UniProtKB - O95528 (GTR10_HUMAN)
Protein
Solute carrier family 2, facilitated glucose transporter member 10
Gene
SLC2A10
Organism
Homo sapiens (Human)
Status
Functioni
Facilitative glucose transporter required for the development of the cardiovascular system.2 Publications
Catalytic activityi
Kineticsi
- KM=0.28 mM for 2-deoxy-D-glucose1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 432 | MonosaccharideBy similarity | 1 |
GO - Molecular functioni
- carbohydrate:proton symporter activity Source: UniProtKB
- dehydroascorbic acid transmembrane transporter activity Source: ARUK-UCL
- D-glucose transmembrane transporter activity Source: ARUK-UCL
GO - Biological processi
- artery development Source: ARUK-UCL
- cell redox homeostasis Source: ARUK-UCL
- dehydroascorbic acid transport Source: ARUK-UCL
- embryonic skeletal joint development Source: ARUK-UCL
- galactose transmembrane transport Source: ARUK-UCL
- glucose import across plasma membrane Source: ARUK-UCL
- glucose transmembrane transport Source: UniProtKB
- hexose transmembrane transport Source: Reactome
- negative regulation of connective tissue growth factor production Source: ARUK-UCL
- negative regulation of gene expression Source: ARUK-UCL
- negative regulation of integrin-mediated signaling pathway Source: ARUK-UCL
- negative regulation of proteoglycan biosynthetic process Source: ARUK-UCL
- negative regulation of SMAD protein signal transduction Source: ARUK-UCL
- negative regulation of transforming growth factor beta receptor signaling pathway Source: ARUK-UCL
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of proteoglycan biosynthetic process Source: ARUK-UCL
- positive regulation of transforming growth factor beta receptor signaling pathway Source: ARUK-UCL
- regulation of extracellular matrix organization Source: ARUK-UCL
- skin development Source: ARUK-UCL
- transport across blood-brain barrier Source: ARUK-UCL
Keywordsi
Biological process | Sugar transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | O95528 |
Reactomei | R-HSA-189200, Cellular hexose transport R-HSA-5619068, Defective SLC2A10 causes arterial tortuosity syndrome (ATS) |
Protein family/group databases
TCDBi | 2.A.1.1.59, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 2, facilitated glucose transporter member 10CuratedAlternative name(s): Glucose transporter type 101 Publication Short name: GLUT-101 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000197496.5 |
HGNCi | HGNC:13444, SLC2A10 |
MIMi | 606145, gene |
neXtProti | NX_O95528 |
Subcellular locationi
Other locations
- Endomembrane system 1 Publication; Multi-pass membrane protein Sequence analysis
- perinuclear region 1 Publication
Plasma Membrane
- plasma membrane Source: ARUK-UCL
Other locations
- endomembrane system Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB
- perinuclear region of cytoplasm Source: ARUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 15 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 16 – 36 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 37 – 48 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 49 – 69 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 70 – 77 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 78 – 98 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 99 – 106 | ExtracellularSequence analysis | 8 | |
Transmembranei | 107 – 127 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 128 – 134 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 135 – 155 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 156 – 166 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 167 – 187 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 188 – 233 | CytoplasmicSequence analysisAdd BLAST | 46 | |
Transmembranei | 234 – 254 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 255 – 269 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 270 – 290 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 291 – 298 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 299 – 319 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 320 – 414 | ExtracellularSequence analysisAdd BLAST | 95 | |
Transmembranei | 415 – 435 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 436 – 445 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 446 – 466 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 467 – 476 | ExtracellularSequence analysis | 10 | |
Transmembranei | 477 – 497 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 498 – 541 | CytoplasmicSequence analysisAdd BLAST | 44 |
