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Protein

Adhesion G protein-coupled receptor L2

Gene

ADGRL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.By similarity

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • G-protein coupled receptor activity Source: GDB
  • latrotoxin receptor activity Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • G-protein coupled receptor signaling pathway Source: GDB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLectin

Protein family/group databases

MEROPSiP02.009

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor L21 Publication
Alternative name(s):
Calcium-independent alpha-latrotoxin receptor 2
Short name:
CIRL-2
Latrophilin homolog 1
Latrophilin-2
Lectomedin-1
Gene namesi
Name:ADGRL2Imported
Synonyms:KIAA0786, LEC1, LPHH1, LPHN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117114.19
HGNCiHGNC:18582 ADGRL2
MIMi607018 gene
neXtProtiNX_O95490

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 851ExtracellularCuratedAdd BLAST826
Transmembranei852 – 872Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini873 – 880CytoplasmicCurated8
Transmembranei881 – 901Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini902 – 907ExtracellularCurated6
Transmembranei908 – 928Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini929 – 952CytoplasmicCuratedAdd BLAST24
Transmembranei953 – 973Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini974 – 990ExtracellularCuratedAdd BLAST17
Transmembranei991 – 1011Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1012 – 1037CytoplasmicCuratedAdd BLAST26
Transmembranei1038 – 1058Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1059 – 1062ExtracellularCurated4
Transmembranei1063 – 1083Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1084 – 1459CytoplasmicCuratedAdd BLAST376

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23266
OpenTargetsiENSG00000117114
PharmGKBiPA38589

Polymorphism and mutation databases

BioMutaiLPHN2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001291026 – 1459Adhesion G protein-coupled receptor L2Add BLAST1434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi136 ↔ 318PROSITE-ProRule annotation
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi520N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi629N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi731N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi744N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi787N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi792N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi813N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1374PhosphoserineBy similarity1
Modified residuei1409PhosphoserineBy similarity1
Modified residuei1430PhosphoserineCombined sources1

Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei824 – 825CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO95490
MaxQBiO95490
PaxDbiO95490
PeptideAtlasiO95490
PRIDEiO95490
ProteomicsDBi50917
50918 [O95490-2]
50919 [O95490-3]
50920 [O95490-4]
50921 [O95490-5]
50922 [O95490-6]
50923 [O95490-7]

PTM databases

iPTMnetiO95490
PhosphoSitePlusiO95490

Expressioni

Tissue specificityi

Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.1 Publication

Gene expression databases

BgeeiENSG00000117114
CleanExiHS_LPHN2
ExpressionAtlasiO95490 baseline and differential
GenevisibleiO95490 HS

Organism-specific databases

HPAiHPA043447

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.By similarity

Protein-protein interaction databases

BioGridi116868, 12 interactors
IntActiO95490, 9 interactors
MINTiO95490
STRINGi9606.ENSP00000322270

Structurei

3D structure databases

ProteinModelPortaliO95490
SMRiO95490
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 130SUEL-type lectinPROSITE-ProRule annotationAdd BLAST90
Domaini135 – 394Olfactomedin-likePROSITE-ProRule annotationAdd BLAST260
Domaini784 – 836GPSPROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3545 Eukaryota
KOG4193 Eukaryota
KOG4729 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00900000140800
HOGENOMiHOG000049065
HOVERGENiHBG052337
InParanoidiO95490
KOiK04593
OMAiYFNANCS
OrthoDBiEOG091G00GJ
PhylomeDBiO95490
TreeFamiTF351999

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003924 GPCR_2_latrophilin
IPR003334 GPCR_2_latrophilin_rcpt_C
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR031240 Latrophilin-2
IPR000922 Lectin_gal-bd_dom
IPR003112 Olfac-like_dom
PANTHERiPTHR12011:SF61 PTHR12011:SF61, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF02140 Gal_Lectin, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF02354 Latrophilin, 1 hit
PF02191 OLF, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR01444 LATROPHILIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00284 OLF, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51132 OLF, 1 hit
PS50228 SUEL_LECTIN, 1 hit

