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Protein

CTD nuclear envelope phosphatase 1

Gene

CTDNEP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=18 mM for p-nitrophenylphosphate1 Publication

    pH dependencei

    Optimum pH is 5.5.1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • phosphoprotein phosphatase activity Source: GO_Central
    • protein serine/threonine phosphatase activity Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Protein phosphatase

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-4419969 Depolymerisation of the Nuclear Lamina

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    O95476

    SignaLink: a signaling pathway resource with multi-layered regulatory networks

    More...
    SignaLinki
    O95476

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    O95476

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    CTD nuclear envelope phosphatase 1 (EC:3.1.3.16)
    Alternative name(s):
    Serine/threonine-protein phosphatase dullard
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CTDNEP1
    Synonyms:DULLARD
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000175826.11

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:19085 CTDNEP1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    610684 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_O95476

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 29HelicalSequence analysisAdd BLAST23

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi67D → N or E: Abolishes phosphatase activity. 1 Publication1

    Organism-specific databases

    Open Targets

    More...
    OpenTargetsi
    ENSG00000175826

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134937999

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    CTDNEP1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002979671 – 244CTD nuclear envelope phosphatase 1Add BLAST244

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    O95476

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    O95476

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    O95476

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O95476

    PeptideAtlas

    More...
    PeptideAtlasi
    O95476

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O95476

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    50907

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    O95476

    PTM databases

    DEPOD human dephosphorylation database

    More...
    DEPODi
    O95476

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O95476

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    O95476

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Muscle specific with lower expression in other metabolic tissues.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000175826 Expressed in 231 organ(s), highest expression level in muscle of leg

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_DULLARD

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    O95476 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O95476 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA037439
    HPA066466

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2.1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    116972, 53 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    O95476, 5 interactors

    Molecular INTeraction database

    More...
    MINTi
    O95476

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000321732

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    O95476

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O95476

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 224FCP1 homologyPROSITE-ProRule annotationAdd BLAST168

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the dullard family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1605 Eukaryota
    COG5190 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000153532

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000236379

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG098153

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O95476

    KEGG Orthology (KO)

    More...
    KOi
    K17617

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    SRIWGFI

    Database of Orthologous Groups

    More...
    OrthoDBi
    1176152at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O95476

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313962

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.1000, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR011948 Dullard_phosphatase
    IPR004274 FCP1_dom
    IPR036412 HAD-like_sf
    IPR023214 HAD_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03031 NIF, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00577 CPDc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF56784 SSF56784, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR02251 HIF-SF_euk, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50969 FCP1, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

    O95476-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MMRTQCLLGL RTFVAFAAKL WSFFIYLLRR QIRTVIQYQT VRYDILPLSP
    60 70 80 90 100
    VSRNRLAQVK RKILVLDLDE TLIHSHHDGV LRPTVRPGTP PDFILKVVID
    110 120 130 140 150
    KHPVRFFVHK RPHVDFFLEV VSQWYELVVF TASMEIYGSA VADKLDNSRS
    160 170 180 190 200
    ILKRRYYRQH CTLELGSYIK DLSVVHSDLS SIVILDNSPG AYRSHPDNAI
    210 220 230 240
    PIKSWFSDPS DTALLNLLPM LDALRFTADV RSVLSRNLHQ HRLW
    Length:244
    Mass (Da):28,377
    Last modified:November 3, 2009 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i062952A90F74575A
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    I3L1D9I3L1D9_HUMAN
    CTD nuclear envelope phosphatase 1
    CTDNEP1
    202Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    I3L4B2I3L4B2_HUMAN
    CTD nuclear envelope phosphatase 1
    CTDNEP1
    223Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    I3L3K5I3L3K5_HUMAN
    CTD nuclear envelope phosphatase 1
    CTDNEP1
    208Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    I3L0X6I3L0X6_HUMAN
    CTD nuclear envelope phosphatase 1
    CTDNEP1
    125Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    I3L2R5I3L2R5_HUMAN
    CTD nuclear envelope phosphatase 1
    CTDNEP1
    111Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    I3L4W0I3L4W0_HUMAN
    CTD nuclear envelope phosphatase 1
    CTDNEP1
    67Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03469912T → A2 PublicationsCorresponds to variant dbSNP:rs3744399Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AJ011916 mRNA Translation: CAA09865.1
    AY364239 mRNA Translation: AAQ76798.1
    AC003688 Genomic DNA No translation available.
    AC120057 Genomic DNA No translation available.
    CH471108 Genomic DNA Translation: EAW90233.1
    CH471108 Genomic DNA Translation: EAW90235.1
    CH471108 Genomic DNA Translation: EAW90236.1
    BC009295 mRNA Translation: AAH09295.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS11093.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001137247.1, NM_001143775.1
    NP_056158.2, NM_015343.4

