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Protein

Pericentrin

Gene

PCNT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

SIGNOR Signaling Network Open Resource

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SIGNORi
O95613

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pericentrin
Alternative name(s):
Kendrin
Pericentrin-B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCNT
Synonyms:KIAA0402, PCNT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000160299.16

Human Gene Nomenclature Database

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HGNCi
HGNC:16068 PCNT

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605925 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O95613

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microcephalic osteodysplastic primordial dwarfism 2 (MOPD2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAdults with this rare inherited condition have an average height of 100 centimeters and a brain size comparable to that of a 3-month-old baby, but are of near-normal intelligence.
See also OMIM:210720

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2231R → A: Produces non-cleavable protein which remains on centrosomes in late mitosis until its levels eventually drop in cells undergoing cytokinesis. 2 Publications1
Mutagenesisi2232K → M: Stabilizes the C-terminal fragment produced by cleavage. 1 Publication1
Mutagenesisi3196 – 3197FR → AA: Decrease in calmodulin binding. 1 Publication2
Mutagenesisi3203V → A: Decrease in calmodulin binding. 1 Publication1
Mutagenesisi3208 – 3209RL → AA: Decrease in calmodulin binding. 1 Publication2

Keywords - Diseasei

Dwarfism

Organism-specific databases

DisGeNET

More...
DisGeNETi
5116

MalaCards human disease database

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MalaCardsi
PCNT
MIMi210720 phenotype

Open Targets

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OpenTargetsi
ENSG00000160299

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
2637 Microcephalic osteodysplastic primordial dwarfism type II
808 Seckel syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33079

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PCNT

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000582571 – 3336PericentrinAdd BLAST3336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei44PhosphoserineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei191PhosphothreonineCombined sources1
Modified residuei610PhosphoserineCombined sources1
Modified residuei682PhosphoserineCombined sources1
Modified residuei1245PhosphoserineCombined sources1
Modified residuei1653PhosphoserineCombined sources1
Modified residuei1712PhosphoserineBy similarity1
Modified residuei2044PhosphoserineCombined sources1
Modified residuei2177PhosphoserineCombined sources1
Modified residuei2192PhosphoserineCombined sources1
Modified residuei2225PhosphoserineBy similarity1
Modified residuei2226PhosphoserineBy similarity1
Modified residuei2327PhosphoserineCombined sources1
Modified residuei2352PhosphoserineCombined sources1
Modified residuei2355PhosphoserineCombined sources1
Modified residuei2477PhosphoserineCombined sources1
Modified residuei2486PhosphoserineCombined sources1
Modified residuei3302PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved during mitotis which leads to removal of CDK5RAP2 from the centrosome and promotes centriole disengagement and subsequent centriole separation (PubMed:22722493, PubMed:25503564). The C-terminal fragment is rapidly degraded following cleavage (PubMed:22722493).2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O95613

MaxQB - The MaxQuant DataBase

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MaxQBi
O95613

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O95613

PeptideAtlas

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PeptideAtlasi
O95613

PRoteomics IDEntifications database

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PRIDEi
O95613

ProteomicsDB human proteome resource

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ProteomicsDBi
50949
50950 [O95613-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O95613

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O95613

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested, including placenta, liver, kidney and thymus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000160299 Expressed in 224 organ(s), highest expression level in gastrocnemius

CleanEx database of gene expression profiles

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CleanExi
HS_PCNT

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O95613 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O95613 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA016820
HPA019887
HPA032101

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CHD3. Interacts with CHD4; the interaction regulates centrosome integrity (By similarity). Interacts with DISC1 and PCM1. Binds calmodulin. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of PCNT and CDK5RAP2. Interacts with isoform 1 of NEK2. Interacts with CEP131. Interacts with CCDC13 (PubMed:24816561). Interacts with CEP68 (PubMed:25503564). Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome (PubMed:26213385).By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111146, 75 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O95613

Database of interacting proteins

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DIPi
DIP-33829N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
O95613

Protein interaction database and analysis system

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IntActi
O95613, 42 interactors

