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Protein

Protein transport protein Sec24B

Gene

SEC24B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi605ZincCombined sources1
Metal bindingi608ZincCombined sources1
Metal bindingi626ZincCombined sources1
Metal bindingi629ZincCombined sources1

GO - Molecular functioni

  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-2132295 MHC class II antigen presentation
R-HSA-5694530 Cargo concentration in the ER
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec24BCurated
Alternative name(s):
SEC24-related protein B
Gene namesi
Name:SEC24BImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138802.11
HGNCiHGNC:10704 SEC24B
MIMi607184 gene
neXtProtiNX_O95487

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi715R → A: Decreased ability to package the SNARE SEC22B cargo into COPII vesicles. Has no effect on other cargos packaging. 1 Publication1

Organism-specific databases

DisGeNETi10427
OpenTargetsiENSG00000138802
PharmGKBiPA35627

Polymorphism and mutation databases

BioMutaiSEC24B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002051552 – 1268Protein transport protein Sec24BAdd BLAST1267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei329PhosphothreonineCombined sources1
Modified residuei1224PhosphoserineCombined sources1
Isoform 3 (identifier: O95487-3)
Modified residuei55PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95487
MaxQBiO95487
PaxDbiO95487
PeptideAtlasiO95487
PRIDEiO95487
ProteomicsDBi50915
50916 [O95487-2]

PTM databases

iPTMnetiO95487
PhosphoSitePlusiO95487

Expressioni

Gene expression databases

BgeeiENSG00000138802
CleanExiHS_SEC24B
GenevisibleiO95487 HS

Organism-specific databases

HPAiHPA038181

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and SAR1 (PubMed:10075675, PubMed:17499046). Interacts with RNF139 (PubMed:19706601). Interacts with TMED2 and TMED10 (PubMed:20427317). Interacts with CNIH4 (PubMed:24405750).5 Publications

Protein-protein interaction databases

BioGridi115696, 56 interactors
IntActiO95487, 44 interactors
MINTiO95487
STRINGi9606.ENSP00000265175

Structurei

Secondary structure

11268
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi520 – 522Combined sources3
Beta strandi524 – 526Combined sources3
Turni527 – 529Combined sources3
Helixi548 – 553Combined sources6
Turni557 – 559Combined sources3
Beta strandi560 – 570Combined sources11
Helixi571 – 577Combined sources7
Beta strandi582 – 585Combined sources4
Turni606 – 608Combined sources3
Beta strandi617 – 625Combined sources9
Turni627 – 629Combined sources3
Beta strandi632 – 634Combined sources3
Helixi637 – 639Combined sources3
Helixi651 – 653Combined sources3
Helixi655 – 658Combined sources4
Beta strandi660 – 666Combined sources7
Helixi668 – 670Combined sources3
Beta strandi672 – 674Combined sources3
Beta strandi679 – 685Combined sources7
Helixi688 – 693Combined sources6
Helixi695 – 706Combined sources12
Turni707 – 709Combined sources3
Beta strandi717 – 731Combined sources15
Beta strandi740 – 745Combined sources6
Helixi755 – 757Combined sources3
Beta strandi759 – 761Combined sources3
Turni762 – 765Combined sources4
Helixi766 – 775Combined sources10
Helixi776 – 778Combined sources3
Helixi790 – 801Combined sources12
Turni802 – 804Combined sources3
Beta strandi806 – 812Combined sources7
Helixi831 – 834Combined sources4
Beta strandi835 – 837Combined sources3
Helixi847 – 857Combined sources11
Beta strandi860 – 866Combined sources7
Helixi874 – 877Combined sources4
Helixi879 – 882Combined sources4
Turni883 – 885Combined sources3
Beta strandi888 – 890Combined sources3
Turni896 – 898Combined sources3
Helixi900 – 915Combined sources16
Beta strandi919 – 928Combined sources10
Beta strandi932 – 943Combined sources12
Beta strandi945 – 954Combined sources10
Beta strandi960 – 968Combined sources9
Beta strandi974 – 985Combined sources12
Beta strandi991 – 1003Combined sources13
Helixi1006 – 1011Combined sources6
Helixi1015 – 1032Combined sources18
Helixi1035 – 1054Combined sources20
Beta strandi1066 – 1068Combined sources3
Helixi1069 – 1071Combined sources3
Helixi1074 – 1082Combined sources9
Turni1085 – 1087Combined sources3
Helixi1095 – 1107Combined sources13
Helixi1110 – 1117Combined sources8
Beta strandi1120 – 1123Combined sources4
Beta strandi1133 – 1135Combined sources3
Beta strandi1138 – 1140Combined sources3
Helixi1150 – 1152Combined sources3
Beta strandi1157 – 1162Combined sources6
Beta strandi1164 – 1171Combined sources8
Helixi1177 – 1182Combined sources6
Helixi1189 – 1191Combined sources3
Beta strandi1194 – 1196Combined sources3
Helixi1205 – 1219Combined sources15
Beta strandi1221 – 1223Combined sources3
Beta strandi1226 – 1236Combined sources11
Helixi1237 – 1241Combined sources5
Helixi1255 – 1267Combined sources13

