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UniProtKB - O95602 (RPA1_HUMAN)

Entry version 189 (02 Dec 2020)
Sequence version 2 (25 Nov 2008)
Previous versions | rss
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Protein

DNA-directed RNA polymerase I subunit RPA1

Gene

POLR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi64ZincBy similarity1
Metal bindingi67ZincBy similarity1
Metal bindingi74ZincBy similarity1
Metal bindingi77ZincBy similarity1
Metal bindingi588Magnesium; catalyticBy similarity1
Metal bindingi590Magnesium; catalyticBy similarity1
Metal bindingi592Magnesium; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • DNA binding Source: InterPro
  • RNA polymerase I activity Source: ParkinsonsUK-UCL
  • zinc ion binding Source: InterPro
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription
LigandMagnesium, Metal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95602

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-427413, NoRC negatively regulates rRNA expression
R-HSA-5250924, B-WICH complex positively regulates rRNA expression
R-HSA-73762, RNA Polymerase I Transcription Initiation
R-HSA-73772, RNA Polymerase I Promoter Escape
R-HSA-73863, RNA Polymerase I Transcription Termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase I subunit RPA1 (EC:2.7.7.6)
Short name:
RNA polymerase I subunit A1
Alternative name(s):
A190
DNA-directed RNA polymerase I largest subunit
DNA-directed RNA polymerase I subunit A
RNA polymerase I 194 kDa subunit
Short name:
RPA194
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLR1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000068654.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:17264, POLR1A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616404, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95602

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Acrofacial dysostosis, Cincinnati type (AFDCIN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of acrofacial dysostosis, a group of disorders which are characterized by malformation of the craniofacial skeleton and, in some patients, the limbs.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073964593E → Q in AFDCIN. 1 PublicationCorresponds to variant dbSNP:rs794729674EnsemblClinVar.1
Natural variantiVAR_0739651299V → F in AFDCIN. 1 PublicationCorresponds to variant dbSNP:rs751377255Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		25885

MalaCards human disease database

More...MalaCardsi		POLR1A
MIMi616462, phenotype

Open Targets

More...OpenTargetsi		ENSG00000068654

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1200, Choanal atresia-hearing loss-cardiac defects-craniofacial dysmorphism syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134891380

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95602, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3286067

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		POLR1A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000739231 – 1720DNA-directed RNA polymerase I subunit RPA1Add BLAST1720

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei240PhosphoserineCombined sources1
Modified residuei1386PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95602

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95602

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95602

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95602

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95602

PeptideAtlas

More...PeptideAtlasi		O95602

PRoteomics IDEntifications database

More...PRIDEi		O95602

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50948

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		O95602

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95602

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O95602

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95602

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O95602

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000068654, Expressed in sural nerve and 163 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95602, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95602, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000068654, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (PubMed:16809778).

Interacts with MYO1C (By similarity).

Interacts with ERBB2 (PubMed:21555369).

Interacts with DDX11 (PubMed:26089203).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117396, 109 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O95602

Database of interacting proteins

More...DIPi		DIP-27537N

Protein interaction database and analysis system

More...IntActi		O95602, 67 interactors

Molecular INTeraction database

More...MINTi		O95602

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263857

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O95602

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95602, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95602

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni961 – 973Bridging helixBy similarityAdd BLAST13

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0262, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00920000149138

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95602

Identification of Orthologs from Complete Genome Data

More...OMAi		RFFNRED

Database of Orthologous Groups

More...OrthoDBi		591636at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95602

TreeFam database of animal gene trees

More...TreeFami		TF103033

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.132.30, 1 hit
1.10.274.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015699, DNA-dir_RNA_pol1_lsu
IPR000722, RNA_pol_asu
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR042102, RNA_pol_Rpb1_3_sf
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR038120, Rpb1_funnel_sf