Molecular INTeraction database

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MINTi
O95613

STRING: functional protein association networks

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STRINGi
9606.ENSP00000352572

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O95613

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2983 – 3246Interaction with NEK21 PublicationAdd BLAST264
Regioni3195 – 3208Calmodulin-bindingAdd BLAST14

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili258 – 553Sequence analysisAdd BLAST296
Coiled coili675 – 835Sequence analysisAdd BLAST161
Coiled coili1010 – 1146Sequence analysisAdd BLAST137
Coiled coili1299 – 1949Sequence analysisAdd BLAST651
Coiled coili2064 – 2082Sequence analysisAdd BLAST19
Coiled coili2536 – 3086Sequence analysisAdd BLAST551

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi214 – 795Glu-richAdd BLAST582

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Composed of a coiled-coil central region flanked by non-helical N- and C-terminals.

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IJHT Eukaryota
ENOG4110FJZ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00730000110871

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000168229

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG079443

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O95613

KEGG Orthology (KO)

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KOi
K16481

Identification of Orthologs from Complete Genome Data

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OMAi
ALKHEQT

Database of Orthologous Groups

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OrthoDBi
EOG091G001R

Database for complete collections of gene phylogenies

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PhylomeDBi
O95613

TreeFam database of animal gene trees

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TreeFami
TF336114

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028745 AKAP9/Pericentrin
IPR019528 PACT_domain

