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Protein

Ribosome biogenesis protein NSA2 homolog

Gene

NSA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein NSA2 homolog
Alternative name(s):
Hairy cell leukemia protein 1
TGF-beta-inducible nuclear protein 1
Gene namesi
Name:NSA2
Synonyms:TINP1
ORF Names:HUSSY-29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164346.9
HGNCiHGNC:30728 NSA2
MIMi612497 gene
neXtProtiNX_O95478

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10412
OpenTargetsiENSG00000164346
PharmGKBiPA165660390

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001222591 – 260Ribosome biogenesis protein NSA2 homologAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei81PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO95478
PaxDbiO95478
PeptideAtlasiO95478
PRIDEiO95478
ProteomicsDBi50909

2D gel databases

SWISS-2DPAGEiO95478

PTM databases

iPTMnetiO95478
PhosphoSitePlusiO95478

Expressioni

Gene expression databases

BgeeiENSG00000164346 Expressed in 227 organ(s), highest expression level in pituitary gland
ExpressionAtlasiO95478 baseline and differential
GenevisibleiO95478 HS

Organism-specific databases

HPAiHPA043487

Interactioni

Subunit structurei

Component of the pre-66S ribosomal particle.By similarity

Protein-protein interaction databases

BioGridi115683, 78 interactors
IntActiO95478, 11 interactors
STRINGi9606.ENSP00000296802

Structurei

3D structure databases

ProteinModelPortaliO95478
SMRiO95478
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 18Nuclear localization signalPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 152Lys-richAdd BLAST130

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3163 Eukaryota
COG2007 LUCA
GeneTreeiENSGT00390000018706
HOGENOMiHOG000234606
HOVERGENiHBG047617
InParanoidiO95478
KOiK14842
OMAiKRQKKAW
OrthoDBiEOG091G0IDG
PhylomeDBiO95478
TreeFamiTF300766

Family and domain databases

CDDicd11381 NSA2, 1 hit
InterProiView protein in InterPro
IPR039411 NSA2_fam
IPR022309 Ribosomal_S8e/biogenesis_NSA2
PANTHERiPTHR12642 PTHR12642, 1 hit
PfamiView protein in Pfam
PF01201 Ribosomal_S8e, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O95478-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQNEYIELH RKRYGYRLDY HEKKRKKESR EAHERSKKAK KMIGLKAKLY
60 70 80 90 100
HKQRHAEKIQ MKKTIKMHEK RNTKQKNDEK TPQGAVPAYL LDREGQSRAK
110 120 130 140 150
VLSNMIKQKR KEKAGKWEVP LPKVRAQGET EVLKVIRTGK RKKKAWKRMV
160 170 180 190 200
TKVCFVGDGF TRKPPKYERF IRPMGLRFKK AHVTHPELKA TFCLPILGVK
210 220 230 240 250
KNPSSPLYTT LGVITKGTVI EVNVSELGLV TQGGKVIWGK YAQVTNNPEN
260
DGCINAVLLV
Length:260
Mass (Da):30,065
Last modified:May 1, 1999 - v1
Checksum:iC42D3E8EFB2669D8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQZ6A0A0A0MQZ6_HUMAN
Ribosome biogenesis protein NSA2 ho...
NSA2
189Annotation score:
H0YAI9H0YAI9_HUMAN
Ribosome biogenesis protein NSA2 ho...
NSA2
98Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05186211R → C. Corresponds to variant dbSNP:rs3733793Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF372458 mRNA Translation: AAK53761.1
AJ012409 mRNA Translation: CAA10008.1
AF077615 mRNA Translation: AAG43048.1
BC005288 mRNA Translation: AAH05288.1
CCDSiCCDS4025.1
RefSeqiNP_001258594.1, NM_001271665.1
NP_055701.1, NM_014886.4
UniGeneiHs.482526

Genome annotation databases

EnsembliENST00000610426; ENSP00000483484; ENSG00000164346
GeneIDi10412
KEGGihsa:10412

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF372458 mRNA Translation: AAK53761.1
AJ012409 mRNA Translation: CAA10008.1
AF077615 mRNA Translation: AAG43048.1
BC005288 mRNA Translation: AAH05288.1
CCDSiCCDS4025.1
RefSeqiNP_001258594.1, NM_001271665.1
NP_055701.1, NM_014886.4
UniGeneiHs.482526

3D structure databases

ProteinModelPortaliO95478
SMRiO95478
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115683, 78 interactors
IntActiO95478, 11 interactors
STRINGi9606.ENSP00000296802

PTM databases

iPTMnetiO95478
PhosphoSitePlusiO95478

2D gel databases

SWISS-2DPAGEiO95478

Proteomic databases

EPDiO95478
PaxDbiO95478
PeptideAtlasiO95478
PRIDEiO95478
ProteomicsDBi50909

Protocols and materials databases

DNASUi10412
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000610426; ENSP00000483484; ENSG00000164346
GeneIDi10412
KEGGihsa:10412

Organism-specific databases

CTDi10412
DisGeNETi10412
EuPathDBiHostDB:ENSG00000164346.9
GeneCardsiNSA2
HGNCiHGNC:30728 NSA2
HPAiHPA043487
MIMi612497 gene
neXtProtiNX_O95478
OpenTargetsiENSG00000164346
PharmGKBiPA165660390
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3163 Eukaryota
COG2007 LUCA
GeneTreeiENSGT00390000018706
HOGENOMiHOG000234606
HOVERGENiHBG047617
InParanoidiO95478
KOiK14842
OMAiKRQKKAW
OrthoDBiEOG091G0IDG
PhylomeDBiO95478
TreeFamiTF300766

Miscellaneous databases

ChiTaRSiNSA2 human
GeneWikiiTINP1
GenomeRNAii10412
PROiPR:O95478
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164346 Expressed in 227 organ(s), highest expression level in pituitary gland
ExpressionAtlasiO95478 baseline and differential
GenevisibleiO95478 HS

Family and domain databases

CDDicd11381 NSA2, 1 hit
InterProiView protein in InterPro
IPR039411 NSA2_fam
IPR022309 Ribosomal_S8e/biogenesis_NSA2
PANTHERiPTHR12642 PTHR12642, 1 hit
PfamiView protein in Pfam
PF01201 Ribosomal_S8e, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNSA2_HUMAN
AccessioniPrimary (citable) accession number: O95478
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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