3D structure databases

ProteinModelPortaliO95487
SMRiO95487
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95487

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1141 – 1213Gelsolin-likeSequence analysisAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni605 – 629Zinc finger-likeAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi379 – 387Poly-Glu9

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC24 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1985 Eukaryota
COG5028 LUCA
GeneTreeiENSGT00590000082962
HOGENOMiHOG000196365
HOVERGENiHBG054850
InParanoidiO95487
KOiK14007
OMAiNILPMTP
OrthoDBiEOG091G011M
PhylomeDBiO95487
TreeFamiTF354244

Family and domain databases

Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit
SSF82919 SSF82919, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95487-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAPAGSSHP AASARIPPKF GGAAVSGAAA PAGPGAGPAP HQQNGPAQNQ
60 70 80 90 100
MQVPSGYGLH HQNYIAPSGH YSQGPGKMTS LPLDTQCGDY YSALYTVPTQ
110 120 130 140 150
NVTPNTVNQQ PGAQQLYSRG PPAPHIVGST LGSFQGAASS ASHLHTSASQ
160 170 180 190 200
PYSSFVNHYN SPAMYSASSS VASQGFPSTC GHYAMSTVSN AAYPSVSYPS
210 220 230 240 250
LPAGDTYGQM FTSQNAPTVR PVKDNSFSGQ NTAISHPSPL PPLPSQQHHQ
260 270 280 290 300
QQSLSGYSTL TWSSPGLPST QDNLIRNHTG SLAVANNNPT ITVADSLSCP
310 320 330 340 350
VMQNVQPPKS SPVVSTVLSG SSGSSSTRTP PTANHPVEPV TSVTQPSELL
360 370 380 390 400
QQKGVQYGEY VNNQASSAPT PLSSTSDDEE EEEEDEEAGV DSSSTTSSAS
410 420 430 440 450
PMPNSYDALE GGSYPDMLSS SASSPAPDPA PEPDPASAPA PASAPAPVVP
460 470 480 490 500
QPSKMAKPFG YGYPTLQPGY QNATAPLISG VQPSNPVYSG FQQYPQQYPG
510 520 530 540 550
VNQLSSSIGG LSLQSSPQPE SLRPVNLTQE RNILPMTPVW APVPNLNADL
560 570 580 590 600
KKLNCSPDSF RCTLTNIPQT QALLNKAKLP LGLLLHPFRD LTQLPVITSN
610 620 630 640 650
TIVRCRSCRT YINPFVSFID QRRWKCNLCY RVNDVPEEFM YNPLTRSYGE
660 670 680 690 700
PHKRPEVQNS TVEFIASSDY MLRPPQPAVY LFVLDVSHNA VEAGYLTILC
710 720 730 740 750
QSLLENLDKL PGDSRTRIGF MTFDSTIHFY NLQEGLSQPQ MLIVSDIDDV
760 770 780 790 800
FLPTPDSLLV NLYESKELIK DLLNALPNMF TNTRETHSAL GPALQAAFKL
810 820 830 840 850
MSPTGGRVSV FQTQLPSLGA GLLQSREDPN QRSSTKVVQH LGPATDFYKK
860 870 880 890 900
LALDCSGQQT AVDLFLLSSQ YSDLASLACM SKYSAGCIYY YPSFHYTHNP
910 920 930 940 950
SQAEKLQKDL KRYLTRKIGF EAVMRIRCTK GLSMHTFHGN FFVRSTDLLS
960 970 980 990 1000
LANINPDAGF AVQLSIEESL TDTSLVCFQT ALLYTSSKGE RRIRVHTLCL
1010 1020 1030 1040 1050
PVVSSLADVY AGVDVQAAIC LLANMAVDRS VSSSLSDARD ALVNAVVDSL
1060 1070 1080 1090 1100
SAYGSTVSNL QHSALMAPSS LKLFPLYVLA LLKQKAFRTG TSTRLDDRVY
1110 1120 1130 1140 1150
AMCQIKSQPL VHLMKMIHPN LYRIDRLTDE GAVHVNDRIV PQPPLQKLSA
1160 1170 1180 1190 1200
EKLTREGAFL MDCGSVFYIW VGKGCDNNFI EDVLGYTNFA SIPQKMTHLP
1210 1220 1230 1240 1250
ELDTLSSERA RSFITWLRDS RPLSPILHIV KDESPAKAEF FQHLIEDRTE
1260
AAFSYYEFLL HVQQQICK
Length:1,268
Mass (Da):137,418
Last modified:December 16, 2008 - v2
Checksum:i0E08B982D0982F84
GO
Isoform 2 (identifier: O95487-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-388: Missing.

