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Protein

Solute carrier family 2, facilitated glucose transporter member 10

Gene

SLC2A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Facilitative glucose transporter.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.28 mM for 2-deoxy-D-glucose

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • carbohydrate:proton symporter activity Source: GO_Central
    • D-glucose transmembrane transporter activity Source: Reactome

    GO - Biological processi

    • glucose transmembrane transport Source: UniProtKB
    • hexose transmembrane transport Source: Reactome

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processSugar transport, Transport

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-189200 Cellular hexose transport
    R-HSA-5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS)

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.1.1.59 the major facilitator superfamily (mfs)

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 10
    Alternative name(s):
    Glucose transporter type 10
    Short name:
    GLUT-10
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC2A10
    Synonyms:GLUT10
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000197496.5

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:13444 SLC2A10

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    606145 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_O95528

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
    Topological domaini37 – 48ExtracellularSequence analysisAdd BLAST12
    Transmembranei49 – 69Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini70 – 77CytoplasmicSequence analysis8
    Transmembranei78 – 98Helical; Name=3Sequence analysisAdd BLAST21
    Topological domaini99 – 106ExtracellularSequence analysis8
    Transmembranei107 – 127Helical; Name=4Sequence analysisAdd BLAST21
    Topological domaini128 – 134CytoplasmicSequence analysis7
    Transmembranei135 – 155Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini156 – 166ExtracellularSequence analysisAdd BLAST11
    Transmembranei167 – 187Helical; Name=6Sequence analysisAdd BLAST21
    Topological domaini188 – 233CytoplasmicSequence analysisAdd BLAST46
    Transmembranei234 – 254Helical; Name=7Sequence analysisAdd BLAST21
    Topological domaini255 – 269ExtracellularSequence analysisAdd BLAST15
    Transmembranei270 – 290Helical; Name=8Sequence analysisAdd BLAST21
    Topological domaini291 – 298CytoplasmicSequence analysis8
    Transmembranei299 – 319Helical; Name=9Sequence analysisAdd BLAST21
    Topological domaini320 – 414ExtracellularSequence analysisAdd BLAST95
    Transmembranei415 – 435Helical; Name=10Sequence analysisAdd BLAST21
    Topological domaini436 – 445CytoplasmicSequence analysis10
    Transmembranei446 – 466Helical; Name=11Sequence analysisAdd BLAST21
    Topological domaini467 – 476ExtracellularSequence analysis10
    Transmembranei477 – 497Helical; Name=12Sequence analysisAdd BLAST21
    Topological domaini498 – 541CytoplasmicSequence analysisAdd BLAST44

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Arterial tortuosity syndrome (ATS)2 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionAn autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries.
    See also OMIM:208050
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02953581S → R in ATS. 1 PublicationCorresponds to variant dbSNP:rs80358230EnsemblClinVar.1
    Natural variantiVAR_042417132R → W in ATS. 1 PublicationCorresponds to variant dbSNP:rs121908173EnsemblClinVar.1
    Natural variantiVAR_042418142G → V in ATS. 1 PublicationCorresponds to variant dbSNP:rs864309480EnsemblClinVar.1
    Natural variantiVAR_042420231R → Q in ATS. 1 PublicationCorresponds to variant dbSNP:rs771028960EnsemblClinVar.1
    Natural variantiVAR_042421246G → E in ATS. 1 PublicationCorresponds to variant dbSNP:rs564317065EnsemblClinVar.1
    Natural variantiVAR_042422426G → W in ATS. 1 PublicationCorresponds to variant dbSNP:rs121908172EnsemblClinVar.1
    Natural variantiVAR_042423437E → K in ATS. 1 PublicationCorresponds to variant dbSNP:rs763220502EnsemblClinVar.1
    Natural variantiVAR_042424445G → E in ATS. Corresponds to variant dbSNP:rs753723351EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    81031

    GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

    More...
    GeneReviewsi
    SLC2A10

    MalaCards human disease database

    More...
    MalaCardsi
    SLC2A10
    MIMi208050 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000197496

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    3342 Arterial tortuosity syndrome

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA37769

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB09502 Fludeoxyglucose F-18

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC2A10

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000503791 – 541Solute carrier family 2, facilitated glucose transporter member 10Add BLAST541

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    O95528

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    O95528

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    O95528

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O95528

    PeptideAtlas

    More...
    PeptideAtlasi
    O95528

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O95528

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    50935

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O95528

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    O95528

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed; highest levels in liver and pancreas.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000197496 Expressed in 179 organ(s), highest expression level in tibia