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.513913

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000318988; ENSP00000321732; ENSG00000175826
    ENST00000573600; ENSP00000461749; ENSG00000175826
    ENST00000574205; ENSP00000458758; ENSG00000175826
    ENST00000574322; ENSP00000460683; ENSG00000175826

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    23399

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:23399

    UCSC genome browser

    More...
    UCSCi
    uc002gfd.3 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ011916 mRNA Translation: CAA09865.1
    AY364239 mRNA Translation: AAQ76798.1
    AC003688 Genomic DNA No translation available.
    AC120057 Genomic DNA No translation available.
    CH471108 Genomic DNA Translation: EAW90233.1
    CH471108 Genomic DNA Translation: EAW90235.1
    CH471108 Genomic DNA Translation: EAW90236.1
    BC009295 mRNA Translation: AAH09295.1
    CCDSiCCDS11093.1
    RefSeqiNP_001137247.1, NM_001143775.1
    NP_056158.2, NM_015343.4
    UniGeneiHs.513913

    3D structure databases

    ProteinModelPortaliO95476
    SMRiO95476
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi116972, 53 interactors
    IntActiO95476, 5 interactors
    MINTiO95476
    STRINGi9606.ENSP00000321732

    PTM databases

    DEPODiO95476
    iPTMnetiO95476
    PhosphoSitePlusiO95476

    Polymorphism and mutation databases

    BioMutaiCTDNEP1

    Proteomic databases

    EPDiO95476
    jPOSTiO95476
    MaxQBiO95476
    PaxDbiO95476
    PeptideAtlasiO95476
    PRIDEiO95476
    ProteomicsDBi50907
    TopDownProteomicsiO95476

    Protocols and materials databases

    The DNASU plasmid repository

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    DNASUi
    23399
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000318988; ENSP00000321732; ENSG00000175826
    ENST00000573600; ENSP00000461749; ENSG00000175826
    ENST00000574205; ENSP00000458758; ENSG00000175826
    ENST00000574322; ENSP00000460683; ENSG00000175826
    GeneIDi23399
    KEGGihsa:23399
    UCSCiuc002gfd.3 human

    Organism-specific databases

    Comparative Toxicogenomics Database

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    CTDi
    23399
    EuPathDBiHostDB:ENSG00000175826.11

    GeneCards: human genes, protein and diseases

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    GeneCardsi
    CTDNEP1
    HGNCiHGNC:19085 CTDNEP1
    HPAiHPA037439
    HPA066466
    MIMi610684 gene
    neXtProtiNX_O95476
    OpenTargetsiENSG00000175826
    PharmGKBiPA134937999

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1605 Eukaryota
    COG5190 LUCA
    GeneTreeiENSGT00940000153532
    HOGENOMiHOG000236379
    HOVERGENiHBG098153
    InParanoidiO95476
    KOiK17617
    OMAiSRIWGFI
    OrthoDBi1176152at2759
    PhylomeDBiO95476
    TreeFamiTF313962

    Enzyme and pathway databases

    ReactomeiR-HSA-4419969 Depolymerisation of the Nuclear Lamina
    SABIO-RKiO95476
    SignaLinkiO95476
    SIGNORiO95476

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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    ChiTaRSi
    CTDNEP1 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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    GenomeRNAii
    23399

    Protein Ontology

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    PROi
    PR:O95476

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000175826 Expressed in 231 organ(s), highest expression level in muscle of leg
    CleanExiHS_DULLARD
    ExpressionAtlasiO95476 baseline and differential
    GenevisibleiO95476 HS

    Family and domain databases

    Gene3Di3.40.50.1000, 1 hit
    InterProiView protein in InterPro
    IPR011948 Dullard_phosphatase
    IPR004274 FCP1_dom
    IPR036412 HAD-like_sf
    IPR023214 HAD_sf
    PfamiView protein in Pfam
    PF03031 NIF, 1 hit
    SMARTiView protein in SMART
    SM00577 CPDc, 1 hit
    SUPFAMiSSF56784 SSF56784, 1 hit
    TIGRFAMsiTIGR02251 HIF-SF_euk, 1 hit
    PROSITEiView protein in PROSITE
    PS50969 FCP1, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNEP1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95476
    Secondary accession number(s): D3DTN7, Q96GQ9
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: November 3, 2009
    Last modified: January 16, 2019
    This is version 126 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
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