UniProtKB - O95628 (CNOT4_HUMAN)
Protein
CCR4-NOT transcription complex subunit 4
Gene
CNOT4
Organism
Homo sapiens (Human)
Status
Functioni
Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038). Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292). Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391).4 Publications
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.3 Publications EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 PublicationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 14 – 57 | RING-type; degeneratePROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 190 – 217 | C3H1-typePROSITE-ProRule annotationAdd BLAST | 28 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
- ubiquitin-protein transferase activity Source: UniProtKB
GO - Biological processi
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
- nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
- protein autoubiquitination Source: UniProtKB
- protein ubiquitination Source: GO_Central
- regulation of megakaryocyte differentiation Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: UniProtKB
Keywordsi
Molecular function | RNA-binding, Transferase |
Biological process | Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O95628 |
Reactomei | R-HSA-429947, Deadenylation of mRNA R-HSA-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: CCR4-NOT transcription complex subunit 4 (EC:2.3.2.273 Publications)Alternative name(s): CCR4-associated factor 4 E3 ubiquitin-protein ligase CNOT4 Potential transcriptional repressor NOT4Hp RING-type E3 ubiquitin transferase CNOT4Curated |
Gene namesi | Name:CNOT4 Synonyms:NOT4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7880, CNOT4 |
MIMi | 604911, gene |
neXtProti | NX_O95628 |
VEuPathDBi | HostDB:ENSG00000080802.18 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- CCR4-NOT complex Source: InterPro
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 16 | L → A or E: Abolishes interaction with E2 ubiquitin ligases. 1 Publication | 1 | |
Mutagenesisi | 17 | C → A: Abolishes interaction with E2 ubiquitin ligases. 1 Publication | 1 | |
Mutagenesisi | 18 | M → A: Strongly reduces interaction with E2 ubiquitin ligases. 1 Publication | 1 | |
Mutagenesisi | 33 | C → R: Abolishes interaction with E2 ubiquitin ligases. 1 Publication | 1 | |
Mutagenesisi | 42 | W → A: Strongly reduces interaction with E2 ubiquitin ligases. 1 Publication | 1 | |
Mutagenesisi | 44 | R → A or E: Strongly reduces interaction with E2 ubiquitin ligases. 1 Publication | 1 | |
Mutagenesisi | 45 | I → A or W: Strongly reduces interaction with E2 ubiquitin ligases. 1 Publication | 1 | |
Mutagenesisi | 49 | E → A: Strongly reduces interaction with E2 ubiquitin ligases. 2 Publications | 1 | |
Mutagenesisi | 49 | E → K: Strongly reduced interaction with UBE2D2. 2 Publications | 1 | |
Mutagenesisi | 54 | P → A: Strongly reduces interaction with E2 ubiquitin ligases. 1 Publication | 1 | |
Mutagenesisi | 57 | R → A or E: Strongly reduces interaction with E2 ubiquitin ligases. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 4850 |
OpenTargetsi | ENSG00000080802 |
PharmGKBi | PA26675 |
Miscellaneous databases
Pharosi | O95628, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4105770 |
Genetic variation databases
BioMutai | CNOT4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081679 | 1 – 575 | CCR4-NOT transcription complex subunit 4Add BLAST | 575 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 71 | PhosphoserineCombined sources | 1 | |
Modified residuei | 301 | PhosphoserineCombined sources | 1 | |
Modified residuei | 324 | PhosphoserineCombined sources | 1 | |
Modified residuei | 432 | PhosphoserineCombined sources | 1 | |
Modified residuei | 475 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 483 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 490 | PhosphoserineCombined sources | 1 | |
