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Protein

Acidic leucine-rich nuclear phosphoprotein 32 family member D

Gene

ANP32D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • histone binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member D
Alternative name(s):
Phosphoprotein 32-related protein 2
Tumorigenic protein pp32r2
Gene namesi
Name:ANP32D
Synonyms:PP32R2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139223.2
HGNCiHGNC:16676 ANP32D
MIMi606878 gene
neXtProtiNX_O95626

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi23519
OpenTargetsiENSG00000139223
PharmGKBiPA24814

Polymorphism and mutation databases

BioMutaiANP32D

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375981 – 131Acidic leucine-rich nuclear phosphoprotein 32 family member DAdd BLAST131

Proteomic databases

EPDiO95626
MaxQBiO95626
PaxDbiO95626
PeptideAtlasiO95626
PRIDEiO95626
ProteomicsDBi50957

PTM databases

iPTMnetiO95626
PhosphoSitePlusiO95626

Expressioni

Gene expression databases

BgeeiENSG00000139223 Expressed in 9 organ(s), highest expression level in left adrenal gland
CleanExiHS_ANP32D
GenevisibleiO95626 HS

Organism-specific databases

HPAiHPA063133
HPA067561

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266594

Structurei

3D structure databases

ProteinModelPortaliO95626
SMRiO95626
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 38LRR 1Add BLAST21
Repeati43 – 64LRR 2Add BLAST22
Repeati65 – 87LRR 3Add BLAST23
Repeati89 – 110LRR 4Add BLAST22
Repeati114 – 131LRR 5Add BLAST18

Sequence similaritiesi

Belongs to the ANP32 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2739 Eukaryota
ENOG4111HZT LUCA
GeneTreeiENSGT00560000077130
HOGENOMiHOG000007361
HOVERGENiHBG053102
InParanoidiO95626
KOiK18646
OMAiKCPNLIH
OrthoDBiEOG091G0R8Z
PhylomeDBiO95626
TreeFamiTF317206

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

Sequencei

Sequence statusi: Complete.

O95626-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEMGKWIHLE LRNRTPSDVK ELFLDNSQSN EGKLEGLTDE FEELELLNTI
60 70 80 90 100
NIGLTSIANL PKLNKLKKLE LSSNRASVGL EVLAEKCPNL IHLNLSGNKI
110 120 130
KDLSTIEPLK KLENLESLDL FTCEVTNLNN Y
Length:131
Mass (Da):14,806
Last modified:October 3, 2006 - v2
Checksum:iC2B2749F83496C53
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38T → A in AAD13667 (PubMed:10086381).Curated1
Sequence conflicti55T → S in AAD13667 (PubMed:10086381).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02783246L → F. Corresponds to variant dbSNP:rs7956679Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71084 Genomic DNA Translation: AAD13667.1
BC069122 mRNA Translation: AAH69122.1
CCDSiCCDS31788.1
RefSeqiNP_036536.2, NM_012404.2
UniGeneiHs.532658

Genome annotation databases

EnsembliENST00000266594; ENSP00000266594; ENSG00000139223
GeneIDi23519
KEGGihsa:23519
UCSCiuc010slt.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71084 Genomic DNA Translation: AAD13667.1
BC069122 mRNA Translation: AAH69122.1
CCDSiCCDS31788.1
RefSeqiNP_036536.2, NM_012404.2
UniGeneiHs.532658

3D structure databases

ProteinModelPortaliO95626
SMRiO95626
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000266594

PTM databases

iPTMnetiO95626
PhosphoSitePlusiO95626

Polymorphism and mutation databases

BioMutaiANP32D

Proteomic databases

EPDiO95626
MaxQBiO95626
PaxDbiO95626
PeptideAtlasiO95626
PRIDEiO95626
ProteomicsDBi50957

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266594; ENSP00000266594; ENSG00000139223
GeneIDi23519
KEGGihsa:23519
UCSCiuc010slt.3 human

Organism-specific databases

CTDi23519
DisGeNETi23519
EuPathDBiHostDB:ENSG00000139223.2
GeneCardsiANP32D
HGNCiHGNC:16676 ANP32D
HPAiHPA063133
HPA067561
MIMi606878 gene
neXtProtiNX_O95626
OpenTargetsiENSG00000139223
PharmGKBiPA24814
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2739 Eukaryota
ENOG4111HZT LUCA
GeneTreeiENSGT00560000077130
HOGENOMiHOG000007361
HOVERGENiHBG053102
InParanoidiO95626
KOiK18646
OMAiKCPNLIH
OrthoDBiEOG091G0R8Z
PhylomeDBiO95626
TreeFamiTF317206

Miscellaneous databases

GeneWikiiANP32D
GenomeRNAii23519
PROiPR:O95626
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139223 Expressed in 9 organ(s), highest expression level in left adrenal gland
CleanExiHS_ANP32D
GenevisibleiO95626 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiAN32D_HUMAN
AccessioniPrimary (citable) accession number: O95626
Secondary accession number(s): Q6NTC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 3, 2006
Last modified: November 7, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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