The PANTHER Classification System

More...PANTHERi		PTHR19376:SF11, PTHR19376:SF11, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 1 hit
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00663, RPOLA_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O95602-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLISKNMPWR RLQGISFGMY SAEELKKLSV KSITNPRYLD SLGNPSANGL 
        60         70         80         90        100
YDLALGPADS KEVCSTCVQD FSNCSGHLGH IELPLTVYNP LLFDKLYLLL 
       110        120        130        140        150
RGSCLNCHML TCPRAVIHLL LCQLRVLEVG ALQAVYELER ILNRFLEENP 
       160        170        180        190        200
DPSASEIREE LEQYTTEIVQ NNLLGSQGAH VKNVCESKSK LIALFWKAHM 
       210        220        230        240        250
NAKRCPHCKT GRSVVRKEHN SKLTITFPAM VHRTAGQKDS EPLGIEEAQI 
       260        270        280        290        300
GKRGYLTPTS AREHLSALWK NEGFFLNYLF SGMDDDGMES RFNPSVFFLD 
       310        320        330        340        350
FLVVPPSRYR PVSRLGDQMF TNGQTVNLQA VMKDVVLIRK LLALMAQEQK 
       360        370        380        390        400
LPEEVATPTT DEEKDSLIAI DRSFLSTLPG QSLIDKLYNI WIRLQSHVNI 
       410        420        430        440        450
VFDSEMDKLM MDKYPGIRQI LEKKEGLFRK HMMGKRVDYA ARSVICPDMY 
       460        470        480        490        500
INTNEIGIPM VFATKLTYPQ PVTPWNVQEL RQAVINGPNV HPGASMVINE 
       510        520        530        540        550
DGSRTALSAV DMTQREAVAK QLLTPATGAP KPQGTKIVCR HVKNGDILLL 
       560        570        580        590        600
NRQPTLHRPS IQAHRARILP EEKVLRLHYA NCKAYNADFD GDEMNAHFPQ 
       610        620        630        640        650
SELGRAEAYV LACTDQQYLV PKDGQPLAGL IQDHMVSGAS MTTRGCFFTR 
       660        670        680        690        700
EHYMELVYRG LTDKVGRVKL LSPSILKPFP LWTGKQVVST LLINIIPEDH 
       710        720        730        740        750
IPLNLSGKAK ITGKAWVKET PRSVPGFNPD SMCESQVIIR EGELLCGVLD 
       760        770        780        790        800
KAHYGSSAYG LVHCCYEIYG GETSGKVLTC LARLFTAYLQ LYRGFTLGVE 
       810        820        830        840        850
DILVKPKADV KRQRIIEEST HCGPQAVRAA LNLPEAASYD EVRGKWQDAH 
       860        870        880        890        900
LGKDQRDFNM IDLKFKEEVN HYSNEINKAC MPFGLHRQFP ENSLQMMVQS 
       910        920        930        940        950
GAKGSTVNTM QISCLLGQIE LEGRRPPLMA SGKSLPCFEP YEFTPRAGGF 
       960        970        980        990       1000
VTGRFLTGIK PPEFFFHCMA GREGLVDTAV KTSRSGYLQR CIIKHLEGLV 
      1010       1020       1030       1040       1050
VQYDLTVRDS DGSVVQFLYG EDGLDIPKTQ FLQPKQFPFL ASNYEVIMKS 
      1060       1070       1080       1090       1100
QHLHEVLSRA DPKKALHHFR AIKKWQSKHP NTLLRRGAFL SYSQKIQEAV 
      1110       1120       1130       1140       1150
KALKLESENR NGRSPGTQEM LRMWYELDEE SRRKYQKKAA ACPDPSLSVW 
      1160       1170       1180       1190       1200
RPDIYFASVS ETFETKVDDY SQEWAAQTEK SYEKSELSLD RLRTLLQLKW 
      1210       1220       1230       1240       1250
QRSLCEPGEA VGLLAAQSIG EPSTQMTLNT FHFAGRGEMN VTLGIPRLRE 
      1260       1270       1280       1290       1300
ILMVASANIK TPMMSVPVLN TKKALKRVKS LKKQLTRVCL GEVLQKIDVQ 
      1310       1320       1330       1340       1350
ESFCMEEKQN KFQVYQLRFQ FLPHAYYQQE KCLRPEDILR FMETRFFKLL 
      1360       1370       1380       1390       1400
