SGPL1

Functionⁱ

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.4 Publications

Catalytic activityⁱ

Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.3 Publications

Cofactorⁱ

pyridoxal 5'-phosphate1 Publication

Kineticsⁱ

K_M=
5.2 µM for sphingosine 1-phosphate
1 Publication
Manual assertion based on experiment inⁱ
- Ref.13
  "Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis."
  Weiler S., Braendlin N., Beerli C., Bergsdorf C., Schubart A., Srinivas H., Oberhauser B., Billich A.
  J. Med. Chem. 57:5074-5084(2014) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 62-568 IN COMPLEX WITH PYRIDOXAL PHOSPHATE AND SYNTHETIC INHIBITOR, CATALYTIC ACTIVITY, PATHWAY, FUNCTION, COFACTOR, SUBUNIT, BIOPHYSICOCHEMICAL PROPERTIES.

Pathwayⁱ: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.3 Publications
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

GO - Molecular functionⁱ

carboxy-lyase activity Source: InterPro
pyridoxal phosphate binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sphinganine-1-phosphate aldolase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 14570870
- 24809814

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ameboidal-type cell migration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
androgen metabolic process Source: Ensembl
apoptotic signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 14570870
ceramide metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 14570870
estrogen metabolic process Source: Ensembl
face morphogenesis Source: Ensembl
fatty acid metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 24809814
fibroblast migration Source: Ensembl
hemopoiesis Source: Ensembl
kidney development Source: Ensembl
Leydig cell differentiation Source: Ensembl
luteinization Source: Ensembl
platelet-derived growth factor receptor signaling pathway Source: Ensembl
post-embryonic development Source: Ensembl
regulation of multicellular organism growth Source: Ensembl
roof of mouth development Source: Ensembl
skeletal system morphogenesis Source: Ensembl
spermatogenesis Source: Ensembl
sphingolipid biosynthetic process Source: Reactome
sphingolipid catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 24809814
sphingolipid metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vasculogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Lyase
Biological process	Apoptosis, Lipid metabolism, Sphingolipid metabolism
Ligand	Pyridoxal phosphate

Enzyme and pathway databases

BRENDAⁱ	4.1.2.27 2681
Reactomeⁱ	R-HSA-1660661 Sphingolipid de novo biosynthesis
UniPathwayⁱ	UPA00222

Chemistry databases

SwissLipidsⁱ	SLP:000000107

SwissLipidsⁱ

SLP:000000107

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sphingosine-1-phosphate lyase 1Curated (EC:4.1.2.273 Publications) Short name: S1PLCurated Short name: SP-lyase 1Curated Short name: SPL 1Curated Short name: hSPL Alternative name(s): Sphingosine-1-phosphate aldolase
Gene namesⁱ	Name:SGPL1Imported Synonyms:KIAA12521 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000166224.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10817 SGPL1
MIMⁱ	603729 gene
neXtProtⁱ	NX_O95470

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 40	LumenalSequence analysisAdd BLAST	40
Transmembraneⁱ	41 – 61	Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	62 – 568	CytoplasmicSequence analysisAdd BLAST	507

