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Entry version 177 (23 Feb 2022)
Sequence version 2 (01 Jun 2001)
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Protein

Solute carrier family 2, facilitated glucose transporter member 10

Gene

SLC2A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Facilitative glucose transporter required for the development of the cardiovascular system.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.28 mM for 2-deoxy-D-glucose1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei432D-glucoseBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O95528

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-189200, Cellular hexose transport
R-HSA-5619068, Defective SLC2A10 causes arterial tortuosity syndrome (ATS)

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.1.59, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 10Curated
Alternative name(s):
Glucose transporter type 101 Publication
Short name:
GLUT-101 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC2A101 PublicationImported
Synonyms:GLUT101 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13444, SLC2A10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606145, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95528

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000197496

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini37 – 48ExtracellularSequence analysisAdd BLAST12
Transmembranei49 – 69Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini70 – 77CytoplasmicSequence analysis8
Transmembranei78 – 98Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini99 – 106ExtracellularSequence analysis8
Transmembranei107 – 127Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini128 – 134CytoplasmicSequence analysis7
Transmembranei135 – 155Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini156 – 166ExtracellularSequence analysisAdd BLAST11
Transmembranei167 – 187Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini188 – 233CytoplasmicSequence analysisAdd BLAST46
Transmembranei234 – 254Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini255 – 269ExtracellularSequence analysisAdd BLAST15
Transmembranei270 – 290Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini291 – 298CytoplasmicSequence analysis8
Transmembranei299 – 319Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini320 – 414ExtracellularSequence analysisAdd BLAST95
Transmembranei415 – 435Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini436 – 445CytoplasmicSequence analysis10
Transmembranei446 – 466Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini467 – 476ExtracellularSequence analysis10
Transmembranei477 – 497Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini498 – 541CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Arterial tortuosity syndrome (ATORS)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02953581S → R in ATORS. 1 PublicationCorresponds to variant dbSNP:rs80358230EnsemblClinVar.1
Natural variantiVAR_042417132R → W in ATORS. 1 PublicationCorresponds to variant dbSNP:rs121908173EnsemblClinVar.1
Natural variantiVAR_042418142G → V in ATORS. 1 PublicationCorresponds to variant dbSNP:rs864309480EnsemblClinVar.1
Natural variantiVAR_042420231R → Q in ATORS. 1 PublicationCorresponds to variant dbSNP:rs771028960EnsemblClinVar.1
Natural variantiVAR_042421246G → E in ATORS. 1 PublicationCorresponds to variant dbSNP:rs564317065EnsemblClinVar.1
Natural variantiVAR_042422426G → W in ATORS. 1 PublicationCorresponds to variant dbSNP:rs121908172EnsemblClinVar.1
Natural variantiVAR_042423437E → K in ATORS. 1 PublicationCorresponds to variant dbSNP:rs763220502EnsemblClinVar.1
Natural variantiVAR_042424445G → E in ATORS. Corresponds to variant dbSNP:rs753723351EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...
DisGeNETi
81031

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SLC2A10

MalaCards human disease database

More...
MalaCardsi
SLC2A10
MIMi208050, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000197496

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3342, Arterial tortuosity syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37769

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O95528, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01914, D-glucose
DB09341, Dextrose, unspecified form
DB09502, Fludeoxyglucose (18F)

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC2A10

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000503791 – 541Solute carrier family 2, facilitated glucose transporter member 10Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95528

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O95528

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95528

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95528

PeptideAtlas

More...
PeptideAtlasi
O95528

PRoteomics IDEntifications database

More...
PRIDEi
O95528

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50935

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O95528, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95528

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95528

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed; highest levels in liver and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197496, Expressed in tibia and 191 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95528, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95528, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197496, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123350, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000352216

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O95528, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95528

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni242 – 243D-glucose bindingBy similarity2
Regioni340 – 388DisorderedSequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi340 – 358Polar residuesSequence analysisAdd BLAST19
Compositional biasi365 – 379Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0254, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159430

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001265_30_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95528