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_SLC2A10

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    O95528 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O95528 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA041015

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    123350, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000352216

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    O95528

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0254 Eukaryota
    ENOG410XNQK LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000159430

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000202868

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG051858

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O95528

    KEGG Orthology (KO)

    More...
    KOi
    K08147

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GFLIDCY

    Database of Orthologous Groups

    More...
    OrthoDBi
    326501at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O95528

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF332408

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd06174 MFS, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR020846 MFS_dom
    IPR005828 MFS_sugar_transport-like
    IPR036259 MFS_trans_sf
    IPR003663 Sugar/inositol_transpt
    IPR005829 Sugar_transporter_CS

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00083 Sugar_tr, 2 hits

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00171 SUGRTRNSPORT

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF103473 SSF103473, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50850 MFS, 1 hit
    PS00216 SUGAR_TRANSPORT_1, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    O95528-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MGHSPPVLPL CASVSLLGGL TFGYELAVIS GALLPLQLDF GLSCLEQEFL
    60 70 80 90 100
    VGSLLLGALL ASLVGGFLID CYGRKQAILG SNLVLLAGSL TLGLAGSLAW
    110 120 130 140 150
    LVLGRAVVGF AISLSSMACC IYVSELVGPR QRGVLVSLYE AGITVGILLS
    160 170 180 190 200
    YALNYALAGT PWGWRHMFGW ATAPAVLQSL SLLFLPAGTD ETATHKDLIP
    210 220 230 240 250
    LQGGEAPKLG PGRPRYSFLD LFRARDNMRG RTTVGLGLVL FQQLTGQPNV
    260 270 280 290 300
    LCYASTIFSS VGFHGGSSAV LASVGLGAVK VAATLTAMGL VDRAGRRALL
    310 320 330 340 350
    LAGCALMALS VSGIGLVSFA VPMDSGPSCL AVPNATGQTG LPGDSGLLQD
    360 370 380 390 400
    SSLPPIPRTN EDQREPILST AKKTKPHPRS GDPSAPPRLA LSSALPGPPL
    410 420 430 440 450
    PARGHALLRW TALLCLMVFV SAFSFGFGPV TWLVLSEIYP VEIRGRAFAF
    460 470 480 490 500
    CNSFNWAANL FISLSFLDLI GTIGLSWTFL LYGLTAVLGL GFIYLFVPET
    510 520 530 540
    KGQSLAEIDQ QFQKRRFTLS FGHRQNSTGI PYSRIEISAA S
    Length:541
    Mass (Da):56,911
    Last modified:June 1, 2001 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D644525FA136908
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A087WUH5A0A087WUH5_HUMAN
    Solute carrier family 2, facilitate...
    SLC2A10
    13Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_02953581S → R in ATS. 1 PublicationCorresponds to variant dbSNP:rs80358230EnsemblClinVar.1
    Natural variantiVAR_029536106A → S. Corresponds to variant dbSNP:rs6094438EnsemblClinVar.1
    Natural variantiVAR_042417132R → W in ATS. 1 PublicationCorresponds to variant dbSNP:rs121908173EnsemblClinVar.1
    Natural variantiVAR_042418142G → V in ATS. 1 PublicationCorresponds to variant dbSNP:rs864309480EnsemblClinVar.1
    Natural variantiVAR_029335206A → T Associated with lower insulin level. Corresponds to variant dbSNP:rs2235491EnsemblClinVar.1
    Natural variantiVAR_042419225R → H. Corresponds to variant dbSNP:rs34295241EnsemblClinVar.1
    Natural variantiVAR_042420231R → Q in ATS. 1 PublicationCorresponds to variant dbSNP:rs771028960EnsemblClinVar.1
    Natural variantiVAR_042421246G → E in ATS. 1 PublicationCorresponds to variant dbSNP:rs564317065EnsemblClinVar.1
    Natural variantiVAR_042422426G → W in ATS. 1 PublicationCorresponds to variant dbSNP:rs121908172EnsemblClinVar.1
    Natural variantiVAR_042423437E → K in ATS. 1 PublicationCorresponds to variant dbSNP:rs763220502EnsemblClinVar.1
    Natural variantiVAR_042424445G → E in ATS. Corresponds to variant dbSNP:rs753723351EnsemblClinVar.1
    Natural variantiVAR_024652518T → A. Corresponds to variant dbSNP:rs6018008EnsemblClinVar.1
    Natural variantiVAR_029537537I → V. Corresponds to variant dbSNP:rs7348121EnsemblClinVar.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF321240 mRNA Translation: AAK26294.1
    AF248053 mRNA Translation: AAK31911.1
    AL137188 mRNA Translation: CAB69822.2
    AK290961 mRNA Translation: BAF83650.1
    AL031055 Genomic DNA No translation available.
    CH471077 Genomic DNA Translation: EAW75724.1
    BC101657 mRNA Translation: AAI01658.1
    BC113423 mRNA Translation: AAI13424.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS13402.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_110404.1, NM_030777.3

