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Entry version 146 (13 Nov 2019)
Sequence version 3 (30 Nov 2010)
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Protein

Sodium-dependent phosphate transport protein 2B

Gene

SLC34A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in actively transporting phosphate into cells via Na+ cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 6.6.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-427589 Type II Na+/Pi cotransporters
R-HSA-5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
R-HSA-5683826 Surfactant metabolism
R-HSA-5687583 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O95436

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.58.1.4 the phosphate:na(+) symporter (pnas) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 2B
Short name:
Sodium-phosphate transport protein 2B
Alternative name(s):
Na(+)-dependent phosphate cotransporter 2B
NaPi3b
Sodium/phosphate cotransporter 2B
Short name:
Na(+)/Pi cotransporter 2B
Short name:
NaPi-2b
Solute carrier family 34 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC34A2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11020 SLC34A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604217 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95436

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 100CytoplasmicSequence analysisAdd BLAST100
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei101 – 121Helical; Name=M1Sequence analysisAdd BLAST21
Topological domaini122 – 135ExtracellularSequence analysisAdd BLAST14
Transmembranei136 – 156Helical; Name=M2Sequence analysisAdd BLAST21
Topological domaini157 – 212CytoplasmicSequence analysisAdd BLAST56
Transmembranei213 – 233Helical; Name=M3Sequence analysisAdd BLAST21
Topological domaini234 – 362ExtracellularSequence analysisAdd BLAST129
Transmembranei363 – 383Helical; Name=M4Sequence analysisAdd BLAST21
Topological domaini384 – 407CytoplasmicSequence analysisAdd BLAST24
Transmembranei408 – 428Helical; Name=M5Sequence analysisAdd BLAST21
Topological domaini429 – 485ExtracellularSequence analysisAdd BLAST57
Transmembranei486 – 506Helical; Name=M6Sequence analysisAdd BLAST21
Topological domaini507 – 525CytoplasmicSequence analysisAdd BLAST19
Transmembranei526 – 546Helical; Name=M7Sequence analysisAdd BLAST21
Topological domaini547 – 552ExtracellularSequence analysis6
Transmembranei553 – 573Helical; Name=M8Sequence analysisAdd BLAST21
Topological domaini574 – 689CytoplasmicSequence analysisAdd BLAST116

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pulmonary alveolar microlithiasis (PALM)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early-onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030677106G → R in PALM. 1 PublicationCorresponds to variant dbSNP:rs137853142EnsemblClinVar.1
A chromosomal aberration involving SLC34A2 is found in a glioblastoma multiforme cell line U-118MG. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei126 – 127Breakpoint for translocation to form a SLC34A2-ROS1 fusion protein2

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
10568

MalaCards human disease database

More...
MalaCardsi
SLC34A2
MIMi265100 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000157765

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
60025 Pulmonary alveolar microlithiasis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35888

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O95436

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB11348 Calcium Phosphate
DB14481 Calcium phosphate dihydrate
DB14502 Sodium phosphate, dibasic
DB09449 Sodium phosphate, monobasic
DB14503 Sodium phosphate, monobasic, unspecified form

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC34A2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000686131 – 690Sodium-dependent phosphate transport protein 2BAdd BLAST690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi303 ↔ 350By similarity
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi313N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O95436

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95436

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95436

PeptideAtlas

More...
PeptideAtlasi
O95436

PRoteomics IDEntifications database

More...
PRIDEi
O95436

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50879 [O95436-1]
50880 [O95436-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95436

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95436

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by EGF.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000157765 Expressed in 116 organ(s), highest expression level in right lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95436 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95436 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037989

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115819, 15 interactors

Protein interaction database and analysis system

More...
IntActi
O95436, 29 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371483

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95436

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi464 – 467Poly-Thr4
Compositional biasi612 – 644Cys-richAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC34A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE8P Eukaryota
COG1283 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183177

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006550

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95436

KEGG Orthology (KO)

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KOi
K14683

Identification of Orthologs from Complete Genome Data

More...
OMAi
SKCCEDL

Database of Orthologous Groups

More...
OrthoDBi
976094at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95436

TreeFam database of animal gene trees

More...
TreeFami
TF313981

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003841 Na/Pi_transpt
IPR029852 Na/Pi_transpt_2B