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95490-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSSGCRMRS LWFIIVISFL PNTEGFSRAA LPFGLVRREL SCEGYSIDLR
60 70 80 90 100
CPGSDVIMIE SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR
110 120 130 140 150
TQCIVVTGSD VFPDPCPGTY KYLEVQYECV PYIFVCPGTL KAIVDSPCIY
160 170 180 190 200
EAEQKAGAWC KDPLQAADKI YFMPWTPYRT DTLIEYASLE DFQNSRQTTT
210 220 230 240 250
YKLPNRVDGT GFVVYDGAVF FNKERTRNIV KFDLRTRIKS GEAIINYANY
260 270 280 290 300
HDTSPYRWGG KTDIDLAVDE NGLWVIYATE QNNGMIVISQ LNPYTLRFEA
310 320 330 340 350
TWETVYDKRA ASNAFMICGV LYVVRSVYQD NESETGKNSI DYIYNTRLNR
360 370 380 390 400
GEYVDVPFPN QYQYIAAVDY NPRDNQLYVW NNNFILRYSL EFGPPDPAQV
410 420 430 440 450
PTTAVTITSS AELFKTIIST TSTTSQKGPM STTVAGSQEG SKGTKPPPAV
460 470 480 490 500
STTKIPPITN IFPLPERFCE ALDSKGIKWP QTQRGMMVER PCPKGTRGTA
510 520 530 540 550
SYLCMISTGT WNPKGPDLSN CTSHWVNQLA QKIRSGENAA SLANELAKHT
560 570 580 590 600
KGPVFAGDVS SSVRLMEQLV DILDAQLQEL KPSEKDSAGR SYNKLQKREK
610 620 630 640 650
TCRAYLKAIV DTVDNLLRPE ALESWKHMNS SEQAHTATML LDTLEEGAFV
660 670 680 690 700
LADNLLEPTR VSMPTENIVL EVAVLSTEGQ IQDFKFPLGI KGAGSSIQLS
710 720 730 740 750
ANTVKQNSRN GLAKLVFIIY RSLGQFLSTE NATIKLGADF IGRNSTIAVN
760 770 780 790 800
SHVISVSINK ESSRVYLTDP VLFTLPHIDP DNYFNANCSF WNYSERTMMG
810 820 830 840 850
YWSTQGCKLV DTNKTRTTCA CSHLTNFAIL MAHREIAYKD GVHELLLTVI
860 870 880 890 900
TWVGIVISLV CLAICIFTFC FFRGLQSDRN TIHKNLCINL FIAEFIFLIG
910 920 930 940 950
IDKTKYAIAC PIFAGLLHFF FLAAFAWMCL EGVQLYLMLV EVFESEYSRK
960 970 980 990 1000
KYYYVAGYLF PATVVGVSAA IDYKSYGTEK ACWLHVDNYF IWSFIGPVTF
1010 1020 1030 1040 1050
IILLNIIFLV ITLCKMVKHS NTLKPDSSRL ENIKSWVLGA FALLCLLGLT
1060 1070 1080 1090 1100
WSFGLLFINE ETIVMAYLFT IFNAFQGVFI FIFHCALQKK VRKEYGKCFR
1110 1120 1130 1140 1150
HSYCCGGLPT ESPHSSVKAS TTRTSARYSS GTQSRIRRMW NDTVRKQSES
1160 1170 1180 1190 1200
SFISGDINST STLNQGMTGN YLLTNPLLRP HGTNNPYNTL LAETVVCNAP
1210 1220 1230 1240 1250
SAPVFNSPGH SLNNARDTSA MDTLPLNGNF NNSYSLHKGD YNDSVQVVDC
1260 1270 1280 1290 1300
GLSLNDTAFE KMIISELVHN NLRGSSKTHN LELTLPVKPV IGGSSSEDDA
1310 1320 1330 1340 1350
IVADASSLMH SDNPGLELHH KELEAPLIPQ RTHSLLYQPQ KKVKSEGTDS
1360 1370 1380 1390 1400
YVSQLTAEAE DHLQSPNRDS LYTSMPNLRD SPYPESSPDM EEDLSPSRRS
1410 1420 1430 1440 1450
ENEDIYYKSM PNLGAGHQLQ MCYQISRGNS DGYIIPINKE GCIPEGDVRE

GQMQLVTSL
Length:1,459
Mass (Da):163,349
Last modified:April 26, 2004 - v2
Checksum:i30707B7C3C069029
GO
Isoform 2 (identifier: O95490-2) [UniParc]FASTAAdd to basket
Also known as: Lectomedin-1 gamma

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1167-1209: Missing.

Show »
Length:1,403
Mass (Da):157,178
Checksum:iCE43AB82916D0D35
GO
Isoform 3 (identifier: O95490-3) [UniParc]FASTAAdd to basket
Also known as: Lectomedin-1 beta

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1134-1136: SRI → DIH
     1137-1459: Missing.

Show »
Length:1,123
Mass (Da):126,163
Checksum:i21DB98B51EBDF4EC
GO
Isoform 4 (identifier: O95490-4) [UniParc]FASTAAdd to basket
Also known as: Lectomedin-1 alpha

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1167-1209: Missing.
     1210-1233: HSLNNARDTSAMDTLPLNGNFNNS → LTSHGLRAHLQDLYHLELLLGQIA
     1234-1459: Missing.

Show »
Length:1,177
Mass (Da):132,245
Checksum:i6D099178841E1E3A
GO
Isoform 5 (identifier: O95490-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1167-1209: Missing.