Identification of Orthologs from Complete Genome Data

More...
OMAi
GCIWLPE

Database of Orthologous Groups

More...
OrthoDBi
326501at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95528

TreeFam database of animal gene trees

More...
TreeFami
TF332408

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1250.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020846, MFS_dom
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR003663, Sugar/inositol_transpt
IPR005829, Sugar_transporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00083, Sugar_tr, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00171, SUGRTRNSPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O95528-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGHSPPVLPL CASVSLLGGL TFGYELAVIS GALLPLQLDF GLSCLEQEFL
60 70 80 90 100
VGSLLLGALL ASLVGGFLID CYGRKQAILG SNLVLLAGSL TLGLAGSLAW
110 120 130 140 150
LVLGRAVVGF AISLSSMACC IYVSELVGPR QRGVLVSLYE AGITVGILLS
160 170 180 190 200
YALNYALAGT PWGWRHMFGW ATAPAVLQSL SLLFLPAGTD ETATHKDLIP
210 220 230 240 250
LQGGEAPKLG PGRPRYSFLD LFRARDNMRG RTTVGLGLVL FQQLTGQPNV
260 270 280 290 300
LCYASTIFSS VGFHGGSSAV LASVGLGAVK VAATLTAMGL VDRAGRRALL
310 320 330 340 350
LAGCALMALS VSGIGLVSFA VPMDSGPSCL AVPNATGQTG LPGDSGLLQD
360 370 380 390 400
SSLPPIPRTN EDQREPILST AKKTKPHPRS GDPSAPPRLA LSSALPGPPL
410 420 430 440 450
PARGHALLRW TALLCLMVFV SAFSFGFGPV TWLVLSEIYP VEIRGRAFAF
460 470 480 490 500
CNSFNWAANL FISLSFLDLI GTIGLSWTFL LYGLTAVLGL GFIYLFVPET
510 520 530 540
KGQSLAEIDQ QFQKRRFTLS FGHRQNSTGI PYSRIEISAA S
Length:541
Mass (Da):56,911
Last modified:June 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D644525FA136908
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUH5A0A087WUH5_HUMAN
Solute carrier family 2, facilitate...
SLC2A10
13Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02953581S → R in ATORS. 1 PublicationCorresponds to variant dbSNP:rs80358230EnsemblClinVar.1
Natural variantiVAR_029536106A → S. Corresponds to variant dbSNP:rs6094438EnsemblClinVar.1
Natural variantiVAR_042417132R → W in ATORS. 1 PublicationCorresponds to variant dbSNP:rs121908173EnsemblClinVar.1
Natural variantiVAR_042418142G → V in ATORS. 1 PublicationCorresponds to variant dbSNP:rs864309480EnsemblClinVar.1
Natural variantiVAR_029335206A → T Associated with lower insulin level. Corresponds to variant dbSNP:rs2235491EnsemblClinVar.1
Natural variantiVAR_042419225R → H. Corresponds to variant dbSNP:rs34295241EnsemblClinVar.1
Natural variantiVAR_042420231R → Q in ATORS. 1 PublicationCorresponds to variant dbSNP:rs771028960EnsemblClinVar.1
Natural variantiVAR_042421246G → E in ATORS. 1 PublicationCorresponds to variant dbSNP:rs564317065EnsemblClinVar.1
Natural variantiVAR_042422426G → W in ATORS. 1 PublicationCorresponds to variant dbSNP:rs121908172EnsemblClinVar.1
Natural variantiVAR_042423437E → K in ATORS. 1 PublicationCorresponds to variant dbSNP:rs763220502EnsemblClinVar.1
Natural variantiVAR_042424445G → E in ATORS. Corresponds to variant dbSNP:rs753723351EnsemblClinVar.1
Natural variantiVAR_024652518T → A. Corresponds to variant dbSNP:rs6018008EnsemblClinVar.1
Natural variantiVAR_029537537I → V. Corresponds to variant dbSNP:rs7348121EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF321240 mRNA Translation: AAK26294.1
AF248053 mRNA Translation: AAK31911.1
AL137188 mRNA Translation: CAB69822.2
AK290961 mRNA Translation: BAF83650.1
AL031055 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75724.1
BC101657 mRNA Translation: AAI01658.1
BC113423 mRNA Translation: AAI13424.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13402.1

