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Protein

Vascular non-inflammatory molecule 2

Gene

VNN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.1 Publication

Catalytic activityi

(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei80Proton acceptorPROSITE-ProRule annotation1
Active sitei179Proton donorPROSITE-ProRule annotation1
Active sitei211NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

  • pantetheine hydrolase activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDAi3.5.1.92 2681
ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-199220 Vitamin B5 (pantothenate) metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular non-inflammatory molecule 2 (EC:3.5.1.92)
Short name:
Vanin-2
Alternative name(s):
Glycosylphosphatidyl inositol-anchored protein GPI-80
Protein FOAP-4
Gene namesi
Name:VNN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112303.13
HGNCiHGNC:12706 VNN2
MIMi603571 gene
neXtProtiNX_O95498

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8875
OpenTargetsiENSG00000112303
PharmGKBiPA37322

Polymorphism and mutation databases

BioMutaiVNN2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001971823 – 493Vascular non-inflammatory molecule 2Add BLAST471
PropeptideiPRO_0000019719494 – 520Removed in mature formSequence analysisAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi357N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi411N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi468N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi493GPI-anchor amidated cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO95498
PeptideAtlasiO95498
PRIDEiO95498
ProteomicsDBi50925
50926 [O95498-2]
50927 [O95498-3]
50928 [O95498-4]
50929 [O95498-5]

PTM databases

iPTMnetiO95498
PhosphoSitePlusiO95498

Expressioni

Tissue specificityi

Widely expressed with higher expression in spleen and blood.1 Publication

Gene expression databases

BgeeiENSG00000112303 Expressed in 127 organ(s), highest expression level in blood
CleanExiHS_VNN2
ExpressionAtlasiO95498 baseline and differential
GenevisibleiO95498 HS

Interactioni

Protein-protein interaction databases

BioGridi114394, 45 interactors
STRINGi9606.ENSP00000322276

Structurei

3D structure databases

ProteinModelPortaliO95498
SMRiO95498
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 306CN hydrolasePROSITE-ProRule annotationAdd BLAST276

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi393 – 396Poly-Arg4

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0806 Eukaryota
COG0388 LUCA
GeneTreeiENSGT00390000013823
HOVERGENiHBG003996
InParanoidiO95498
KOiK08069
OMAiEYWQVCT
OrthoDBiEOG091G04QD
PhylomeDBiO95498
TreeFamiTF323645

Family and domain databases

CDDicd07567 biotinidase_like, 1 hit
Gene3Di3.60.110.10, 1 hit
InterProiView protein in InterPro
IPR012101 Biotinidase-like_euk
IPR003010 C-N_Hydrolase
IPR036526 C-N_Hydrolase_sf
PfamiView protein in Pfam
PF00795 CN_hydrolase, 1 hit
PIRSFiPIRSF011861 Biotinidase, 1 hit
SUPFAMiSSF56317 SSF56317, 1 hit
PROSITEiView protein in PROSITE
PS50263 CN_HYDROLASE, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95498-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVTSSFPISV AVFALITLQV GTQDSFIAAV YEHAVILPNK TETPVSQEDA
60 70 80 90 100
LNLMNENIDI LETAIKQAAE QGARIIVTPE DALYGWKFTR ETVFPYLEDI
110 120 130 140 150
PDPQVNWIPC QDPHRFGHTP VQARLSCLAK DNSIYVLANL GDKKPCNSRD
160 170 180 190 200
STCPPNGYFQ YNTNVVYNTE GKLVARYHKY HLYSEPQFNV PEKPELVTFN
210 220 230 240 250
TAFGRFGIFT CFDIFFYDPG VTLVKDFHVD TILFPTAWMN VLPLLTAIEF
260 270 280 290 300
HSAWAMGMGV NLLVANTHHV SLNMTGSGIY APNGPKVYHY DMKTELGKLL
310 320 330 340 350
LSEVDSHPLS SLAYPTAVNW NAYATTIKPF PVQKNTFRGF ISRDGFNFTE
360 370 380 390 400
LFENAGNLTV CQKELCCHLS YRMLQKEENE VYVLGAFTGL HGRRRREYWQ
410 420 430 440 450
VCTLLKCKTT NLTTCGRPVE TASTRFEMFS LSGTFGTEYV FPEVLLTEIH
460 470 480 490 500
LSPGKFEVLK DGRLVNKNGS SGPILTVSLF GRWYTKDSLY SSCGTSNSAI
510 520
TYLLIFILLM IIALQNIVML
Length:520
Mass (Da):58,503
Last modified:March 20, 2007 - v3
Checksum:i14460E1DE5B04870
GO
Isoform 2 (identifier: O95498-2) [UniParc]FASTAAdd to basket
Also known as: GPI-80 variant protein 3

The sequence of this isoform differs from the canonical sequence as follows:
     180-400: Missing.

Show »
Length:299
Mass (Da):33,239
Checksum:iB8314877CAEF51B7
GO
Isoform 3 (identifier: O95498-3) [UniParc]FASTAAdd to basket
Also known as: GPI-80 variant protein 2

The sequence of this isoform differs from the canonical sequence as follows:
     180-192: YHLYSEPQFNVPE → ETLQSVKRSFAVI
     193-520: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:192
Mass (Da):21,478
Checksum:iA961ABF6593C813D
GO
Isoform 4 (identifier: O95498-4) [UniParc]FASTAAdd to basket
Also known as: GPI-80 variant protein 1

The sequence of this isoform differs from the canonical sequence as follows:
     180-195: YHLYSEPQFNVPEKPE → EVVFMHQMVPKCIIMT
     196-520: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:195
Mass (Da):21,907
Checksum:i0E80EC968942F874
GO
Isoform 5 (identifier: O95498-5) [UniParc]FASTAAdd to basket
Also known as: GPI-80 variant protein 4

The sequence of this isoform differs from the canonical sequence as follows:
     116-119: FGHT → SAQC
     120-520: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:119
Mass (Da):13,247
Checksum:i0479B5ED49E725DB
GO
Isoform 6 (identifier: O95498-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Note: No experimental confirmation available.
Show »
Length:467
Mass (Da):52,844
Checksum:iC47D4720E11BF156
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QT03J3QT03_HUMAN
Vascular non-inflammatory molecule ...
VNN2
290Annotation score:
B4DQB2B4DQB2_HUMAN
cDNA FLJ55137, highly similar to Va...
VNN2
184Annotation score:
J3KQ55J3KQ55_HUMAN
Vascular non-inflammatory molecule ...
VNN2
219Annotation score:
J3KQQ7J3KQQ7_HUMAN
Vascular non-inflammatory molecule ...
VNN2
216Annotation score:
E9PL76E9PL76_HUMAN
Vascular non-inflammatory molecule ...
VNN2
166Annotation score:
E9PK31E9PK31_HUMAN
Vascular non-inflammatory molecule ...
VNN2
101Annotation score:
E9PLK5E9PLK5_HUMAN
Vascular non-inflammatory molecule ...
VNN2
119Annotation score:
E9PQ75E9PQ75_HUMAN
Vascular non-inflammatory molecule ...
VNN2
131Annotation score:
E9PRD9E9PRD9_HUMAN
Vascular non-inflammatory molecule ...
VNN2
102Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218D → Y in CAA10569 (PubMed:9790769).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02517717T → N1 PublicationCorresponds to variant dbSNP:rs33950336Ensembl.1
Natural variantiVAR_03126130V → A. Corresponds to variant dbSNP:rs2294760Ensembl.1
Natural variantiVAR_025178112D → E1 PublicationCorresponds to variant dbSNP:rs35993077Ensembl.1
Natural variantiVAR_025179241V → I1 PublicationCorresponds to variant dbSNP:rs33920182Ensembl.1
Natural variantiVAR_025180349T → S1 PublicationCorresponds to variant dbSNP:rs36092168Ensembl.1
Natural variantiVAR_023530404L → M7 PublicationsCorresponds to variant dbSNP:rs4895944Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0449121 – 53Missing in isoform 6. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_038554116 – 119FGHT → SAQC in isoform 5. 1 Publication4
Alternative sequenceiVSP_038555120 – 520Missing in isoform 5. 1 PublicationAdd BLAST401
Alternative sequenceiVSP_038557180 – 400Missing in isoform 2. 1 PublicationAdd BLAST221
Alternative sequenceiVSP_038556180 – 195YHLYS…PEKPE → EVVFMHQMVPKCIIMT in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_038558180 – 192YHLYS…FNVPE → ETLQSVKRSFAVI in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_038559193 – 520Missing in isoform 3. 1 PublicationAdd BLAST328
Alternative sequenceiVSP_038560196 – 520Missing in isoform 4. 1 PublicationAdd BLAST325

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132100 mRNA Translation: CAA10569.1
D89974 mRNA Translation: BAA82525.1
AB435062 mRNA Translation: BAG30934.1
AB435063 mRNA Translation: BAG30935.1
AB435064 mRNA Translation: BAG30936.1
AB435065 mRNA Translation: BAG30937.1
AB026705 mRNA Translation: BAB61019.1
AK290908 mRNA Translation: BAF83597.1
AK292125 mRNA Translation: BAF84814.1
DQ249347 Genomic DNA Translation: ABB72673.1
AL032821 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48016.1
BC126145 mRNA Translation: AAI26146.1
BC126147 mRNA Translation: AAI26148.1
CCDSiCCDS5161.1 [O95498-1]
CCDS5162.1 [O95498-6]
CCDS56451.1 [O95498-2]
RefSeqiNP_001229279.1, NM_001242350.2
NP_004656.2, NM_004665.4
NP_511043.1, NM_078488.2
XP_006715656.1, XM_006715593.3 [O95498-6]
XP_016866896.1, XM_017011407.1
UniGeneiHs.293130

Genome annotation databases

EnsembliENST00000326499; ENSP00000322276; ENSG00000112303 [O95498-1]
ENST00000525270; ENSP00000436822; ENSG00000112303 [O95498-6]
ENST00000525289; ENSP00000436935; ENSG00000112303 [O95498-2]
ENST00000525674; ENSP00000436863; ENSG00000112303 [O95498-4]
ENST00000532053; ENSP00000434077; ENSG00000112303 [O95498-3]
GeneIDi8875
KEGGihsa:8875
UCSCiuc003qdt.4 human [O95498-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132100 mRNA Translation: CAA10569.1
D89974 mRNA Translation: BAA82525.1
AB435062 mRNA Translation: BAG30934.1
AB435063 mRNA Translation: BAG30935.1
AB435064 mRNA Translation: BAG30936.1
AB435065 mRNA Translation: BAG30937.1
AB026705 mRNA Translation: BAB61019.1
AK290908 mRNA Translation: BAF83597.1
AK292125 mRNA Translation: BAF84814.1
DQ249347 Genomic DNA Translation: ABB72673.1
AL032821 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48016.1
BC126145 mRNA Translation: AAI26146.1
BC126147 mRNA Translation: AAI26148.1
CCDSiCCDS5161.1 [O95498-1]
CCDS5162.1 [O95498-6]
CCDS56451.1 [O95498-2]
RefSeqiNP_001229279.1, NM_001242350.2
NP_004656.2, NM_004665.4
NP_511043.1, NM_078488.2
XP_006715656.1, XM_006715593.3 [O95498-6]
XP_016866896.1, XM_017011407.1
UniGeneiHs.293130

3D structure databases

ProteinModelPortaliO95498
SMRiO95498
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114394, 45 interactors
STRINGi9606.ENSP00000322276

PTM databases

iPTMnetiO95498
PhosphoSitePlusiO95498

Polymorphism and mutation databases

BioMutaiVNN2

Proteomic databases

PaxDbiO95498
PeptideAtlasiO95498
PRIDEiO95498
ProteomicsDBi50925
50926 [O95498-2]
50927 [O95498-3]
50928 [O95498-4]
50929 [O95498-5]

Protocols and materials databases

DNASUi8875
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326499; ENSP00000322276; ENSG00000112303 [O95498-1]
ENST00000525270; ENSP00000436822; ENSG00000112303 [O95498-6]
ENST00000525289; ENSP00000436935; ENSG00000112303 [O95498-2]
ENST00000525674; ENSP00000436863; ENSG00000112303 [O95498-4]
ENST00000532053; ENSP00000434077; ENSG00000112303 [O95498-3]
GeneIDi8875
KEGGihsa:8875
UCSCiuc003qdt.4 human [O95498-1]

Organism-specific databases

CTDi8875
DisGeNETi8875
EuPathDBiHostDB:ENSG00000112303.13
GeneCardsiVNN2
HGNCiHGNC:12706 VNN2
MIMi603571 gene
neXtProtiNX_O95498
OpenTargetsiENSG00000112303
PharmGKBiPA37322
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0806 Eukaryota
COG0388 LUCA
GeneTreeiENSGT00390000013823
HOVERGENiHBG003996
InParanoidiO95498
KOiK08069
OMAiEYWQVCT
OrthoDBiEOG091G04QD
PhylomeDBiO95498
TreeFamiTF323645

Enzyme and pathway databases

BRENDAi3.5.1.92 2681
ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-199220 Vitamin B5 (pantothenate) metabolism

Miscellaneous databases

GeneWikiiVNN2
GenomeRNAii8875
PROiPR:O95498
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112303 Expressed in 127 organ(s), highest expression level in blood
CleanExiHS_VNN2
ExpressionAtlasiO95498 baseline and differential
GenevisibleiO95498 HS

Family and domain databases

CDDicd07567 biotinidase_like, 1 hit
Gene3Di3.60.110.10, 1 hit
InterProiView protein in InterPro
IPR012101 Biotinidase-like_euk
IPR003010 C-N_Hydrolase
IPR036526 C-N_Hydrolase_sf
PfamiView protein in Pfam
PF00795 CN_hydrolase, 1 hit
PIRSFiPIRSF011861 Biotinidase, 1 hit
SUPFAMiSSF56317 SSF56317, 1 hit
PROSITEiView protein in PROSITE
PS50263 CN_HYDROLASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVNN2_HUMAN
AccessioniPrimary (citable) accession number: O95498
Secondary accession number(s): A0AUZ3
, A6NDY1, A8K4E3, A8K7W0, B2DFZ0, B2DFZ1, B2DFZ2, B2DFZ3, F6XL73, Q2XUN1, Q9UJF3, Q9UMW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 20, 2007
Last modified: October 10, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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