The PANTHER Classification System

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PANTHERi
PTHR44981 PTHR44981, 7 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF10495 PACT_coil_coil, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O95613-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVEQEQRRR KVEAGRTKLA HFRQRKTKGD SSHSEKKTAK RKGSAVDASV
60 70 80 90 100
QEESPVTKED SALCGGGDIC KSTSCDDTPD GAGGAFAAQP EDCDGEKRED
110 120 130 140 150
LEQLQQKQVN DHPPEQCGMF TVSDHPPEQH GMFTVGDHPP EQRGMFTVSD
160 170 180 190 200
HPPEQHGMFT VSDHPPEQRG MFTISDHQPE QRGMFTVSDH TPEQRGIFTI
210 220 230 240 250
SDHPAEQRGM FTKECEQECE LAITDLESGR EDEAGLHQSQ AVHGLELEAL
260 270 280 290 300
RLSLSNMHTA QLELTQANLQ KEKETALTEL REMLNSRRAQ ELALLQSRQQ
310 320 330 340 350
HELELLREQH AREKEEVVLR CGQEAAELKE KLQSEMEKNA QIVKTLKEDW
360 370 380 390 400
ESEKDLCLEN LRKELSAKHQ SEMEDLQNQF QKELAEQRAE LEKIFQDKNQ
410 420 430 440 450
AERALRNLES HHQAAIEKLR EDLQSEHGRC LEDLEFKFKE SEKEKQLELE
460 470 480 490 500
NLQASYEDLK AQSQEEIRRL WSQLDSARTS RQELSELHEQ LLARTSRVED
510 520 530 540 550
LEQLKQREKT QHESELEQLR IYFEKKLRDA EKTYQEDLTL LQQRLQGARE
560 570 580 590 600
DALLDSVEVG LSCVGLEEKP EKGRKDHVDE LEPERHKESL PRFQAELEES
610 620 630 640 650
HRHQLEALES PLCIQHEGHV SDRCCVETSA LGHEWRLEPS EGHSQELPWV
660 670 680 690 700
HLQGVQDGDL EADTERAARV LGLETEHKVQ LSLLQTELKE EIELLKIENR
710 720 730 740 750
NLYGKLQHET RLKDDLEKVK HNLIEDHQKE LNNAKQKTEL MKQEFQRKET
760 770 780 790 800
DWKVMKEELQ REAEEKLTLM LLELREKAES EKQTIINKFE LREAEMRQLQ
810 820 830 840 850
DQQAAQILDL ERSLTEQQGR LQQLEQDLTS DDALHCSQCG REPPTAQDGE
860 870 880 890 900
LAALHVKEDC ALQLMLARSR FLEERKEITE KFSAEQDAFL QEAQEQHARE
910 920 930 940 950
LQLLQERHQQ QLLSVTAELE ARHQAALGEL TASLESKQGA LLAARVAELQ
960 970 980 990 1000
TKHAADLGAL ETRHLSSLDS LESCYLSEFQ TIREEHRQAL ELLRADFEEQ
1010 1020 1030 1040 1050
LWKKDSLHQT ILTQELEKLK RKHEGELQSV RDHLRTEVST ELAGTVAHEL
1060 1070 1080 1090 1100
QGVHQGEFGS EKKTALHEKE ETLRLQSAQA QPFHQEEKES LSLQLQKKNH
1110 1120 1130 1140 1150
QVQQLKDQVL SLSHEIEECR SELEVLQQRR ERENREGANL LSMLKADVNL
1160 1170 1180 1190 1200
SHSERGALQD ALRRLLGLFG ETLRAAVTLR SRIGERVGLC LDDAGAGLAL
1210 1220 1230 1240 1250
STAPALEETW SDVALPELDR TLSECAEMSS VAEISSHMRE SFLMSPESVR
1260 1270 1280 1290 1300
ECEQPIRRVF QSLSLAVDGL MEMALDSSRQ LEEARQIHSR FEKEFSFKNE
1310 1320 1330 1340 1350
ETAQVVRKHQ ELLECLKEES AAKAELALEL HKTQGTLEGF KVETADLKEV
1360 1370 1380 1390 1400
LAGKEDSEHR LVLELESLRR QLQQAAQEQA ALREECTRLW SRGEATATDA
1410 1420 1430 1440 1450
EAREAALRKE VEDLTKEQSE TRKQAEKDRS ALLSQMKILE SELEEQLSQH
1460 1470 1480 1490 1500
RGCAKQAEAV TALEQQVASL DKHLRNQRQF MDEQAAEREH EREEFQQEIQ
1510 1520 1530 1540 1550
RLEGQLRQAA KPQPWGPRDS QQAPLDGEVE LLQQKLREKL DEFNELAIQK
1560 1570 1580 1590 1600
ESADRQVLMQ EEEIKRLEEM NINIRKKVAQ LQEEVEKQKN IVKGLEQDKE
1610 1620 1630 1640 1650
VLKKQQMSSL LLASTLQSTL DAGRCPEPPS GSPPEGPEIQ LEVTQRALLR
1660 1670 1680 1690 1700
RESEVLDLKE QLEKMKGDLE SKNEEILHLN LKLDMQNSQT AVSLRELEEE
