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Protein

Proteasome assembly chaperone 1

Gene

PSMG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • proteasome binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proteasome assembly chaperone 1
Short name:
PAC-1
Alternative name(s):
Chromosome 21 leucine-rich protein
Short name:
C21-LRP
Down syndrome critical region protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSMG1
Synonyms:C21LRP, DSCR2, PAC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000183527.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3043 PSMG1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605296 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95456

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8624

Open Targets

More...
OpenTargetsi
ENSG00000183527

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162400229

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3885624

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PSMG1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000800182 – 288Proteasome assembly chaperone 1Add BLAST287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei18PhosphothreonineCombined sources1
Modified residuei54PhosphothreonineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei264N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Degraded by the proteasome upon completion of 20S proteasome maturation.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95456

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95456

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95456

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95456

PeptideAtlas

More...
PeptideAtlasi
O95456

PRoteomics IDEntifications database

More...
PRIDEi
O95456

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50890
50891 [O95456-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95456

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95456

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183527 Expressed in 228 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_PSMG1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95456 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95456 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA057193
HPA070225

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PSMG2Q969U74EBI-6286129,EBI-723276

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114179, 51 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O95456

Protein interaction database and analysis system

More...
IntActi
O95456, 10 interactors

Molecular INTeraction database

More...
MINTi
O95456

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000329915

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95456

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PSMG1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGRN Eukaryota
ENOG4111EZT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044950

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000072680

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051410

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95456

KEGG Orthology (KO)

More...
KOi
K11875

Identification of Orthologs from Complete Genome Data

More...
OMAi
FLCQCSC

Database of Orthologous Groups

More...
OrthoDBi
1232038at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95456

TreeFam database of animal gene trees

More...
TreeFami
TF331909

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016565 Proteasome_assmbl_chp_1

The PANTHER Classification System

More...
PANTHERi
PTHR15069 PTHR15069, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16094 PAC1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010076 Psome_chaperone-1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95456-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAATFFGEVV KAPCRAGTED EEEEEEGRRE TPEDREVRLQ LARKREVRLL
60 70 80 90 100
RRQTKTSLEV SLLEKYPCSK FIIAIGNNAV AFLSSFVMNS GVWEEVGCAK
110 120 130 140 150
LWNEWCRTTD TTHLSSTEAF CVFYHLKSNP SVFLCQCSCY VAEDQQYQWL
160 170 180 190 200
EKVFGSCPRK NMQITILTCR HVTDYKTSES TGSLPSPFLR ALKTQNFKDS
210 220 230 240 250
ACCPLLEQPN IVHDLPAAVL SYCQVWKIPA ILYLCYTDVM KLDLITVEAF
260 270 280
KPILSTRSLK GLVKNIPQST EILKKLMTTN EIQSNIYT
Length:288
Mass (Da):32,854
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D4A84485C290839
GO
Isoform 2 (identifier: O95456-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-152: Missing.

Show »
Length:267
Mass (Da):30,288
Checksum:iABC452F240DF79E7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WBH7F8WBH7_HUMAN
Proteasome assembly chaperone 1
PSMG1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3B4H7C3B4_HUMAN
Proteasome assembly chaperone 1
PSMG1
13Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4T → S in CAG46650 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054014166I → V. Corresponds to variant dbSNP:rs8131611Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017261132 – 152Missing in isoform 2. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ006291 mRNA Translation: CAA06957.1
AY463963 mRNA Translation: AAR25628.1
CR541821 mRNA Translation: CAG46620.1
CR541852 mRNA Translation: CAG46650.1
AB451468 mRNA Translation: BAG70282.1
AL163279 Genomic DNA Translation: CAB90451.1
CH471079 Genomic DNA Translation: EAX09664.1
CH471079 Genomic DNA Translation: EAX09665.1
BC003619 mRNA Translation: AAH03619.1
BC010424 mRNA Translation: AAH10424.1
BC011755 mRNA Translation: AAH11755.1
BC012809 mRNA Translation: AAH12809.1
BR000236 mRNA Translation: FAA00022.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13660.1 [O95456-1]
CCDS13661.1 [O95456-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JE0290