MESIKKKNNK ASAFRNVNTR RATQRDLDNA GELGRSRGEQ EGDEEEEGHI 
      1410       1420       1430       1440       1450
VDAEAEEGDA DASDAKRKEK QEEEVDYESE EEEEREGEEN DDEDMQEERN 
      1460       1470       1480       1490       1500
PHREGARKTQ EQDEEVGLGT EEDPSLPALL TQPRKPTHSQ EPQGPEAMER 
      1510       1520       1530       1540       1550
RVQAVREIHP FIDDYQYDTE ESLWCQVTVK LPLMKINFDM SSLVVSLAHG 
      1560       1570       1580       1590       1600
AVIYATKGIT RCLLNETTNN KNEKELVLNT EGINLPELFK YAEVLDLRRL 
      1610       1620       1630       1640       1650
YSNDIHAIAN TYGIEAALRV IEKEIKDVFA VYGIAVDPRH LSLVADYMCF 
      1660       1670       1680       1690       1700
EGVYKPLNRF GIRSNSSPLQ QMTFETSFQF LKQATMLGSH DELRSPSACL 
      1710       1720
VVGKVVRGGT GLFELKQPLR
Length:1,720
Mass (Da):194,811
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD4BA543FFB98DC6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B9ZVN9B9ZVN9_HUMAN
DNA-directed RNA polymerase subunit
POLR1A
1,659Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3I7F2Z3I7_HUMAN
DNA-directed RNA polymerase I subun...
POLR1A
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC99959 differs from that shown. Reason: Frameshift.Curated
The sequence AAD09356 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti143N → S in AAC99959 (Ref. 1) Curated1
Sequence conflicti309Y → S in AAC99959 (Ref. 1) Curated1
Sequence conflicti411M → R in AAC99959 (Ref. 1) Curated1
Sequence conflicti439 – 440YA → ST in AAC99959 (Ref. 1) Curated2
Sequence conflicti808A → R in AAC99959 (Ref. 1) Curated1
Sequence conflicti893S → T in AAC99959 (Ref. 1) Curated1
Sequence conflicti896M → L in AAC99959 (Ref. 1) Curated1
Sequence conflicti925 – 926RP → ST in AAC99959 (Ref. 1) Curated2
Sequence conflicti986G → A in AAD09356 (Ref. 1) Curated1
Sequence conflicti1371 – 1373RAT → TRI in AAD09356 (Ref. 1) Curated3
Sequence conflicti1470 – 1471Missing in AAC99959 (Ref. 1) Curated2
Sequence conflicti1616Missing in AAC99959 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047493150P → A2 PublicationsCorresponds to variant dbSNP:rs4832242Ensembl.1
Natural variantiVAR_047494349Q → E. Corresponds to variant dbSNP:rs17026866Ensembl.1
Natural variantiVAR_047495364K → E. Corresponds to variant dbSNP:rs35239368Ensembl.1
Natural variantiVAR_047496396S → N. Corresponds to variant dbSNP:rs35443467EnsemblClinVar.1
Natural variantiVAR_073964593E → Q in AFDCIN. 1 PublicationCorresponds to variant dbSNP:rs794729674EnsemblClinVar.1
Natural variantiVAR_047497815I → V. Corresponds to variant dbSNP:rs34302587EnsemblClinVar.1
Natural variantiVAR_0474981141A → T. Corresponds to variant dbSNP:rs34892520Ensembl.1
Natural variantiVAR_0739651299V → F in AFDCIN. 1 PublicationCorresponds to variant dbSNP:rs751377255Ensembl.1
Natural variantiVAR_0474991608I → M. Corresponds to variant dbSNP:rs35093541EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U33460 mRNA Translation: AAC99959.1 Frameshift.
AH007280 Transcribed RNA Translation: AAD09356.1 Frameshift.
AK302458 mRNA Translation: BAH13716.1
CH471053 Genomic DNA Translation: EAW99467.1
CH471053 Genomic DNA Translation: EAW99469.1
BC117173 mRNA Translation: AAI17174.1
BC126303 mRNA Translation: AAI26304.1
AL117467 mRNA Translation: CAB55942.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42706.1