Modified residuei | 497 | Asymmetric dimethylarginineCombined sources | 1 |
Post-translational modificationi
Autoubiquitinated.2 Publications
Keywords - PTMi
Methylation, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | O95628 |
MassIVEi | O95628 |
MaxQBi | O95628 |
PaxDbi | O95628 |
PeptideAtlasi | O95628 |
PRIDEi | O95628 |
ProteomicsDBi | 18118 28333 50958 [O95628-1] 50959 [O95628-2] 50960 [O95628-3] 50961 [O95628-4] 50962 [O95628-5] 50963 [O95628-6] 50964 [O95628-7] 50965 [O95628-8] |
PTM databases
GlyGeni | O95628, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O95628 |
PhosphoSitePlusi | O95628 |
Expressioni
Gene expression databases
Bgeei | ENSG00000080802, Expressed in corpus callosum and 241 other tissues |
ExpressionAtlasi | O95628, baseline and differential |
Genevisiblei | O95628, HS |
Organism-specific databases
HPAi | ENSG00000080802, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Isoform 2 [O95628-2]
With | #Exp. | IntAct |
---|---|---|
IL36RN [Q9UBH0] | 5 | EBI-12019444,EBI-465156 |
Protein-protein interaction databases
BioGRIDi | 110912, 44 interactors |
IntActi | O95628, 11 interactors |
STRINGi | 9606.ENSP00000445508 |
Miscellaneous databases
RNActi | O95628, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | O95628 |
SMRi | O95628 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O95628 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 109 – 189 | RRMPROSITE-ProRule annotationAdd BLAST | 81 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 68 – 104 | Sequence analysisAdd BLAST | 37 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 14 – 57 | RING-type; degeneratePROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 190 – 217 | C3H1-typePROSITE-ProRule annotationAdd BLAST | 28 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2068, Eukaryota |
GeneTreei | ENSGT00390000000068 |
HOGENOMi | CLU_011836_0_0_1 |
InParanoidi | O95628 |
OMAi | MSRSPDV |
OrthoDBi | 1200559at2759 |
PhylomeDBi | O95628 |
TreeFami | TF106134 |
Family and domain databases
CDDi | cd16618, mRING-HC-C4C4_CNOT4, 1 hit cd12438, RRM_CNOT4, 1 hit |
Gene3Di | 3.30.40.10, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR034261, CNOT4_RRM IPR039780, Mot2 IPR039515, NOT4_mRING-HC-C4C4 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR003954, RRM_dom_euk IPR000571, Znf_CCCH IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR12603, PTHR12603, 2 hits |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00361, RRM_1, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit PS50103, ZF_C3H1, 1 hit PS50089, ZF_RING_2, 1 hit |
s (10)i Sequence
Sequence statusi: Complete.
This entry describes 10 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: O95628-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRSPDAKED PVECPLCMEP LEIDDINFFP CTCGYQICRF CWHRIRTDEN
60 70 80 90 100
GLCPACRKPY PEDPAVYKPL SQEELQRIKN EKKQKQNERK QKISENRKHL
110 120 130 140 150
ASVRVVQKNL VFVVGLSQRL ADPEVLKRPE YFGKFGKIHK VVINNSTSYA
160 170 180 190 200
GSQGPSASAY VTYIRSEDAL RAIQCVNNVV VDGRTLKASL GTTKYCSYFL
210 220 230 240 250
KNMQCPKPDC MYLHELGDEA ASFTKEEMQA GKHQEYEQKL LQELYKLNPN
260 270 280 290 300
FLQLSTGSVD KNKNKVTPLQ RYDTPIDKPS DSLSIGNGDN SQQISNSDTP
310 320 330 340 350
SPPPGLSKSN PVIPISSSNH SARSPFEGAV TESQSLFSDN FRHPNPIPSG
360 370 380 390 400
LPPFPSSPQT SSDWPTAPEP QSLFTSETIP VSSSTDWQAA FGFGSSKQPE
410 420 430 440 450
DDLGFDPFDV TRKALADLIE KELSVQDQPS LSPTSLQNSS SHTTTAKGPG
460 470 480 490 500
SGFLHPAAAT NANSLNSTFS VLPQRFPQFQ QHRAVYNSFS FPGQAARYPW
510 520 530 540 550
MAFPRNSIMH LNHTANPTSN SNFLDLNLPP QHNTGLGGIP VAGEEEVKVS
560 570
TMPLSTSSHS LQQGQQPTSL HTTVA
Isoform 10 (identifier: O95628-10) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
543-575: GEEEVKVSTMPLSTSSHSLQQGQQPTSLHTTVA → DNSSSVESLN...LLQSSTLDRH
Sequence cautioni
