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Protein

Sodium-dependent phosphate transport protein 2B

Gene

SLC34A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in actively transporting phosphate into cells via Na+ cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.

pH dependencei

Optimum pH is 6.6.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-427589 Type II Na+/Pi cotransporters
R-HSA-5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
R-HSA-5683826 Surfactant metabolism
R-HSA-5687583 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
SIGNORiO95436

Protein family/group databases

TCDBi2.A.58.1.4 the phosphate:na(+) symporter (pnas) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 2B
Short name:
Sodium-phosphate transport protein 2B
Alternative name(s):
Na(+)-dependent phosphate cotransporter 2B
NaPi3b
Sodium/phosphate cotransporter 2B
Short name:
Na(+)/Pi cotransporter 2B
Short name:
NaPi-2b
Solute carrier family 34 member 2
Gene namesi
Name:SLC34A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000157765.11
HGNCiHGNC:11020 SLC34A2
MIMi604217 gene
neXtProtiNX_O95436

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 100CytoplasmicSequence analysisAdd BLAST100
Transmembranei101 – 121Helical; Name=M1Sequence analysisAdd BLAST21
Topological domaini122 – 135ExtracellularSequence analysisAdd BLAST14
Transmembranei136 – 156Helical; Name=M2Sequence analysisAdd BLAST21
Topological domaini157 – 212CytoplasmicSequence analysisAdd BLAST56
Transmembranei213 – 233Helical; Name=M3Sequence analysisAdd BLAST21
Topological domaini234 – 362ExtracellularSequence analysisAdd BLAST129
Transmembranei363 – 383Helical; Name=M4Sequence analysisAdd BLAST21
Topological domaini384 – 407CytoplasmicSequence analysisAdd BLAST24
Transmembranei408 – 428Helical; Name=M5Sequence analysisAdd BLAST21
Topological domaini429 – 485ExtracellularSequence analysisAdd BLAST57
Transmembranei486 – 506Helical; Name=M6Sequence analysisAdd BLAST21
Topological domaini507 – 525CytoplasmicSequence analysisAdd BLAST19
Transmembranei526 – 546Helical; Name=M7Sequence analysisAdd BLAST21
Topological domaini547 – 552ExtracellularSequence analysis6
Transmembranei553 – 573Helical; Name=M8Sequence analysisAdd BLAST21
Topological domaini574 – 689CytoplasmicSequence analysisAdd BLAST116

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Pulmonary alveolar microlithiasis (PALM)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early-onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance.
See also OMIM:265100
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030677106G → R in PALM. 1 PublicationCorresponds to variant dbSNP:rs137853142EnsemblClinVar.1
A chromosomal aberration involving SLC34A2 is found in a glioblastoma multiforme cell line U-118MG. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei126 – 127Breakpoint for translocation to form a SLC34A2-ROS1 fusion protein2

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi10568
MalaCardsiSLC34A2
MIMi265100 phenotype
OpenTargetsiENSG00000157765
Orphaneti60025 Pulmonary alveolar microlithiasis
PharmGKBiPA35888

Polymorphism and mutation databases

BioMutaiSLC34A2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686131 – 690Sodium-dependent phosphate transport protein 2BAdd BLAST690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi303 ↔ 350By similarity
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi313N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO95436
PaxDbiO95436
PeptideAtlasiO95436
PRIDEiO95436
ProteomicsDBi50879
50880 [O95436-2]

PTM databases

iPTMnetiO95436
PhosphoSitePlusiO95436

Expressioni

Tissue specificityi

Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.2 Publications

Inductioni

Down-regulated by EGF.1 Publication

Gene expression databases

BgeeiENSG00000157765 Expressed in 116 organ(s), highest expression level in right lung
CleanExiHS_SLC34A2
ExpressionAtlasiO95436 baseline and differential
GenevisibleiO95436 HS

Organism-specific databases

HPAiHPA037989

Interactioni

Protein-protein interaction databases

BioGridi115819, 15 interactors
IntActiO95436, 16 interactors
STRINGi9606.ENSP00000371483

Structurei

3D structure databases

ProteinModelPortaliO95436
SMRiO95436
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi464 – 467Poly-Thr4
Compositional biasi612 – 644Cys-richAdd BLAST33

Sequence similaritiesi

Belongs to the SLC34A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8P Eukaryota
COG1283 LUCA
GeneTreeiENSGT00390000005032
HOGENOMiHOG000006550
HOVERGENiHBG006527
InParanoidiO95436
KOiK14683
OMAiIWCKTFT
OrthoDBiEOG091G0DR5
PhylomeDBiO95436
TreeFamiTF313981

