FSTL3

Functionⁱ

Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.6 Publications

GO - Molecular functionⁱ

activin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12697670
fibronectin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16336961

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adrenal gland development Source: Ensembl
cellular protein metabolic process Source: Reactome
cellular response to metal ion Source: Ensembl
hematopoietic progenitor cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 15451575
kidney development Source: Ensembl
lung development Source: Ensembl
male gonad development Source: Ensembl
negative regulation of activin receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 11948405
- 12697670
negative regulation of BMP signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 17878677
negative regulation of osteoclast differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 15574124
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 17878677
ossification Source: UniProtKB-KW
positive regulation of cell-cell adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 16336961
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 17868029
post-translational protein modification Source: Reactome
regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 11948405
spermatogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Osteogenesis, Transcription, Transcription regulation

Biological process

Osteogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2473224 Antagonism of Activin by Follistatin R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation
SIGNORⁱ	O95633

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I01.968

MEROPSⁱ

I01.968

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Follistatin-related protein 3 Alternative name(s): Follistatin-like protein 3 Follistatin-related gene protein
Gene namesⁱ	Name:FSTL3 Synonyms:FLRG ORF Names:UNQ674/PRO1308
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000070404.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3973 FSTL3
MIMⁱ	605343 gene
neXtProtⁱ	NX_O95633

Keywords - Cellular componentⁱ

Nucleus, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	27	M → A: Nuclear localization. 1 Publication		1

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10272
Open Targets More...OpenTargetsⁱ	ENSG00000070404
PharmGKBⁱ	PA28390

Polymorphism and mutation databases

BioMutaⁱ	FSTL3

BioMutaⁱ

FSTL3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	1 PublicationAdd BLAST		26
ChainⁱPRO_0000010115	27 – 263	Follistatin-related protein 3Add BLAST		237

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	38 ↔ 61	PROSITE-ProRule annotation
Disulfide bondⁱ	48 ↔ 92	PROSITE-ProRule annotation
Disulfide bondⁱ	62 ↔ 95	PROSITE-ProRule annotation
Glycosylationⁱ	73	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	99 ↔ 110
Disulfide bondⁱ	104 ↔ 119
Disulfide bondⁱ	121 ↔ 153
Disulfide bondⁱ	125 ↔ 146
Disulfide bondⁱ	135 ↔ 167
Disulfide bondⁱ	171 ↔ 182
Disulfide bondⁱ	176 ↔ 192
Disulfide bondⁱ	195 ↔ 229
Disulfide bondⁱ	200 ↔ 222
Disulfide bondⁱ	211 ↔ 243
Glycosylationⁱ	215	N-linked (GlcNAc...) asparagine1 Publication	1
Modified residueⁱ	255	Phosphoserine; by FAM20C1 Publication	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95633
PaxDbⁱ	O95633
PeptideAtlas More...PeptideAtlasⁱ	O95633
PRIDEⁱ	O95633
ProteomicsDBⁱ	50968 50969 [O95633-2]
TopDownProteomicsⁱ	O95633-1 [O95633-1]

PTM databases

iPTMnetⁱ	O95633
PhosphoSitePlusⁱ	O95633

Miscellaneous databases

PMAP-CutDBⁱ	O95633

PMAP-CutDBⁱ

O95633

Expressionⁱ

Tissue specificityⁱ

Expressed in a wide range of tissues.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000070404 Expressed in 138 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_FSTL3
ExpressionAtlasⁱ	O95633 baseline and differential
Genevisibleⁱ	O95633 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB024899 HPA045378

HPAⁱ

CAB024899
HPA045378

Interactionⁱ

Subunit structureⁱ

Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Isoform 2 interacts with MLLT10; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with MSTN.7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ADAM12	O43184-2	4	EBI-2625790,EBI-2625865

With

Entry

#Exp.