NCBI Reference Sequences

More...
RefSeqi
NP_003711.1, NM_003720.3 [O95456-1]
NP_982257.1, NM_203433.2 [O95456-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.473838

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331573; ENSP00000329915; ENSG00000183527 [O95456-1]
ENST00000380900; ENSP00000370286; ENSG00000183527 [O95456-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8624

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8624

UCSC genome browser

More...
UCSCi
uc002yxi.5 human [O95456-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006291 mRNA Translation: CAA06957.1
AY463963 mRNA Translation: AAR25628.1
CR541821 mRNA Translation: CAG46620.1
CR541852 mRNA Translation: CAG46650.1
AB451468 mRNA Translation: BAG70282.1
AL163279 Genomic DNA Translation: CAB90451.1
CH471079 Genomic DNA Translation: EAX09664.1
CH471079 Genomic DNA Translation: EAX09665.1
BC003619 mRNA Translation: AAH03619.1
BC010424 mRNA Translation: AAH10424.1
BC011755 mRNA Translation: AAH11755.1
BC012809 mRNA Translation: AAH12809.1
BR000236 mRNA Translation: FAA00022.1
CCDSiCCDS13660.1 [O95456-1]
CCDS13661.1 [O95456-2]
PIRiJE0290
RefSeqiNP_003711.1, NM_003720.3 [O95456-1]
NP_982257.1, NM_203433.2 [O95456-2]
UniGeneiHs.473838

3D structure databases

ProteinModelPortaliO95456
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114179, 51 interactors
CORUMiO95456
IntActiO95456, 10 interactors
MINTiO95456
STRINGi9606.ENSP00000329915

Chemistry databases

ChEMBLiCHEMBL3885624

PTM databases

iPTMnetiO95456
PhosphoSitePlusiO95456

Polymorphism and mutation databases

BioMutaiPSMG1

Proteomic databases

EPDiO95456
jPOSTiO95456
MaxQBiO95456
PaxDbiO95456
PeptideAtlasiO95456
PRIDEiO95456
ProteomicsDBi50890
50891 [O95456-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8624
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331573; ENSP00000329915; ENSG00000183527 [O95456-1]
ENST00000380900; ENSP00000370286; ENSG00000183527 [O95456-2]
GeneIDi8624
KEGGihsa:8624
UCSCiuc002yxi.5 human [O95456-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8624
DisGeNETi8624
EuPathDBiHostDB:ENSG00000183527.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PSMG1
HGNCiHGNC:3043 PSMG1
HPAiHPA057193
HPA070225
MIMi605296 gene
neXtProtiNX_O95456
OpenTargetsiENSG00000183527
PharmGKBiPA162400229

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGRN Eukaryota
ENOG4111EZT LUCA
GeneTreeiENSGT00500000044950
HOGENOMiHOG000072680
HOVERGENiHBG051410
InParanoidiO95456
KOiK11875
OMAiFLCQCSC
OrthoDBi1232038at2759
PhylomeDBiO95456
TreeFamiTF331909

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DSCR2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8624

Protein Ontology

More...
PROi
PR:O95456

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000183527 Expressed in 228 organ(s), highest expression level in secondary oocyte
CleanExiHS_PSMG1
ExpressionAtlasiO95456 baseline and differential
GenevisibleiO95456 HS

Family and domain databases

InterProiView protein in InterPro
IPR016565 Proteasome_assmbl_chp_1
PANTHERiPTHR15069 PTHR15069, 1 hit
PfamiView protein in Pfam
PF16094 PAC1, 1 hit
PIRSFiPIRSF010076 Psome_chaperone-1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSMG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95456
Secondary accession number(s): B5BUN2
, Q6FHA3, Q6FHD3, Q6S713
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: January 16, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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