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Protein

STAM-binding protein

Gene

STAMBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.By similarity5 Publications

Miscellaneous

X-ray crystallography studies of STAMBPL1, another member of the peptidase M67C family, has shown that Glu-280 binds zinc indirectly via a water molecule. Nevertheless, this residue is essential for catalytic activity.

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by N-ethylmaleimide.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei280Indirect zinc-bindingBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi335Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi337Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi348Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi350Zinc 2By similarity1
Metal bindingi390Zinc 2By similarity1
Metal bindingi396Zinc 2By similarity1
Metal bindingi398Zinc 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Lys63-specific deubiquitinase activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • metallopeptidase activity Source: UniProtKB-KW
  • protein domain specific binding Source: UniProtKB
  • thiol-dependent ubiquitin-specific protease activity Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-5689901 Metalloprotease DUBs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O95630

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O95630

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M67.006

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
STAM-binding protein (EC:3.4.19.-)
Alternative name(s):
Associated molecule with the SH3 domain of STAM
Endosome-associated ubiquitin isopeptidase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STAMBP
Synonyms:AMSH
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000124356.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16950 STAMBP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606247 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95630

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microcephaly-capillary malformation syndrome (MICCAP)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital disorder characterized by severe progressive microcephaly, early-onset refractory epilepsy, profound developmental delay, and multiple small capillary malformations spread diffusely on the body. Additional more variable features include dysmorphic facial features, distal limb abnormalities, and mild heart defects.
See also OMIM:614261
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06980614R → P in MICCAP. 1 Publication1
Natural variantiVAR_06980738R → C in MICCAP. 1 PublicationCorresponds to variant dbSNP:rs143739249EnsemblClinVar.1
Natural variantiVAR_06980842E → G in MICCAP. 1 PublicationCorresponds to variant dbSNP:rs397509387EnsemblClinVar.1
Natural variantiVAR_06980963Y → C in MICCAP. 1 PublicationCorresponds to variant dbSNP:rs781694797Ensembl.1
Natural variantiVAR_069810100F → Y in MICCAP. 1 PublicationCorresponds to variant dbSNP:rs397514697EnsemblClinVar.1
Natural variantiVAR_069811313T → I in MICCAP. 1 PublicationCorresponds to variant dbSNP:rs202100019EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi348D → A: Promotes accumulation of ubiquitin on endosomes, ablates enzymatic activity toward polyubiquitin substrate and allows ubiquitinated STAM stabilization. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
10617

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
STAMBP

MalaCards human disease database

More...
MalaCardsi
STAMBP
MIMi614261 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000124356

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
294016 Microcephaly-capillary malformation syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134955569

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STAMBP

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001948691 – 424STAM-binding proteinAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2PhosphoserineCombined sources1 Publication1
Modified residuei48Phosphoserine1 Publication1
Modified residuei243PhosphoserineCombined sources1 Publication1
Modified residuei245Phosphoserine1 Publication1
Modified residuei247PhosphoserineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated after BMP type I receptor activation.1 Publication
Ubiquitinated by SMURF2 in the presence of RNF11.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O95630

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O95630

MaxQB - The MaxQuant DataBase

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MaxQBi
O95630

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O95630

PeptideAtlas

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PeptideAtlasi
O95630

PRoteomics IDEntifications database

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PRIDEi
O95630

ProteomicsDB human proteome resource

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ProteomicsDBi
50966

2D gel databases

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00007943

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O95630

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O95630

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124356 Expressed in 237 organ(s), highest expression level in C1 segment of cervical spinal cord

CleanEx database of gene expression profiles

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CleanExi
HS_STAMBP

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O95630 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O95630 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA035800
HPA035801

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with STAM. Interacts with SMAD6 and SMAD7. Interacts with CHMP3; the interaction appears to relieve the autoinhibition of CHMP3. Interacts with SMURF2 and RNF11; this interaction promotes ubiquitination.6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115863, 69 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O95630

Database of interacting proteins

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DIPi
DIP-33062N

Protein interaction database and analysis system

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IntActi
O95630, 41 interactors

Molecular INTeraction database

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MINTi
O95630

STRING: functional protein association networks

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STRINGi
9606.ENSP00000344742

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
O95630

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1424
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XZEX-ray1.75A/B1-146[»]
3RZUX-ray2.50A/B/C/D/E/F/G243-424[»]
3RZVX-ray1.67A219-424[»]
5IXFNMR-B228-241[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O95630

