KLF8

Functionⁱ

Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G₁ phase as a downstream target of focal adhesion kinase (FAK).3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	274 – 298	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	304 – 328	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	334 – 356	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10756197
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10756197

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from mutant phenotypeⁱ
- 10756197
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SIGNORⁱ	O95600

SIGNORⁱ

O95600

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Krueppel-like factor 8 Alternative name(s): Basic krueppel-like factor 3 Zinc finger protein 741
Gene namesⁱ	Name:KLF8 Synonyms:BKLF3, ZNF741
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000102349.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6351 KLF8
MIMⁱ	300286 gene
neXtProtⁱ	NX_O95600

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	67	K → R: Abolishes sumoylation. No change in nuclear location. Increases transcriptional activity and cell cycle progression. Abolishes sumoylation; when associated with R-217. 1 Publication		1
Mutagenesisⁱ	217	K → R: No change in sumoylation. Abolishes sumoylation; when associated with R-67. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11279
Open Targets More...OpenTargetsⁱ	ENSG00000102349
PharmGKBⁱ	PA30141

Polymorphism and mutation databases

BioMutaⁱ	KLF8

BioMutaⁱ

KLF8

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047176	1 – 359	Krueppel-like factor 8Add BLAST		359

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	67	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modificationⁱ

Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G₁ phase. Has no effect on subcellular location.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbⁱ	O95600
PeptideAtlas More...PeptideAtlasⁱ	O95600
PRIDEⁱ	O95600
ProteomicsDBⁱ	50947

PTM databases

iPTMnetⁱ	O95600
PhosphoSitePlusⁱ	O95600

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000102349 Expressed in 189 organ(s), highest expression level in forebrain
CleanExⁱ	HS_KLF8
ExpressionAtlasⁱ	O95600 baseline and differential
Genevisibleⁱ	O95600 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA071740

HPAⁱ

HPA071740

Interactionⁱ

Subunit structureⁱ

Interacts with corepressor CtBP2. Interacts with PIAS1, PIAS2, AND PIAS4; the interaction with each ligase sumoylates KLF8.2 Publications

Protein-protein interaction databases

BioGridⁱ	116435, 14 interactors
ELMⁱ	O95600
IntActⁱ	O95600, 6 interactors
Molecular INTeraction database More...MINTⁱ	O95600
STRINGⁱ	9606.ENSP00000417303

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95600
SMRⁱ	O95600
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	274 – 298	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	304 – 328	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	334 – 356	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118998
HOVERGENⁱ	HBG003941
InParanoidⁱ	O95600
KEGG Orthology (KO) More...KOⁱ	K09205
OMAⁱ	PAAMTQM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1BN0
PhylomeDBⁱ	O95600
TreeFamⁱ	TF350556

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: O95600-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVDMDKLINN LEVQLNSEGG SMQVFKQVTA SVRNRDPPEI EYRSNMTSPT 
        60         70         80         90        100
LLDANPMENP ALFNDIKIEP PEELLASDFS LPQVEPVDLS FHKPKAPLQP 
       110        120        130        140        150
ASMLQAPIRP PKPQSSPQTL VVSTSTSDMS TSANIPTVLT PGSVLTSSQS 
       160        170        180        190        200
TGSQQILHVI HTIPSVSLPN KMGGLKTIPV VVQSLPMVYT TLPADGGPAA 
       210        220        230        240        250
ITVPLIGGDG KNAGSVKVDP TSMSPLEIPS DSEESTIESG SSALQSLQGL 
       260        270        280        290        300
QQEPAAMAQM QGEESLDLKR RRIHQCDFAG CSKVYTKSSH LKAHRRIHTG 
       310        320        330        340        350
EKPYKCTWDG CSWKFARSDE LTRHFRKHTG IKPFRCTDCN RSFSRSDHLS 

LHRRRHDTM

Length:359

Mass (Da):39,314

Last modified:November 2, 2001 - v2

Checksum:ⁱF8FDCC1FD477C04F

GO

Isoform 2 (identifier: O95600-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
254-359: PAAMAQMQGE...SLHRRRHDTM → REAL

