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UniProtKB - O95528 (GTR10_HUMAN)

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Protein

Solute carrier family 2, facilitated glucose transporter member 10

Gene

SLC2A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter.

Kineticsi

  1. KM=0.28 mM for 2-deoxy-D-glucose

    GO - Molecular functioni

    View the complete GO annotation on QuickGO ...

    GO - Biological processi

    • glucose import Source: GO_Central
    • glucose transmembrane transport Source: UniProtKB
    • hexose transmembrane transport Source: Reactome
    View the complete GO annotation on QuickGO ...

    Keywordsi

    Biological processSugar transport, Transport

    Enzyme and pathway databases

    ReactomeiR-HSA-189200 Cellular hexose transport
    R-HSA-5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS)

    Protein family/group databases

    TCDBi2.A.1.1.59 the major facilitator superfamily (mfs)

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 10
    Alternative name(s):
    Glucose transporter type 10
    Short name:
    GLUT-10
    Gene namesi
    Name:SLC2A10
    Synonyms:GLUT10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    Proteomesi
    • UP000005640 Componenti: Chromosome 20

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000197496.5
    HGNCiHGNC:13444 SLC2A10
    MIMi606145 gene
    neXtProtiNX_O95528

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
    Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
    Topological domaini37 – 48ExtracellularSequence analysisAdd BLAST12
    Transmembranei49 – 69Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini70 – 77CytoplasmicSequence analysis8
    Transmembranei78 – 98Helical; Name=3Sequence analysisAdd BLAST21
    Topological domaini99 – 106ExtracellularSequence analysis8
    Transmembranei107 – 127Helical; Name=4Sequence analysisAdd BLAST21
    Topological domaini128 – 134CytoplasmicSequence analysis7
    Transmembranei135 – 155Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini156 – 166ExtracellularSequence analysisAdd BLAST11
    Transmembranei167 – 187Helical; Name=6Sequence analysisAdd BLAST21
    Topological domaini188 – 233CytoplasmicSequence analysisAdd BLAST46
    Transmembranei234 – 254Helical; Name=7Sequence analysisAdd BLAST21
    Topological domaini255 – 269ExtracellularSequence analysisAdd BLAST15
    Transmembranei270 – 290Helical; Name=8Sequence analysisAdd BLAST21
    Topological domaini291 – 298CytoplasmicSequence analysis8
    Transmembranei299 – 319Helical; Name=9Sequence analysisAdd BLAST21
    Topological domaini320 – 414ExtracellularSequence analysisAdd BLAST95
    Transmembranei415 – 435Helical; Name=10Sequence analysisAdd BLAST21
    Topological domaini436 – 445CytoplasmicSequence analysis10
    Transmembranei446 – 466Helical; Name=11Sequence analysisAdd BLAST21
    Topological domaini467 – 476ExtracellularSequence analysis10
    Transmembranei477 – 497Helical; Name=12Sequence analysisAdd BLAST21
    Topological domaini498 – 541CytoplasmicSequence analysisAdd BLAST44

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Arterial tortuosity syndrome (ATS)2 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionAn autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries.
    See also OMIM:208050
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_02953581S → R in ATS. 1 PublicationCorresponds to variant dbSNP:rs80358230EnsemblClinVar.1
    Natural variantiVAR_042417132R → W in ATS. 1 PublicationCorresponds to variant dbSNP:rs121908173EnsemblClinVar.1
    Natural variantiVAR_042418142G → V in ATS. 1 PublicationCorresponds to variant dbSNP:rs864309480EnsemblClinVar.1
    Natural variantiVAR_042420231R → Q in ATS. 1 PublicationCorresponds to variant dbSNP:rs771028960EnsemblClinVar.1
    Natural variantiVAR_042421246G → E in ATS. 1 PublicationCorresponds to variant dbSNP:rs564317065EnsemblClinVar.1
    Natural variantiVAR_042422426G → W in ATS. 1 PublicationCorresponds to variant dbSNP:rs121908172EnsemblClinVar.1
    Natural variantiVAR_042423437E → K in ATS. 1 PublicationCorresponds to variant dbSNP:rs763220502EnsemblClinVar.1
    Natural variantiVAR_042424445G → E in ATS. Corresponds to variant dbSNP:rs753723351EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNETi81031
    MalaCardsiSLC2A10
    MIMi208050 phenotype
    OpenTargetsiENSG00000197496
    Orphaneti3342 Arterial tortuosity syndrome
    PharmGKBiPA37769

    Chemistry databases

    DrugBankiDB09502 Fludeoxyglucose F-18

    Polymorphism and mutation databases

    BioMutaiSLC2A10

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000503791 – 541Solute carrier family 2, facilitated glucose transporter member 10Add BLAST541

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    EPDiO95528
    MaxQBiO95528
    PaxDbiO95528
    PeptideAtlasiO95528
    PRIDEiO95528
    ProteomicsDBi50935

    PTM databases

    iPTMnetiO95528
    PhosphoSitePlusiO95528

    Expressioni

    Tissue specificityi

    Widely expressed; highest levels in liver and pancreas.1 Publication

    Gene expression databases

    BgeeiENSG00000197496
    CleanExiHS_SLC2A10
    ExpressionAtlasiO95528 baseline and differential
    GenevisibleiO95528 HS

    Organism-specific databases

    HPAiHPA041015

    Interactioni

    Protein-protein interaction databases

    BioGridi123350, 1 interactor
    STRINGi9606.ENSP00000352216

    Structurei

    3D structure databases

    ProteinModelPortaliO95528
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0254 Eukaryota
    ENOG410XNQK LUCA
    GeneTreeiENSGT00920000149002
    HOGENOMiHOG000202868
    HOVERGENiHBG051858
    InParanoidiO95528
    KOiK08147
    OMAiGFLIDCY
    OrthoDBiEOG091G085H
    PhylomeDBiO95528
    TreeFamiTF332408