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Nephrotic syndrome 14 (NPHS14)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. NPHS14 is an autosomal recessive syndromic, steroid-resistant form that progresses to end-stage renal failure. Some NPHS14 patients manifest ichthyosis, adrenal insufficiency, immunodeficiency, and neurological defects.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_079213	222	R → Q in NPHS14; decreased protein abundance; increased aggregation; decreased sphinganine-1-phosphate aldolase activity. 2 PublicationsCorresponds to variant dbSNP:rs769259446EnsemblClinVar.	1
Natural variantⁱVAR_079214	222	R → W in NPHS14. 1 PublicationCorresponds to variant dbSNP:rs1131692255Ensembl.	1
Natural variantⁱVAR_079216	416	Y → C in NPHS14; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs779485098Ensembl.	1
Natural variantⁱVAR_079217	505 – 568	Missing in NPHS14. 1 PublicationAdd BLAST	64
Natural variantⁱVAR_079218	545	Missing in NPHS14; decreased protein abundance. 1 Publication	1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	132	E → G: No effect on the sphinganine-1-phosphate aldolase activity; no effect on protein abundance. 1 Publication	1
Mutagenesisⁱ	218	C → G: Loss of sphinganine-1-phosphate aldolase activity. 1 Publication	1
Mutagenesisⁱ	317	C → S: Almost no sphinganine-1-phosphate aldolase activity. 1 Publication	1
Mutagenesisⁱ	353	K → L: Loss of sphinganine-1-phosphate aldolase activity. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8879
MalaCards human disease database More...MalaCardsⁱ	SGPL1
MIMⁱ	617575 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000166224
Orphanetⁱ	506334 Familial steroid-resistant nephrotic syndrome with adrenal insufficiency
PharmGKBⁱ	PA35725

Chemistry databases

ChEMBLⁱ	CHEMBL3286061
Drug and drug target database More...DrugBankⁱ	DB00114 Pyridoxal Phosphate
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2522

Polymorphism and mutation databases

BioMutaⁱ	SGPL1

BioMutaⁱ

SGPL1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000147012	1 – 568	Sphingosine-1-phosphate lyase 1Add BLAST		568

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	353	N6-(pyridoxal phosphate)lysine; alternate	1
Modified residueⁱ	353	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	356	Nitrated tyrosineCombined sources	1
Modified residueⁱ	366	Nitrated tyrosineCombined sources	1
Modified residueⁱ	564	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Nitration, Phosphoprotein

Proteomic databases

EPDⁱ	O95470
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95470
PaxDbⁱ	O95470
PeptideAtlas More...PeptideAtlasⁱ	O95470
PRIDEⁱ	O95470
ProteomicsDBⁱ	50902

PTM databases

iPTMnetⁱ	O95470
PhosphoSitePlusⁱ	O95470
SwissPalmⁱ	O95470

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed (PubMed:11018465, PubMed:28165343). Expressed in fetal and adult adrenal gland (at protein level) (PubMed:28165343).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000166224 Expressed in 217 organ(s), highest expression level in esophagus squamous epithelium
CleanExⁱ	HS_SGPL1
ExpressionAtlasⁱ	O95470 baseline and differential
Genevisibleⁱ	O95470 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA021125 HPA023086

HPAⁱ

HPA021125
HPA023086

Interactionⁱ

Subunit structureⁱ

Homodimer.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TMEM173	Q86WV6	2	EBI-1046170,EBI-2800345

With

Entry

#Exp.

IntAct

Notes

TMEM173

Q86WV6

2

EBI-1046170,EBI-2800345

Protein-protein interaction databases

BioGridⁱ	114398, 54 interactors
IntActⁱ	O95470, 36 interactors
Molecular INTeraction database More...MINTⁱ	O95470
STRINGⁱ	9606.ENSP00000362298