IntAct

Notes

ADAM12

O43184-2

4

EBI-2625790,EBI-2625865

GO - Molecular functionⁱ

fibronectin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16336961

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115562, 2 interactors
IntActⁱ	O95633, 2 interactors
STRINGⁱ	9606.ENSP00000166139

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	37 – 40	Combined sources	4
Beta strandⁱ	50 – 55	Combined sources	6
Helixⁱ	58 – 62	Combined sources	5
Beta strandⁱ	67 – 72	Combined sources	6
Helixⁱ	81 – 86	Combined sources	6
Beta strandⁱ	93 – 95	Combined sources	3
Beta strandⁱ	97 – 99	Combined sources	3
Beta strandⁱ	108 – 111	Combined sources	4
Beta strandⁱ	113 – 116	Combined sources	4
Beta strandⁱ	118 – 121	Combined sources	4
Beta strandⁱ	126 – 128	Combined sources	3
Beta strandⁱ	134 – 136	Combined sources	3
Beta strandⁱ	141 – 144	Combined sources	4
Helixⁱ	145 – 153	Combined sources	9
Beta strandⁱ	161 – 166	Combined sources	6
Beta strandⁱ	169 – 171	Combined sources	3
Beta strandⁱ	181 – 184	Combined sources	4
Beta strandⁱ	190 – 193	Combined sources	4
Beta strandⁱ	204 – 207	Combined sources	4
Beta strandⁱ	210 – 212	Combined sources	3
Beta strandⁱ	217 – 220	Combined sources	4
Helixⁱ	221 – 231	Combined sources	11
Beta strandⁱ	237 – 241	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	O95633
SMRⁱ	O95633
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O95633

EvolutionaryTraceⁱ

O95633

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	36 – 107	TBPROSITE-ProRule annotationAdd BLAST	72
Domainⁱ	99 – 119	Follistatin-like 1Add BLAST	21
Domainⁱ	113 – 169	Kazal-like 1PROSITE-ProRule annotationAdd BLAST	57
Domainⁱ	170 – 193	Follistatin-like 2Add BLAST	24
Domainⁱ	189 – 245	Kazal-like 2PROSITE-ProRule annotationAdd BLAST	57

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG3649 Eukaryota ENOG410YC3T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000033501
HOGENOMⁱ	HOG000261649
HOVERGENⁱ	HBG051666
InParanoidⁱ	O95633
OMAⁱ	GAPGPLW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09I0
PhylomeDBⁱ	O95633
TreeFamⁱ	TF106409

Family and domain databases

Gene3Dⁱ	3.90.290.10, 1 hit
InterProⁱ	View protein in InterPro IPR003645 Fol_N IPR015369 Follistatin/Osteonectin_EGF IPR002350 Kazal_dom IPR036058 Kazal_dom_sf IPR017878 TB_dom IPR036773 TB_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09289 FOLN, 1 hit PF07648 Kazal_2, 2 hits
SMARTⁱ	View protein in SMART SM00274 FOLN, 2 hits SM00280 KAZAL, 2 hits
SUPFAMⁱ	SSF100895 SSF100895, 2 hits SSF57581 SSF57581, 1 hit
PROSITEⁱ	View protein in PROSITE PS51465 KAZAL_2, 2 hits PS51364 TB, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative initiation. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O95633-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPGAPGPLW PLPWGALAWA VGFVSSMGSG NPAPGGVCWL QQGQEATCSL 
        60         70         80         90        100
VLQTDVTRAE CCASGNIDTA WSNLTHPGNK INLLGFLGLV HCLPCKDSCD 
       110        120        130        140        150
GVECGPGKAC RMLGGRPRCE CAPDCSGLPA RLQVCGSDGA TYRDECELRA 
       160        170        180        190        200
ARCRGHPDLS VMYRGRCRKS CEHVVCPRPQ SCVVDQTGSA HCVVCRAAPC 
       210        220        230        240        250
PVPSSPGQEL CGNNNVTYIS SCHMRQATCF LGRSIGVRHA GSCAGTPEEP 
       260 
PGGESAEEEE NFV

Length:263

Mass (Da):27,663

Last modified:May 1, 1999 - v1

Checksum:ⁱ6A9AB86ADD4FD09C

GO

Isoform 2 (identifier: O95633-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-26: Missing.