1710 1720 1730 1740 1750
NTSLKVIYTR SSEIEELKAT IENLQENQKR LQKEKAEEIE QLHEVIEKLQ
1760 1770 1780 1790 1800
HELSLMGPVV HEVSDSQAGS LQSELLCSQA GGPRGQALQG ELEAALEAKE
1810 1820 1830 1840 1850
ALSRLLADQE RRHSQALEAL QQRLQGAEEA AELQLAELER NVALREAEVE
1860 1870 1880 1890 1900
DMASRIQEFE AALKAKEATI AERNLEIDAL NQRKAAHSAE LEAVLLALAR
1910 1920 1930 1940 1950
IRRALEQQPL AAGAAPPELQ WLRAQCARLS RQLQVLHQRF LRCQVELDRR
1960 1970 1980 1990 2000
QARRATAHTR VPGAHPQPRM DGGAKAQVTG DVEASHDAAL EPVVPDPQGD
2010 2020 2030 2040 2050
LQPVLVTLKD APLCKQEGVM SVLTVCQRQL QSELLLVKNE MRLSLEDGGK
2060 2070 2080 2090 2100
GKEKVLEDCQ LPKVDLVAQV KQLQEKLNRL LYSMTFQNVD AADTKSLWPM
2110 2120 2130 2140 2150
ASAHLLESSW SDDSCDGEEP DISPHIDTCD ANTATGGVTD VIKNQAIDAC
2160 2170 2180 2190 2200
DANTTPGGVT DVIKNWDSLI PDEMPDSPIQ EKSECQDMSL SSPTSVLGGS
2210 2220 2230 2240 2250
RHQSHTAEAG PRKSPVGMLD LSSWSSPEVL RKDWTLEPWP SLPVTPHSGA
2260 2270 2280 2290 2300
LSLCSADTSL GDRADTSLPQ TQGPGLLCSP GVSAAALALQ WAESPPADDH
2310 2320 2330 2340 2350
HVQRTAVEKD VEDFITTSFD SQETLSSPPP GLEGKADRSE KSDGSGFGAR
2360 2370 2380 2390 2400
LSPGSGGPEA QTAGPVTPAS ISGRFQPLPE AMKEKEVRPK HVKALLQMVR
2410 2420 2430 2440 2450
DESHQILALS EGLAPPSGEP HPPRKEDEIQ DISLHGGKTQ EVPTACPDWR
2460 2470 2480 2490 2500
GDLLQVVQEA FEKEQEMQGV ELQPRLSGSD LGGHSSLLER LEKIIREQGD
2510 2520 2530 2540 2550
LQEKSLEHLR LPDRSSLLSE IQALRAQLRM THLQNQEKLQ HLRTALTSAE
2560 2570 2580 2590 2600
ARGSQQEHQL RRQVELLAYK VEQEKCIAGD LQKTLSEEQE KANSVQKLLA
2610 2620 2630 2640 2650
AEQTVVRDLK SDLCESRQKS EQLSRSLCEV QQEVLQLRSM LSSKENELKA
2660 2670 2680 2690 2700
ALQELESEQG KGRALQSQLE EEQLRHLQRE SQSAKALEEL RASLETQRAQ
2710 2720 2730 2740 2750
SSRLCVALKH EQTAKDNLQK ELRIEHSRCE ALLAQERSQL SELQKDLAAE
2760 2770 2780 2790 2800
KSRTLELSEA LRHERLLTEQ LSQRTQEACV HQDTQAHHAL LQKLKEEKSR
2810 2820 2830 2840 2850
VVDLQAMLEK VQQQALHSQQ QLEAEAQKHC EALRREKEVS ATLKSTVEAL
2860 2870 2880 2890 2900
HTQKRELRCS LEREREKPAW LQAELEQSHP RLKEQEGRKA ARRSAEARQS
2910 2920 2930 2940 2950
PAAAEQWRKW QRDKEKLREL ELQRQRDLHK IKQLQQTVRD LESKDEVPGS
2960 2970 2980 2990 3000
RLHLGSARRA AGSDADHLRE QQRELEAMRQ RLLSAARLLT SFTSQAVDRT
3010 3020 3030 3040 3050
VNDWTSSNEK AVMSLLHTLE ELKSDLSRPT SSQKKMAAEL QFQFVDVLLK
3060 3070 3080 3090 3100
DNVSLTKALS TVTQEKLELS RAVSKLEKLL KHHLQKGCSP SRSERSAWKP
3110 3120 3130 3140 3150
DETAPQSSLR RPDPGRLPPA ASEEAHTSNV KMEKLYLHYL RAESFRKALI
3160 3170 3180 3190 3200
YQKKYLLLLI GGFQDSEQET LSMIAHLGVF PSKAERKITS RPFTRFRTAV
3210 3220 3230 3240 3250
RVVIAILRLR FLVKKWQEVD RKGALAQGKA PRPGPRARQP QSPPRTRESP
3260 3270 3280 3290 3300
PTRDVPSGHT RDPARGRRLA AAASPHSGGR ATPSPNSRLE RSLTASQDPE
3310 3320 3330
HSLTEYIHHL EVIQQRLGGV LPDSTSKKSC HPMIKQ
Length:3,336
Mass (Da):378,037
Last modified:November 30, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F182D2C201662A8
GO
Isoform 2 (identifier: O95613-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.
     2839-2917: Missing.

