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UniProtKB - O95490 (AGRL2_HUMAN)

Entry version 162 (13 Feb 2019)
Sequence version 2 (26 Apr 2004)
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Protein

Adhesion G protein-coupled receptor L2

Gene

ADGRL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • G protein-coupled receptor activity Source: GO_Central
  • latrotoxin receptor activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLectin

Protein family/group databases

MEROPS protease database

More...MEROPSi		P02.009

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G protein-coupled receptor L21 Publication
Alternative name(s):
Calcium-independent alpha-latrotoxin receptor 2
Short name:
CIRL-2
Latrophilin homolog 1
Latrophilin-2
Lectomedin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRL2Imported
Synonyms:KIAA0786, LEC1, LPHH1, LPHN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000117114.19

Human Gene Nomenclature Database

More...HGNCi		HGNC:18582 ADGRL2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607018 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95490

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 851ExtracellularCuratedAdd BLAST826
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei852 – 872Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini873 – 880CytoplasmicCurated8
Transmembranei881 – 901Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini902 – 907ExtracellularCurated6
Transmembranei908 – 928Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini929 – 952CytoplasmicCuratedAdd BLAST24
Transmembranei953 – 973Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini974 – 990ExtracellularCuratedAdd BLAST17
Transmembranei991 – 1011Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1012 – 1037CytoplasmicCuratedAdd BLAST26
Transmembranei1038 – 1058Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1059 – 1062ExtracellularCurated4
Transmembranei1063 – 1083Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1084 – 1459CytoplasmicCuratedAdd BLAST376

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23266

Open Targets

More...OpenTargetsi		ENSG00000117114

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38589

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADGRL2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001291026 – 1459Adhesion G protein-coupled receptor L2Add BLAST1434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi136 ↔ 318PROSITE-ProRule annotation
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi520N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi629N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi731N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi744N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi787N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi792N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi813N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1374PhosphoserineBy similarity1
Modified residuei1409PhosphoserineBy similarity1
Modified residuei1430PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei824 – 825CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95490

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95490

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95490

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95490

PeptideAtlas

More...PeptideAtlasi		O95490

PRoteomics IDEntifications database

More...PRIDEi		O95490

ProteomicsDB human proteome resource

More...ProteomicsDBi		50917
50918 [O95490-2]
50919 [O95490-3]
50920 [O95490-4]
50921 [O95490-5]
50922 [O95490-6]
50923 [O95490-7]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		994

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95490

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95490

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000117114 Expressed in 103 organ(s), highest expression level in right lung

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95490 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95490 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA043447

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		116868, 13 interactors

Protein interaction database and analysis system

More...IntActi		O95490, 9 interactors

Molecular INTeraction database

More...MINTi		O95490

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000322270

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O95490

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95490

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 130SUEL-type lectinPROSITE-ProRule annotationAdd BLAST90
Domaini135 – 394Olfactomedin-likePROSITE-ProRule annotationAdd BLAST260
Domaini784 – 836GPSPROSITE-ProRule annotationAdd BLAST53

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3545 Eukaryota
KOG4193 Eukaryota
KOG4729 Eukaryota
ENOG410XSD2 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156348

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000049065

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG052337

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95490

KEGG Orthology (KO)

More...KOi		K04593

Identification of Orthologs from Complete Genome Data

More...OMAi		LQMYYQI

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95490

TreeFam database of animal gene trees

More...TreeFami		TF351999

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003924 GPCR_2_latrophilin
IPR003334 GPCR_2_latrophilin_rcpt_C
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR031240 Latrophilin-2
IPR000922 Lectin_gal-bd_dom
IPR003112 Olfac-like_dom