Show »
Length:1,233
Mass (Da):133,629
Checksum:i95EEBB976F613B6B
GO
Isoform 3 (identifier: O95487-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: N → NETGFHHVAQASLELLDPSNLPASASQIAGST
     496-496: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:1,298
Mass (Da):140,421
Checksum:i3B649E12AEF0F17C
GO

Sequence cautioni

The sequence CAA10335 differs from that shown. Reason: Frameshift at positions 459 and 483.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23A → S in CAA10335 (PubMed:10075675).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047934456A → G. Corresponds to variant dbSNP:rs35705351Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05443244N → NETGFHHVAQASLELLDPSN LPASASQIAGST in isoform 3. 1 Publication1
Alternative sequenceiVSP_035987354 – 388Missing in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_054433496Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131245 mRNA Translation: CAA10335.1 Frameshift.
AC105314 Genomic DNA No translation available.
AC138782 Genomic DNA No translation available.
BC040137 mRNA Translation: AAH40137.1
BC117135 mRNA Translation: AAI17136.1
BC143268 mRNA Translation: AAI43269.1
BC143276 mRNA Translation: AAI43277.1
CCDSiCCDS43260.1 [O95487-2]
CCDS47124.1 [O95487-1]
CCDS75179.1 [O95487-3]
RefSeqiNP_001036199.1, NM_001042734.3 [O95487-2]
NP_001287742.1, NM_001300813.2 [O95487-3]
NP_001305014.1, NM_001318085.1
NP_001305015.1, NM_001318086.1
NP_006314.2, NM_006323.4 [O95487-1]
UniGeneiHs.292472

Genome annotation databases

EnsembliENST00000265175; ENSP00000265175; ENSG00000138802 [O95487-1]
ENST00000399100; ENSP00000382051; ENSG00000138802 [O95487-2]
ENST00000504968; ENSP00000428564; ENSG00000138802 [O95487-3]
GeneIDi10427
KEGGihsa:10427
UCSCiuc003hzk.4 human [O95487-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSC24B_HUMAN
AccessioniPrimary (citable) accession number: O95487
Secondary accession number(s): B7ZKM8, B7ZKN4, Q0VG08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: December 16, 2008
Last modified: July 18, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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