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Protein

Neuronal pentraxin receptor

Gene

NPTXR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi347Calcium 1By similarity1
Metal bindingi425Calcium 1By similarity1
Metal bindingi425Calcium 2PROSITE-ProRule annotation1
Metal bindingi426Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi427Calcium 1By similarity1
Metal bindingi427Calcium 2PROSITE-ProRule annotation1
Metal bindingi437Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • neuron projection development Source: GO_Central
  • regulation of postsynaptic neurotransmitter receptor activity Source: SynGO

Keywordsi

Molecular functionReceptor
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin receptor
Gene namesi
Name:NPTXR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000221890.2
HGNCiHGNC:7954 NPTXR
MIMi609474 gene
neXtProtiNX_O95502

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2CytoplasmicSequence analysis2
Transmembranei3 – 23Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini24 – 500ExtracellularSequence analysisAdd BLAST477

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23467
OpenTargetsiENSG00000221890
PharmGKBiPA31740

Polymorphism and mutation databases

BioMutaiNPTXR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001625061 – 500Neuronal pentraxin receptorAdd BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi322 ↔ 383PROSITE-ProRule annotation
Glycosylationi463N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing KLHL2.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiO95502
MaxQBiO95502
PaxDbiO95502
PeptideAtlasiO95502
PRIDEiO95502
ProteomicsDBi50931

PTM databases

GlyConnecti1556
iPTMnetiO95502
PhosphoSitePlusiO95502

Expressioni

Gene expression databases

BgeeiENSG00000221890 Expressed in 168 organ(s), highest expression level in superior frontal gyrus
CleanExiHS_NPTXR
ExpressionAtlasiO95502 baseline and differential
GenevisibleiO95502 HS

Organism-specific databases

HPAiHPA001079

Interactioni

Subunit structurei

Heteropentamer with NPTX1 and/or NPTX2. Also binds taipoxin-associated calcium-binding protein 49 (TCBP49/RCN2). Interacts with KLHL2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi117029, 3 interactors
STRINGi9606.ENSP00000327545

Structurei

3D structure databases

ProteinModelPortaliO95502
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini292 – 494Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST203

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8X4 Eukaryota
ENOG410XTA3 LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000231267
HOVERGENiHBG003608
InParanoidiO95502
OrthoDBiEOG091G0AHP
PhylomeDBiO95502
TreeFamiTF330208

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51828 PTX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O95502-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFLAVLLAA GMLAFLGAVI CIIASVPLAA SPARALPGGA DNASVASGAA
60 70 80 90 100
ASPGPQRSLS ALHGAGGSAG PPALPGAPAA SAHPLPPGPL FSRFLCTPLA
110 120 130 140 150
AACPSGAQQG DAAGAAPGER EELLLLQSTA EQLRQTALQQ EARIRADQDT
160 170 180 190 200
IRELTGKLGR CESGLPRGLQ GAGPRRDTMA DGPWDSPALI LELEDAVRAL
210 220 230 240 250
RDRIDRLEQE LPARVNLSAA PAPVSAVPTG LHSKMDQLEG QLLAQVLALE
260 270 280 290 300
KERVALSHSS RRQRQEVEKE LDVLQGRVAE LEHGSSAYSP PDAFKISIPI
310 320 330 340 350
RNNYMYARVR KALPELYAFT ACMWLRSRSS GTGQGTPFSY SVPGQANEIV
360 370 380 390 400
LLEAGHEPME LLINDKVAQL PLSLKDNGWH HICIAWTTRD GLWSAYQDGE
410 420 430 440 450
LQGSGENLAA WHPIKPHGIL ILGQEQDTLG GRFDATQAFV GDIAQFNLWD
460 470 480 490 500
HALTPAQVLG IANCTAPLLG NVLPWEDKLV EAFGGATKAA FDVCKGRAKA
Length:500
Mass (Da):52,846
Last modified:May 5, 2009 - v2
Checksum:i831D12AB76ACCA00
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1X7SBT7A0A1X7SBT7_HUMAN
Neuronal pentraxin receptor
NPTXR
500Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL008583 Genomic DNA No translation available.
CCDSiCCDS33647.1
RefSeqiNP_055108.2, NM_014293.3
UniGeneiHs.91622

Genome annotation databases

EnsembliENST00000640136; ENSP00000492079; ENSG00000221890
GeneIDi23467
KEGGihsa:23467
UCSCiuc062eix.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL008583 Genomic DNA No translation available.
CCDSiCCDS33647.1
RefSeqiNP_055108.2, NM_014293.3
UniGeneiHs.91622

3D structure databases

ProteinModelPortaliO95502
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117029, 3 interactors
STRINGi9606.ENSP00000327545

PTM databases

GlyConnecti1556
iPTMnetiO95502
PhosphoSitePlusiO95502

Polymorphism and mutation databases

BioMutaiNPTXR

Proteomic databases

EPDiO95502
MaxQBiO95502
PaxDbiO95502
PeptideAtlasiO95502
PRIDEiO95502
ProteomicsDBi50931

Protocols and materials databases

DNASUi23467
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000640136; ENSP00000492079; ENSG00000221890
GeneIDi23467
KEGGihsa:23467
UCSCiuc062eix.1 human

Organism-specific databases

CTDi23467
DisGeNETi23467
EuPathDBiHostDB:ENSG00000221890.2
GeneCardsiNPTXR
HGNCiHGNC:7954 NPTXR
HPAiHPA001079
MIMi609474 gene
neXtProtiNX_O95502
OpenTargetsiENSG00000221890
PharmGKBiPA31740
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8X4 Eukaryota
ENOG410XTA3 LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000231267
HOVERGENiHBG003608
InParanoidiO95502
OrthoDBiEOG091G0AHP
PhylomeDBiO95502
TreeFamiTF330208

Miscellaneous databases

ChiTaRSiNPTXR human
GeneWikiiNPTXR
GenomeRNAii23467
PROiPR:O95502
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000221890 Expressed in 168 organ(s), highest expression level in superior frontal gyrus
CleanExiHS_NPTXR
ExpressionAtlasiO95502 baseline and differential
GenevisibleiO95502 HS

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51828 PTX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPTXR_HUMAN
AccessioniPrimary (citable) accession number: O95502
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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