« Hide

        10         20         30         40         50
MVDMDKLINN LEVQLNSEGG SMQVFKQVTA SVRNRDPPEI EYRSNMTSPT 
        60         70         80         90        100
LLDANPMENP ALFNDIKIEP PEELLASDFS LPQVEPVDLS FHKPKAPLQP 
       110        120        130        140        150
ASMLQAPIRP PKPQSSPQTL VVSTSTSDMS TSANIPTVLT PGSVLTSSQS 
       160        170        180        190        200
TGSQQILHVI HTIPSVSLPN KMGGLKTIPV VVQSLPMVYT TLPADGGPAA 
       210        220        230        240        250
ITVPLIGGDG KNAGSVKVDP TSMSPLEIPS DSEESTIESG SSALQSLQGL 

QQEREAL

Show »

Length:257

Mass (Da):27,242

Checksum:ⁱ86CF13DBD7494270

GO

Isoform 3 (identifier: O95600-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-27: MVDMDKLINNLEVQLNSEGGSMQVFKQ → MSLPEDGMSSGHFRSPQLVTWS
254-359: PAAMAQMQGE...SLHRRRHDTM → REAL

« Hide

        10         20         30         40         50
MSLPEDGMSS GHFRSPQLVT WSVTASVRNR DPPEIEYRSN MTSPTLLDAN 
        60         70         80         90        100
PMENPALFND IKIEPPEELL ASDFSLPQVE PVDLSFHKPK APLQPASMLQ 
       110        120        130        140        150
APIRPPKPQS SPQTLVVSTS TSDMSTSANI PTVLTPGSVL TSSQSTGSQQ 
       160        170        180        190        200
ILHVIHTIPS VSLPNKMGGL KTIPVVVQSL PMVYTTLPAD GGPAAITVPL 
       210        220        230        240        250
IGGDGKNAGS VKVDPTSMSP LEIPSDSEES TIESGSSALQ SLQGLQQERE 

AL

Show »

Length:252

Mass (Da):26,623

Checksum:ⁱ0B68B09E33AC87A8

GO

Isoform 4 (identifier: O95600-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
216-299: Missing.

« Hide

        10         20         30         40         50
MVDMDKLINN LEVQLNSEGG SMQVFKQVTA SVRNRDPPEI EYRSNMTSPT 
        60         70         80         90        100
LLDANPMENP ALFNDIKIEP PEELLASDFS LPQVEPVDLS FHKPKAPLQP 
       110        120        130        140        150
ASMLQAPIRP PKPQSSPQTL VVSTSTSDMS TSANIPTVLT PGSVLTSSQS 
       160        170        180        190        200
TGSQQILHVI HTIPSVSLPN KMGGLKTIPV VVQSLPMVYT TLPADGGPAA 
       210        220        230        240        250
ITVPLIGGDG KNAGSGEKPY KCTWDGCSWK FARSDELTRH FRKHTGIKPF 
       260        270 
RCTDCNRSFS RSDHLSLHRR RHDTM

Show »

Length:275

Mass (Da):30,050

Checksum:ⁱ7CB5F2431F0E06D0

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q05BZ3	Q05BZ3_HUMAN		KLF8 protein KLF8 protein (Krueppel-like factor 8) (Kruppel-like factor 8, isoform CRA_b)	KLF8 hCG_17979	228	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	167	S → I in BAG58895 (PubMed:14702039).Curated		1
Sequence conflictⁱ	263	E → G in AAC99849 (Ref. 1) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_047480	1 – 27	MVDMD…QVFKQ → MSLPEDGMSSGHFRSPQLVT WS in isoform 3. 1 PublicationAdd BLAST	27
Alternative sequenceⁱVSP_047481	216 – 299	Missing in isoform 4. 1 PublicationAdd BLAST	84
Alternative sequenceⁱVSP_045460	254 – 359	PAAMA…RHDTM → REAL in isoform 2 and isoform 3. 2 PublicationsAdd BLAST	106