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR020846 MFS_dom
    IPR005828 MFS_sugar_transport-like
    IPR036259 MFS_trans_sf
    IPR003663 Sugar/inositol_transpt
    IPR005829 Sugar_transporter_CS
    PfamiView protein in Pfam
    PF00083 Sugar_tr, 2 hits
    PRINTSiPR00171 SUGRTRNSPORT
    SUPFAMiSSF103473 SSF103473, 2 hits
    PROSITEiView protein in PROSITE
    PS50850 MFS, 1 hit
    PS00216 SUGAR_TRANSPORT_1, 2 hits

    Sequencei

    Sequence statusi: Complete.

    O95528-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MGHSPPVLPL CASVSLLGGL TFGYELAVIS GALLPLQLDF GLSCLEQEFL 
            60         70         80         90        100
    VGSLLLGALL ASLVGGFLID CYGRKQAILG SNLVLLAGSL TLGLAGSLAW 
           110        120        130        140        150
    LVLGRAVVGF AISLSSMACC IYVSELVGPR QRGVLVSLYE AGITVGILLS 
           160        170        180        190        200
    YALNYALAGT PWGWRHMFGW ATAPAVLQSL SLLFLPAGTD ETATHKDLIP 
           210        220        230        240        250
    LQGGEAPKLG PGRPRYSFLD LFRARDNMRG RTTVGLGLVL FQQLTGQPNV 
           260        270        280        290        300
    LCYASTIFSS VGFHGGSSAV LASVGLGAVK VAATLTAMGL VDRAGRRALL 
           310        320        330        340        350
    LAGCALMALS VSGIGLVSFA VPMDSGPSCL AVPNATGQTG LPGDSGLLQD 
           360        370        380        390        400
    SSLPPIPRTN EDQREPILST AKKTKPHPRS GDPSAPPRLA LSSALPGPPL 
           410        420        430        440        450
    PARGHALLRW TALLCLMVFV SAFSFGFGPV TWLVLSEIYP VEIRGRAFAF 
           460        470        480        490        500
    CNSFNWAANL FISLSFLDLI GTIGLSWTFL LYGLTAVLGL GFIYLFVPET 
           510        520        530        540 
    KGQSLAEIDQ QFQKRRFTLS FGHRQNSTGI PYSRIEISAA S
    Length:541
    Mass (Da):56,911
    Last modified:June 1, 2001 - v2
    Checksum:i6D644525FA136908
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_02953581S → R in ATS. 1 PublicationCorresponds to variant dbSNP:rs80358230EnsemblClinVar.1
    Natural variantiVAR_029536106A → S. Corresponds to variant dbSNP:rs6094438EnsemblClinVar.1
    Natural variantiVAR_042417132R → W in ATS. 1 PublicationCorresponds to variant dbSNP:rs121908173EnsemblClinVar.1
    Natural variantiVAR_042418142G → V in ATS. 1 PublicationCorresponds to variant dbSNP:rs864309480EnsemblClinVar.1
    Natural variantiVAR_029335206A → T Associated with lower insulin level. Corresponds to variant dbSNP:rs2235491EnsemblClinVar.1
    Natural variantiVAR_042419225R → H. Corresponds to variant dbSNP:rs34295241EnsemblClinVar.1
    Natural variantiVAR_042420231R → Q in ATS. 1 PublicationCorresponds to variant dbSNP:rs771028960EnsemblClinVar.1
    Natural variantiVAR_042421246G → E in ATS. 1 PublicationCorresponds to variant dbSNP:rs564317065EnsemblClinVar.1
    Natural variantiVAR_042422426G → W in ATS. 1 PublicationCorresponds to variant dbSNP:rs121908172EnsemblClinVar.1
    Natural variantiVAR_042423437E → K in ATS. 1 PublicationCorresponds to variant dbSNP:rs763220502EnsemblClinVar.1
    Natural variantiVAR_042424445G → E in ATS. Corresponds to variant dbSNP:rs753723351EnsemblClinVar.1
    Natural variantiVAR_024652518T → A. Corresponds to variant dbSNP:rs6018008EnsemblClinVar.1
    Natural variantiVAR_029537537I → V. Corresponds to variant dbSNP:rs7348121EnsemblClinVar.1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF321240 mRNA Translation: AAK26294.1
    AF248053 mRNA Translation: AAK31911.1
    AL137188 mRNA Translation: CAB69822.2
    AK290961 mRNA Translation: BAF83650.1
    AL031055 Genomic DNA No translation available.
    CH471077 Genomic DNA Translation: EAW75724.1
    BC101657 mRNA Translation: AAI01658.1
    BC113423 mRNA Translation: AAI13424.1
    CCDSiCCDS13402.1
    RefSeqiNP_110404.1, NM_030777.3
    UniGeneiHs.305971

    Genome annotation databases

    EnsembliENST00000359271; ENSP00000352216; ENSG00000197496
    GeneIDi81031
    KEGGihsa:81031
    UCSCiuc002xsl.4 human

    Keywords - Coding sequence diversityi

    Polymorphism

    Similar proteinsi

    Entry informationi

    Entry nameiGTR10_HUMAN
    AccessioniPrimary (citable) accession number: O95528
    Secondary accession number(s): A8K4J6, Q3MIX5, Q9H4I6
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: June 1, 2001
    Last modified: June 20, 2018
    This is version 155 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

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