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
Arterial tortuosity syndrome (ATORS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029535 | 81 | S → R in ATORS. 1 PublicationCorresponds to variant dbSNP:rs80358230EnsemblClinVar. | 1 | |
Natural variantiVAR_042417 | 132 | R → W in ATORS. 1 PublicationCorresponds to variant dbSNP:rs121908173EnsemblClinVar. | 1 | |
Natural variantiVAR_042418 | 142 | G → V in ATORS. 1 PublicationCorresponds to variant dbSNP:rs864309480EnsemblClinVar. | 1 | |
Natural variantiVAR_042420 | 231 | R → Q in ATORS. 1 PublicationCorresponds to variant dbSNP:rs771028960EnsemblClinVar. | 1 | |
Natural variantiVAR_042421 | 246 | G → E in ATORS. 1 PublicationCorresponds to variant dbSNP:rs564317065EnsemblClinVar. | 1 | |
Natural variantiVAR_042422 | 426 | G → W in ATORS. 1 PublicationCorresponds to variant dbSNP:rs121908172EnsemblClinVar. | 1 | |
Natural variantiVAR_042423 | 437 | E → K in ATORS. 1 PublicationCorresponds to variant dbSNP:rs763220502EnsemblClinVar. | 1 | |
Natural variantiVAR_042424 | 445 | G → E in ATORS. Corresponds to variant dbSNP:rs753723351EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 81031 |
GeneReviewsi | SLC2A10 |
MalaCardsi | SLC2A10 |
MIMi | 208050, phenotype |
OpenTargetsi | ENSG00000197496 |
Orphaneti | 3342, Arterial tortuosity syndrome |
PharmGKBi | PA37769 |
Miscellaneous databases
Pharosi | O95528, Tbio |
Chemistry databases
DrugBanki | DB01914, D-glucose DB09341, Dextrose, unspecified form DB09502, Fludeoxyglucose (18F) |
Polymorphism and mutation databases
BioMutai | SLC2A10 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050379 | 1 – 541 | Solute carrier family 2, facilitated glucose transporter member 10Add BLAST | 541 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 334 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | O95528 |
MassIVEi | O95528 |
MaxQBi | O95528 |
PaxDbi | O95528 |
PeptideAtlasi | O95528 |
PRIDEi | O95528 |
ProteomicsDBi | 50935 |
PTM databases
GlyGeni | O95528, 1 site |
iPTMneti | O95528 |
PhosphoSitePlusi | O95528 |
Expressioni
Tissue specificityi
Widely expressed; highest levels in liver and pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000197496, Expressed in tibia and 190 other tissues |
ExpressionAtlasi | O95528, baseline and differential |
Genevisiblei | O95528, HS |
Organism-specific databases
HPAi | ENSG00000197496, Tissue enhanced (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123350, 2 interactors |
STRINGi | 9606.ENSP00000352216 |
Miscellaneous databases
RNActi | O95528, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 242 – 248 | Monosaccharide bindingBy similarity | 7 |
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0254, Eukaryota |
GeneTreei | ENSGT00940000159430 |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | O95528 |
OMAi | IAFMPES |
OrthoDBi | 326501at2759 |
PhylomeDBi | O95528 |
TreeFami | TF332408 |
Family and domain databases
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 2 hits |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O95528-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGHSPPVLPL CASVSLLGGL TFGYELAVIS GALLPLQLDF GLSCLEQEFL
60 70 80 90 100
VGSLLLGALL ASLVGGFLID CYGRKQAILG SNLVLLAGSL TLGLAGSLAW
110 120 130 140 150
LVLGRAVVGF AISLSSMACC IYVSELVGPR QRGVLVSLYE AGITVGILLS
160 170 180 190 200
YALNYALAGT PWGWRHMFGW ATAPAVLQSL SLLFLPAGTD ETATHKDLIP
210 220 230 240 250
LQGGEAPKLG PGRPRYSFLD LFRARDNMRG RTTVGLGLVL FQQLTGQPNV
260 270 280 290 300
LCYASTIFSS VGFHGGSSAV LASVGLGAVK VAATLTAMGL VDRAGRRALL
310 320 330 340 350
LAGCALMALS VSGIGLVSFA VPMDSGPSCL AVPNATGQTG LPGDSGLLQD
360 370 380 390 400
SSLPPIPRTN EDQREPILST AKKTKPHPRS GDPSAPPRLA LSSALPGPPL
410 420 430 440 450
PARGHALLRW TALLCLMVFV SAFSFGFGPV TWLVLSEIYP VEIRGRAFAF
460 470 480 490 500
CNSFNWAANL FISLSFLDLI GTIGLSWTFL LYGLTAVLGL GFIYLFVPET
510 520 530 540
KGQSLAEIDQ QFQKRRFTLS FGHRQNSTGI PYSRIEISAA S
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WUH5 | A0A087WUH5_HUMAN | Solute carrier family 2, facilitate... | SLC2A10 | 13 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029535 | 81 | S → R in ATORS. 1 PublicationCorresponds to variant dbSNP:rs80358230EnsemblClinVar. | 1 | |
Natural variantiVAR_029536 | 106 | A → S. Corresponds to variant dbSNP:rs6094438EnsemblClinVar. | 1 | |
Natural variantiVAR_042417 | 132 | R → W in ATORS. 1 PublicationCorresponds to variant dbSNP:rs121908173EnsemblClinVar. | 1 | |
Natural variantiVAR_042418 | 142 | G → V in ATORS. 1 PublicationCorresponds to variant dbSNP:rs864309480EnsemblClinVar. | 1 | |
