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Entry version 141 (08 May 2019)
Sequence version 1 (01 May 1999)
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Protein

Mitochondrial pyruvate carrier 2

Gene

MPC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the uptake of pyruvate into mitochondria.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • pyruvate transmembrane transporter activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-70268 Pyruvate metabolism

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.105.1.2 the mitochondrial pyruvate carrier (mpc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial pyruvate carrier 2
Alternative name(s):
Brain protein 44
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MPC2
Synonyms:BRP44
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24515 MPC2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614737 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95563

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei73 – 90HelicalSequence analysisAdd BLAST18
Transmembranei96 – 115HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25874

Open Targets

More...
OpenTargetsi
ENSG00000143158

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672547

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MPC2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002127931 – 127Mitochondrial pyruvate carrier 2Add BLAST127

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95563

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95563

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95563

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95563

PeptideAtlas

More...
PeptideAtlasi
O95563

PRoteomics IDEntifications database

More...
PRIDEi
O95563

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50942

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O95563

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95563

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95563

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O95563

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143158 Expressed in 233 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95563 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95563 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056091

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117389, 14 interactors

Protein interaction database and analysis system

More...
IntActi
O95563, 18 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356820

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1589 Eukaryota
ENOG4111UER LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047120

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000188910

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95563

KEGG Orthology (KO)

More...
KOi
K22139

Identification of Orthologs from Complete Genome Data

More...
OMAi
QLYRIWR

Database of Orthologous Groups

More...
OrthoDBi
1422466at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95563

TreeFam database of animal gene trees

More...
TreeFami
TF300066

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005336 MPC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03650 MPC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O95563-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAGARGLR ATYHRLLDKV ELMLPEKLRP LYNHPAGPRT VFFWAPIMKW
60 70 80 90 100
GLVCAGLADM ARPAEKLSTA QSAVLMATGF IWSRYSLVII PKNWSLFAVN
110 120
FFVGAAGASQ LFRIWRYNQE LKAKAHK
Length:127
Mass (Da):14,279
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD82E5879AB2EEA68
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5R3B4Q5R3B4_HUMAN
Mitochondrial pyruvate carrier
MPC2
105Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL035304 mRNA Translation: CAA22909.1
AL110297 mRNA Translation: CAB53738.1
AK290126 mRNA Translation: BAF82815.1
CR407632 mRNA Translation: CAG28560.1
CR533473 mRNA Translation: CAG38504.1
Z97876 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90814.1
BC104157 mRNA Translation: AAI04158.1
BC104158 mRNA Translation: AAI04159.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1266.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T14797

NCBI Reference Sequences

More...
RefSeqi
NP_001137146.1, NM_001143674.3
NP_056230.1, NM_015415.3
XP_006711329.1, XM_006711266.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000271373; ENSP00000271373; ENSG00000143158
ENST00000367846; ENSP00000356820; ENSG00000143158

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25874

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25874

UCSC genome browser

More...
UCSCi
uc001ges.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035304 mRNA Translation: CAA22909.1
AL110297 mRNA Translation: CAB53738.1
AK290126 mRNA Translation: BAF82815.1
CR407632 mRNA Translation: CAG28560.1
CR533473 mRNA Translation: CAG38504.1
Z97876 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90814.1
BC104157 mRNA Translation: AAI04158.1
BC104158 mRNA Translation: AAI04159.1
CCDSiCCDS1266.1
PIRiT14797
RefSeqiNP_001137146.1, NM_001143674.3
NP_056230.1, NM_015415.3
XP_006711329.1, XM_006711266.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi117389, 14 interactors
IntActiO95563, 18 interactors
STRINGi9606.ENSP00000356820

Protein family/group databases

TCDBi2.A.105.1.2 the mitochondrial pyruvate carrier (mpc) family

PTM databases

iPTMnetiO95563
PhosphoSitePlusiO95563
SwissPalmiO95563

Polymorphism and mutation databases

BioMutaiMPC2

Proteomic databases

EPDiO95563
jPOSTiO95563
MaxQBiO95563
PaxDbiO95563
PeptideAtlasiO95563
PRIDEiO95563
ProteomicsDBi50942
TopDownProteomicsiO95563

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
25874
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271373; ENSP00000271373; ENSG00000143158
ENST00000367846; ENSP00000356820; ENSG00000143158
GeneIDi25874
KEGGihsa:25874
UCSCiuc001ges.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25874
DisGeNETi25874

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MPC2
HGNCiHGNC:24515 MPC2
HPAiHPA056091
MIMi614737 gene
neXtProtiNX_O95563
OpenTargetsiENSG00000143158
PharmGKBiPA142672547

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1589 Eukaryota
ENOG4111UER LUCA
GeneTreeiENSGT00510000047120
HOGENOMiHOG000188910
InParanoidiO95563
KOiK22139
OMAiQLYRIWR
OrthoDBi1422466at2759
PhylomeDBiO95563
TreeFamiTF300066

Enzyme and pathway databases

ReactomeiR-HSA-70268 Pyruvate metabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MPC2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BRP44

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25874

Protein Ontology

More...
PROi
PR:O95563

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143158 Expressed in 233 organ(s), highest expression level in right testis
ExpressionAtlasiO95563 baseline and differential
GenevisibleiO95563 HS

Family and domain databases

InterProiView protein in InterPro
IPR005336 MPC
PfamiView protein in Pfam
PF03650 MPC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95563
Secondary accession number(s): A8K261, Q3SXR6, Q6FIF3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1999
Last modified: May 8, 2019
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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