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Protein

Pantetheinase

Gene

VNN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.3 Publications

Catalytic activityi

(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79Proton acceptorPROSITE-ProRule annotation1 Publication1
Active sitei178Proton donorPROSITE-ProRule annotation1 Publication1
Active sitei211NucleophilePROSITE-ProRule annotation1 Publication1

GO - Molecular functioni

  • pantetheine hydrolase activity Source: UniProtKB

GO - Biological processi

  • acute inflammatory response Source: BHF-UCL
  • cell-cell adhesion Source: BHF-UCL
  • chronic inflammatory response Source: BHF-UCL
  • inflammatory response Source: BHF-UCL
  • innate immune response Source: BHF-UCL
  • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: BHF-UCL
  • neutrophil degranulation Source: Reactome
  • pantothenate metabolic process Source: UniProtKB
  • positive regulation of T cell differentiation in thymus Source: BHF-UCL
  • response to oxidative stress Source: BHF-UCL

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDAi3.5.1.92 2681
ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-199220 Vitamin B5 (pantothenate) metabolism
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Pantetheinase (EC:3.5.1.922 Publications)
Alternative name(s):
Pantetheine hydrolase
Tiff66
Vascular non-inflammatory molecule 1
Short name:
Vanin-1
Gene namesi
Name:VNN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112299.7
HGNCiHGNC:12705 VNN1
MIMi603570 gene
neXtProtiNX_O95497

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi79E → A: Abolishes enzyme activity. 1 Publication1
Mutagenesisi178K → A: Abolishes enzyme activity. 1 Publication1

Organism-specific databases

DisGeNETi8876
OpenTargetsiENSG00000112299
PharmGKBiPA37321

Polymorphism and mutation databases

BioMutaiVNN1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001971222 – 491PantetheinaseAdd BLAST470
PropeptideiPRO_0000019713492 – 513Removed in mature formSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi130N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysisCombined sources1
Glycosylationi283N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi315N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi353N-linked (GlcNAc...) asparagineCombined sources3 Publications1
Lipidationi491GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO95497
PeptideAtlasiO95497
PRIDEiO95497
ProteomicsDBi50924

PTM databases

iPTMnetiO95497
PhosphoSitePlusiO95497

Expressioni

Tissue specificityi

Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin.1 Publication

Inductioni

By Th17/Th1 type cytokines, but not by Th2-type.1 Publication

Gene expression databases

BgeeiENSG00000112299
CleanExiHS_VNN1
GenevisibleiO95497 HS

Organism-specific databases

HPAiHPA064145

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi114395, 9 interactors
STRINGi9606.ENSP00000356905

Structurei

Secondary structure

1513
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 32Combined sources9
Helixi46 – 68Combined sources23
Turni69 – 71Combined sources3
Beta strandi73 – 76Combined sources4
Turni79 – 83Combined sources5
Helixi89 – 92Combined sources4
Helixi93 – 95Combined sources3
Helixi102 – 104Combined sources3
Turni108 – 110Combined sources3
Turni112 – 115Combined sources4
Helixi119 – 130Combined sources12
Beta strandi134 – 144Combined sources11
Beta strandi156 – 166Combined sources11
Beta strandi172 – 177Combined sources6
Beta strandi198 – 201Combined sources4
Beta strandi204 – 208Combined sources5
Helixi211 – 215Combined sources5
Turni217 – 219Combined sources3
Helixi220 – 225Combined sources6
Beta strandi230 – 236Combined sources7
Turni242 – 244Combined sources3
Helixi247 – 258Combined sources12
Beta strandi261 – 267Combined sources7
Helixi270 – 272Combined sources3
Beta strandi277 – 280Combined sources4
Beta strandi282 – 289Combined sources8
Beta strandi298 – 307Combined sources10
Helixi318 – 321Combined sources4
Beta strandi332 – 337Combined sources6
Beta strandi340 – 346Combined sources7
Beta strandi349 – 358Combined sources10
Beta strandi361 – 371Combined sources11
Beta strandi378 – 387Combined sources10
Beta strandi393 – 402Combined sources10
Beta strandi404 – 407Combined sources4
Helixi408 – 410Combined sources3
Beta strandi422 – 429Combined sources8
Beta strandi436 – 442Combined sources7
Helixi443 – 445Combined sources3
Beta strandi451 – 454Combined sources4
Beta strandi460 – 465Combined sources6
Beta strandi470 – 478Combined sources9
Helixi480 – 482Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CYFX-ray2.25A/B22-513[»]
4CYGX-ray2.30A/B22-513[»]
4CYYX-ray2.89A27-513[»]
ProteinModelPortaliO95497
SMRiO95497
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 306CN hydrolasePROSITE-ProRule annotationAdd BLAST268