NCBI Reference Sequences

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RefSeqi
NP_110404.1, NM_030777.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000359271; ENSP00000352216; ENSG00000197496

Database of genes from NCBI RefSeq genomes

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GeneIDi
81031

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:81031

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

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MANE-Selecti
ENST00000359271.4; ENSP00000352216.2; NM_030777.4; NP_110404.1

UCSC genome browser

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UCSCi
uc002xsl.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321240 mRNA Translation: AAK26294.1
AF248053 mRNA Translation: AAK31911.1
AL137188 mRNA Translation: CAB69822.2
AK290961 mRNA Translation: BAF83650.1
AL031055 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75724.1
BC101657 mRNA Translation: AAI01658.1
BC113423 mRNA Translation: AAI13424.1
CCDSiCCDS13402.1
RefSeqiNP_110404.1, NM_030777.3

3D structure databases

SMRiO95528
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123350, 2 interactors
STRINGi9606.ENSP00000352216

Chemistry databases

DrugBankiDB01914, D-glucose
DB09341, Dextrose, unspecified form
DB09502, Fludeoxyglucose (18F)

Protein family/group databases

TCDBi2.A.1.1.59, the major facilitator superfamily (mfs)

PTM databases

GlyGeniO95528, 1 site
iPTMnetiO95528
PhosphoSitePlusiO95528

Genetic variation databases

BioMutaiSLC2A10

Proteomic databases

jPOSTiO95528
MassIVEiO95528
MaxQBiO95528
PaxDbiO95528
PeptideAtlasiO95528
PRIDEiO95528
ProteomicsDBi50935

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
13253, 157 antibodies from 26 providers

The DNASU plasmid repository

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DNASUi
81031

Genome annotation databases

EnsembliENST00000359271; ENSP00000352216; ENSG00000197496
GeneIDi81031
KEGGihsa:81031
MANE-SelectiENST00000359271.4; ENSP00000352216.2; NM_030777.4; NP_110404.1
UCSCiuc002xsl.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
81031
DisGeNETi81031

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC2A10
GeneReviewsiSLC2A10
HGNCiHGNC:13444, SLC2A10
HPAiENSG00000197496, Low tissue specificity
MalaCardsiSLC2A10
MIMi208050, phenotype
606145, gene
neXtProtiNX_O95528
OpenTargetsiENSG00000197496
Orphaneti3342, Arterial tortuosity syndrome
PharmGKBiPA37769
VEuPathDBiHostDB:ENSG00000197496

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0254, Eukaryota
GeneTreeiENSGT00940000159430
HOGENOMiCLU_001265_30_5_1
InParanoidiO95528
OMAiGCIWLPE
OrthoDBi326501at2759
PhylomeDBiO95528
TreeFamiTF332408

Enzyme and pathway databases

PathwayCommonsiO95528
ReactomeiR-HSA-189200, Cellular hexose transport
R-HSA-5619068, Defective SLC2A10 causes arterial tortuosity syndrome (ATS)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
81031, 5 hits in 1030 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC2A10, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC2A10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81031
PharosiO95528, Tbio

Protein Ontology

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PROi
PR:O95528
RNActiO95528, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197496, Expressed in tibia and 191 other tissues
ExpressionAtlasiO95528, baseline and differential
GenevisibleiO95528, HS

Family and domain databases

Gene3Di1.20.1250.20, 3 hits
InterProiView protein in InterPro
IPR020846, MFS_dom
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR003663, Sugar/inositol_transpt
IPR005829, Sugar_transporter_CS
PfamiView protein in Pfam
PF00083, Sugar_tr, 2 hits
PRINTSiPR00171, SUGRTRNSPORT
SUPFAMiSSF103473, SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGTR10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95528
Secondary accession number(s): A8K4J6, Q3MIX5, Q9H4I6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: February 23, 2022
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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