Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 176 (16 Jan 2019)
Sequence version 3 (30 Aug 2005)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Matrilin-4

Gene

MATN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major component of the extracellular matrix of cartilage.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • extracellular matrix organization Source: Reactome
  • growth plate cartilage chondrocyte morphogenesis Source: GO_Central

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3000178 ECM proteoglycans

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Matrilin-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MATN4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000124159.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6910 MATN4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603897 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95460

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000124159

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30653

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MATN4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18By similarityAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000766019 – 622Matrilin-4Add BLAST604

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi219 ↔ 230PROSITE-ProRule annotation
Disulfide bondi226 ↔ 239PROSITE-ProRule annotation
Disulfide bondi241 ↔ 254PROSITE-ProRule annotation
Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi260 ↔ 271PROSITE-ProRule annotation
Disulfide bondi267 ↔ 280PROSITE-ProRule annotation
Disulfide bondi282 ↔ 295PROSITE-ProRule annotation
Disulfide bondi301 ↔ 312PROSITE-ProRule annotation
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi308 ↔ 321PROSITE-ProRule annotation
Disulfide bondi323 ↔ 336PROSITE-ProRule annotation
Disulfide bondi342 ↔ 353PROSITE-ProRule annotation
Disulfide bondi349 ↔ 362PROSITE-ProRule annotation
Disulfide bondi364 ↔ 377PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95460

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95460

PeptideAtlas

More...
PeptideAtlasi
O95460

PRoteomics IDEntifications database

More...
PRIDEi
O95460

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50892
50893 [O95460-2]
50894 [O95460-3]
50895 [O95460-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1493

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95460

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95460

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Embryonic kidney, lung and placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124159 Expressed in 89 organ(s), highest expression level in body of pancreas

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95460 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95460 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with COMP.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114313, 11 interactors

Protein interaction database and analysis system

More...
IntActi
O95460, 7 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95460

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95460

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 213VWFA 1PROSITE-ProRule annotationAdd BLAST180
Domaini215 – 255EGF-like 1; incompletePROSITE-ProRule annotationAdd BLAST41
Domaini256 – 292EGF-like 2PROSITE-ProRule annotationAdd BLAST37
Domaini297 – 337EGF-like 3PROSITE-ProRule annotationAdd BLAST41
Domaini342 – 377EGF-like 4PROSITE-ProRule annotationAdd BLAST36
Domaini386 – 561VWFA 2PROSITE-ProRule annotationAdd BLAST176

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili591 – 622Sequence analysisAdd BLAST32

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157086

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056906

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95460

Identification of Orthologs from Complete Genome Data

More...
OMAi
ARDLCNG

Database of Orthologous Groups

More...
OrthoDBi
1174178at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95460

TreeFam database of animal gene trees

More...
TreeFami
TF330078

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.30, 1 hit
3.40.50.410, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR009030 Growth_fac_rcpt_cys_sf
IPR034306 Matrilin-4
IPR036337 Matrilin_cc_sf
IPR019466 Matrilin_coiled-coil_trimer
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45365 PTHR45365, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662 cEGF, 1 hit
PF10393 Matrilin_ccoil, 1 hit
PF00092 VWA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 4 hits
SM01279 Matrilin_ccoil, 1 hit
SM00327 VWA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 2 hits
SSF57184 SSF57184, 1 hit
SSF58002 SSF58002, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
PS50234 VWFA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O95460-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGLLCWPVL LLLLQPWETQ LQLTGPRCHT GPLDLVFVID SSRSVRPFEF
60 70 80 90 100
ETMRQFLMGL LRGLNVGPNA TRVGVIQYSS QVQSVFPLRA FSRREDMERA
110 120 130 140 150
IRDLVPLAQG TMTGLAIQYA MNVAFSVAEG ARPPEERVPR VAVIVTDGRP
160 170 180 190 200
QDRVAEVAAQ ARARGIEIYA VGVQRADVGS LRAMASPPLD EHVFLVESFD
210 220 230 240 250
LIQEFGLQFQ SRLCGKDQCA EGGHGCQHQC VNAWAMFHCT CNPGYKLAAD
260 270 280 290 300
NKSCLAIDLC AEGTHGCEHH CVNSPGSYFC HCQVGFVLQQ DQRSCRAIDY
310 320 330 340 350
CSFGNHSCQH ECVSTPGGPR CHCREGHDLQ PDGRSCQVRD LCNGVDHGCE
360 370 380 390 400
FQCVSEGLSY RCLCPEGRQL QADGKSCNRC REGHVDLVLL VDGSKSVRPQ
410 420 430 440 450
NFELVKRFVN QIVDFLDVSP EGTRVGLVQF SSRVRTEFPL GRYGTAAEVK
460 470 480 490 500
QAVLAVEYME RGTMTGLALR HMVEHSFSEA QGARPRALNV PRVGLVFTDG
510 520 530 540 550
RSQDDISVWA ARAKEEGIVM YAVGVGKAVE AELREIASEP AELHVSYAPD
560 570 580 590 600
FGTMTHLLEN LRGSICPEEG ISAGTELRSP CECESLVEFQ GRTLGALESL
610 620
TLNLAQLTAR LEDLENQLAN QK
Note: No experimental confirmation available.
Length:622
Mass (Da):68,487
Last modified:August 30, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i283C32AF7EA58C68
GO
Isoform 2 (identifier: O95460-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-255: Missing.

