UniProtKB - O95619 (YETS4_HUMAN)
YEATS domain-containing protein 4
YEATS4
Functioni
Caution
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 73 | Diacetylated histoneCombined sources2 Publications | 1 |
GO - Molecular functioni
- lysine-acetylated histone binding Source: UniProtKB
- modification-dependent protein binding Source: UniProtKB
- protein C-terminus binding Source: UniProtKB
- structural constituent of cytoskeleton Source: UniProtKB
GO - Biological processi
- histone H2A acetylation Source: UniProtKB
- histone H4 acetylation Source: UniProtKB
- mitotic cell cycle Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: Reactome
- regulation of growth Source: UniProtKB-KW
Keywordsi
Molecular function | Chromatin regulator |
Biological process | Growth regulation, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | O95619 |
Reactomei | R-HSA-3214847, HATs acetylate histones R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
Names & Taxonomyi
Protein namesi | Recommended name: YEATS domain-containing protein 4CuratedAlternative name(s): Glioma-amplified sequence 411 Publication Short name: Gas411 Publication NuMA-binding protein 1 Short name: NuBI-1 Short name: NuBI1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24859, YEATS4 |
MIMi | 602116, gene |
neXtProti | NX_O95619 |
VEuPathDBi | HostDB:ENSG00000127337.6 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation2 Publications
Nucleus
- NuA4 histone acetyltransferase complex Source: UniProtKB
- nuclear matrix Source: UniProtKB
- nuclear membrane Source: HPA
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 43 | H → A: Impaired binding to histone H3 succinylated at 'Lys-122' (H3K122succ). 1 Publication | 1 | |
Mutagenesisi | 74 | Y → A: Impaired binding to histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac), and subsequent deposition of histone H2AZ1/H2A.Z into specific chromatin regions; when associated with A-93. 1 Publication | 1 | |
Mutagenesisi | 93 | W → A: Impaired binding to histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac), and subsequent deposition of histone H2AZ1/H2A.Z into specific chromatin regions; when associated with A-74. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8089 |
OpenTargetsi | ENSG00000127337 |
PharmGKBi | PA134992686 |
Miscellaneous databases
Pharosi | O95619, Tbio |
Genetic variation databases
BioMutai | YEATS4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066204 | 1 – 227 | YEATS domain-containing protein 4Add BLAST | 227 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 37 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | O95619 |
jPOSTi | O95619 |
MassIVEi | O95619 |
MaxQBi | O95619 |
PaxDbi | O95619 |
PeptideAtlasi | O95619 |
PRIDEi | O95619 |
ProteomicsDBi | 50951 |
PTM databases
iPTMneti | O95619 |
MetOSitei | O95619 |
PhosphoSitePlusi | O95619 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000127337, Expressed in testis and 226 other tissues |
ExpressionAtlasi | O95619, baseline and differential |
Genevisiblei | O95619, HS |
Organism-specific databases
HPAi | ENSG00000127337, Low tissue specificity |
Interactioni
Subunit structurei
Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity (PubMed:12963728, PubMed:14966270).
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 (PubMed:12963728, PubMed:14966270). The NuA4 complex interacts with MYC and the adenovirus E1A protein (PubMed:12963728, PubMed:14966270).
Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41 (PubMed:14966270, PubMed:29437725).
Interacts with MLLT10/AF10 (PubMed:11756182).
Also interacts with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1 (PubMed:10913114, PubMed:11903063, PubMed:12620397, PubMed:11756182).
7 PublicationsBinary interactionsi
Hide detailsO95619
With | #Exp. | IntAct |
---|---|---|
ANKK1 [Q8NFD2] | 3 | EBI-399269,EBI-13280688 |
TACC1 [O75410] | 6 | EBI-399269,EBI-624237 |
TPM1 - isoform 10 [P09493-10] | 3 | EBI-399269,EBI-12123928 |
GO - Molecular functioni
- lysine-acetylated histone binding Source: UniProtKB
- modification-dependent protein binding Source: UniProtKB
- protein C-terminus binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113761, 155 interactors |
ComplexPortali | CPX-974, SRCAP histone exchanging complex CPX-978, NuA4 histone acetyltransferase complex |
CORUMi | O95619 |
IntActi | O95619, 94 interactors |
MINTi | O95619 |
STRINGi | 9606.ENSP00000247843 |
Miscellaneous databases
RNActi | O95619, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O95619 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 158 | YEATSPROSITE-ProRule annotationAdd BLAST | 144 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 93 – 97 | Diacetylated histone bindingCombined sources2 Publications | 5 | |
Regioni | 163 – 227 | Interaction with MLLT101 PublicationAdd BLAST | 65 | |