Note: No experimental confirmation available.
Show »
Length:3,139
Mass (Da):355,882
Checksum:iA0FD227ABCF410FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C2A3H7C2A3_HUMAN
Pericentrin
PCNT
228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD10838 differs from that shown. Reason: Frameshift at position 3320.Curated
The sequence BAA23698 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC04252 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti703Y → F in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti789F → L in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti819G → A in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti890 – 900Missing in AAD10838 (PubMed:11171385).CuratedAdd BLAST11
Sequence conflicti967S → T in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti1024E → K in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti1036T → A in BAC04252 (PubMed:14702039).Curated1
Sequence conflicti1287I → L in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti1317K → T in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti1534Q → H in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti3136Y → S in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti3300E → G in AAD10838 (PubMed:11171385).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043878539T → I. Corresponds to variant dbSNP:rs2249060EnsemblClinVar.1
Natural variantiVAR_043879704G → E3 PublicationsCorresponds to variant dbSNP:rs2839223EnsemblClinVar.1
Natural variantiVAR_043880879T → A1 PublicationCorresponds to variant dbSNP:rs2839227EnsemblClinVar.1
Natural variantiVAR_0438811038V → A3 PublicationsCorresponds to variant dbSNP:rs6518289EnsemblClinVar.1
Natural variantiVAR_0438821163R → C. Corresponds to variant dbSNP:rs7279204EnsemblClinVar.1
Natural variantiVAR_0438831194A → T. Corresponds to variant dbSNP:rs35044802EnsemblClinVar.1
Natural variantiVAR_0694201452G → R Found in a patient with mental retardation, no speech, facial and limbs dysmorphisms. 1 PublicationCorresponds to variant dbSNP:rs143796569EnsemblClinVar.1
Natural variantiVAR_0438841639I → V. Corresponds to variant dbSNP:rs6518291EnsemblClinVar.1
Natural variantiVAR_0438851841N → S. Corresponds to variant dbSNP:rs35940413EnsemblClinVar.1
Natural variantiVAR_0438861953R → H. Corresponds to variant dbSNP:rs34268261EnsemblClinVar.1
Natural variantiVAR_0438871960R → Q. Corresponds to variant dbSNP:rs34813667EnsemblClinVar.1
Natural variantiVAR_0438882097L → P. Corresponds to variant dbSNP:rs2839245EnsemblClinVar.1
Natural variantiVAR_0438892125H → P. Corresponds to variant dbSNP:rs35978208EnsemblClinVar.1
Natural variantiVAR_0438902188M → R1 PublicationCorresponds to variant dbSNP:rs1044998EnsemblClinVar.1
Natural variantiVAR_0438912191S → P. Corresponds to variant dbSNP:rs34151633EnsemblClinVar.1
Natural variantiVAR_0569612239W → R. Corresponds to variant dbSNP:rs35346764EnsemblClinVar.1
Natural variantiVAR_0569622274P → L. Corresponds to variant dbSNP:rs2070425EnsemblClinVar.1
Natural variantiVAR_0569632329P → R. Corresponds to variant dbSNP:rs35848602EnsemblClinVar.1
Natural variantiVAR_0569642361Q → R. Corresponds to variant dbSNP:rs7277175EnsemblClinVar.1
Natural variantiVAR_0694212424R → Q Found in a patient with mental retardation, no speech, facial and limbs dysmorphisms. 1 PublicationCorresponds to variant dbSNP:rs371893416Ensembl.1
Natural variantiVAR_0569652549A → T1 PublicationCorresponds to variant dbSNP:rs2839256EnsemblClinVar.1
Natural variantiVAR_0569662625R → Q. Corresponds to variant dbSNP:rs8131693EnsemblClinVar.1
Natural variantiVAR_0569672659Q → H. Corresponds to variant dbSNP:rs2070426EnsemblClinVar.1
Natural variantiVAR_0569682753R → H. Corresponds to variant dbSNP:rs743346EnsemblClinVar.1
Natural variantiVAR_0569692792Q → R. Corresponds to variant dbSNP:rs2073376EnsemblClinVar.1
Natural variantiVAR_0569702903A → T. Corresponds to variant dbSNP:rs35147998EnsemblClinVar.1
Natural variantiVAR_0569712975L → P. Corresponds to variant dbSNP:rs35881595EnsemblClinVar.1
Natural variantiVAR_0569723091S → G. Corresponds to variant dbSNP:rs4818842EnsemblClinVar.1
Natural variantiVAR_0569733245R → S. Corresponds to variant dbSNP:rs2073380EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0401041 – 118Missing in isoform 2. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_0401052839 – 2917Missing in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U52962 mRNA Translation: AAD10838.1 Frameshift.
AF515282 mRNA Translation: AAP46636.1
AB007862 mRNA Translation: BAA23698.3 Different initiation.
AP000471 Genomic DNA No translation available.
AP001477 Genomic DNA No translation available.
AP000335 Genomic DNA No translation available.
AP000336 Genomic DNA No translation available.
AP000337 Genomic DNA No translation available.
AK093923 mRNA Translation: BAC04252.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33592.1 [O95613-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001302458.1, NM_001315529.1 [O95613-2]
NP_006022.3, NM_006031.5 [O95613-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.474069