« Hide

        10         20         30         40         50
MGSGNPAPGG VCWLQQGQEA TCSLVLQTDV TRAECCASGN IDTAWSNLTH 
        60         70         80         90        100
PGNKINLLGF LGLVHCLPCK DSCDGVECGP GKACRMLGGR PRCECAPDCS 
       110        120        130        140        150
GLPARLQVCG SDGATYRDEC ELRAARCRGH PDLSVMYRGR CRKSCEHVVC 
       160        170        180        190        200
PRPQSCVVDQ TGSAHCVVCR AAPCPVPSSP GQELCGNNNV TYISSCHMRQ 
       210        220        230 
ATCFLGRSIG VRHAGSCAGT PEEPPGGESA EEEENFV

Show »

Length:237

Mass (Da):24,960

Checksum:ⁱ499A1E50592DDFE4

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087X1Q2	A0A087X1Q2_HUMAN	Follistatin-related protein 3 Follistatin-related protein 3	FSTL3	84	Annotation score:
K7EM71	K7EM71_HUMAN	Follistatin-related protein 3 Follistatin-related protein 3	FSTL3	40	Annotation score:
A0A087WTD3	A0A087WTD3_HUMAN	Follistatin-related protein 3 Follistatin-related protein 3	FSTL3	91	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_038553	1 – 26	Missing in isoform 2. CuratedAdd BLAST		26

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U76702 mRNA Translation: AAC64321.1 AY358917 mRNA Translation: AAQ89276.1 AK291958 mRNA Translation: BAF84647.1 CH471242 Genomic DNA Translation: EAW61165.1 BC005839 mRNA Translation: AAH05839.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12040.1 [O95633-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_005851.1, NM_005860.2 [O95633-1]
UniGeneⁱ	Hs.529038

Genome annotation databases

Ensemblⁱ	ENST00000166139; ENSP00000166139; ENSG00000070404 [O95633-1]
GeneIDⁱ	10272
KEGGⁱ	hsa:10272
UCSC genome browser More...UCSCⁱ	uc002lpk.2 human [O95633-1]

Keywords - Coding sequence diversityⁱ

Alternative initiation, Chromosomal rearrangement

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95633	Follistatin-like 3 (Secreted glycoprotein), isoform CRA_a		HUMAN		263	UniRef100_O95633
FSTL3 isoform 3 (Fragment)		PANTR		84
Follistatin-related protein 3 (Fragment)		HUMAN		84
Isoform 2 of Follistatin-related protein 3		HUMAN		237
Follistatin-related protein 3		HUMAN		40
+1

Protein	Similar proteins		Species	Score	Length	Source
O95633	Follistatin-like 3 (Secreted glycoprotein), isoform CRA_a		HUMAN		263	UniRef90_O95633
FSTL3 isoform 3 (Fragment)		PANTR		84
FSTL3 isoform 1		PONAB		267
Uncharacterized protein		PANPA		40
Follistatin like 3		GORGO		263
+12

Protein	Similar proteins		Species	Score	Length	Source
O95633	Follistatin-like 3 (Secreted glycoprotein), isoform CRA_a		HUMAN		263	UniRef50_O95633
FSTL3 isoform 3 (Fragment)		PANTR		84
FSTL3 isoform 1		PONAB		267
Uncharacterized protein		PANPA		40
Follistatin like 3		GORGO		263
+84

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U76702 mRNA Translation: AAC64321.1 AY358917 mRNA Translation: AAQ89276.1 AK291958 mRNA Translation: BAF84647.1 CH471242 Genomic DNA Translation: EAW61165.1 BC005839 mRNA Translation: AAH05839.1
CCDSⁱ	CCDS12040.1 [O95633-1]
RefSeqⁱ	NP_005851.1, NM_005860.2 [O95633-1]
UniGeneⁱ	Hs.529038