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95630

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini257 – 388MPNPROSITE-ProRule annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 127Interaction with CHMP3Add BLAST127
Regioni227 – 231Interaction with STAM5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi335 – 348JAMM motifPROSITE-ProRule annotationAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi104 – 177Glu-richAdd BLAST74

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The JAMM motif is essential for the protease activity.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M67C family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2880 Eukaryota
COG1310 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153710

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000195792

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG058519

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O95630

KEGG Orthology (KO)

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KOi
K11866

Identification of Orthologs from Complete Genome Data

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OMAi
CNTMHEE

Database of Orthologous Groups

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OrthoDBi
411229at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O95630

TreeFam database of animal gene trees

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TreeFami
TF323215

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR015063 USP8_dimer

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01398 JAB, 1 hit
PF08969 USP8_dimer, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00232 JAB_MPN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50249 MPN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95630-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDHGDVSLP PEDRVRALSQ LGSAVEVNED IPPRRYFRSG VEIIRMASIY
60 70 80 90 100
SEEGNIEHAF ILYNKYITLF IEKLPKHRDY KSAVIPEKKD TVKKLKEIAF
110 120 130 140 150
PKAEELKAEL LKRYTKEYTE YNEEKKKEAE ELARNMAIQQ ELEKEKQRVA
160 170 180 190 200
QQKQQQLEQE QFHAFEEMIR NQELEKERLK IVQEFGKVDP GLGGPLVPDL
210 220 230 240 250
EKPSLDVFPT LTVSSIQPSD CHTTVRPAKP PVVDRSLKPG ALSNSESIPT
260 270 280 290 300
IDGLRHVVVP GRLCPQFLQL ASANTARGVE TCGILCGKLM RNEFTITHVL
310 320 330 340 350
IPKQSAGSDY CNTENEEELF LIQDQQGLIT LGWIHTHPTQ TAFLSSVDLH
360 370 380 390 400
THCSYQMMLP ESVAIVCSPK FQETGFFKLT DHGLEEISSC RQKGFHPHSK
410 420
DPPLFCSCSH VTVVDRAVTI TDLR
Length:424
Mass (Da):48,077
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B6E08A245BD9D43
GO
Isoform 2 (identifier: O95630-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     336-424: THPTQTAFLS...DRAVTITDLR → VETLWSLKSLHAP

Show »
Length:348
Mass (Da):39,596
Checksum:iEE94242C85A11070
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JK83C9JK83_HUMAN
STAM-binding protein
STAMBP
318Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JEK5C9JEK5_HUMAN
STAM-binding protein
STAMBP
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H5B9F5H5B9_HUMAN
STAM-binding protein
STAMBP
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZ93C9JZ93_HUMAN
STAM-binding protein
STAMBP
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06980614R → P in MICCAP. 1 Publication1
Natural variantiVAR_06980738R → C in MICCAP. 1 PublicationCorresponds to variant dbSNP:rs143739249EnsemblClinVar.1
Natural variantiVAR_06980842E → G in MICCAP. 1 PublicationCorresponds to variant dbSNP:rs397509387EnsemblClinVar.1
Natural variantiVAR_06980963Y → C in MICCAP. 1 PublicationCorresponds to variant dbSNP:rs781694797Ensembl.1
Natural variantiVAR_069810100F → Y in MICCAP. 1 PublicationCorresponds to variant dbSNP:rs397514697EnsemblClinVar.1
Natural variantiVAR_069811313T → I in MICCAP. 1 PublicationCorresponds to variant dbSNP:rs202100019EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_057197336 – 424THPTQ…ITDLR → VETLWSLKSLHAP in isoform 2. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U73522 mRNA Translation: AAD05037.1
AC073046 Genomic DNA Translation: AAX88908.1
CH471053 Genomic DNA Translation: EAW99715.1
CH471053 Genomic DNA Translation: EAW99716.1
BC007682 mRNA Translation: AAH07682.1
BC065574 mRNA Translation: AAH65574.1
BC101467 mRNA Translation: AAI01468.1
BC101469 mRNA Translation: AAI01470.1
EU927390 mRNA Translation: ACH57452.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1929.1 [O95630-1]

NCBI Reference Sequences

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RefSeqi
NP_006454.1, NM_006463.4 [O95630-1]
NP_964010.1, NM_201647.2 [O95630-1]
NP_998787.1, NM_213622.2 [O95630-1]
XP_005264145.1, XM_005264088.3
XP_011530785.1, XM_011532483.2 [O95630-1]
XP_016858664.1, XM_017003175.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.469018