Show »
Length:581
Mass (Da):64,107
Checksum:iCD61982098A4C706
GO
Isoform 3 (identifier: O95460-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-214: Missing.

Note: No experimental confirmation available.
Show »
Length:432
Mass (Da):47,503
Checksum:iD88DD393F26EAB81
GO
Isoform 4 (identifier: O95460-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-255: Missing.
     256-296: Missing.

Note: No experimental confirmation available.
Show »
Length:540
Mass (Da):59,588
Checksum:iBA8481C2D0A4A56C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NNA4A6NNA4_HUMAN
Matrilin-4
MATN4
499Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11081 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti173V → L in BAC11083 (PubMed:14702039).Curated1
Sequence conflicti563G → S in BAC11083 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05575813L → F. Corresponds to variant dbSNP:rs2743307Ensembl.1
Natural variantiVAR_055759164R → S1 PublicationCorresponds to variant dbSNP:rs2072788Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01525525 – 214Missing in isoform 3. CuratedAdd BLAST190
Alternative sequenceiVSP_001400215 – 255Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST41
Alternative sequenceiVSP_015256256 – 296Missing in isoform 4. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ007581 mRNA Translation: CAA07569.1
AK074595 mRNA Translation: BAC11081.1 Different initiation.
AK074597 mRNA Translation: BAC11083.1
AL021578 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13348.1 [O95460-2]
CCDS46607.1 [O95460-4]

NCBI Reference Sequences

More...
RefSeqi
NP_085080.1, NM_030590.3 [O95460-4]
NP_085095.1, NM_030592.3
XP_005260654.1, XM_005260597.1 [O95460-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.278489

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360607; ENSP00000353819; ENSG00000124159 [O95460-4]
ENST00000372754; ENSP00000361840; ENSG00000124159 [O95460-1]
ENST00000372756; ENSP00000361842; ENSG00000124159 [O95460-2]
ENST00000537548; ENSP00000440328; ENSG00000124159 [O95460-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8785

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8785

UCSC genome browser

More...
UCSCi
uc002xno.4 human [O95460-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007581 mRNA Translation: CAA07569.1
AK074595 mRNA Translation: BAC11081.1 Different initiation.
AK074597 mRNA Translation: BAC11083.1
AL021578 Genomic DNA No translation available.
CCDSiCCDS13348.1 [O95460-2]
CCDS46607.1 [O95460-4]
RefSeqiNP_085080.1, NM_030590.3 [O95460-4]
NP_085095.1, NM_030592.3
XP_005260654.1, XM_005260597.1 [O95460-2]
UniGeneiHs.278489

3D structure databases

ProteinModelPortaliO95460
SMRiO95460
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114313, 11 interactors
IntActiO95460, 7 interactors

PTM databases

GlyConnecti1493
iPTMnetiO95460
PhosphoSitePlusiO95460

Polymorphism and mutation databases

BioMutaiMATN4

Proteomic databases

EPDiO95460
jPOSTiO95460
PeptideAtlasiO95460
PRIDEiO95460
ProteomicsDBi50892
50893 [O95460-2]
50894 [O95460-3]
50895 [O95460-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360607; ENSP00000353819; ENSG00000124159 [O95460-4]
ENST00000372754; ENSP00000361840; ENSG00000124159 [O95460-1]
ENST00000372756; ENSP00000361842; ENSG00000124159 [O95460-2]
ENST00000537548; ENSP00000440328; ENSG00000124159 [O95460-2]
GeneIDi8785
KEGGihsa:8785
UCSCiuc002xno.4 human [O95460-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8785
EuPathDBiHostDB:ENSG00000124159.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MATN4
HGNCiHGNC:6910 MATN4
MIMi603897 gene
neXtProtiNX_O95460
OpenTargetsiENSG00000124159
PharmGKBiPA30653

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000157086
HOVERGENiHBG056906
InParanoidiO95460
OMAiARDLCNG
OrthoDBi1174178at2759
PhylomeDBiO95460
TreeFamiTF330078

Enzyme and pathway databases

ReactomeiR-HSA-3000178 ECM proteoglycans

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8785

Protein Ontology

More...
PROi
PR:O95460

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000124159 Expressed in 89 organ(s), highest expression level in body of pancreas
ExpressionAtlasiO95460 baseline and differential
GenevisibleiO95460 HS

Family and domain databases

Gene3Di1.20.5.30, 1 hit
3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR009030 Growth_fac_rcpt_cys_sf
IPR034306 Matrilin-4
IPR036337 Matrilin_cc_sf
IPR019466 Matrilin_coiled-coil_trimer
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR45365 PTHR45365, 1 hit
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF10393 Matrilin_ccoil, 1 hit
PF00092 VWA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 4 hits
SM01279 Matrilin_ccoil, 1 hit
SM00327 VWA, 2 hits
SUPFAMiSSF53300 SSF53300, 2 hits
SSF57184 SSF57184, 1 hit
SSF58002 SSF58002, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
PS50234 VWFA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMATN4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95460
Secondary accession number(s): A6NH94
, A6NKN5, Q5QPU2, Q5QPU3, Q5QPU4, Q8N2M5, Q8N2M7, Q9H1F8, Q9H1F9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 30, 2005
Last modified: January 16, 2019
This is version 176 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again