Note: No experimental confirmation.
Show »
Length:1,416
Mass (Da):158,797
Checksum:iFB5C1C0A9A9ED3C5
GO
Isoform 6 (identifier: O95490-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1034-1034: K → NNYRVCDGYYNTDLPG

Show »
Length:1,474
Mass (Da):165,067
Checksum:iA78543DA2A149746
GO
Isoform 7 (identifier: O95490-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1034-1034: K → NNYRVCDGYYNTDLPG

Note: No experimental confirmation.
Show »
Length:1,461
Mass (Da):163,448
Checksum:iB528698BA07BBC46
GO

Sequence cautioni

The sequence CAI22406 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1059N → S in ABL59902 (PubMed:17456239).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077836467R → T Found in a child with sporadic epilepsy; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010104595 – 607Missing in isoform 2, isoform 3, isoform 4 and isoform 7. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_0422671034K → NNYRVCDGYYNTDLPG in isoform 6 and isoform 7. 1 Publication1
Alternative sequenceiVSP_0101051134 – 1136SRI → DIH in isoform 3. 1 Publication3
Alternative sequenceiVSP_0101061137 – 1459Missing in isoform 3. 1 PublicationAdd BLAST323
Alternative sequenceiVSP_0101071167 – 1209Missing in isoform 2, isoform 4 and isoform 5. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_0101081210 – 1233HSLNN…NFNNS → LTSHGLRAHLQDLYHLELLL GQIA in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0101091234 – 1459Missing in isoform 4. 1 PublicationAdd BLAST226

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131581 mRNA Translation: CAA10458.1
AJ244492
, AJ244493, AJ244494, AJ244496, AJ244497, AJ244498, AJ244499, AJ244501, AJ244502, AJ244503, AJ244504, AJ244505, AJ244506, AJ244507, AJ244510, AJ244511, AJ244512, AJ244516 Genomic DNA Translation: CAB60229.1
AF104266 mRNA Translation: AAD54675.1
AF104938 mRNA Translation: AAD54676.1
AF104939 mRNA Translation: AAD54677.1
AL359705, AC113949, AL157903 Genomic DNA Translation: CAH71340.1
AL359705, AC113949, AL157903 Genomic DNA Translation: CAH71341.1
AL359705, AC113949, AL157903 Genomic DNA Translation: CAH71342.1
AL359705, AC113949, AL157903 Genomic DNA Translation: CAH71343.1
AL359705, AC113949, AL157903 Genomic DNA Translation: CAH71345.1
AL359705, AC113949, AL157903 Genomic DNA Translation: CAH71346.1
AL359705, AC113949, AL157903 Genomic DNA Translation: CAH71347.1
AL157903, AC113949, AL359705 Genomic DNA Translation: CAI22397.1
AL157903, AC113949, AL359705 Genomic DNA Translation: CAI22398.1
AL157903, AC113949, AL359705 Genomic DNA Translation: CAI22399.1
AL157903, AC113949, AL359705 Genomic DNA Translation: CAI22401.1
AL157903, AC113949, AL359705 Genomic DNA Translation: CAI22402.1
AL157903, AC113949, AL359705 Genomic DNA Translation: CAI22403.1
AL157903, AC113949, AL359705 Genomic DNA Translation: CAI22405.1
AL157903, AC113949 Genomic DNA Translation: CAI22406.1 Sequence problems.
CH471059 Genomic DNA Translation: EAX06327.1
CH471059 Genomic DNA Translation: EAX06330.1
CH471059 Genomic DNA Translation: EAX06333.1
CH471059 Genomic DNA Translation: EAX06335.1
CH471059 Genomic DNA Translation: EAX06336.1
CH471059 Genomic DNA Translation: EAX06339.1
AB018329 mRNA Translation: BAA34506.1
DQ925675 mRNA Translation: ABL59902.1
CCDSiCCDS689.1 [O95490-2]
CCDS72811.1 [O95490-4]
CCDS76174.1 [O95490-3]
CCDS81345.1 [O95490-5]
RefSeqiNP_001284633.1, NM_001297704.1 [O95490-2]
NP_001284634.1, NM_001297705.1 [O95490-4]
NP_001284635.1, NM_001297706.1 [O95490-3]
NP_001317574.1, NM_001330645.1 [O95490-5]
NP_036434.1, NM_012302.3 [O95490-2]
XP_005270723.1, XM_005270666.4 [O95490-1]
XP_016856276.1, XM_017000787.1 [O95490-1]
UniGeneiHs.24212
Hs.406863
Hs.649282

Genome annotation databases

EnsembliENST00000319517; ENSP00000322270; ENSG00000117114 [O95490-2]
ENST00000359929; ENSP00000353006; ENSG00000117114 [O95490-2]
ENST00000370713; ENSP00000359748; ENSG00000117114 [O95490-3]
ENST00000370715; ENSP00000359750; ENSG00000117114 [O95490-4]
ENST00000370717; ENSP00000359752; ENSG00000117114 [O95490-1]
ENST00000370723; ENSP00000359758; ENSG00000117114 [O95490-7]
ENST00000370725; ENSP00000359760; ENSG00000117114 [O95490-6]
ENST00000370728; ENSP00000359763; ENSG00000117114 [O95490-1]
ENST00000370730; ENSP00000359765; ENSG00000117114 [O95490-5]
GeneIDi23266
KEGGihsa:23266
UCSCiuc001dit.5 human [O95490-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAGRL2_HUMAN
AccessioniPrimary (citable) accession number: O95490
Secondary accession number(s): A5XEI2
, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, Q5VX76, Q9UKY5, Q9UKY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: July 18, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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