The sequence AAC72963 differs from that shown. Reason: Frameshift.Curated
The sequence AAD00180 differs from that shown. Reason: Frameshift.Curated
The sequence BAC11125 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 178 | N → D in BAH13270 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 201 | K → R in BAH13270 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 340 | N → I in AAH35590 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 570 | L → F in AAD00179 (Ref. 1) Curated | 1 | ||
Sequence conflicti | 570 | L → F in AAD00180 (Ref. 1) Curated | 1 | ||
Isoform 9 (identifier: O95628-9) | |||||
Sequence conflicti | 545 | V → I in BAH13270 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027833 | 7 | A → G1 PublicationCorresponds to variant dbSNP:rs17480616Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009923 | 1 – 17 | Missing in isoform 3. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_009924 | 271 – 274 | RYDT → S in isoform 2, isoform 8 and isoform 9. 3 Publications | 4 | |
Alternative sequenceiVSP_009925 | 419 – 433 | IEKEL…PSLSP → TEPIERKRLAVLKRR in isoform 5. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_009926 | 434 – 575 | Missing in isoform 5. 1 PublicationAdd BLAST | 142 | |
Alternative sequenceiVSP_009927 | 543 – 575 | GEEEV…HTTVA → DNSSSIESLNMKEWQDGLRA LLPNININFGGLPNSSSPSN ANHSAPTSNTATTDSLSWDS PGSWTDPAIITGIPASSGNS LDSLQDDNPPHWLKSLQALT EMDGPSAAPSQTHHSAPFST QIPLHRASWNPYPPPSNPSS FHSPPPQIYYRVQHWTAIRQ RGATIRKCRICPTLFSPSQP TTHSSLLISYVLKNPVPDQF FFSLTPDAMRSQGHYHLFIN CKNFC in isoform 6. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_045469 | 543 – 575 | GEEEV…HTTVA → DNSSSVESLNMKEWQDGLRA LLPNININFGGLPNSSSPSN ANHSAPTSNTATTDSLSWDS PGSWTDPAIITGIPASSGNS LDSLQDDNPPHWLKSLQALT EMDGPSAAPSQTHHSAPFST QIPLHRASWNPYPPPSNPSS FHSPPPGFQTAFRPPSKTPT DLLQSSTLDRH in isoform 9 and isoform 10. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_009928 | 544 – 575 | EEEVK…HTTVA → IPASSGNSLDSLQDDNPPHW LKSLQALTEMDGPSAAPSQT HHSAPFSTQIPLHRASWNPY PPPSNPSSFHSPPPGFQTAF RPPSKTPTDLLQSSTLDRH in isoform 4 and isoform 8. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_009929 | 544 – 575 | EEEVK…HTTVA → IPASSGNSLDSLQDDNPPHW LKSLQALTEMDGQRCSITDP PQRPLQHTDPAAQSQLESLP SSFKPFQLPLPTPRLSDGLQ TPQQNPHRFTTEFNTGPPLG KEEQPLENAGFVPLCFLPLS PPPTAPFSSLMF in isoform 7. 1 PublicationAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U71267 mRNA Translation: AAD00179.1 Frameshift. U71268 mRNA Translation: AAD00180.1 Frameshift. AF180475 mRNA Translation: AAF29829.1 AL389980 mRNA Translation: CAB97536.1 AK074671 mRNA Translation: BAC11125.1 Different initiation. AK300365 mRNA Translation: BAH13270.1 AC083871 Genomic DNA No translation available. AC074002 Genomic DNA No translation available. BC035590 mRNA Translation: AAH35590.1 AF091094 mRNA Translation: AAC72963.1 Sequence problems. |
CCDSi | CCDS43650.1 [O95628-8] CCDS47719.1 [O95628-2] CCDS55164.1 [O95628-4] CCDS55165.1 [O95628-10] CCDS55166.1 [O95628-1] CCDS55167.1 [O95628-9] |
RefSeqi | NP_001008226.1, NM_001008225.2 [O95628-2] NP_001177776.1, NM_001190847.1 [O95628-4] NP_001177777.1, NM_001190848.1 [O95628-1] NP_001177778.1, NM_001190849.1 [O95628-9] NP_001177779.1, NM_001190850.1 [O95628-10] NP_037448.2, NM_013316.3 [O95628-8] XP_016867724.1, XM_017012235.1 [O95628-10] |
Genome annotation databases
Ensembli | ENST00000315544; ENSP00000326731; ENSG00000080802 [O95628-1] ENST00000361528; ENSP00000354673; ENSG00000080802 [O95628-8] ENST00000414802; ENSP00000416532; ENSG00000080802 [O95628-5] ENST00000423368; ENSP00000406777; ENSG00000080802 [O95628-4] ENST00000428680; ENSP00000399108; ENSG00000080802 [O95628-2] ENST00000451834; ENSP00000388491; ENSG00000080802 [O95628-9] ENST00000541284; ENSP00000445508; ENSG00000080802 [O95628-10] |
GeneIDi | 4850 |
KEGGi | hsa:4850 |
