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Protein

Proteasome assembly chaperone 1

Gene

PSMG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome assembly chaperone 1
Short name:
PAC-1
Alternative name(s):
Chromosome 21 leucine-rich protein
Short name:
C21-LRP
Down syndrome critical region protein 2
Gene namesi
Name:PSMG1
Synonyms:C21LRP, DSCR2, PAC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000183527.11
HGNCiHGNC:3043 PSMG1
MIMi605296 gene
neXtProtiNX_O95456

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi8624
OpenTargetsiENSG00000183527
PharmGKBiPA162400229

Chemistry databases

ChEMBLiCHEMBL3885624

Polymorphism and mutation databases

BioMutaiPSMG1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000800182 – 288Proteasome assembly chaperone 1Add BLAST287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei18PhosphothreonineCombined sources1
Modified residuei54PhosphothreonineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei264N6-acetyllysineCombined sources1

Post-translational modificationi

Degraded by the proteasome upon completion of 20S proteasome maturation.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95456
MaxQBiO95456
PaxDbiO95456
PeptideAtlasiO95456
PRIDEiO95456
ProteomicsDBi50890
50891 [O95456-2]

PTM databases

iPTMnetiO95456
PhosphoSitePlusiO95456

Expressioni

Tissue specificityi

In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines.2 Publications

Gene expression databases

BgeeiENSG00000183527 Expressed in 228 organ(s), highest expression level in secondary oocyte
CleanExiHS_PSMG1
ExpressionAtlasiO95456 baseline and differential
GenevisibleiO95456 HS

Organism-specific databases

HPAiHPA057193
HPA070225

Interactioni

Subunit structurei

Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMG2Q969U74EBI-6286129,EBI-723276

Protein-protein interaction databases

BioGridi114179, 51 interactors
CORUMiO95456
IntActiO95456, 10 interactors
MINTiO95456
STRINGi9606.ENSP00000329915

Structurei

3D structure databases

ProteinModelPortaliO95456
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PSMG1 family.Curated

Phylogenomic databases

eggNOGiENOG410IGRN Eukaryota
ENOG4111EZT LUCA
GeneTreeiENSGT00500000044950
HOGENOMiHOG000072680
HOVERGENiHBG051410
InParanoidiO95456
KOiK11875
OMAiDYKTSES
OrthoDBiEOG091G19W8
PhylomeDBiO95456
TreeFamiTF331909

Family and domain databases

InterProiView protein in InterPro
IPR016565 Proteasome_assmbl_chp_1
PANTHERiPTHR15069 PTHR15069, 1 hit
PfamiView protein in Pfam
PF16094 PAC1, 1 hit
PIRSFiPIRSF010076 Psome_chaperone-1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95456-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAATFFGEVV KAPCRAGTED EEEEEEGRRE TPEDREVRLQ LARKREVRLL
60 70 80 90 100
RRQTKTSLEV SLLEKYPCSK FIIAIGNNAV AFLSSFVMNS GVWEEVGCAK
110 120 130 140 150
LWNEWCRTTD TTHLSSTEAF CVFYHLKSNP SVFLCQCSCY VAEDQQYQWL
160 170 180 190 200
EKVFGSCPRK NMQITILTCR HVTDYKTSES TGSLPSPFLR ALKTQNFKDS
210 220 230 240 250
ACCPLLEQPN IVHDLPAAVL SYCQVWKIPA ILYLCYTDVM KLDLITVEAF
260 270 280
KPILSTRSLK GLVKNIPQST EILKKLMTTN EIQSNIYT
Length:288
Mass (Da):32,854
Last modified:May 1, 1999 - v1
Checksum:i2D4A84485C290839
GO
Isoform 2 (identifier: O95456-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-152: Missing.

Show »
Length:267
Mass (Da):30,288
Checksum:iABC452F240DF79E7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WBH7F8WBH7_HUMAN
Proteasome assembly chaperone 1
PSMG1
63Annotation score:
H7C3B4H7C3B4_HUMAN
Proteasome assembly chaperone 1
PSMG1
13Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4T → S in CAG46650 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054014166I → V. Corresponds to variant dbSNP:rs8131611Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017261132 – 152Missing in isoform 2. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006291 mRNA Translation: CAA06957.1
AY463963 mRNA Translation: AAR25628.1
CR541821 mRNA Translation: CAG46620.1
CR541852 mRNA Translation: CAG46650.1
AB451468 mRNA Translation: BAG70282.1
AL163279 Genomic DNA Translation: CAB90451.1
CH471079 Genomic DNA Translation: EAX09664.1
CH471079 Genomic DNA Translation: EAX09665.1
BC003619 mRNA Translation: AAH03619.1
BC010424 mRNA Translation: AAH10424.1
BC011755 mRNA Translation: AAH11755.1
BC012809 mRNA Translation: AAH12809.1
BR000236 mRNA Translation: FAA00022.1
CCDSiCCDS13660.1 [O95456-1]
CCDS13661.1 [O95456-2]
PIRiJE0290
RefSeqiNP_003711.1, NM_003720.3 [O95456-1]
NP_982257.1, NM_203433.2 [O95456-2]
UniGeneiHs.473838