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U28282 mRNA Translation: AAC99849.1 HF546207 mRNA Translation: CCO02793.1 HF546208 mRNA Translation: CCO02794.1 HF546209 mRNA Translation: CCO02795.1 AK296156 mRNA Translation: BAG58895.1 AB209004 mRNA Translation: BAD92241.1 Sequence problems. BX641066 mRNA Translation: CAE46033.1 Sequence problems. AL050309 Genomic DNA No translation available. BX322609 Genomic DNA No translation available. BC105130 mRNA Translation: AAI05131.1 BC112109 mRNA Translation: AAI12110.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14373.1 [O95600-1] CCDS55428.1 [O95600-3] CCDS87749.1 [O95600-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001152768.1, NM_001159296.2 [O95600-3] NP_001311028.1, NM_001324099.1 [O95600-4] NP_001311029.1, NM_001324100.1 [O95600-5] NP_001311031.1, NM_001324102.1 [O95600-1] NP_009181.2, NM_007250.5 [O95600-1] XP_005262034.1, XM_005261977.2 [O95600-1] XP_005262036.1, XM_005261979.3 XP_006724638.1, XM_006724575.2 [O95600-3]
UniGeneⁱ	Hs.646614

Genome annotation databases

Ensemblⁱ	ENST00000374928; ENSP00000364063; ENSG00000102349 [O95600-3] ENST00000468660; ENSP00000417303; ENSG00000102349 [O95600-1] ENST00000640927; ENSP00000492126; ENSG00000102349 [O95600-4]
GeneIDⁱ	11279
KEGGⁱ	hsa:11279
UCSC genome browser More...UCSCⁱ	uc004dur.4 human [O95600-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
O95600	Kruppel-like factor 8, isoform CRA_a		HUMAN		359	UniRef100_O95600
KLF8 isoform 4		PANTR		359
Uncharacterized protein		PANPA		356
Krueppel-like factor 8 isoform 1 (Fragment)		MACMU		126
UPI0007DBDE72		PANTR		499
O95600-3	KLF8 isoform 1		PANTR		257	UniRef100_A0A2I3RNS0
UPI0007DBEBD1		PANTR		397
O95600-4	KLF8 isoform 5		PANTR		252	UniRef100_H2R432
O95600-5	Uncharacterized protein (Fragment)		AILME		61	UniRef100_O95600-5

Protein	Similar proteins		Species	Score	Length	Source
O95600	Kruppel-like factor 8, isoform CRA_a		HUMAN		359	UniRef90_O95600
KLF8 isoform 4		PANTR		359
Uncharacterized protein		PANPA		356
Krueppel-like factor 8 isoform 1 (Fragment)		MACMU		126
UPI0007DBDE72		PANTR		499
O95600-3	KLF8 isoform 1		PANTR		257	UniRef90_A0A2I3RNS0
UPI0007DBEBD1		PANTR		397
O95600-4	KLF8 isoform 5		PANTR		252	UniRef90_H2R432
Kruppel like factor 8		SAIBB		252
Uncharacterized protein		NOMLE		252
Kruppel like factor 8		GORGO		252
O95600-5	Uncharacterized protein (Fragment)		AILME		61	UniRef90_O95600-5
KLF8 protein		HUMAN		228
KLF8 isoform 3		PANTR		228
Uncharacterized protein		PANPA		225
KLF8 isoform 5		PONAB		227
+5

Protein	Similar proteins		Species	Score	Length	Source
O95600	Krueppel-like factor 8		MOUSE		355	UniRef50_O95600
Kruppel-like factor 8, isoform CRA_a		HUMAN		359
KLF8 isoform 4		PANTR		359
Uncharacterized protein		PANPA		356
Krueppel-like factor 8 isoform 1 (Fragment)		MACMU		126
+31
O95600-3	Uncharacterized protein		RABIT		359	UniRef50_G1SN48
Basic krueppel-like factor 3		MACMU		395
Basic krueppel-like factor 3		MACFA		395
Uncharacterized protein		CALJA		360
Kruppel like factor 8		GORGO		359
+119
O95600-4	Isoform 4 of Krueppel-like factor 8		HUMAN		275	UniRef50_O95600-5
Uncharacterized protein (Fragment)		AILME		61
KLF8 isoform 3		PANTR		228
Uncharacterized protein		PANPA		225
KLF8 isoform 5		PONAB		227
+28
O95600-5	Uncharacterized protein (Fragment)		AILME		61	UniRef50_O95600-5
KLF8 protein		HUMAN		228
KLF8 isoform 3		PANTR		228
Uncharacterized protein		PANPA		225
KLF8 isoform 5		PONAB		227
+28