Family and domain databases

InterProiView protein in InterPro
IPR003841 Na/Pi_transpt
IPR029852 Na/Pi_transpt_2B
PANTHERiPTHR10010 PTHR10010, 1 hit
PTHR10010:SF23 PTHR10010:SF23, 1 hit
PfamiView protein in Pfam
PF02690 Na_Pi_cotrans, 2 hits
TIGRFAMsiTIGR01013 2a58, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95436-1) [UniParc]FASTAAdd to basket
Also known as: NaPi-3b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPWPELGDA QPNPDKYLEG AAGQQPTAPD KSKETNKTDN TEAPVTKIEL
60 70 80 90 100
LPSYSTATLI DEPTEVDDPW NLPTLQDSGI KWSERDTKGK ILCFFQGIGR
110 120 130 140 150
LILLLGFLYF FVCSLDILSS AFQLVGGKMA GQFFSNSSIM SNPLLGLVIG
160 170 180 190 200
VLVTVLVQSS STSTSIVVSM VSSSLLTVRA AIPIIMGANI GTSITNTIVA
210 220 230 240 250
LMQVGDRSEF RRAFAGATVH DFFNWLSVLV LLPVEVATHY LEIITQLIVE
260 270 280 290 300
SFHFKNGEDA PDLLKVITKP FTKLIVQLDK KVISQIAMND EKAKNKSLVK
310 320 330 340 350
IWCKTFTNKT QINVTVPSTA NCTSPSLCWT DGIQNWTMKN VTYKENIAKC
360 370 380 390 400
QHIFVNFHLP DLAVGTILLI LSLLVLCGCL IMIVKILGSV LKGQVATVIK
410 420 430 440 450
KTINTDFPFP FAWLTGYLAI LVGAGMTFIV QSSSVFTSAL TPLIGIGVIT
460 470 480 490 500
IERAYPLTLG SNIGTTTTAI LAALASPGNA LRSSLQIALC HFFFNISGIL
510 520 530 540 550
LWYPIPFTRL PIRMAKGLGN ISAKYRWFAV FYLIIFFFLI PLTVFGLSLA
560 570 580 590 600
GWRVLVGVGV PVVFIIILVL CLRLLQSRCP RVLPKKLQNW NFLPLWMRSL
610 620 630 640 650
KPWDAVVSKF TGCFQMRCCC CCRVCCRACC LLCDCPKCCR CSKCCEDLEE
660 670 680 690
AQEGQDVPVK APETFDNITI SREAQGEVPA SDSKTECTAL
Length:690
Mass (Da):75,759
Last modified:November 30, 2010 - v3
Checksum:i3BDB1920CA92C035
GO
Isoform 2 (identifier: O95436-2) [UniParc]FASTAAdd to basket
Also known as: NaPi-2b, NaPi-IIb

The sequence of this isoform differs from the canonical sequence as follows:
     38-39: TD → N

Show »
Length:689
Mass (Da):75,657
Checksum:iB8D40075B1266490
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RA94D6RA94_HUMAN
Sodium-dependent phosphate transpor...
SLC34A2
163Annotation score:
D6RBC0D6RBC0_HUMAN
Sodium-dependent phosphate transpor...
SLC34A2
161Annotation score:

Sequence cautioni

The sequence BAC11354 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228V → L in AAF31328 (PubMed:10610722).Curated1
Sequence conflicti228V → L in AAL55657 (PubMed:11171583).Curated1
Sequence conflicti330T → V in BAC11354 (PubMed:14702039).Curated1
Sequence conflicti590 – 595Missing in BAC11354 (PubMed:14702039).Curated6
Sequence conflicti620C → Y in AAC98695 (PubMed:10329428).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03415645V → A. Corresponds to variant dbSNP:rs35426730Ensembl.1
Natural variantiVAR_030677106G → R in PALM. 1 PublicationCorresponds to variant dbSNP:rs137853142EnsemblClinVar.1
Natural variantiVAR_030678634D → G4 PublicationsCorresponds to variant dbSNP:rs6448389Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01675538 – 39TD → N in isoform 2. 2 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111856 mRNA Translation: AAC98695.1
AF146796 mRNA Translation: AAF31328.1
AC092436 Genomic DNA No translation available.
BC142704 mRNA Translation: AAI42705.1
BC146666 mRNA Translation: AAI46667.1
AH011306 Genomic DNA Translation: AAL55657.1
AK075015 mRNA Translation: BAC11354.1 Different initiation.
CCDSiCCDS3435.1 [O95436-1]
CCDS54750.1 [O95436-2]
RefSeqiNP_001171469.1, NM_001177998.1
NP_001171470.1, NM_001177999.1
NP_006415.2, NM_006424.2
UniGeneiHs.479372