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.305971

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000359271; ENSP00000352216; ENSG00000197496

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    81031

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:81031

    UCSC genome browser

    More...
    UCSCi
    uc002xsl.4 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF321240 mRNA Translation: AAK26294.1
    AF248053 mRNA Translation: AAK31911.1
    AL137188 mRNA Translation: CAB69822.2
    AK290961 mRNA Translation: BAF83650.1
    AL031055 Genomic DNA No translation available.
    CH471077 Genomic DNA Translation: EAW75724.1
    BC101657 mRNA Translation: AAI01658.1
    BC113423 mRNA Translation: AAI13424.1
    CCDSiCCDS13402.1
    RefSeqiNP_110404.1, NM_030777.3
    UniGeneiHs.305971

    3D structure databases

    ProteinModelPortaliO95528
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi123350, 1 interactor
    STRINGi9606.ENSP00000352216

    Chemistry databases

    DrugBankiDB09502 Fludeoxyglucose F-18

    Protein family/group databases

    TCDBi2.A.1.1.59 the major facilitator superfamily (mfs)

    PTM databases

    iPTMnetiO95528
    PhosphoSitePlusiO95528

    Polymorphism and mutation databases

    BioMutaiSLC2A10

    Proteomic databases

    EPDiO95528
    jPOSTiO95528
    MaxQBiO95528
    PaxDbiO95528
    PeptideAtlasiO95528
    PRIDEiO95528
    ProteomicsDBi50935

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    81031
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000359271; ENSP00000352216; ENSG00000197496
    GeneIDi81031
    KEGGihsa:81031
    UCSCiuc002xsl.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    81031
    DisGeNETi81031
    EuPathDBiHostDB:ENSG00000197496.5

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC2A10
    GeneReviewsiSLC2A10
    HGNCiHGNC:13444 SLC2A10
    HPAiHPA041015
    MalaCardsiSLC2A10
    MIMi208050 phenotype
    606145 gene
    neXtProtiNX_O95528
    OpenTargetsiENSG00000197496
    Orphaneti3342 Arterial tortuosity syndrome
    PharmGKBiPA37769

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0254 Eukaryota
    ENOG410XNQK LUCA
    GeneTreeiENSGT00940000159430
    HOGENOMiHOG000202868
    HOVERGENiHBG051858
    InParanoidiO95528
    KOiK08147
    OMAiGFLIDCY
    OrthoDBi326501at2759
    PhylomeDBiO95528
    TreeFamiTF332408

    Enzyme and pathway databases

    ReactomeiR-HSA-189200 Cellular hexose transport
    R-HSA-5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS)

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLC2A10 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    SLC2A10

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    81031

    Protein Ontology

    More...
    PROi
    PR:O95528

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000197496 Expressed in 179 organ(s), highest expression level in tibia
    CleanExiHS_SLC2A10
    ExpressionAtlasiO95528 baseline and differential
    GenevisibleiO95528 HS

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR020846 MFS_dom
    IPR005828 MFS_sugar_transport-like
    IPR036259 MFS_trans_sf
    IPR003663 Sugar/inositol_transpt
    IPR005829 Sugar_transporter_CS
    PfamiView protein in Pfam
    PF00083 Sugar_tr, 2 hits
    PRINTSiPR00171 SUGRTRNSPORT
    SUPFAMiSSF103473 SSF103473, 1 hit
    PROSITEiView protein in PROSITE
    PS50850 MFS, 1 hit
    PS00216 SUGAR_TRANSPORT_1, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGTR10_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95528
    Secondary accession number(s): A8K4J6, Q3MIX5, Q9H4I6
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: June 1, 2001
    Last modified: January 16, 2019
    This is version 159 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
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