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U28282 mRNA Translation: AAC99849.1 HF546207 mRNA Translation: CCO02793.1 HF546208 mRNA Translation: CCO02794.1 HF546209 mRNA Translation: CCO02795.1 AK296156 mRNA Translation: BAG58895.1 AB209004 mRNA Translation: BAD92241.1 Sequence problems. BX641066 mRNA Translation: CAE46033.1 Sequence problems. AL050309 Genomic DNA No translation available. BX322609 Genomic DNA No translation available. BC105130 mRNA Translation: AAI05131.1 BC112109 mRNA Translation: AAI12110.1
CCDSⁱ	CCDS14373.1 [O95600-1] CCDS55428.1 [O95600-3] CCDS87749.1 [O95600-4]
RefSeqⁱ	NP_001152768.1, NM_001159296.2 [O95600-3] NP_001311028.1, NM_001324099.1 [O95600-4] NP_001311029.1, NM_001324100.1 [O95600-5] NP_001311031.1, NM_001324102.1 [O95600-1] NP_009181.2, NM_007250.5 [O95600-1] XP_005262034.1, XM_005261977.2 [O95600-1] XP_005262036.1, XM_005261979.3 XP_006724638.1, XM_006724575.2 [O95600-3]
UniGeneⁱ	Hs.646614

3D structure databases

ProteinModelPortalⁱ	O95600
SMRⁱ	O95600
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116435, 14 interactors
ELMⁱ	O95600
IntActⁱ	O95600, 6 interactors
MINTⁱ	O95600
STRINGⁱ	9606.ENSP00000417303

PTM databases

iPTMnetⁱ	O95600
PhosphoSitePlusⁱ	O95600

Polymorphism and mutation databases

BioMutaⁱ	KLF8

BioMutaⁱ

KLF8

Proteomic databases

PaxDbⁱ	O95600
PeptideAtlasⁱ	O95600
PRIDEⁱ	O95600
ProteomicsDBⁱ	50947

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11279
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000374928; ENSP00000364063; ENSG00000102349 [O95600-3] ENST00000468660; ENSP00000417303; ENSG00000102349 [O95600-1] ENST00000640927; ENSP00000492126; ENSG00000102349 [O95600-4]
GeneIDⁱ	11279
KEGGⁱ	hsa:11279
UCSCⁱ	uc004dur.4 human [O95600-1]

Organism-specific databases

CTDⁱ	11279
DisGeNETⁱ	11279
EuPathDBⁱ	HostDB:ENSG00000102349.15
GeneCardsⁱ	KLF8
HGNCⁱ	HGNC:6351 KLF8
HPAⁱ	HPA071740
MIMⁱ	300286 gene
neXtProtⁱ	NX_O95600
OpenTargetsⁱ	ENSG00000102349
PharmGKBⁱ	PA30141
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118998
HOVERGENⁱ	HBG003941
InParanoidⁱ	O95600
KOⁱ	K09205
OMAⁱ	PAAMTQM
OrthoDBⁱ	EOG091G1BN0
PhylomeDBⁱ	O95600
TreeFamⁱ	TF350556

Enzyme and pathway databases

SIGNORⁱ	O95600

SIGNORⁱ

O95600

Miscellaneous databases

ChiTaRSⁱ	KLF8 human
GeneWikiⁱ	KLF8
GenomeRNAiⁱ	11279
Protein Ontology More...PROⁱ	PR:O95600
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000102349 Expressed in 189 organ(s), highest expression level in forebrain
CleanExⁱ	HS_KLF8
ExpressionAtlasⁱ	O95600 baseline and differential
Genevisibleⁱ	O95600 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KLF8_HUMAN
Accessionⁱ	O95600Primary (citable) accession number: O95600 Secondary accession number(s): B4DJN3 Q9UGC4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
	Last sequence update:	November 2, 2001
	Last modified:	October 10, 2018
	This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O95600 (KLF8_HUMAN)

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Krueppel-like factor 8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