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0806 Eukaryota
COG0388 LUCA
GeneTreeiENSGT00390000013823
HOVERGENiHBG003996
InParanoidiO95497
KOiK08069
OMAiVVNWTSY
OrthoDBiEOG091G04QD
PhylomeDBiO95497
TreeFamiTF323645

Family and domain databases

CDDicd07567 biotinidase_like, 1 hit
Gene3Di3.60.110.10, 1 hit
InterProiView protein in InterPro
IPR012101 Biotinidase-like_euk
IPR003010 C-N_Hydrolase
IPR036526 C-N_Hydrolase_sf
PfamiView protein in Pfam
PF00795 CN_hydrolase, 1 hit
PIRSFiPIRSF011861 Biotinidase, 1 hit
SUPFAMiSSF56317 SSF56317, 1 hit
PROSITEiView protein in PROSITE
PS50263 CN_HYDROLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQLPAYVA ILLFYVSRAS CQDTFTAAVY EHAAILPNAT LTPVSREEAL
60 70 80 90 100
ALMNRNLDIL EGAITSAADQ GAHIIVTPED AIYGWNFNRD SLYPYLEDIP
110 120 130 140 150
DPEVNWIPCN NRNRFGQTPV QERLSCLAKN NSIYVVANIG DKKPCDTSDP
160 170 180 190 200
QCPPDGRYQY NTDVVFDSQG KLVARYHKQN LFMGENQFNV PKEPEIVTFN
210 220 230 240 250
TTFGSFGIFT CFDILFHDPA VTLVKDFHVD TIVFPTAWMN VLPHLSAVEF
260 270 280 290 300
HSAWAMGMRV NFLASNIHYP SKKMTGSGIY APNSSRAFHY DMKTEEGKLL
310 320 330 340 350
LSQLDSHPSH SAVVNWTSYA SSIEALSSGN KEFKGTVFFD EFTFVKLTGV
360 370 380 390 400
AGNYTVCQKD LCCHLSYKMS ENIPNEVYAL GAFDGLHTVE GRYYLQICTL
410 420 430 440 450
LKCKTTNLNT CGDSAETAST RFEMFSLSGT FGTQYVFPEV LLSENQLAPG
460 470 480 490 500
EFQVSTDGRL FSLKPTSGPV LTVTLFGRLY EKDWASNASS GLTAQARIIM
510
LIVIAPIVCS LSW
Length:513
Mass (Da):57,012
Last modified:September 27, 2005 - v2
Checksum:i018D2417C12E403F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101D → N in AAH96268 (PubMed:15489334).Curated1
Sequence conflicti113N → I in AAY88742 (Ref. 4) Curated1
Sequence conflicti423E → D in AAF21453 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02352926T → I4 PublicationsCorresponds to variant dbSNP:rs2294757Ensembl.1
Natural variantiVAR_02396763A → T1 Publication1
Natural variantiVAR_023968131N → S2 PublicationsCorresponds to variant dbSNP:rs2272996Ensembl.1
Natural variantiVAR_023969136V → L1 PublicationCorresponds to variant dbSNP:rs45610032Ensembl.1
Natural variantiVAR_023970146D → N1 PublicationCorresponds to variant dbSNP:rs45624336Ensembl.1
Natural variantiVAR_023971296E → D1 PublicationCorresponds to variant dbSNP:rs45523444Ensembl.1
Natural variantiVAR_023972325A → E1 PublicationCorresponds to variant dbSNP:rs34535050Ensembl.1
Natural variantiVAR_023973336T → A1 PublicationCorresponds to variant dbSNP:rs45562238Ensembl.1
Natural variantiVAR_023974373I → T1 PublicationCorresponds to variant dbSNP:rs35938565Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132099 mRNA Translation: CAA10568.1
U39664 mRNA Translation: AAF21453.1
AK290425 mRNA Translation: BAF83114.1
DQ100297 Genomic DNA Translation: AAY88742.1
AL032821 Genomic DNA No translation available.
BC096265 mRNA Translation: AAH96265.1
BC096266 mRNA Translation: AAH96266.1
BC096267 mRNA Translation: AAH96267.1
BC096268 mRNA Translation: AAH96268.1
CCDSiCCDS5159.1
RefSeqiNP_004657.2, NM_004666.2
UniGeneiHs.12114
Hs.720659

Genome annotation databases

EnsembliENST00000367928; ENSP00000356905; ENSG00000112299
GeneIDi8876
KEGGihsa:8876
UCSCiuc003qdo.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVNN1_HUMAN
AccessioniPrimary (citable) accession number: O95497
Secondary accession number(s): A8K310
, Q4JFW6, Q4VAS7, Q4VAS8, Q4VAS9, Q9UF16, Q9UJF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: September 27, 2005
Last modified: June 20, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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