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Protein

Apolipoprotein M

Gene

APOM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136Fatty acid1
Binding sitei143Fatty acid1

GO - Molecular functioni

  • antioxidant activity Source: BHF-UCL
  • lipid transporter activity Source: BHF-UCL
  • phospholipid binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein M
Short name:
Apo-M
Short name:
ApoM
Alternative name(s):
Protein G3a
Gene namesi
Name:APOM
Synonyms:G3A, NG20
ORF Names:HSPC336
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204444.10
HGNCiHGNC:13916 APOM
MIMi606907 gene
neXtProtiNX_O95445

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi22Q → A: Introduces a signal cleavage site. Abolishes interaction with lipoprotein particles. Leads to rapid elimination from plasma. 3 Publications1
Mutagenesisi135N → Q: Loss of glycosylation. 1 Publication1
Mutagenesisi148N → Q: No loss of glycosylation. 1 Publication1

Organism-specific databases

DisGeNETi55937
OpenTargetsiENSG00000204444
PharmGKBiPA38370

Chemistry databases

DrugBankiDB08231 MYRISTIC ACID

Polymorphism and mutation databases

BioMutaiAPOM

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232781 – 188Apolipoprotein MAdd BLAST188
Signal peptidei1 – ?22Not cleavedAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 1671 Publication
Disulfide bondi95 ↔ 1831 Publication
Disulfide bondi128 ↔ 1571 Publication
Glycosylationi135N-linked (GlcNAc...) asparagine2 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO95445
PaxDbiO95445
PeptideAtlasiO95445
PRIDEiO95445
ProteomicsDBi50881

PTM databases

iPTMnetiO95445
PhosphoSitePlusiO95445

Expressioni

Tissue specificityi

Plasma protein. Expressed in liver and kidney.

Gene expression databases

BgeeiENSG00000204444 Expressed in 159 organ(s), highest expression level in liver
CleanExiHS_APOM
ExpressionAtlasiO95445 baseline and differential
GenevisibleiO95445 HS

Organism-specific databases

HPAiCAB034086
HPA051006

Interactioni

Subunit structurei

Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.By similarity

Protein-protein interaction databases

BioGridi121006, 7 interactors
IntActiO95445, 2 interactors
STRINGi9606.ENSP00000365081

Structurei

Secondary structure

1188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95445
SMRiO95445
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95445

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IG6S Eukaryota
ENOG4111Z0U LUCA
GeneTreeiENSGT00390000001026
HOGENOMiHOG000034009
HOVERGENiHBG018735
InParanoidiO95445
OMAiWYFIAGA
OrthoDBiEOG09370S12
PhylomeDBiO95445
TreeFamiTF330771

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR022734 ApoM
IPR012674 Calycin
PANTHERiPTHR32028 PTHR32028, 1 hit
PfamiView protein in Pfam
PF11032 ApoM, 1 hit
SUPFAMiSSF50814 SSF50814, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: O95445-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFHQIWAALL YFYGIILNSI YQCPEHSQLT TLGVDGKEFP EVHLGQWYFI
60 70 80 90 100
AGAAPTKEEL ATFDPVDNIV FNMAAGSAPM QLHLRATIRM KDGLCVPRKW
110 120 130 140 150
IYHLTEGSTD LRTEGRPDMK TELFSSSCPG GIMLNETGQG YQRFLLYNRS
160 170 180
PHPPEKCVEE FKSLTSCLDS KAFLLTPRNQ EACELSNN
Length:188
Mass (Da):21,253
Last modified:May 1, 2000 - v2
Checksum:iE4C35FEC32B7CB86
GO
Isoform 2 (identifier: O95445-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Note: No experimental confirmation available.
Show »
Length:116
Mass (Da):13,051
Checksum:iF78244DE4A76A382
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SRP5Q5SRP5_HUMAN
Apolipoprotein M
APOM
129Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 38MFHQI…VDGKE → RFPDSIWGSRSDTSGSPQVP KLYFCGARRESPQPQT in AAF29014 (Ref. 3) CuratedAdd BLAST38
Sequence conflicti175 – 188LTPRN…ELSNN → VDS in CAB51604 (Ref. 2) CuratedAdd BLAST14

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0455861 – 72Missing in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118393 mRNA Translation: AAD11443.2
AJ245434 mRNA Translation: CAB51604.1
AF161454 mRNA Translation: AAF29014.1
AF129756 Genomic DNA Translation: AAD18084.1
CN428415 mRNA No translation available.
BA000025 Genomic DNA Translation: BAB63389.1
AL662801 Genomic DNA No translation available.
AL670886 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR753842 Genomic DNA No translation available.
CR354443 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03461.1
CH471081 Genomic DNA Translation: EAX03463.1
BC020683 mRNA Translation: AAH20683.1
CCDSiCCDS4710.1 [O95445-1]
CCDS59004.1 [O95445-2]
RefSeqiNP_001243098.1, NM_001256169.1 [O95445-2]
NP_061974.2, NM_019101.2 [O95445-1]
UniGeneiHs.534468

Genome annotation databases

EnsembliENST00000375916; ENSP00000365081; ENSG00000204444 [O95445-1]
ENST00000375920; ENSP00000365085; ENSG00000204444 [O95445-2]
ENST00000383438; ENSP00000372930; ENSG00000206409 [O95445-1]
ENST00000400157; ENSP00000383021; ENSG00000206409 [O95445-2]
ENST00000416324; ENSP00000393581; ENSG00000224290 [O95445-2]
ENST00000422771; ENSP00000392021; ENSG00000226215 [O95445-2]
ENST00000425177; ENSP00000403062; ENSG00000235754 [O95445-2]
ENST00000426800; ENSP00000405730; ENSG00000227567 [O95445-1]
ENST00000430282; ENSP00000401684; ENSG00000224290 [O95445-1]
ENST00000432598; ENSP00000389591; ENSG00000235754 [O95445-1]
ENST00000436931; ENSP00000394610; ENSG00000231974 [O95445-1]
ENST00000439902; ENSP00000413446; ENSG00000227567 [O95445-2]
ENST00000441436; ENSP00000398944; ENSG00000226215 [O95445-1]
ENST00000443975; ENSP00000416335; ENSG00000231974 [O95445-2]
GeneIDi55937
KEGGihsa:55937
UCSCiuc003nvk.5 human [O95445-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAPOM_HUMAN
AccessioniPrimary (citable) accession number: O95445
Secondary accession number(s): B0UX98
, Q5SRP4, Q9P046, Q9UMP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health

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