Chemistry databases

BindingDBⁱ

O95470

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	123 – 134	Combined sources	12
Helixⁱ	135 – 137	Combined sources	3
Helixⁱ	139 – 142	Combined sources	4
Beta strandⁱ	145 – 148	Combined sources	4
Helixⁱ	154 – 165	Combined sources	12
Turnⁱ	166 – 169	Combined sources	4
Turnⁱ	175 – 177	Combined sources	3
Helixⁱ	179 – 195	Combined sources	17
Beta strandⁱ	203 – 209	Combined sources	7
Helixⁱ	210 – 227	Combined sources	18
Beta strandⁱ	234 – 238	Combined sources	5
Helixⁱ	244 – 252	Combined sources	9
Beta strandⁱ	255 – 259	Combined sources	5
Beta strandⁱ	265 – 267	Combined sources	3
Helixⁱ	269 – 273	Combined sources	5
Beta strandⁱ	280 – 286	Combined sources	7
Turnⁱ	290 – 292	Combined sources	3
Helixⁱ	298 – 308	Combined sources	11
Beta strandⁱ	312 – 316	Combined sources	5
Turnⁱ	317 – 319	Combined sources	3
Helixⁱ	320 – 323	Combined sources	4
Turnⁱ	324 – 330	Combined sources	7
Beta strandⁱ	344 – 349	Combined sources	6
Beta strandⁱ	362 – 368	Combined sources	7
Helixⁱ	369 – 372	Combined sources	4
Turnⁱ	373 – 375	Combined sources	3
Beta strandⁱ	377 – 381	Combined sources	5
Beta strandⁱ	387 – 392	Combined sources	6
Helixⁱ	398 – 434	Combined sources	37
Beta strandⁱ	448 – 454	Combined sources	7
Beta strandⁱ	456 – 458	Combined sources	3
Helixⁱ	461 – 469	Combined sources	9
Beta strandⁱ	475 – 477	Combined sources	3
Turnⁱ	478 – 481	Combined sources	4
Beta strandⁱ	482 – 486	Combined sources	5
Helixⁱ	489 – 494	Combined sources	6
Helixⁱ	497 – 513	Combined sources	17
Helixⁱ	521 – 531	Combined sources	11
Helixⁱ	535 – 549	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	O95470
SMRⁱ	O95470
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1383 Eukaryota COG0076 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000046
HOGENOMⁱ	HOG000190693
HOVERGENⁱ	HBG056982
InParanoidⁱ	O95470
KEGG Orthology (KO) More...KOⁱ	K01634
OMAⁱ	DPHKMGL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G040L
PhylomeDBⁱ	O95470
TreeFamⁱ	TF300777

Family and domain databases

Gene3Dⁱ	3.40.640.10, 1 hit 3.90.1150.10, 2 hits
InterProⁱ	View protein in InterPro IPR002129 PyrdxlP-dep_de-COase IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00282 Pyridoxal_deC, 1 hit
SUPFAMⁱ	SSF53383 SSF53383, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

O95470-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPSTDLLMLK AFEPYLEILE VYSTKAKNYV NGHCTKYEPW QLIAWSVVWT 
        60         70         80         90        100
LLIVWGYEFV FQPESLWSRF KKKCFKLTRK MPIIGRKIQD KLNKTKDDIS 
       110        120        130        140        150
KNMSFLKVDK EYVKALPSQG LSSSAVLEKL KEYSSMDAFW QEGRASGTVY 
       160        170        180        190        200
SGEEKLTELL VKAYGDFAWS NPLHPDIFPG LRKIEAEIVR IACSLFNGGP 
       210        220        230        240        250
DSCGCVTSGG TESILMACKA YRDLAFEKGI KTPEIVAPQS AHAAFNKAAS 
       260        270        280        290        300
YFGMKIVRVP LTKMMEVDVR AMRRAISRNT AMLVCSTPQF PHGVIDPVPE 
       310        320        330        340        350
VAKLAVKYKI PLHVDACLGG FLIVFMEKAG YPLEHPFDFR VKGVTSISAD 
       360        370        380        390        400
THKYGYAPKG SSLVLYSDKK YRNYQFFVDT DWQGGIYASP TIAGSRPGGI 
       410        420        430        440        450
SAACWAALMH FGENGYVEAT KQIIKTARFL KSELENIKGI FVFGNPQLSV 
       460        470        480        490        500
IALGSRDFDI YRLSNLMTAK GWNLNQLQFP PSIHFCITLL HARKRVAIQF 
       510        520        530        540        550
LKDIRESVTQ IMKNPKAKTT GMGAIYGMAQ TTVDRNMVAE LSSVFLDSLY 
       560 
STDTVTQGSQ MNGSPKPH