Genome annotation databases

EnsembliENST00000331573; ENSP00000329915; ENSG00000183527 [O95456-1]
ENST00000380900; ENSP00000370286; ENSG00000183527 [O95456-2]
GeneIDi8624
KEGGihsa:8624
UCSCiuc002yxi.5 human [O95456-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006291 mRNA Translation: CAA06957.1
AY463963 mRNA Translation: AAR25628.1
CR541821 mRNA Translation: CAG46620.1
CR541852 mRNA Translation: CAG46650.1
AB451468 mRNA Translation: BAG70282.1
AL163279 Genomic DNA Translation: CAB90451.1
CH471079 Genomic DNA Translation: EAX09664.1
CH471079 Genomic DNA Translation: EAX09665.1
BC003619 mRNA Translation: AAH03619.1
BC010424 mRNA Translation: AAH10424.1
BC011755 mRNA Translation: AAH11755.1
BC012809 mRNA Translation: AAH12809.1
BR000236 mRNA Translation: FAA00022.1
CCDSiCCDS13660.1 [O95456-1]
CCDS13661.1 [O95456-2]
PIRiJE0290
RefSeqiNP_003711.1, NM_003720.3 [O95456-1]
NP_982257.1, NM_203433.2 [O95456-2]
UniGeneiHs.473838

3D structure databases

ProteinModelPortaliO95456
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114179, 51 interactors
CORUMiO95456
IntActiO95456, 10 interactors
MINTiO95456
STRINGi9606.ENSP00000329915

Chemistry databases

ChEMBLiCHEMBL3885624

PTM databases

iPTMnetiO95456
PhosphoSitePlusiO95456

Polymorphism and mutation databases

BioMutaiPSMG1

Proteomic databases

EPDiO95456
MaxQBiO95456
PaxDbiO95456
PeptideAtlasiO95456
PRIDEiO95456
ProteomicsDBi50890
50891 [O95456-2]

Protocols and materials databases

DNASUi8624
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331573; ENSP00000329915; ENSG00000183527 [O95456-1]
ENST00000380900; ENSP00000370286; ENSG00000183527 [O95456-2]
GeneIDi8624
KEGGihsa:8624
UCSCiuc002yxi.5 human [O95456-1]

Organism-specific databases

CTDi8624
DisGeNETi8624
EuPathDBiHostDB:ENSG00000183527.11
GeneCardsiPSMG1
HGNCiHGNC:3043 PSMG1
HPAiHPA057193
HPA070225
MIMi605296 gene
neXtProtiNX_O95456
OpenTargetsiENSG00000183527
PharmGKBiPA162400229
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGRN Eukaryota
ENOG4111EZT LUCA
GeneTreeiENSGT00500000044950
HOGENOMiHOG000072680
HOVERGENiHBG051410
InParanoidiO95456
KOiK11875
OMAiDYKTSES
OrthoDBiEOG091G19W8
PhylomeDBiO95456
TreeFamiTF331909

Miscellaneous databases

GeneWikiiDSCR2
GenomeRNAii8624
PROiPR:O95456
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183527 Expressed in 228 organ(s), highest expression level in secondary oocyte
CleanExiHS_PSMG1
ExpressionAtlasiO95456 baseline and differential
GenevisibleiO95456 HS

Family and domain databases

InterProiView protein in InterPro
IPR016565 Proteasome_assmbl_chp_1
PANTHERiPTHR15069 PTHR15069, 1 hit
PfamiView protein in Pfam
PF16094 PAC1, 1 hit
PIRSFiPIRSF010076 Psome_chaperone-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSMG1_HUMAN
AccessioniPrimary (citable) accession number: O95456
Secondary accession number(s): B5BUN2
, Q6FHA3, Q6FHD3, Q6S713
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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