosylationi215N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei255Phosphoserine; by FAM20C1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO95633
PaxDbiO95633
PeptideAtlasiO95633
PRIDEiO95633
ProteomicsDBi50968
50969 [O95633-2]
TopDownProteomicsiO95633-1 [O95633-1]

PTM databases

iPTMnetiO95633
PhosphoSitePlusiO95633

Miscellaneous databases

PMAP-CutDBiO95633

Expressioni

Tissue specificityi

Expressed in a wide range of tissues.1 Publication

Gene expression databases

BgeeiENSG00000070404 Expressed in 138 organ(s), highest expression level in left adrenal gland
CleanExiHS_FSTL3
ExpressionAtlasiO95633 baseline and differential
GenevisibleiO95633 HS

Organism-specific databases

HPAiCAB024899
HPA045378

Interactioni

Subunit structurei

Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Isoform 2 interacts with MLLT10; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with MSTN.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAM12O43184-24EBI-2625790,EBI-2625865

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115562, 2 interactors
IntActiO95633, 2 interactors
STRINGi9606.ENSP00000166139

Structurei

Secondary structure

1263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95633
SMRiO95633
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95633

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 107TBPROSITE-ProRule annotationAdd BLAST72
Domaini99 – 119Follistatin-like 1Add BLAST21
Domaini113 – 169Kazal-like 1PROSITE-ProRule annotationAdd BLAST57
Domaini170 – 193Follistatin-like 2Add BLAST24
Domaini189 – 245Kazal-like 2PROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3649 Eukaryota
ENOG410YC3T LUCA
GeneTreeiENSGT00440000033501
HOGENOMiHOG000261649
HOVERGENiHBG051666
InParanoidiO95633
OMAiGAPGPLW
OrthoDBiEOG091G09I0
PhylomeDBiO95633
TreeFamiTF106409

Family and domain databases

Gene3Di3.90.290.10, 1 hit
InterProiView protein in InterPro
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF09289 FOLN, 1 hit
PF07648 Kazal_2, 2 hits
SMARTiView protein in SMART
SM00274 FOLN, 2 hits
SM00280 KAZAL, 2 hits
SUPFAMiSSF100895 SSF100895, 2 hits
SSF57581 SSF57581, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 2 hits
PS51364 TB, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95633-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPGAPGPLW PLPWGALAWA VGFVSSMGSG NPAPGGVCWL QQGQEATCSL
60 70 80 90 100
VLQTDVTRAE CCASGNIDTA WSNLTHPGNK INLLGFLGLV HCLPCKDSCD
110 120 130 140 150
GVECGPGKAC RMLGGRPRCE CAPDCSGLPA RLQVCGSDGA TYRDECELRA
160 170 180 190 200
ARCRGHPDLS VMYRGRCRKS CEHVVCPRPQ SCVVDQTGSA HCVVCRAAPC
210 220 230 240 250
PVPSSPGQEL CGNNNVTYIS SCHMRQATCF LGRSIGVRHA GSCAGTPEEP
260
PGGESAEEEE NFV
Length:263
Mass (Da):27,663
Last modified:May 1, 1999 - v1
Checksum:i6A9AB86ADD4FD09C
GO
Isoform 2 (identifier: O95633-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.

Show »
Length:237
Mass (Da):24,960
Checksum:i499A1E50592DDFE4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1Q2A0A087X1Q2_HUMAN
Follistatin-related protein 3
FSTL3
84Annotation score:
K7EM71K7EM71_HUMAN
Follistatin-related protein 3
FSTL3
40Annotation score:
A0A087WTD3A0A087WTD3_HUMAN
Follistatin-related protein 3
FSTL3
91Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0385531 – 26Missing in isoform 2. CuratedAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76702 mRNA Translation: AAC64321.1
AY358917 mRNA Translation: AAQ89276.1
AK291958 mRNA Translation: BAF84647.1
CH471242 Genomic DNA Translation: EAW61165.1
BC005839 mRNA Translation: AAH05839.1
CCDSiCCDS12040.1 [O95633-1]
RefSeqiNP_005851.1, NM_005860.2 [O95633-1]
UniGeneiHs.529038

Genome annotation databases

EnsembliENST00000166139; ENSP00000166139; ENSG00000070404 [O95633-1]
GeneIDi10272
KEGGihsa:10272
UCSCiuc002lpk.2 human [O95633-1]

Keywords - Coding sequence diversityi

Alternative initiation, Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76702 mRNA Translation: AAC64321.1
AY358917 mRNA Translation: AAQ89276.1
AK291958 mRNA Translation: BAF84647.1
CH471242 Genomic DNA Translation: EAW61165.1
BC005839 mRNA Translation: AAH05839.1
CCDSiCCDS12040.1 [O95633-1]
RefSeqiNP_005851.1, NM_005860.2 [O95633-1]
UniGeneiHs.529038

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KCXNMR-A97-169[»]
3B4VX-ray2.48C/D/G/H27-263[»]
3SEKX-ray2.40C36-244[»]
ProteinModelPortaliO95633
SMRiO95633
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115562, 2 interactors
IntActiO95633, 2 interactors
STRINGi9606.ENSP00000166139

Protein family/group databases

MEROPSiI01.968

PTM databases

iPTMnetiO95633
PhosphoSitePlusiO95633

Polymorphism and mutation databases

BioMutaiFSTL3

Proteomic databases

MaxQBiO95633
PaxDbiO95633
PeptideAtlasiO95633
PRIDEiO95633
ProteomicsDBi50968
50969 [O95633-2]
TopDownProteomicsiO95633-1 [O95633-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000166139; ENSP00000166139; ENSG00000070404 [O95633-1]
GeneIDi10272
KEGGihsa:10272
UCSCiuc002lpk.2 human [O95633-1]

Organism-specific databases

CTDi10272
DisGeNETi10272
EuPathDBiHostDB:ENSG00000070404.9
GeneCardsiFSTL3
HGNCiHGNC:3973 FSTL3
HPAiCAB024899
HPA045378
MIMi605343 gene
neXtProtiNX_O95633
OpenTargetsiENSG00000070404
PharmGKBiPA28390
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3649 Eukaryota
ENOG410YC3T LUCA
GeneTreeiENSGT00440000033501
HOGENOMiHOG000261649
HOVERGENiHBG051666
InParanoidiO95633
OMAiGAPGPLW
OrthoDBiEOG091G09I0
PhylomeDBiO95633
TreeFamiTF106409

Enzyme and pathway databases

ReactomeiR-HSA-2473224 Antagonism of Activin by Follistatin
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiO95633

Miscellaneous databases

ChiTaRSiFSTL3 human
EvolutionaryTraceiO95633
GeneWikiiFSTL3
GenomeRNAii10272
PMAP-CutDBiO95633
PROiPR:O95633
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070404 Expressed in 138 organ(s), highest expression level in left adrenal gland
CleanExiHS_FSTL3
ExpressionAtlasiO95633 baseline and differential
GenevisibleiO95633 HS

Family and domain databases

Gene3Di3.90.290.10, 1 hit
InterProiView protein in InterPro
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF09289 FOLN, 1 hit
PF07648 Kazal_2, 2 hits
SMARTiView protein in SMART
SM00274 FOLN, 2 hits
SM00280 KAZAL, 2 hits
SUPFAMiSSF100895 SSF100895, 2 hits
SSF57581 SSF57581, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 2 hits
PS51364 TB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFSTL3_HUMAN
AccessioniPrimary (citable) accession number: O95633
Secondary accession number(s): A8K7E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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