YEATS4

Functionⁱ

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.1 Publication

GO - Molecular functionⁱ

DNA binding
Source: ProtInc
Traceable author statementⁱ
- 9302258
DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 9302258
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10913114
structural constituent of cytoskeleton
Source: UniProtKB
Non-traceable author statementⁱ
- 10913114

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

histone H2A acetylation
Source: UniProtKB
Inferred from direct assayⁱ
- 14966270
histone H4 acetylation
Source: UniProtKB
Inferred from direct assayⁱ
- 14966270
mitotic cell cycle
Source: UniProtKB
Non-traceable author statementⁱ
- 10913114
positive regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 10913114
positive regulation of transcription by RNA polymerase II Source: Reactome
regulation of growth Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator
Biological process	Growth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214847 HATs acetylate histones R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Reactomeⁱ

R-HSA-3214847 HATs acetylate histones
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: YEATS domain-containing protein 4 Alternative name(s): Glioma-amplified sequence 41 Short name: Gas41 NuMA-binding protein 1 Short name: NuBI-1 Short name: NuBI1
Gene namesⁱ	Name:YEATS4 Synonyms:GAS41
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000127337.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24859 YEATS4
MIMⁱ	602116 gene
neXtProtⁱ	NX_O95619

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8089
Open Targets More...OpenTargetsⁱ	ENSG00000127337
PharmGKBⁱ	PA134992686

Polymorphism and mutation databases

BioMutaⁱ	YEATS4

BioMutaⁱ

YEATS4

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000066204	1 – 227	YEATS domain-containing protein 4Add BLAST		227

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	37	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	O95619
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95619
PaxDbⁱ	O95619
PeptideAtlas More...PeptideAtlasⁱ	O95619
PRIDEⁱ	O95619
ProteomicsDBⁱ	50951

PTM databases

iPTMnetⁱ	O95619
PhosphoSitePlusⁱ	O95619

Expressionⁱ

Tissue specificityⁱ

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000127337 Expressed in 212 organ(s), highest expression level in testis
CleanExⁱ	HS_YEATS4
ExpressionAtlasⁱ	O95619 baseline and differential
Genevisibleⁱ	O95619 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA072532

HPAⁱ

HPA072532

Interactionⁱ

Subunit structureⁱ

Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. YEATS4 interacts with MLLT10/AF10. YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1.6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TACC1	O75410	6	EBI-399269,EBI-624237

With

Entry

#Exp.

IntAct

Notes

TACC1

O75410

6

EBI-399269,EBI-624237

GO - Molecular functionⁱ

protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10913114

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113761, 145 interactors
ComplexPortalⁱ	CPX-974 SRCAP histone exchanging complex CPX-978 NuA4 histone acetyltransferase complex
CORUMⁱ	O95619
IntActⁱ	O95619, 66 interactors
Molecular INTeraction database More...MINTⁱ	O95619
STRINGⁱ	9606.ENSP00000247843

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	20 – 33	Combined sources	14
Turnⁱ	39 – 41	Combined sources	3
Beta strandⁱ	45 – 56	Combined sources	12
Turnⁱ	60 – 62	Combined sources	3
Beta strandⁱ	63 – 69	Combined sources	7
Beta strandⁱ	74 – 76	Combined sources	3
Beta strandⁱ	78 – 81	Combined sources	4
Beta strandⁱ	83 – 93	Combined sources	11
Beta strandⁱ	97 – 106	Combined sources	10
Beta strandⁱ	112 – 117	Combined sources	6
Helixⁱ	124 – 128	Combined sources	5
Beta strandⁱ	134 – 146	Combined sources	13
Helixⁱ	149 – 155	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	O95619
SMRⁱ	O95619
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	22 – 126	YEATSPROSITE-ProRule annotationAdd BLAST		105

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	163 – 227	Interaction with MLLT101 PublicationAdd BLAST		65
Regionⁱ	168 – 227	Interaction with TACC11 PublicationAdd BLAST		60

