Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Claudin-9

Gene

CLDN9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.2 Publications

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • structural molecule activity Source: Ensembl
  • virus receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-9
Gene namesi
Name:CLDN9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000213937.3
HGNCiHGNC:2051 CLDN9
MIMi615799 gene
neXtProtiNX_O95484

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 116CytoplasmicSequence analysisAdd BLAST14
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 159ExtracellularSequence analysisAdd BLAST22
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 217CytoplasmicSequence analysisAdd BLAST37

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38N → S: Mildly decrease HCV infection susceptibility in cell culture. 1 Publication1
Mutagenesisi43A → S: No effect on HCV infection susceptibility in cell culture. 1 Publication1
Mutagenesisi45V → N: Abolishes HCV infection susceptibility in cell culture. 1 Publication1
Mutagenesisi53S → N: No effect on HCV infection susceptibility in cell culture. 1 Publication1

Organism-specific databases

DisGeNETi9080
OpenTargetsiENSG00000213937
PharmGKBiPA26577

Polymorphism and mutation databases

BioMutaiCLDN9

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447551 – 217Claudin-9Add BLAST217

Proteomic databases

MaxQBiO95484
PaxDbiO95484
PeptideAtlasiO95484
PRIDEiO95484
ProteomicsDBi50911

PTM databases

iPTMnetiO95484
PhosphoSitePlusiO95484

Expressioni

Tissue specificityi

Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.1 Publication

Gene expression databases

BgeeiENSG00000213937 Expressed in 77 organ(s), highest expression level in pituitary gland
CleanExiHS_CLDN9
GenevisibleiO95484 HS

Organism-specific databases

HPAiHPA076613

Interactioni

Subunit structurei

Interacts with CLDN1, CD81 and OCLN (PubMed:20375010).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiO95484, 15 interactors
STRINGi9606.ENSP00000398017

Structurei

3D structure databases

ProteinModelPortaliO95484
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIJR Eukaryota
ENOG410YA61 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiO95484
KOiK06087
OMAiCPPPQID
OrthoDBiEOG091G0MMR
PhylomeDBiO95484
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003553 Claudin9
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF42 PTHR12002:SF42, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01382 CLAUDIN9
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

O95484-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTGLELLG MTLAVLGWLG TLVSCALPLW KVTAFIGNSI VVAQVVWEGL
60 70 80 90 100
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVIALLL ALLGLLVAIT
110 120 130 140 150
GAQCTTCVED EGAKARIVLT AGVILLLAGI LVLIPVCWTA HAIIQDFYNP
160 170 180 190 200
LVAEALKREL GASLYLGWAA AALLMLGGGL LCCTCPPPQV ERPRGPRLGY
210
SIPSRSGASG LDKRDYV
Length:217
Mass (Da):22,848
Last modified:May 1, 1999 - v1
Checksum:i0E49C5B5CB3AAC9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ130941 Genomic DNA Translation: CAA10254.1
BC051870 mRNA Translation: AAH51870.1
BC065830 mRNA Translation: AAH65830.1
CCDSiCCDS10487.1
RefSeqiNP_066192.1, NM_020982.3
UniGeneiHs.296949

Genome annotation databases

EnsembliENST00000445369; ENSP00000398017; ENSG00000213937
GeneIDi9080
KEGGihsa:9080
UCSCiuc010uwo.1 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ130941 Genomic DNA Translation: CAA10254.1
BC051870 mRNA Translation: AAH51870.1
BC065830 mRNA Translation: AAH65830.1
CCDSiCCDS10487.1
RefSeqiNP_066192.1, NM_020982.3
UniGeneiHs.296949

3D structure databases

ProteinModelPortaliO95484
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO95484, 15 interactors
STRINGi9606.ENSP00000398017

PTM databases

iPTMnetiO95484
PhosphoSitePlusiO95484

Polymorphism and mutation databases

BioMutaiCLDN9

Proteomic databases

MaxQBiO95484
PaxDbiO95484
PeptideAtlasiO95484
PRIDEiO95484
ProteomicsDBi50911

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445369; ENSP00000398017; ENSG00000213937
GeneIDi9080
KEGGihsa:9080
UCSCiuc010uwo.1 human

Organism-specific databases

CTDi9080
DisGeNETi9080
EuPathDBiHostDB:ENSG00000213937.3
GeneCardsiCLDN9
HGNCiHGNC:2051 CLDN9
HPAiHPA076613
MIMi615799 gene
neXtProtiNX_O95484
OpenTargetsiENSG00000213937
PharmGKBiPA26577
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIJR Eukaryota
ENOG410YA61 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiO95484
KOiK06087
OMAiCPPPQID
OrthoDBiEOG091G0MMR
PhylomeDBiO95484
TreeFamiTF331936

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Miscellaneous databases

GeneWikiiCLDN9
GenomeRNAii9080
PROiPR:O95484
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213937 Expressed in 77 organ(s), highest expression level in pituitary gland
CleanExiHS_CLDN9
GenevisibleiO95484 HS

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003553 Claudin9
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF42 PTHR12002:SF42, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01382 CLAUDIN9
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD9_HUMAN
AccessioniPrimary (citable) accession number: O95484
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again