Regioni | 168 – 227 | Interaction with TACC11 PublicationAdd BLAST | 60 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 178 – 226 | Sequence analysisAdd BLAST | 49 |
Domaini
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3149, Eukaryota |
GeneTreei | ENSGT00940000155811 |
HOGENOMi | CLU_051385_3_0_1 |
InParanoidi | O95619 |
OrthoDBi | 1482359at2759 |
PhylomeDBi | O95619 |
Family and domain databases
Gene3Di | 2.60.40.1970, 1 hit |
InterProi | View protein in InterPro IPR038704, YEAST_sf IPR005033, YEATS |
Pfami | View protein in Pfam PF03366, YEATS, 1 hit |
PROSITEi | View protein in PROSITE PS51037, YEATS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MFKRMAEFGP DSGGRVKGVT IVKPIVYGNV ARYFGKKREE DGHTHQWTVY
60 70 80 90 100
VKPYRNEDMS AYVKKIQFKL HESYGNPLRV VTKPPYEITE TGWGEFEIII
110 120 130 140 150
KIFFIDPNER PVTLYHLLKL FQSDTNAMLG KKTVVSEFYD EMIFQDPTAM
160 170 180 190 200
MQQLLTTSRQ LTLGAYKHET EFAELEVKTR EKLEAAKKKT SFEIAELKER
210 220
LKASRETINC LKNEIRKLEE DDQAKDI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W0J4 | F8W0J4_HUMAN | YEATS domain-containing protein 4 | YEATS4 | 173 | Annotation score: | ||
F8W1B9 | F8W1B9_HUMAN | YEATS domain-containing protein 4 | YEATS4 | 211 | Annotation score: | ||
F8VTR4 | F8VTR4_HUMAN | YEATS domain-containing protein 4 | YEATS4 | 113 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 159 | R → C in CAC01935 (PubMed:10913114).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U61384 mRNA Translation: AAD12188.1 AJ245746 mRNA Translation: CAC01935.1 Different initiation. AK001413 mRNA Translation: BAA91678.1 BC000994 mRNA Translation: AAH00994.1 |
CCDSi | CCDS8990.1 |
RefSeqi | NP_001287879.1, NM_001300950.1 NP_006521.1, NM_006530.3 |
Genome annotation databases
Ensembli | ENST00000247843; ENSP00000247843; ENSG00000127337 |
GeneIDi | 8089 |
KEGGi | hsa:8089 |
UCSCi | uc001sux.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U61384 mRNA Translation: AAD12188.1 AJ245746 mRNA Translation: CAC01935.1 Different initiation. AK001413 mRNA Translation: BAA91678.1 BC000994 mRNA Translation: AAH00994.1 |
CCDSi | CCDS8990.1 |
RefSeqi | NP_001287879.1, NM_001300950.1 NP_006521.1, NM_006530.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5VNA | X-ray | 2.10 | A/B/C/D | 1-148 | [»] | |
5VNB | X-ray | 2.40 | A/B/C/D | 1-148 | [»] | |
5XTZ | X-ray | 2.10 | A/B/C/D | 15-159 | [»] | |
5Y8V | X-ray | 2.61 | A/B/C/D | 21-160 | [»] | |
SMRi | O95619 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113761, 155 interactors |
ComplexPortali | CPX-974, SRCAP histone exchanging complex CPX-978, NuA4 histone acetyltransferase complex |
CORUMi | O95619 |
IntActi | O95619, 94 interactors |
MINTi | O95619 |
STRINGi | 9606.ENSP00000247843 |
PTM databases
iPTMneti | O95619 |
MetOSitei | O95619 |
PhosphoSitePlusi | O95619 |
Genetic variation databases
BioMutai | YEATS4 |
Proteomic databases
EPDi | O95619 |
jPOSTi | O95619 |
MassIVEi | O95619 |
MaxQBi | O95619 |
PaxDbi | O95619 |
PeptideAtlasi | O95619 |
PRIDEi | O95619 |
ProteomicsDBi | 50951 |
Protocols and materials databases
Antibodypediai | 16961, 380 antibodies |
DNASUi | 8089 |
Genome annotation databases
Ensembli | ENST00000247843; ENSP00000247843; ENSG00000127337 |
GeneIDi | 8089 |
KEGGi | hsa:8089 |
UCSCi | uc001sux.4, human |
Organism-specific databases
CTDi | 8089 |
DisGeNETi | 8089 |
GeneCardsi | YEATS4 |
HGNCi | HGNC:24859, YEATS4 |
HPAi | ENSG00000127337, Low tissue specificity |
MIMi | 602116, gene |
neXtProti | NX_O95619 |
OpenTargetsi | ENSG00000127337 |
PharmGKBi | PA134992686 |
VEuPathDBi | HostDB:ENSG00000127337.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3149, Eukaryota |
GeneTreei | ENSGT00940000155811 |
HOGENOMi | CLU_051385_3_0_1 |
InParanoidi | O95619 |
OrthoDBi | 1482359at2759 |
PhylomeDBi | O95619 |
Enzyme and pathway databases
PathwayCommonsi | O95619 |
Reactomei | R-HSA-3214847, HATs acetylate histones R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
Miscellaneous databases
BioGRID-ORCSi | 8089, 530 hits in 890 CRISPR screens |
ChiTaRSi | YEATS4, human |
GenomeRNAii | 8089 |
Pharosi | O95619, Tbio |
PROi | PR:O95619 |
RNActi | O95619, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000127337, Expressed in testis and 226 other tissues |
ExpressionAtlasi | O95619, baseline and differential |
Genevisiblei | O95619, HS |
Family and domain databases
Gene3Di | 2.60.40.1970, 1 hit |
InterProi | View protein in InterPro IPR038704, YEAST_sf IPR005033, YEATS |
Pfami | View protein in Pfam PF03366, YEATS, 1 hit |
PROSITEi | View protein in PROSITE PS51037, YEATS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YETS4_HUMAN | |
Accessioni | O95619Primary (citable) accession number: O95619 Secondary accession number(s): Q9NQD0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references