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	178 – 226	Sequence analysisAdd BLAST		49

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG3149 Eukaryota COG5033 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063543
HOGENOMⁱ	HOG000190181
HOVERGENⁱ	HBG061271
InParanoidⁱ	O95619
KEGG Orthology (KO) More...KOⁱ	K11341
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L66
PhylomeDBⁱ	O95619

Family and domain databases

Gene3Dⁱ	2.60.40.1970, 1 hit
InterProⁱ	View protein in InterPro IPR037989 Yaf9/YEATS4 IPR038704 YEAST_sf IPR005033 YEATS
PANTHERⁱ	PTHR23195 PTHR23195, 1 hit PTHR23195:SF15 PTHR23195:SF15, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03366 YEATS, 1 hit
PROSITEⁱ	View protein in PROSITE PS51037 YEATS, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

O95619-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFKRMAEFGP DSGGRVKGVT IVKPIVYGNV ARYFGKKREE DGHTHQWTVY 
        60         70         80         90        100
VKPYRNEDMS AYVKKIQFKL HESYGNPLRV VTKPPYEITE TGWGEFEIII 
       110        120        130        140        150
KIFFIDPNER PVTLYHLLKL FQSDTNAMLG KKTVVSEFYD EMIFQDPTAM 
       160        170        180        190        200
MQQLLTTSRQ LTLGAYKHET EFAELEVKTR EKLEAAKKKT SFEIAELKER 
       210        220 
LKASRETINC LKNEIRKLEE DDQAKDI

Length:227

Mass (Da):26,499

Last modified:May 1, 1999 - v1

Checksum:ⁱ34C4692B227A7B85

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8W0J4	F8W0J4_HUMAN	YEATS domain-containing protein 4 YEATS domain-containing protein 4	YEATS4	173	Annotation score:
F8VTR4	F8VTR4_HUMAN	YEATS domain-containing protein 4 YEATS domain-containing protein 4	YEATS4	113	Annotation score:
F8W1B9	F8W1B9_HUMAN	YEATS domain-containing protein 4 YEATS domain-containing protein 4	YEATS4	211	Annotation score:

Sequence cautionⁱ

The sequence CAC01935 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	159	R → C in CAC01935 (PubMed:10913114).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U61384 mRNA Translation: AAD12188.1 AJ245746 mRNA Translation: CAC01935.1 Different initiation. AK001413 mRNA Translation: BAA91678.1 BC000994 mRNA Translation: AAH00994.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8990.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001287879.1, NM_001300950.1 NP_006521.1, NM_006530.3
UniGeneⁱ	Hs.4029

Genome annotation databases

Ensemblⁱ	ENST00000247843; ENSP00000247843; ENSG00000127337
GeneIDⁱ	8089
KEGGⁱ	hsa:8089
UCSC genome browser More...UCSCⁱ	uc001sux.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95619	YEATS domain containing 4		CALJA		227	UniRef100_O95619
YEATS domain containing 4		PANTR		227
Glioma-amplified sequence 41		MACMU		227
Glioma-amplified sequence 41		MACFA		227
YEATS domain containing 4		PONAB		227
+13

Protein	Similar proteins		Species	Score	Length	Source
O95619	YEATS domain-containing protein 4		MOUSE		227	UniRef90_O95619
YEATS domain containing 4		CALJA		227
YEATS domain containing 4		PANTR		227
Glioma-amplified sequence 41		MACMU		227
Glioma-amplified sequence 41		MACFA		227
+95

Protein	Similar proteins		Species	Score	Length	Source
O95619	YEATS domain-containing protein 4		MOUSE		227	UniRef50_O95619
YEATS domain containing 4		CALJA		227
YEATS domain containing 4		PANTR		227
Glioma-amplified sequence 41		MACMU		227
Glioma-amplified sequence 41		MACFA		227
+252