Protein sequence database of the Protein Information Resource

More...PIRi		T17252

NCBI Reference Sequences

More...RefSeqi		NP_056240.2, NM_015425.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263857; ENSP00000263857; ENSG00000068654

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25885

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25885

UCSC genome browser

More...UCSCi		uc002sqs.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33460 mRNA Translation: AAC99959.1 Frameshift.
AH007280 Transcribed RNA Translation: AAD09356.1 Frameshift.
AK302458 mRNA Translation: BAH13716.1
CH471053 Genomic DNA Translation: EAW99467.1
CH471053 Genomic DNA Translation: EAW99469.1
BC117173 mRNA Translation: AAI17174.1
BC126303 mRNA Translation: AAI26304.1
AL117467 mRNA Translation: CAB55942.1
CCDSiCCDS42706.1
PIRiT17252
RefSeqiNP_056240.2, NM_015425.4

3D structure databases

SMRiO95602
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117396, 109 interactors
CORUMiO95602
DIPiDIP-27537N
IntActiO95602, 67 interactors
MINTiO95602
STRINGi9606.ENSP00000263857

Chemistry databases

BindingDBiO95602
ChEMBLiCHEMBL3286067

PTM databases

iPTMnetiO95602
MetOSiteiO95602
PhosphoSitePlusiO95602
SwissPalmiO95602

Polymorphism and mutation databases

BioMutaiPOLR1A

2D gel databases

SWISS-2DPAGEiO95602

Proteomic databases

EPDiO95602
jPOSTiO95602
MassIVEiO95602
MaxQBiO95602
PaxDbiO95602
PeptideAtlasiO95602
PRIDEiO95602
ProteomicsDBi50948

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4117, 111 antibodies

Genome annotation databases

EnsembliENST00000263857; ENSP00000263857; ENSG00000068654
GeneIDi25885
KEGGihsa:25885
UCSCiuc002sqs.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25885
DisGeNETi25885
EuPathDBiHostDB:ENSG00000068654.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		POLR1A
HGNCiHGNC:17264, POLR1A
HPAiENSG00000068654, Low tissue specificity
MalaCardsiPOLR1A
MIMi616404, gene
616462, phenotype
neXtProtiNX_O95602
OpenTargetsiENSG00000068654
Orphaneti1200, Choanal atresia-hearing loss-cardiac defects-craniofacial dysmorphism syndrome
PharmGKBiPA134891380

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0262, Eukaryota
GeneTreeiENSGT00920000149138
InParanoidiO95602
OMAiRFFNRED
OrthoDBi591636at2759
PhylomeDBiO95602
TreeFamiTF103033

Enzyme and pathway databases

PathwayCommonsiO95602
ReactomeiR-HSA-427413, NoRC negatively regulates rRNA expression
R-HSA-5250924, B-WICH complex positively regulates rRNA expression
R-HSA-73762, RNA Polymerase I Transcription Initiation
R-HSA-73772, RNA Polymerase I Promoter Escape
R-HSA-73863, RNA Polymerase I Transcription Termination

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		25885, 655 hits in 849 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		POLR1A, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		POLR1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25885
PharosiO95602, Tchem

Protein Ontology

More...PROi		PR:O95602
RNActiO95602, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000068654, Expressed in sural nerve and 163 other tissues
ExpressionAtlasiO95602, baseline and differential
GenevisibleiO95602, HS

Family and domain databases

Gene3Di1.10.132.30, 1 hit
1.10.274.100, 1 hit
InterProiView protein in InterPro
IPR015699, DNA-dir_RNA_pol1_lsu
IPR000722, RNA_pol_asu
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR042102, RNA_pol_Rpb1_3_sf
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR038120, Rpb1_funnel_sf
PANTHERiPTHR19376:SF11, PTHR19376:SF11, 1 hit
PfamiView protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 1 hit
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit
SMARTiView protein in SMART
SM00663, RPOLA_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95602
Secondary accession number(s): B7Z7T0
, D6W5M0, Q0VG05, Q9UEH0, Q9UFT9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 25, 2008
Last modified: December 2, 2020
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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