Natural variantiVAR_029335 | 206 | A → T Associated with lower insulin level. Corresponds to variant dbSNP:rs2235491EnsemblClinVar. | 1 | |
Natural variantiVAR_042419 | 225 | R → H. Corresponds to variant dbSNP:rs34295241EnsemblClinVar. | 1 | |
Natural variantiVAR_042420 | 231 | R → Q in ATORS. 1 PublicationCorresponds to variant dbSNP:rs771028960EnsemblClinVar. | 1 | |
Natural variantiVAR_042421 | 246 | G → E in ATORS. 1 PublicationCorresponds to variant dbSNP:rs564317065EnsemblClinVar. | 1 | |
Natural variantiVAR_042422 | 426 | G → W in ATORS. 1 PublicationCorresponds to variant dbSNP:rs121908172EnsemblClinVar. | 1 | |
Natural variantiVAR_042423 | 437 | E → K in ATORS. 1 PublicationCorresponds to variant dbSNP:rs763220502EnsemblClinVar. | 1 | |
Natural variantiVAR_042424 | 445 | G → E in ATORS. Corresponds to variant dbSNP:rs753723351EnsemblClinVar. | 1 | |
Natural variantiVAR_024652 | 518 | T → A. Corresponds to variant dbSNP:rs6018008EnsemblClinVar. | 1 | |
Natural variantiVAR_029537 | 537 | I → V. Corresponds to variant dbSNP:rs7348121EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF321240 mRNA Translation: AAK26294.1 AF248053 mRNA Translation: AAK31911.1 AL137188 mRNA Translation: CAB69822.2 AK290961 mRNA Translation: BAF83650.1 AL031055 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75724.1 BC101657 mRNA Translation: AAI01658.1 BC113423 mRNA Translation: AAI13424.1 |
CCDSi | CCDS13402.1 |
RefSeqi | NP_110404.1, NM_030777.3 |
Genome annotation databases
Ensembli | ENST00000359271; ENSP00000352216; ENSG00000197496 |
GeneIDi | 81031 |
KEGGi | hsa:81031 |
UCSCi | uc002xsl.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF321240 mRNA Translation: AAK26294.1 AF248053 mRNA Translation: AAK31911.1 AL137188 mRNA Translation: CAB69822.2 AK290961 mRNA Translation: BAF83650.1 AL031055 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75724.1 BC101657 mRNA Translation: AAI01658.1 BC113423 mRNA Translation: AAI13424.1 |
CCDSi | CCDS13402.1 |
RefSeqi | NP_110404.1, NM_030777.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123350, 2 interactors |
STRINGi | 9606.ENSP00000352216 |
Chemistry databases
DrugBanki | DB01914, D-glucose DB09341, Dextrose, unspecified form DB09502, Fludeoxyglucose (18F) |
Protein family/group databases
TCDBi | 2.A.1.1.59, the major facilitator superfamily (mfs) |
PTM databases
GlyGeni | O95528, 1 site |
iPTMneti | O95528 |
PhosphoSitePlusi | O95528 |
Polymorphism and mutation databases
BioMutai | SLC2A10 |
Proteomic databases
jPOSTi | O95528 |
MassIVEi | O95528 |
MaxQBi | O95528 |
PaxDbi | O95528 |
PeptideAtlasi | O95528 |
PRIDEi | O95528 |
ProteomicsDBi | 50935 |
Protocols and materials databases
Antibodypediai | 13253, 151 antibodies |
DNASUi | 81031 |
Genome annotation databases
Ensembli | ENST00000359271; ENSP00000352216; ENSG00000197496 |
GeneIDi | 81031 |
KEGGi | hsa:81031 |
UCSCi | uc002xsl.4, human |
Organism-specific databases
CTDi | 81031 |
DisGeNETi | 81031 |
EuPathDBi | HostDB:ENSG00000197496.5 |
GeneCardsi | SLC2A10 |
GeneReviewsi | SLC2A10 |
HGNCi | HGNC:13444, SLC2A10 |
HPAi | ENSG00000197496, Tissue enhanced (liver) |
MalaCardsi | SLC2A10 |
MIMi | 208050, phenotype 606145, gene |
neXtProti | NX_O95528 |
OpenTargetsi | ENSG00000197496 |
Orphaneti | 3342, Arterial tortuosity syndrome |
PharmGKBi | PA37769 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0254, Eukaryota |
GeneTreei | ENSGT00940000159430 |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | O95528 |
OMAi | IAFMPES |
OrthoDBi | 326501at2759 |
PhylomeDBi | O95528 |
TreeFami | TF332408 |
Enzyme and pathway databases
PathwayCommonsi | O95528 |
Reactomei | R-HSA-189200, Cellular hexose transport R-HSA-5619068, Defective SLC2A10 causes arterial tortuosity syndrome (ATS) |
Miscellaneous databases
BioGRID-ORCSi | 81031, 2 hits in 838 CRISPR screens |
ChiTaRSi | SLC2A10, human |
GeneWikii | SLC2A10 |
GenomeRNAii | 81031 |
Pharosi | O95528, Tbio |
PROi | PR:O95528 |
RNActi | O95528, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197496, Expressed in tibia and 190 other tissues |
ExpressionAtlasi | O95528, baseline and differential |
Genevisiblei | O95528, HS |
Family and domain databases
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 2 hits |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GTR10_HUMAN | |
Accessioni | O95528Primary (citable) accession number: O95528 Secondary accession number(s): A8K4J6, Q3MIX5, Q9H4I6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations