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Protein

Vascular non-inflammatory molecule 2

Gene

VNN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei80Proton acceptorPROSITE-ProRule annotation1
Active sitei179Proton donorPROSITE-ProRule annotation1
Active sitei211NucleophilePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • pantetheine hydrolase activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.1.92 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-199220 Vitamin B5 (pantothenate) metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vascular non-inflammatory molecule 2 (EC:3.5.1.92)
Short name:
Vanin-2
Alternative name(s):
Glycosylphosphatidyl inositol-anchored protein GPI-80
Protein FOAP-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VNN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000112303.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12706 VNN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603571 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95498

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8875

Open Targets

More...
OpenTargetsi
ENSG00000112303

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37322

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VNN2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001971823 – 493Vascular non-inflammatory molecule 2Add BLAST471
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000019719494 – 520Removed in mature formSequence analysisAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi357N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi411N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi468N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi493GPI-anchor amidated cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95498

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95498

PeptideAtlas

More...
PeptideAtlasi
O95498

PRoteomics IDEntifications database

More...
PRIDEi
O95498

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50925
50926 [O95498-2]
50927 [O95498-3]
50928 [O95498-4]
50929 [O95498-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95498

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95498

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with higher expression in spleen and blood.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112303 Expressed in 127 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_VNN2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95498 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95498 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114394, 45 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000322276

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95498

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95498

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 306CN hydrolasePROSITE-ProRule annotationAdd BLAST276

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi393 – 396Poly-Arg4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0806 Eukaryota
COG0388 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013823

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG003996

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95498

KEGG Orthology (KO)

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KOi
K08069

Identification of Orthologs from Complete Genome Data

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OMAi
EYWQVCT

Database of Orthologous Groups

More...
OrthoDBi
1276751at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95498

TreeFam database of animal gene trees

More...
TreeFami
TF323645

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07567 biotinidase_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012101 Biotinidase-like_euk
IPR040154 Biotinidase/VNN
IPR003010 C-N_Hydrolase
IPR036526 C-N_Hydrolase_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10609 PTHR10609, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00795 CN_hydrolase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF011861 Biotinidase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56317 SSF56317, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50263 CN_HYDROLASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95498-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVTSSFPISV AVFALITLQV GTQDSFIAAV YEHAVILPNK TETPVSQEDA
60 70 80 90 100
LNLMNENIDI LETAIKQAAE QGARIIVTPE DALYGWKFTR ETVFPYLEDI
110 120 130 140 150
PDPQVNWIPC QDPHRFGHTP VQARLSCLAK DNSIYVLANL GDKKPCNSRD
160 170 180 190 200
STCPPNGYFQ YNTNVVYNTE GKLVARYHKY HLYSEPQFNV PEKPELVTFN
210 220 230 240 250
TAFGRFGIFT CFDIFFYDPG VTLVKDFHVD TILFPTAWMN VLPLLTAIEF
260 270 280 290 300
HSAWAMGMGV NLLVANTHHV SLNMTGSGIY APNGPKVYHY DMKTELGKLL
310 320 330 340 350
LSEVDSHPLS SLAYPTAVNW NAYATTIKPF PVQKNTFRGF ISRDGFNFTE
360 370 380 390 400
LFENAGNLTV CQKELCCHLS YRMLQKEENE VYVLGAFTGL HGRRRREYWQ
410 420 430 440 450
VCTLLKCKTT NLTTCGRPVE TASTRFEMFS LSGTFGTEYV FPEVLLTEIH
460 470 480 490 500
LSPGKFEVLK DGRLVNKNGS SGPILTVSLF GRWYTKDSLY SSCGTSNSAI
510 520
TYLLIFILLM IIALQNIVML
Length:520
Mass (Da):58,503
Last modified:March 20, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14460E1DE5B04870
GO
Isoform 2 (identifier: O95498-2) [UniParc]FASTAAdd to basket
Also known as: GPI-80 variant protein 3

The sequence of this isoform differs from the canonical sequence as follows:
     180-400: Missing.

Show »
Length:299
Mass (Da):33,239
Checksum:iB8314877CAEF51B7
GO
Isoform 3 (identifier: O95498-3) [UniParc]FASTAAdd to basket
Also known as: GPI-80 variant protein 2

The sequence of this isoform differs from the canonical sequence as follows:
     180-192: YHLYSEPQFNVPE → ETLQSVKRSFAVI
     193-520: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:192
Mass (Da):21,478
Checksum:iA961ABF6593C813D
GO
Isoform 4 (identifier: O95498-4) [UniParc]FASTAAdd to basket
Also known as: GPI-80 variant protein 1

The sequence of this isoform differs from the canonical sequence as follows:
     180-195: YHLYSEPQFNVPEKPE → EVVFMHQMVPKCIIMT
     196-520: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:195
Mass (Da):21,907
Checksum:i0E80EC968942F874
GO
Isoform 5 (identifier: O95498-5) [UniParc]FASTAAdd to basket
Also known as: GPI-80 variant protein 4

The sequence of this isoform differs from the canonical sequence as follows:
     116-119: FGHT → SAQC
     120-520: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:119
Mass (Da):13,247
Checksum:i0479B5ED49E725DB
GO
Isoform 6 (identifier: O95498-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Note: No experimental confirmation available.
Show »
Length:467
Mass (Da):52,844
Checksum:iC47D4720E11BF156
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QT03J3QT03_HUMAN
Vascular non-inflammatory molecule ...
VNN2
290Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DQB2B4DQB2_HUMAN
cDNA FLJ55137, highly similar to Va...
VNN2
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQ55J3KQ55_HUMAN
Vascular non-inflammatory molecule ...
VNN2
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQQ7J3KQQ7_HUMAN
Vascular non-inflammatory molecule ...
VNN2
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL76E9PL76_HUMAN
Vascular non-inflammatory molecule ...
VNN2
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK31E9PK31_HUMAN
Vascular non-inflammatory molecule ...
VNN2
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLK5E9PLK5_HUMAN
Vascular non-inflammatory molecule ...
VNN2
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRD9E9PRD9_HUMAN
Vascular non-inflammatory molecule ...
VNN2
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQ75E9PQ75_HUMAN
Vascular non-inflammatory molecule ...
VNN2
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti218D → Y in CAA10569 (PubMed:9790769).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02517717T → N1 PublicationCorresponds to variant dbSNP:rs33950336Ensembl.1
Natural variantiVAR_03126130V → A. Corresponds to variant dbSNP:rs2294760Ensembl.1
Natural variantiVAR_025178112D → E1 PublicationCorresponds to variant dbSNP:rs35993077Ensembl.1
Natural variantiVAR_025179241V → I1 PublicationCorresponds to variant dbSNP:rs33920182Ensembl.1
Natural variantiVAR_025180349T → S1 PublicationCorresponds to variant dbSNP:rs36092168Ensembl.1
Natural variantiVAR_023530404L → M7 PublicationsCorresponds to variant dbSNP:rs4895944Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0449121 – 53Missing in isoform 6. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_038554116 – 119FGHT → SAQC in isoform 5. 1 Publication4
Alternative sequenceiVSP_038555120 – 520Missing in isoform 5. 1 PublicationAdd BLAST401
Alternative sequenceiVSP_038557180 – 400Missing in isoform 2. 1 PublicationAdd BLAST221
Alternative sequenceiVSP_038556180 – 195YHLYS…PEKPE → EVVFMHQMVPKCIIMT in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_038558180 – 192YHLYS…FNVPE → ETLQSVKRSFAVI in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_038559193 – 520Missing in isoform 3. 1 PublicationAdd BLAST328
Alternative sequenceiVSP_038560196 – 520Missing in isoform 4. 1 PublicationAdd BLAST325

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ132100 mRNA Translation: CAA10569.1
D89974 mRNA Translation: BAA82525.1
AB435062 mRNA Translation: BAG30934.1
AB435063 mRNA Translation: BAG30935.1
AB435064 mRNA Translation: BAG30936.1
AB435065 mRNA Translation: BAG30937.1
AB026705 mRNA Translation: BAB61019.1
AK290908 mRNA Translation: BAF83597.1
AK292125 mRNA Translation: BAF84814.1
DQ249347 Genomic DNA Translation: ABB72673.1
AL032821 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48016.1
BC126145 mRNA Translation: AAI26146.1
BC126147 mRNA Translation: AAI26148.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5161.1 [O95498-1]
CCDS5162.1 [O95498-6]
CCDS56451.1 [O95498-2]

NCBI Reference Sequences

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RefSeqi
NP_001229279.1, NM_001242350.2
NP_004656.2, NM_004665.4
NP_511043.1, NM_078488.2
XP_006715656.1, XM_006715593.3 [O95498-6]
XP_016866896.1, XM_017011407.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.293130

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000326499; ENSP00000322276; ENSG00000112303 [O95498-1]
ENST00000525270; ENSP00000436822; ENSG00000112303 [O95498-6]
ENST00000525289; ENSP00000436935; ENSG00000112303 [O95498-2]
ENST00000525674; ENSP00000436863; ENSG00000112303 [O95498-4]
ENST00000532053; ENSP00000434077; ENSG00000112303 [O95498-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8875

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8875

UCSC genome browser

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UCSCi
uc003qdt.4 human [O95498-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132100 mRNA Translation: CAA10569.1
D89974 mRNA Translation: BAA82525.1
AB435062 mRNA Translation: BAG30934.1
AB435063 mRNA Translation: BAG30935.1
AB435064 mRNA Translation: BAG30936.1
AB435065 mRNA Translation: BAG30937.1
AB026705 mRNA Translation: BAB61019.1
AK290908 mRNA Translation: BAF83597.1
AK292125 mRNA Translation: BAF84814.1
DQ249347 Genomic DNA Translation: ABB72673.1
AL032821 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48016.1
BC126145 mRNA Translation: AAI26146.1
BC126147 mRNA Translation: AAI26148.1
CCDSiCCDS5161.1 [O95498-1]
CCDS5162.1 [O95498-6]
CCDS56451.1 [O95498-2]
RefSeqiNP_001229279.1, NM_001242350.2
NP_004656.2, NM_004665.4
NP_511043.1, NM_078488.2
XP_006715656.1, XM_006715593.3 [O95498-6]
XP_016866896.1, XM_017011407.1
UniGeneiHs.293130

3D structure databases

ProteinModelPortaliO95498
SMRiO95498
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114394, 45 interactors
STRINGi9606.ENSP00000322276

PTM databases

iPTMnetiO95498
PhosphoSitePlusiO95498

Polymorphism and mutation databases

BioMutaiVNN2

Proteomic databases

jPOSTiO95498
PaxDbiO95498
PeptideAtlasiO95498
PRIDEiO95498
ProteomicsDBi50925
50926 [O95498-2]
50927 [O95498-3]
50928 [O95498-4]
50929 [O95498-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8875
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326499; ENSP00000322276; ENSG00000112303 [O95498-1]
ENST00000525270; ENSP00000436822; ENSG00000112303 [O95498-6]
ENST00000525289; ENSP00000436935; ENSG00000112303 [O95498-2]
ENST00000525674; ENSP00000436863; ENSG00000112303 [O95498-4]
ENST00000532053; ENSP00000434077; ENSG00000112303 [O95498-3]
GeneIDi8875
KEGGihsa:8875
UCSCiuc003qdt.4 human [O95498-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8875
DisGeNETi8875
EuPathDBiHostDB:ENSG00000112303.13

GeneCards: human genes, protein and diseases

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GeneCardsi
VNN2
HGNCiHGNC:12706 VNN2
MIMi603571 gene
neXtProtiNX_O95498
OpenTargetsiENSG00000112303
PharmGKBiPA37322

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0806 Eukaryota
COG0388 LUCA
GeneTreeiENSGT00390000013823
HOVERGENiHBG003996
InParanoidiO95498
KOiK08069
OMAiEYWQVCT
OrthoDBi1276751at2759
PhylomeDBiO95498
TreeFamiTF323645

Enzyme and pathway databases

BRENDAi3.5.1.92 2681
ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-199220 Vitamin B5 (pantothenate) metabolism

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
VNN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8875

Protein Ontology

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PROi
PR:O95498

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112303 Expressed in 127 organ(s), highest expression level in blood
CleanExiHS_VNN2
ExpressionAtlasiO95498 baseline and differential
GenevisibleiO95498 HS

Family and domain databases

CDDicd07567 biotinidase_like, 1 hit
Gene3Di3.60.110.10, 1 hit
InterProiView protein in InterPro
IPR012101 Biotinidase-like_euk
IPR040154 Biotinidase/VNN
IPR003010 C-N_Hydrolase
IPR036526 C-N_Hydrolase_sf
PANTHERiPTHR10609 PTHR10609, 1 hit
PfamiView protein in Pfam
PF00795 CN_hydrolase, 1 hit
PIRSFiPIRSF011861 Biotinidase, 1 hit
SUPFAMiSSF56317 SSF56317, 1 hit
PROSITEiView protein in PROSITE
PS50263 CN_HYDROLASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVNN2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95498
Secondary accession number(s): A0AUZ3
, A6NDY1, A8K4E3, A8K7W0, B2DFZ0, B2DFZ1, B2DFZ2, B2DFZ3, F6XL73, Q2XUN1, Q9UJF3, Q9UMW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 20, 2007
Last modified: January 16, 2019
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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