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2KCX	NMR	-	A	97-169	[»]
	3B4V	X-ray	2.48	C/D/G/H	27-263	[»]
	3SEK	X-ray	2.40	C	36-244	[»]
ProteinModelPortalⁱ	O95633
SMRⁱ	O95633
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115562, 2 interactors
IntActⁱ	O95633, 2 interactors
STRINGⁱ	9606.ENSP00000166139

Protein family/group databases

MEROPSⁱ	I01.968

MEROPSⁱ

I01.968

PTM databases

iPTMnetⁱ	O95633
PhosphoSitePlusⁱ	O95633

Polymorphism and mutation databases

BioMutaⁱ	FSTL3

BioMutaⁱ

FSTL3

Proteomic databases

MaxQBⁱ	O95633
PaxDbⁱ	O95633
PeptideAtlasⁱ	O95633
PRIDEⁱ	O95633
ProteomicsDBⁱ	50968 50969 [O95633-2]
TopDownProteomicsⁱ	O95633-1 [O95633-1]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000166139; ENSP00000166139; ENSG00000070404 [O95633-1]
GeneIDⁱ	10272
KEGGⁱ	hsa:10272
UCSCⁱ	uc002lpk.2 human [O95633-1]

Organism-specific databases

CTDⁱ	10272
DisGeNETⁱ	10272
EuPathDBⁱ	HostDB:ENSG00000070404.9
GeneCardsⁱ	FSTL3
HGNCⁱ	HGNC:3973 FSTL3
HPAⁱ	CAB024899 HPA045378
MIMⁱ	605343 gene
neXtProtⁱ	NX_O95633
OpenTargetsⁱ	ENSG00000070404
PharmGKBⁱ	PA28390
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3649 Eukaryota ENOG410YC3T LUCA
GeneTreeⁱ	ENSGT00440000033501
HOGENOMⁱ	HOG000261649
HOVERGENⁱ	HBG051666
InParanoidⁱ	O95633
OMAⁱ	GAPGPLW
OrthoDBⁱ	EOG091G09I0
PhylomeDBⁱ	O95633
TreeFamⁱ	TF106409

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2473224 Antagonism of Activin by Follistatin R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation
SIGNORⁱ	O95633

Miscellaneous databases

ChiTaRSⁱ	FSTL3 human
EvolutionaryTraceⁱ	O95633
GeneWikiⁱ	FSTL3
GenomeRNAiⁱ	10272
PMAP-CutDBⁱ	O95633
Protein Ontology More...PROⁱ	PR:O95633
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000070404 Expressed in 138 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_FSTL3
ExpressionAtlasⁱ	O95633 baseline and differential
Genevisibleⁱ	O95633 HS

Family and domain databases

Gene3Dⁱ	3.90.290.10, 1 hit
InterProⁱ	View protein in InterPro IPR003645 Fol_N IPR015369 Follistatin/Osteonectin_EGF IPR002350 Kazal_dom IPR036058 Kazal_dom_sf IPR017878 TB_dom IPR036773 TB_dom_sf
Pfamⁱ	View protein in Pfam PF09289 FOLN, 1 hit PF07648 Kazal_2, 2 hits
SMARTⁱ	View protein in SMART SM00274 FOLN, 2 hits SM00280 KAZAL, 2 hits
SUPFAMⁱ	SSF100895 SSF100895, 2 hits SSF57581 SSF57581, 1 hit
PROSITEⁱ	View protein in PROSITE PS51465 KAZAL_2, 2 hits PS51364 TB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FSTL3_HUMAN
Accessionⁱ	O95633Primary (citable) accession number: O95633 Secondary accession number(s): A8K7E3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O95633 (FSTL3_HUMAN)

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Follistatin-related protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Nucleus

Endoplasmic reticulum

Extracellular region or secreted

Golgi apparatus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