The PANTHER Classification System

More...PANTHERi		PTHR12011:SF61 PTHR12011:SF61, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF02140 Gal_Lectin, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF02354 Latrophilin, 1 hit
PF02191 OLF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00249 GPCRSECRETIN
PR01444 LATROPHILIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00284 OLF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111418 SSF111418, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51132 OLF, 1 hit
PS50228 SUEL_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95490-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSSGCRMRS LWFIIVISFL PNTEGFSRAA LPFGLVRREL SCEGYSIDLR 
        60         70         80         90        100
CPGSDVIMIE SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR 
       110        120        130        140        150
TQCIVVTGSD VFPDPCPGTY KYLEVQYECV PYIFVCPGTL KAIVDSPCIY 
       160        170        180        190        200
EAEQKAGAWC KDPLQAADKI YFMPWTPYRT DTLIEYASLE DFQNSRQTTT 
       210        220        230        240        250
YKLPNRVDGT GFVVYDGAVF FNKERTRNIV KFDLRTRIKS GEAIINYANY 
       260        270        280        290        300
HDTSPYRWGG KTDIDLAVDE NGLWVIYATE QNNGMIVISQ LNPYTLRFEA 
       310        320        330        340        350
TWETVYDKRA ASNAFMICGV LYVVRSVYQD NESETGKNSI DYIYNTRLNR 
       360        370        380        390        400
GEYVDVPFPN QYQYIAAVDY NPRDNQLYVW NNNFILRYSL EFGPPDPAQV 
       410        420        430        440        450
PTTAVTITSS AELFKTIIST TSTTSQKGPM STTVAGSQEG SKGTKPPPAV 
       460        470        480        490        500
STTKIPPITN IFPLPERFCE ALDSKGIKWP QTQRGMMVER PCPKGTRGTA 
       510        520        530        540        550
SYLCMISTGT WNPKGPDLSN CTSHWVNQLA QKIRSGENAA SLANELAKHT 
       560        570        580        590        600
KGPVFAGDVS SSVRLMEQLV DILDAQLQEL KPSEKDSAGR SYNKLQKREK 
       610        620        630        640        650
TCRAYLKAIV DTVDNLLRPE ALESWKHMNS SEQAHTATML LDTLEEGAFV 
       660        670        680        690        700
LADNLLEPTR VSMPTENIVL EVAVLSTEGQ IQDFKFPLGI KGAGSSIQLS 
       710        720        730        740        750
ANTVKQNSRN GLAKLVFIIY RSLGQFLSTE NATIKLGADF IGRNSTIAVN 
       760        770        780        790        800
SHVISVSINK ESSRVYLTDP VLFTLPHIDP DNYFNANCSF WNYSERTMMG 
       810        820        830        840        850
YWSTQGCKLV DTNKTRTTCA CSHLTNFAIL MAHREIAYKD GVHELLLTVI 
       860        870        880        890        900
TWVGIVISLV CLAICIFTFC FFRGLQSDRN TIHKNLCINL FIAEFIFLIG 
       910        920        930        940        950
IDKTKYAIAC PIFAGLLHFF FLAAFAWMCL EGVQLYLMLV EVFESEYSRK 
       960        970        980        990       1000
KYYYVAGYLF PATVVGVSAA IDYKSYGTEK ACWLHVDNYF IWSFIGPVTF 
      1010       1020       1030       1040       1050
IILLNIIFLV ITLCKMVKHS NTLKPDSSRL ENIKSWVLGA FALLCLLGLT 
      1060       1070       1080       1090       1100
WSFGLLFINE ETIVMAYLFT IFNAFQGVFI FIFHCALQKK VRKEYGKCFR 
      1110       1120       1130       1140       1150
HSYCCGGLPT ESPHSSVKAS TTRTSARYSS GTQSRIRRMW NDTVRKQSES 
      1160       1170       1180       1190       1200
SFISGDINST STLNQGMTGN YLLTNPLLRP HGTNNPYNTL LAETVVCNAP 
      1210       1220       1230       1240       1250
SAPVFNSPGH SLNNARDTSA MDTLPLNGNF NNSYSLHKGD YNDSVQVVDC 
      1260       1270       1280       1290       1300
GLSLNDTAFE KMIISELVHN NLRGSSKTHN LELTLPVKPV IGGSSSEDDA 
      1310       1320       1330       1340       1350
IVADASSLMH SDNPGLELHH KELEAPLIPQ RTHSLLYQPQ KKVKSEGTDS 
      1360       1370       1380       1390       1400
YVSQLTAEAE DHLQSPNRDS LYTSMPNLRD SPYPESSPDM EEDLSPSRRS 
      1410       1420       1430       1440       1450
ENEDIYYKSM PNLGAGHQLQ MCYQISRGNS DGYIIPINKE GCIPEGDVRE 

GQMQLVTSL
Length:1,459
Mass (Da):163,349
Last modified:April 26, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30707B7C3C069029
GO
Isoform 2 (identifier: O95490-2) [UniParc]FASTAAdd to basket
Also known as: Lectomedin-1 gamma

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1167-1209: Missing.

Show »
Length:1,403
Mass (Da):157,178
Checksum:iCE43AB82916D0D35
GO
Isoform 3 (identifier: O95490-3) [UniParc]FASTAAdd to basket
Also known as: Lectomedin-1 beta

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1134-1136: SRI → DIH
     1137-1459: Missing.

Show »
Length:1,123
Mass (Da):126,163
Checksum:i21DB98B51EBDF4EC
GO
Isoform 4 (identifier: O95490-4) [UniParc]FASTAAdd to basket
Also known as: Lectomedin-1 alpha

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1167-1209: Missing.
     1210-1233: HSLNNARDTSAMDTLPLNGNFNNS → LTSHGLRAHLQDLYHLELLLGQIA
     1234-1459: Missing.

