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Entry version 118 (13 Feb 2019)
Sequence version 2 (20 Jan 2016)
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Protein

PRAME family member 12

Gene

PRAMEF12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PRAME family member 12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRAMEF12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000116726.4

Human Gene Nomenclature Database

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HGNCi
HGNC:22125 PRAMEF12

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95522

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000116726

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145148158

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRAMEF12

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001569861 – 483PRAME family member 12Add BLAST483

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O95522

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O95522

PeptideAtlas

More...
PeptideAtlasi
O95522

PRoteomics IDEntifications database

More...
PRIDEi
O95522

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50934

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95522

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95522

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116726 Expressed in 14 organ(s), highest expression level in prostate gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95522 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045286
HPA051704

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000350358

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95522

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati97 – 122LRR 1; degenerateBy similarityAdd BLAST26
Repeati177 – 201LRR 2; degenerateBy similarityAdd BLAST25
Repeati202 – 228LRR 3; degenerateBy similarityAdd BLAST27
Repeati229 – 264LRR 4; degenerateBy similarityAdd BLAST36
Repeati265 – 290LRR 5By similarityAdd BLAST26
Repeati291 – 322LRR 6By similarityAdd BLAST32
Repeati323 – 341LRR 7By similarityAdd BLAST19
Repeati347 – 374LRR 8By similarityAdd BLAST28
Repeati375 – 399LRR 9By similarityAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PRAME family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KFA8 Eukaryota
ENOG411141V LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153708

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231112

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006326

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95522

Identification of Orthologs from Complete Genome Data

More...
OMAi
WELSILI

Database of Orthologous Groups

More...
OrthoDBi
631249at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332708

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038286 PRAME, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O95522-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLQAPPRLL ELAEQSLLRD RALAIPTLEE LPRELFPPLF MEAFTRRCCE
60 70 80 90 100
TLTTMVQAWP FTCLPLGSLM KSCNLEIFRA VLEGLDALLA QKVRPRRWKL
110 120 130 140 150
QVLDLRNVDE NFWGIWSGAS ALSPEALSKR RTAGNCPRPG GQQPLMVILD
160 170 180 190 200
LCFKNGTLDE CLTHFLEWGK QRKGLLHVCC KELQIFGIAI HRIIEVLNTV
210 220 230 240 250
ELDCIQEVEV CCPWELSILI RFAPYLGQMR NLRKLVLFNI HVSACIPLDR
260 270 280 290 300
KEQFVIQFTS QFLKLDYFQK LYMHSVSFLE GHLDQLLRCL QAPLETVVMT
310 320 330 340 350
ECLLSESDLK HLSWCPSIRQ LKELDLRGIT LTHFSPEPLS VLLEQAEATL
360 370 380 390 400
QTLDLEDCGI VDSQLSAILP ALSRCSQLST FSFCGNLISM AALENLLRHT
410 420 430 440 450
VGLSKLSLEL YPAPLESYDA QGALCWGRFS QLGAELMKTL RDLRQPKIIV
460 470 480
FSTVPCPRCG IRASYDLEPS HCLLNACCQG GFI
Length:483
Mass (Da):54,633
Last modified:January 20, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13B493FE043B119C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05360853T → K. Corresponds to variant dbSNP:rs17346571Ensembl.1
Natural variantiVAR_053609157T → M. Corresponds to variant dbSNP:rs1812242Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC244670 Genomic DNA No translation available.
AL023753 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41254.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074299.2, NM_001080830.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.156406

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357726; ENSP00000350358; ENSG00000116726

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
390999

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:390999

UCSC genome browser

More...
UCSCi
uc001aui.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244670 Genomic DNA No translation available.
AL023753 Genomic DNA No translation available.
CCDSiCCDS41254.1
RefSeqiNP_001074299.2, NM_001080830.4
UniGeneiHs.156406

3D structure databases

ProteinModelPortaliO95522
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000350358

PTM databases

iPTMnetiO95522
PhosphoSitePlusiO95522

Polymorphism and mutation databases

BioMutaiPRAMEF12

Proteomic databases

jPOSTiO95522
PaxDbiO95522
PeptideAtlasiO95522
PRIDEiO95522
ProteomicsDBi50934

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
390999
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357726; ENSP00000350358; ENSG00000116726
GeneIDi390999
KEGGihsa:390999
UCSCiuc001aui.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
390999
EuPathDBiHostDB:ENSG00000116726.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRAMEF12
HGNCiHGNC:22125 PRAMEF12
HPAiHPA045286
HPA051704
neXtProtiNX_O95522
OpenTargetsiENSG00000116726
PharmGKBiPA145148158

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KFA8 Eukaryota
ENOG411141V LUCA
GeneTreeiENSGT00940000153708
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiO95522
OMAiWELSILI
OrthoDBi631249at2759
TreeFamiTF332708

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
390999

Protein Ontology

More...
PROi
PR:O95522

Gene expression databases

BgeeiENSG00000116726 Expressed in 14 organ(s), highest expression level in prostate gland
GenevisibleiO95522 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRA12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95522
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 20, 2016
Last modified: February 13, 2019
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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