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U61384 mRNA Translation: AAD12188.1 AJ245746 mRNA Translation: CAC01935.1 Different initiation. AK001413 mRNA Translation: BAA91678.1 BC000994 mRNA Translation: AAH00994.1
CCDSⁱ	CCDS8990.1
RefSeqⁱ	NP_001287879.1, NM_001300950.1 NP_006521.1, NM_006530.3
UniGeneⁱ	Hs.4029

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5VNA	X-ray	2.10	A/B/C/D	1-148	[»]
	5VNB	X-ray	2.40	A/B/C/D	1-148	[»]
	5XTZ	X-ray	2.10	A/B/C/D	15-159	[»]
	5Y8V	X-ray	2.61	A/B/C/D	21-160	[»]
ProteinModelPortalⁱ	O95619
SMRⁱ	O95619
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113761, 145 interactors
ComplexPortalⁱ	CPX-974 SRCAP histone exchanging complex CPX-978 NuA4 histone acetyltransferase complex
CORUMⁱ	O95619
IntActⁱ	O95619, 66 interactors
MINTⁱ	O95619
STRINGⁱ	9606.ENSP00000247843

PTM databases

iPTMnetⁱ	O95619
PhosphoSitePlusⁱ	O95619

Polymorphism and mutation databases

BioMutaⁱ	YEATS4

BioMutaⁱ

YEATS4

Proteomic databases

EPDⁱ	O95619
MaxQBⁱ	O95619
PaxDbⁱ	O95619
PeptideAtlasⁱ	O95619
PRIDEⁱ	O95619
ProteomicsDBⁱ	50951

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8089
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000247843; ENSP00000247843; ENSG00000127337
GeneIDⁱ	8089
KEGGⁱ	hsa:8089
UCSCⁱ	uc001sux.4 human

Organism-specific databases

CTDⁱ	8089
DisGeNETⁱ	8089
EuPathDBⁱ	HostDB:ENSG00000127337.6
GeneCardsⁱ	YEATS4
HGNCⁱ	HGNC:24859 YEATS4
HPAⁱ	HPA072532
MIMⁱ	602116 gene
neXtProtⁱ	NX_O95619
OpenTargetsⁱ	ENSG00000127337
PharmGKBⁱ	PA134992686
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3149 Eukaryota COG5033 LUCA
GeneTreeⁱ	ENSGT00530000063543
HOGENOMⁱ	HOG000190181
HOVERGENⁱ	HBG061271
InParanoidⁱ	O95619
KOⁱ	K11341
OrthoDBⁱ	EOG091G0L66
PhylomeDBⁱ	O95619

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214847 HATs acetylate histones R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Reactomeⁱ

R-HSA-3214847 HATs acetylate histones
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Miscellaneous databases

ChiTaRSⁱ	YEATS4 human
GenomeRNAiⁱ	8089
Protein Ontology More...PROⁱ	PR:O95619
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000127337 Expressed in 212 organ(s), highest expression level in testis
CleanExⁱ	HS_YEATS4
ExpressionAtlasⁱ	O95619 baseline and differential
Genevisibleⁱ	O95619 HS

Family and domain databases

Gene3Dⁱ	2.60.40.1970, 1 hit
InterProⁱ	View protein in InterPro IPR037989 Yaf9/YEATS4 IPR038704 YEAST_sf IPR005033 YEATS
PANTHERⁱ	PTHR23195 PTHR23195, 1 hit PTHR23195:SF15 PTHR23195:SF15, 1 hit
Pfamⁱ	View protein in Pfam PF03366 YEATS, 1 hit
PROSITEⁱ	View protein in PROSITE PS51037 YEATS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	YETS4_HUMAN
Accessionⁱ	O95619Primary (citable) accession number: O95619 Secondary accession number(s): Q9NQD0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - O95619 (YETS4_HUMAN)

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YEATS domain-containing protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