Show »
Length:1,177
Mass (Da):132,245
Checksum:i6D099178841E1E3A
GO
Isoform 5 (identifier: O95490-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1167-1209: Missing.

Note: No experimental confirmation.
Show »
Length:1,416
Mass (Da):158,797
Checksum:iFB5C1C0A9A9ED3C5
GO
Isoform 6 (identifier: O95490-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1034-1034: K → NNYRVCDGYYNTDLPG

Show »
Length:1,474
Mass (Da):165,067
Checksum:iA78543DA2A149746
GO
Isoform 7 (identifier: O95490-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1034-1034: K → NNYRVCDGYYNTDLPG

Note: No experimental confirmation.
Show »
Length:1,461
Mass (Da):163,448
Checksum:iB528698BA07BBC46
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ALU3B1ALU3_HUMAN
Adhesion G protein-coupled receptor...
ADGRL2 LPHN2, hCG_14669
1,431Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ALU1B1ALU1_HUMAN
Adhesion G protein-coupled receptor...
ADGRL2
1,384Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5C0H0Y5C0_HUMAN
Adhesion G protein-coupled receptor...
ADGRL2
1,351Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3V3H0Y3V3_HUMAN
Adhesion G protein-coupled receptor...
ADGRL2
471Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1059N → S in ABL59902 (PubMed:17456239).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_077836467R → T Found in a child with sporadic epilepsy; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010104595 – 607Missing in isoform 2, isoform 3, isoform 4 and isoform 7. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_0422671034K → NNYRVCDGYYNTDLPG in isoform 6 and isoform 7. 1 Publication1
Alternative sequenceiVSP_0101051134 – 1136SRI → DIH in isoform 3. 1 Publication3
Alternative sequenceiVSP_0101061137 – 1459Missing in isoform 3. 1 PublicationAdd BLAST323
Alternative sequenceiVSP_0101071167 – 1209Missing in isoform 2, isoform 4 and isoform 5. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_0101081210 – 1233HSLNN…NFNNS → LTSHGLRAHLQDLYHLELLL GQIA in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0101091234 – 1459Missing in isoform 4. 1 PublicationAdd BLAST226

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ131581 mRNA Translation: CAA10458.1
AJ244492
, AJ244493, AJ244494, AJ244496, AJ244497, AJ244498, AJ244499, AJ244501, AJ244502, AJ244503, AJ244504, AJ244505, AJ244506, AJ244507, AJ244510, AJ244511, AJ244512, AJ244516 Genomic DNA Translation: CAB60229.1
AF104266 mRNA Translation: AAD54675.1
AF104938 mRNA Translation: AAD54676.1
AF104939 mRNA Translation: AAD54677.1
AC113949 Genomic DNA No translation available.
AL157903 Genomic DNA No translation available.
AL359705 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06327.1
CH471059 Genomic DNA Translation: EAX06330.1
CH471059 Genomic DNA Translation: EAX06333.1
CH471059 Genomic DNA Translation: EAX06335.1
CH471059 Genomic DNA Translation: EAX06336.1
CH471059 Genomic DNA Translation: EAX06339.1
AB018329 mRNA Translation: BAA34506.1
DQ925675 mRNA Translation: ABL59902.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS689.1 [O95490-2]
CCDS72811.1 [O95490-4]
CCDS76174.1 [O95490-3]
CCDS81345.1 [O95490-5]

NCBI Reference Sequences

More...RefSeqi		NP_001284633.1, NM_001297704.1 [O95490-2]
NP_001284634.1, NM_001297705.1 [O95490-4]
NP_001284635.1, NM_001297706.1 [O95490-3]
NP_001317574.1, NM_001330645.1 [O95490-5]
NP_036434.1, NM_012302.3 [O95490-2]
XP_005270723.1, XM_005270666.4 [O95490-1]
XP_016856276.1, XM_017000787.1

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.24212
Hs.406863
Hs.649282

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000319517; ENSP00000322270; ENSG00000117114 [O95490-2]
ENST00000359929; ENSP00000353006; ENSG00000117114 [O95490-2]
ENST00000370713; ENSP00000359748; ENSG00000117114 [O95490-3]
ENST00000370715; ENSP00000359750; ENSG00000117114 [O95490-4]
ENST00000370717; ENSP00000359752; ENSG00000117114 [O95490-1]
ENST00000370723; ENSP00000359758; ENSG00000117114 [O95490-7]
ENST00000370725; ENSP00000359760; ENSG00000117114 [O95490-6]
ENST00000370728; ENSP00000359763; ENSG00000117114 [O95490-1]
ENST00000370730; ENSP00000359765; ENSG00000117114 [O95490-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23266