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000339566; ENSP00000344742; ENSG00000124356 [O95630-1]
ENST00000394070; ENSP00000377633; ENSG00000124356 [O95630-1]
ENST00000394073; ENSP00000377636; ENSG00000124356 [O95630-1]
ENST00000409707; ENSP00000386548; ENSG00000124356 [O95630-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10617

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10617

UCSC genome browser

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UCSCi
uc002sjs.3 human [O95630-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73522 mRNA Translation: AAD05037.1
AC073046 Genomic DNA Translation: AAX88908.1
CH471053 Genomic DNA Translation: EAW99715.1
CH471053 Genomic DNA Translation: EAW99716.1
BC007682 mRNA Translation: AAH07682.1
BC065574 mRNA Translation: AAH65574.1
BC101467 mRNA Translation: AAI01468.1
BC101469 mRNA Translation: AAI01470.1
EU927390 mRNA Translation: ACH57452.1
CCDSiCCDS1929.1 [O95630-1]
RefSeqiNP_006454.1, NM_006463.4 [O95630-1]
NP_964010.1, NM_201647.2 [O95630-1]
NP_998787.1, NM_213622.2 [O95630-1]
XP_005264145.1, XM_005264088.3
XP_011530785.1, XM_011532483.2 [O95630-1]
XP_016858664.1, XM_017003175.1
UniGeneiHs.469018

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XZEX-ray1.75A/B1-146[»]
3RZUX-ray2.50A/B/C/D/E/F/G243-424[»]
3RZVX-ray1.67A219-424[»]
5IXFNMR-B228-241[»]
ProteinModelPortaliO95630
SMRiO95630
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115863, 69 interactors
CORUMiO95630
DIPiDIP-33062N
IntActiO95630, 41 interactors
MINTiO95630
STRINGi9606.ENSP00000344742

Chemistry databases

BindingDBiO95630

Protein family/group databases

MEROPSiM67.006

PTM databases

iPTMnetiO95630
PhosphoSitePlusiO95630

Polymorphism and mutation databases

BioMutaiSTAMBP

2D gel databases

REPRODUCTION-2DPAGEiIPI00007943

Proteomic databases

EPDiO95630
jPOSTiO95630
MaxQBiO95630
PaxDbiO95630
PeptideAtlasiO95630
PRIDEiO95630
ProteomicsDBi50966

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10617
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339566; ENSP00000344742; ENSG00000124356 [O95630-1]
ENST00000394070; ENSP00000377633; ENSG00000124356 [O95630-1]
ENST00000394073; ENSP00000377636; ENSG00000124356 [O95630-1]
ENST00000409707; ENSP00000386548; ENSG00000124356 [O95630-1]
GeneIDi10617
KEGGihsa:10617
UCSCiuc002sjs.3 human [O95630-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10617
DisGeNETi10617
EuPathDBiHostDB:ENSG00000124356.15

GeneCards: human genes, protein and diseases

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GeneCardsi
STAMBP
GeneReviewsiSTAMBP
HGNCiHGNC:16950 STAMBP
HPAiHPA035800
HPA035801
MalaCardsiSTAMBP
MIMi606247 gene
614261 phenotype
neXtProtiNX_O95630
OpenTargetsiENSG00000124356
Orphaneti294016 Microcephaly-capillary malformation syndrome
PharmGKBiPA134955569

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2880 Eukaryota
COG1310 LUCA
GeneTreeiENSGT00940000153710
HOGENOMiHOG000195792
HOVERGENiHBG058519
InParanoidiO95630
KOiK11866
OMAiCNTMHEE
OrthoDBi411229at2759
PhylomeDBiO95630
TreeFamiTF323215

Enzyme and pathway databases

ReactomeiR-HSA-5689901 Metalloprotease DUBs
SignaLinkiO95630
SIGNORiO95630

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
STAMBP human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
STAMBP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10617

Protein Ontology

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PROi
PR:O95630

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000124356 Expressed in 237 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_STAMBP
ExpressionAtlasiO95630 baseline and differential
GenevisibleiO95630 HS

Family and domain databases

InterProiView protein in InterPro
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR015063 USP8_dimer
PfamiView protein in Pfam
PF01398 JAB, 1 hit
PF08969 USP8_dimer, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTABP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95630
Secondary accession number(s): B5M0B6, D6W5H7, Q3MJE7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 1, 1999
Last modified: January 16, 2019
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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