Length:568

Mass (Da):63,524

Last modified:October 24, 2003 - v3

Checksum:ⁱ3B16FDEFC4B2FDB6

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H7BXL7	H7BXL7_HUMAN	Sphingosine-1-phosphate lyase 1 Sphingosine-1-phosphate lyase 1	SGPL1	202	Annotation score:
H0Y3V8	H0Y3V8_HUMAN	Sphingosine-1-phosphate lyase 1 Sphingosine-1-phosphate lyase 1	SGPL1	135	Annotation score:

Sequence cautionⁱ

The sequence BAA86566 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	404	C → A in CAA09590 (PubMed:11018465).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_048875	21	V → L. Corresponds to variant dbSNP:rs12770335Ensembl.	1
Natural variantⁱVAR_079213	222	R → Q in NPHS14; decreased protein abundance; increased aggregation; decreased sphinganine-1-phosphate aldolase activity. 2 PublicationsCorresponds to variant dbSNP:rs769259446EnsemblClinVar.	1
Natural variantⁱVAR_079214	222	R → W in NPHS14. 1 PublicationCorresponds to variant dbSNP:rs1131692255Ensembl.	1
Natural variantⁱVAR_079215	346	S → I in NPHS1; decreased protein abundance in cells of patients homozygous for the mutation; increased aggregation; decreased sphinganine-1-phosphate aldolase activity. 1 PublicationCorresponds to variant dbSNP:rs1131692256Ensembl.	1
Natural variantⁱVAR_079216	416	Y → C in NPHS14; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs779485098Ensembl.	1
Natural variantⁱVAR_079217	505 – 568	Missing in NPHS14. 1 PublicationAdd BLAST	64
Natural variantⁱVAR_079218	545	Missing in NPHS14; decreased protein abundance. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ011304 mRNA Translation: CAA09590.2 AF144638 mRNA Translation: AAD44755.1 AB033078 mRNA Translation: BAA86566.1 Different initiation. AK314615 mRNA Translation: BAG37181.1 CH471083 Genomic DNA Translation: EAW54414.1 BC052991 mRNA Translation: AAH52991.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31216.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003892.2, NM_003901.3 XP_005270320.1, XM_005270263.1 XP_011538618.1, XM_011540316.2 XP_011538619.1, XM_011540317.1
UniGeneⁱ	Hs.499984

Genome annotation databases

Ensemblⁱ	ENST00000373202; ENSP00000362298; ENSG00000166224
GeneIDⁱ	8879
KEGGⁱ	hsa:8879
UCSC genome browser More...UCSCⁱ	uc001jrm.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95470	Sphingosine-1-phosphate lyase 1		PONAB		568	UniRef90_O95470
Uncharacterized protein		FELCA		671
Uncharacterized protein		PIG		597
Uncharacterized protein		MUSPF		582
Sphingosine-1-phosphate lyase 1		AILME		570
+102

Protein	Similar proteins		Species	Score	Length	Source
O95470	Sphingosine-1-phosphate lyase 1		PONAB		568	UniRef50_O95470
Uncharacterized protein		FELCA		671
Uncharacterized protein		PIG		597
Uncharacterized protein		MUSPF		582
Sphingosine-1-phosphate lyase 1		AILME		570
+254

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ011304 mRNA Translation: CAA09590.2 AF144638 mRNA Translation: AAD44755.1 AB033078 mRNA Translation: BAA86566.1 Different initiation. AK314615 mRNA Translation: BAG37181.1 CH471083 Genomic DNA Translation: EAW54414.1 BC052991 mRNA Translation: AAH52991.1
CCDSⁱ	CCDS31216.1
RefSeqⁱ	NP_003892.2, NM_003901.3 XP_005270320.1, XM_005270263.1 XP_011538618.1, XM_011540316.2 XP_011538619.1, XM_011540317.1
UniGeneⁱ	Hs.499984