Genome annotation databases

EnsembliENST00000382051; ENSP00000371483; ENSG00000157765 [O95436-1]
ENST00000503434; ENSP00000423021; ENSG00000157765 [O95436-2]
ENST00000504570; ENSP00000425501; ENSG00000157765 [O95436-2]
ENST00000645788; ENSP00000494094; ENSG00000157765 [O95436-2]
GeneIDi10568
KEGGihsa:10568
UCSCiuc003grr.4 human [O95436-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111856 mRNA Translation: AAC98695.1
AF146796 mRNA Translation: AAF31328.1
AC092436 Genomic DNA No translation available.
BC142704 mRNA Translation: AAI42705.1
BC146666 mRNA Translation: AAI46667.1
AH011306 Genomic DNA Translation: AAL55657.1
AK075015 mRNA Translation: BAC11354.1 Different initiation.
CCDSiCCDS3435.1 [O95436-1]
CCDS54750.1 [O95436-2]
RefSeqiNP_001171469.1, NM_001177998.1
NP_001171470.1, NM_001177999.1
NP_006415.2, NM_006424.2
UniGeneiHs.479372

3D structure databases

ProteinModelPortaliO95436
SMRiO95436
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115819, 15 interactors
IntActiO95436, 16 interactors
STRINGi9606.ENSP00000371483

Protein family/group databases

TCDBi2.A.58.1.4 the phosphate:na(+) symporter (pnas) family

PTM databases

iPTMnetiO95436
PhosphoSitePlusiO95436

Polymorphism and mutation databases

BioMutaiSLC34A2

Proteomic databases

MaxQBiO95436
PaxDbiO95436
PeptideAtlasiO95436
PRIDEiO95436
ProteomicsDBi50879
50880 [O95436-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382051; ENSP00000371483; ENSG00000157765 [O95436-1]
ENST00000503434; ENSP00000423021; ENSG00000157765 [O95436-2]
ENST00000504570; ENSP00000425501; ENSG00000157765 [O95436-2]
ENST00000645788; ENSP00000494094; ENSG00000157765 [O95436-2]
GeneIDi10568
KEGGihsa:10568
UCSCiuc003grr.4 human [O95436-1]

Organism-specific databases

CTDi10568
DisGeNETi10568
EuPathDBiHostDB:ENSG00000157765.11
GeneCardsiSLC34A2
HGNCiHGNC:11020 SLC34A2
HPAiHPA037989
MalaCardsiSLC34A2
MIMi265100 phenotype
604217 gene
neXtProtiNX_O95436
OpenTargetsiENSG00000157765
Orphaneti60025 Pulmonary alveolar microlithiasis
PharmGKBiPA35888
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE8P Eukaryota
COG1283 LUCA
GeneTreeiENSGT00390000005032
HOGENOMiHOG000006550
HOVERGENiHBG006527
InParanoidiO95436
KOiK14683
OMAiIWCKTFT
OrthoDBiEOG091G0DR5
PhylomeDBiO95436
TreeFamiTF313981

Enzyme and pathway databases

ReactomeiR-HSA-427589 Type II Na+/Pi cotransporters
R-HSA-5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
R-HSA-5683826 Surfactant metabolism
R-HSA-5687583 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
SIGNORiO95436

Miscellaneous databases

ChiTaRSiSLC34A2 human
GeneWikiiSLC34A2
GenomeRNAii10568
PROiPR:O95436
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157765 Expressed in 116 organ(s), highest expression level in right lung
CleanExiHS_SLC34A2
ExpressionAtlasiO95436 baseline and differential
GenevisibleiO95436 HS

Family and domain databases

InterProiView protein in InterPro
IPR003841 Na/Pi_transpt
IPR029852 Na/Pi_transpt_2B
PANTHERiPTHR10010 PTHR10010, 1 hit
PTHR10010:SF23 PTHR10010:SF23, 1 hit
PfamiView protein in Pfam
PF02690 Na_Pi_cotrans, 2 hits
TIGRFAMsiTIGR01013 2a58, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPT2B_HUMAN
AccessioniPrimary (citable) accession number: O95436
Secondary accession number(s): A5PL17
, Q8N2K2, Q8WYA9, Q9P0V7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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