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000359568; ENSP00000352572; ENSG00000160299 [O95613-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5116

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5116

UCSC genome browser

More...
UCSCi
uc002zji.4 human [O95613-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52962 mRNA Translation: AAD10838.1 Frameshift.
AF515282 mRNA Translation: AAP46636.1
AB007862 mRNA Translation: BAA23698.3 Different initiation.
AP000471 Genomic DNA No translation available.
AP001477 Genomic DNA No translation available.
AP000335 Genomic DNA No translation available.
AP000336 Genomic DNA No translation available.
AP000337 Genomic DNA No translation available.
AK093923 mRNA Translation: BAC04252.1 Different initiation.
CCDSiCCDS33592.1 [O95613-1]
RefSeqiNP_001302458.1, NM_001315529.1 [O95613-2]
NP_006022.3, NM_006031.5 [O95613-1]
UniGeneiHs.474069

3D structure databases

ProteinModelPortaliO95613
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111146, 75 interactors
CORUMiO95613
DIPiDIP-33829N
ELMiO95613
IntActiO95613, 42 interactors
MINTiO95613
STRINGi9606.ENSP00000352572

PTM databases

iPTMnetiO95613
PhosphoSitePlusiO95613

Polymorphism and mutation databases

BioMutaiPCNT

Proteomic databases

EPDiO95613
MaxQBiO95613
PaxDbiO95613
PeptideAtlasiO95613
PRIDEiO95613
ProteomicsDBi50949
50950 [O95613-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359568; ENSP00000352572; ENSG00000160299 [O95613-1]
GeneIDi5116
KEGGihsa:5116
UCSCiuc002zji.4 human [O95613-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5116
DisGeNETi5116
EuPathDBiHostDB:ENSG00000160299.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PCNT

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0203117
HGNCiHGNC:16068 PCNT
HPAiHPA016820
HPA019887
HPA032101
MalaCardsiPCNT
MIMi210720 phenotype
605925 gene
neXtProtiNX_O95613
OpenTargetsiENSG00000160299
Orphaneti2637 Microcephalic osteodysplastic primordial dwarfism type II
808 Seckel syndrome
PharmGKBiPA33079

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJHT Eukaryota
ENOG4110FJZ LUCA
GeneTreeiENSGT00730000110871
HOGENOMiHOG000168229
HOVERGENiHBG079443
InParanoidiO95613
KOiK16481
OMAiALKHEQT
OrthoDBiEOG091G001R
PhylomeDBiO95613
TreeFamiTF336114

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2
SIGNORiO95613

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PCNT human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PCNT

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5116

Protein Ontology

More...
PROi
PR:O95613

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160299 Expressed in 224 organ(s), highest expression level in gastrocnemius
CleanExiHS_PCNT
ExpressionAtlasiO95613 baseline and differential
GenevisibleiO95613 HS

Family and domain databases

InterProiView protein in InterPro
IPR028745 AKAP9/Pericentrin
IPR019528 PACT_domain
PANTHERiPTHR44981 PTHR44981, 7 hits
PfamiView protein in Pfam
PF10495 PACT_coil_coil, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCNT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95613
Secondary accession number(s): O43152, Q7Z7C9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 179 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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