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4Q6R	X-ray	2.40	A/B	62-568	[»]
ProteinModelPortalⁱ	O95470
SMRⁱ	O95470
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114398, 54 interactors
IntActⁱ	O95470, 36 interactors
MINTⁱ	O95470
STRINGⁱ	9606.ENSP00000362298

Chemistry databases

BindingDBⁱ	O95470
ChEMBLⁱ	CHEMBL3286061
DrugBankⁱ	DB00114 Pyridoxal Phosphate
GuidetoPHARMACOLOGYⁱ	2522
SwissLipidsⁱ	SLP:000000107

PTM databases

iPTMnetⁱ	O95470
PhosphoSitePlusⁱ	O95470
SwissPalmⁱ	O95470

Polymorphism and mutation databases

BioMutaⁱ	SGPL1

BioMutaⁱ

SGPL1

Proteomic databases

EPDⁱ	O95470
MaxQBⁱ	O95470
PaxDbⁱ	O95470
PeptideAtlasⁱ	O95470
PRIDEⁱ	O95470
ProteomicsDBⁱ	50902

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000373202; ENSP00000362298; ENSG00000166224
GeneIDⁱ	8879
KEGGⁱ	hsa:8879
UCSCⁱ	uc001jrm.4 human

Organism-specific databases

CTDⁱ	8879
DisGeNETⁱ	8879
EuPathDBⁱ	HostDB:ENSG00000166224.16
GeneCardsⁱ	SGPL1
HGNCⁱ	HGNC:10817 SGPL1
HPAⁱ	HPA021125 HPA023086
MalaCardsⁱ	SGPL1
MIMⁱ	603729 gene 617575 phenotype
neXtProtⁱ	NX_O95470
OpenTargetsⁱ	ENSG00000166224
Orphanetⁱ	506334 Familial steroid-resistant nephrotic syndrome with adrenal insufficiency
PharmGKBⁱ	PA35725
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1383 Eukaryota COG0076 LUCA
GeneTreeⁱ	ENSGT00390000000046
HOGENOMⁱ	HOG000190693
HOVERGENⁱ	HBG056982
InParanoidⁱ	O95470
KOⁱ	K01634
OMAⁱ	DPHKMGL
OrthoDBⁱ	EOG091G040L
PhylomeDBⁱ	O95470
TreeFamⁱ	TF300777

Enzyme and pathway databases

UniPathwayⁱ	UPA00222
BRENDAⁱ	4.1.2.27 2681
Reactomeⁱ	R-HSA-1660661 Sphingolipid de novo biosynthesis

Miscellaneous databases

ChiTaRSⁱ	SGPL1 human
GeneWikiⁱ	SGPL1
GenomeRNAiⁱ	8879
Protein Ontology More...PROⁱ	PR:O95470
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000166224 Expressed in 217 organ(s), highest expression level in esophagus squamous epithelium
CleanExⁱ	HS_SGPL1
ExpressionAtlasⁱ	O95470 baseline and differential
Genevisibleⁱ	O95470 HS

Family and domain databases

Gene3Dⁱ	3.40.640.10, 1 hit 3.90.1150.10, 2 hits
InterProⁱ	View protein in InterPro IPR002129 PyrdxlP-dep_de-COase IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
Pfamⁱ	View protein in Pfam PF00282 Pyridoxal_deC, 1 hit
SUPFAMⁱ	SSF53383 SSF53383, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SGPL1_HUMAN
Accessionⁱ	O95470Primary (citable) accession number: O95470 Secondary accession number(s): B2RBD4 , Q7Z732, Q9ULG8, Q9UN89
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
	Last sequence update:	October 24, 2003
	Last modified:	November 7, 2018
	This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

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Supporting data

UniProtKB - O95470 (SGPL1_HUMAN)

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Sphingosine-1-phosphate lyase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: sphingolipid metabolism

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Kineticsⁱ

Pathwayⁱ: sphingolipid metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