UCSCi | uc003vss.4, human [O95628-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U71267 mRNA Translation: AAD00179.1 Frameshift. U71268 mRNA Translation: AAD00180.1 Frameshift. AF180475 mRNA Translation: AAF29829.1 AL389980 mRNA Translation: CAB97536.1 AK074671 mRNA Translation: BAC11125.1 Different initiation. AK300365 mRNA Translation: BAH13270.1 AC083871 Genomic DNA No translation available. AC074002 Genomic DNA No translation available. BC035590 mRNA Translation: AAH35590.1 AF091094 mRNA Translation: AAC72963.1 Sequence problems. |
CCDSi | CCDS43650.1 [O95628-8] CCDS47719.1 [O95628-2] CCDS55164.1 [O95628-4] CCDS55165.1 [O95628-10] CCDS55166.1 [O95628-1] CCDS55167.1 [O95628-9] |
RefSeqi | NP_001008226.1, NM_001008225.2 [O95628-2] NP_001177776.1, NM_001190847.1 [O95628-4] NP_001177777.1, NM_001190848.1 [O95628-1] NP_001177778.1, NM_001190849.1 [O95628-9] NP_001177779.1, NM_001190850.1 [O95628-10] NP_037448.2, NM_013316.3 [O95628-8] XP_016867724.1, XM_017012235.1 [O95628-10] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1E4U | NMR | - | A | 1-78 | [»] | |
1UR6 | NMR | - | B | 12-63 | [»] | |
BMRBi | O95628 | |||||
SMRi | O95628 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110912, 44 interactors |
IntActi | O95628, 11 interactors |
STRINGi | 9606.ENSP00000445508 |
Chemistry databases
ChEMBLi | CHEMBL4105770 |
PTM databases
GlyGeni | O95628, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O95628 |
PhosphoSitePlusi | O95628 |
Genetic variation databases
BioMutai | CNOT4 |
Proteomic databases
jPOSTi | O95628 |
MassIVEi | O95628 |
MaxQBi | O95628 |
PaxDbi | O95628 |
PeptideAtlasi | O95628 |
PRIDEi | O95628 |
ProteomicsDBi | 18118 28333 50958 [O95628-1] 50959 [O95628-2] 50960 [O95628-3] 50961 [O95628-4] 50962 [O95628-5] 50963 [O95628-6] 50964 [O95628-7] 50965 [O95628-8] |
Protocols and materials databases
Antibodypediai | 1419, 597 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 4850 |
DisGeNETi | 4850 |
GeneCardsi | CNOT4 |
HGNCi | HGNC:7880, CNOT4 |
HPAi | ENSG00000080802, Low tissue specificity |
MIMi | 604911, gene |
neXtProti | NX_O95628 |
OpenTargetsi | ENSG00000080802 |
PharmGKBi | PA26675 |
VEuPathDBi | HostDB:ENSG00000080802.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2068, Eukaryota |
GeneTreei | ENSGT00390000000068 |
HOGENOMi | CLU_011836_0_0_1 |
InParanoidi | O95628 |
OMAi | MSRSPDV |
OrthoDBi | 1200559at2759 |
PhylomeDBi | O95628 |
TreeFami | TF106134 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | O95628 |
Reactomei | R-HSA-429947, Deadenylation of mRNA R-HSA-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
Miscellaneous databases
BioGRID-ORCSi | 4850, 46 hits in 1009 CRISPR screens |
ChiTaRSi | CNOT4, human |
EvolutionaryTracei | O95628 |
GenomeRNAii | 4850 |
Pharosi | O95628, Tbio |
PROi | PR:O95628 |
RNActi | O95628, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000080802, Expressed in corpus callosum and 241 other tissues |
ExpressionAtlasi | O95628, baseline and differential |
Genevisiblei | O95628, HS |
Family and domain databases
CDDi | cd16618, mRING-HC-C4C4_CNOT4, 1 hit cd12438, RRM_CNOT4, 1 hit |
Gene3Di | 3.30.40.10, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR034261, CNOT4_RRM IPR039780, Mot2 IPR039515, NOT4_mRING-HC-C4C4 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR003954, RRM_dom_euk IPR000571, Znf_CCCH IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR12603, PTHR12603, 2 hits |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00361, RRM_1, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit PS50103, ZF_C3H1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CNOT4_HUMAN | |
Accessioni | O95628Primary (citable) accession number: O95628 Secondary accession number(s): B7Z6I4 Q9NZN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | October 3, 2006 | |
Last modified: | April 7, 2021 | |
This is version 188 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references