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23266

UCSC genome browser

More...UCSCi		uc001dit.5 human [O95490-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131581 mRNA Translation: CAA10458.1
AJ244492
, AJ244493, AJ244494, AJ244496, AJ244497, AJ244498, AJ244499, AJ244501, AJ244502, AJ244503, AJ244504, AJ244505, AJ244506, AJ244507, AJ244510, AJ244511, AJ244512, AJ244516 Genomic DNA Translation: CAB60229.1
AF104266 mRNA Translation: AAD54675.1
AF104938 mRNA Translation: AAD54676.1
AF104939 mRNA Translation: AAD54677.1
AC113949 Genomic DNA No translation available.
AL157903 Genomic DNA No translation available.
AL359705 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06327.1
CH471059 Genomic DNA Translation: EAX06330.1
CH471059 Genomic DNA Translation: EAX06333.1
CH471059 Genomic DNA Translation: EAX06335.1
CH471059 Genomic DNA Translation: EAX06336.1
CH471059 Genomic DNA Translation: EAX06339.1
AB018329 mRNA Translation: BAA34506.1
DQ925675 mRNA Translation: ABL59902.1
CCDSiCCDS689.1 [O95490-2]
CCDS72811.1 [O95490-4]
CCDS76174.1 [O95490-3]
CCDS81345.1 [O95490-5]
RefSeqiNP_001284633.1, NM_001297704.1 [O95490-2]
NP_001284634.1, NM_001297705.1 [O95490-4]
NP_001284635.1, NM_001297706.1 [O95490-3]
NP_001317574.1, NM_001330645.1 [O95490-5]
NP_036434.1, NM_012302.3 [O95490-2]
XP_005270723.1, XM_005270666.4 [O95490-1]
XP_016856276.1, XM_017000787.1
UniGeneiHs.24212
Hs.406863
Hs.649282

3D structure databases

ProteinModelPortaliO95490
SMRiO95490
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116868, 13 interactors
IntActiO95490, 9 interactors
MINTiO95490
STRINGi9606.ENSP00000322270

Protein family/group databases

MEROPSiP02.009

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyConnecti994
iPTMnetiO95490
PhosphoSitePlusiO95490

Polymorphism and mutation databases

BioMutaiADGRL2

Proteomic databases

EPDiO95490
jPOSTiO95490
MaxQBiO95490
PaxDbiO95490
PeptideAtlasiO95490
PRIDEiO95490
ProteomicsDBi50917
50918 [O95490-2]
50919 [O95490-3]
50920 [O95490-4]
50921 [O95490-5]
50922 [O95490-6]
50923 [O95490-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319517; ENSP00000322270; ENSG00000117114 [O95490-2]
ENST00000359929; ENSP00000353006; ENSG00000117114 [O95490-2]
ENST00000370713; ENSP00000359748; ENSG00000117114 [O95490-3]
ENST00000370715; ENSP00000359750; ENSG00000117114 [O95490-4]
ENST00000370717; ENSP00000359752; ENSG00000117114 [O95490-1]
ENST00000370723; ENSP00000359758; ENSG00000117114 [O95490-7]
ENST00000370725; ENSP00000359760; ENSG00000117114 [O95490-6]
ENST00000370728; ENSP00000359763; ENSG00000117114 [O95490-1]
ENST00000370730; ENSP00000359765; ENSG00000117114 [O95490-5]
GeneIDi23266
KEGGihsa:23266
UCSCiuc001dit.5 human [O95490-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23266
DisGeNETi23266
EuPathDBiHostDB:ENSG00000117114.19

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADGRL2
HGNCiHGNC:18582 ADGRL2
HPAiHPA043447
MIMi607018 gene
neXtProtiNX_O95490
OpenTargetsiENSG00000117114
PharmGKBiPA38589

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3545 Eukaryota
KOG4193 Eukaryota
KOG4729 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00940000156348
HOGENOMiHOG000049065
HOVERGENiHBG052337
InParanoidiO95490
KOiK04593
OMAiLQMYYQI
PhylomeDBiO95490
TreeFamiTF351999

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ADGRL2 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		LPHN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23266

Protein Ontology

More...PROi		PR:O95490

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000117114 Expressed in 103 organ(s), highest expression level in right lung
ExpressionAtlasiO95490 baseline and differential
GenevisibleiO95490 HS

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003924 GPCR_2_latrophilin
IPR003334 GPCR_2_latrophilin_rcpt_C
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR031240 Latrophilin-2
IPR000922 Lectin_gal-bd_dom
IPR003112 Olfac-like_dom
PANTHERiPTHR12011:SF61 PTHR12011:SF61, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF02140 Gal_Lectin, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF02354 Latrophilin, 1 hit
PF02191 OLF, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR01444 LATROPHILIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00284 OLF, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51132 OLF, 1 hit
PS50228 SUEL_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRL2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95490
Secondary accession number(s): A5XEI2
, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, Q5VX76, Q9UKY5, Q9UKY6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: February 13, 2019
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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