The PANTHER Classification System

More...
PANTHERi
PTHR10010 PTHR10010, 1 hit
PTHR10010:SF23 PTHR10010:SF23, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02690 Na_Pi_cotrans, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01013 2a58, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95436-1) [UniParc]FASTAAdd to basket
Also known as: NaPi-3b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPWPELGDA QPNPDKYLEG AAGQQPTAPD KSKETNKTDN TEAPVTKIEL
60 70 80 90 100
LPSYSTATLI DEPTEVDDPW NLPTLQDSGI KWSERDTKGK ILCFFQGIGR
110 120 130 140 150
LILLLGFLYF FVCSLDILSS AFQLVGGKMA GQFFSNSSIM SNPLLGLVIG
160 170 180 190 200
VLVTVLVQSS STSTSIVVSM VSSSLLTVRA AIPIIMGANI GTSITNTIVA
210 220 230 240 250
LMQVGDRSEF RRAFAGATVH DFFNWLSVLV LLPVEVATHY LEIITQLIVE
260 270 280 290 300
SFHFKNGEDA PDLLKVITKP FTKLIVQLDK KVISQIAMND EKAKNKSLVK
310 320 330 340 350
IWCKTFTNKT QINVTVPSTA NCTSPSLCWT DGIQNWTMKN VTYKENIAKC
360 370 380 390 400
QHIFVNFHLP DLAVGTILLI LSLLVLCGCL IMIVKILGSV LKGQVATVIK
410 420 430 440 450
KTINTDFPFP FAWLTGYLAI LVGAGMTFIV QSSSVFTSAL TPLIGIGVIT
460 470 480 490 500
IERAYPLTLG SNIGTTTTAI LAALASPGNA LRSSLQIALC HFFFNISGIL
510 520 530 540 550
LWYPIPFTRL PIRMAKGLGN ISAKYRWFAV FYLIIFFFLI PLTVFGLSLA
560 570 580 590 600
GWRVLVGVGV PVVFIIILVL CLRLLQSRCP RVLPKKLQNW NFLPLWMRSL
610 620 630 640 650
KPWDAVVSKF TGCFQMRCCC CCRVCCRACC LLCDCPKCCR CSKCCEDLEE
660 670 680 690
AQEGQDVPVK APETFDNITI SREAQGEVPA SDSKTECTAL
Length:690
Mass (Da):75,759
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3BDB1920CA92C035
GO
Isoform 2 (identifier: O95436-2) [UniParc]FASTAAdd to basket
Also known as: NaPi-2b, NaPi-IIb

The sequence of this isoform differs from the canonical sequence as follows:
     38-39: TD → N

Show »
Length:689
Mass (Da):75,657
Checksum:iB8D40075B1266490
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RA94D6RA94_HUMAN
Sodium-dependent phosphate transpor...
SLC34A2
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBC0D6RBC0_HUMAN
Sodium-dependent phosphate transpor...
SLC34A2
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11354 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti228V → L in AAF31328 (PubMed:10610722).Curated1
Sequence conflicti228V → L in AAL55657 (PubMed:11171583).Curated1
Sequence conflicti330T → V in BAC11354 (PubMed:14702039).Curated1
Sequence conflicti590 – 595Missing in BAC11354 (PubMed:14702039).Curated6
Sequence conflicti620C → Y in AAC98695 (PubMed:10329428).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03415645V → A. Corresponds to variant dbSNP:rs35426730Ensembl.1
Natural variantiVAR_030677106G → R in PALM. 1 PublicationCorresponds to variant dbSNP:rs137853142EnsemblClinVar.1
Natural variantiVAR_030678634D → G4 PublicationsCorresponds to variant dbSNP:rs6448389EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01675538 – 39TD → N in isoform 2. 2 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF111856 mRNA Translation: AAC98695.1
AF146796 mRNA Translation: AAF31328.1
AC092436 Genomic DNA No translation available.
BC142704 mRNA Translation: AAI42705.1
BC146666 mRNA Translation: AAI46667.1
AH011306 Genomic DNA Translation: AAL55657.1
AK075015 mRNA Translation: BAC11354.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS3435.1 [O95436-1]
CCDS54750.1 [O95436-2]

NCBI Reference Sequences

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RefSeqi
NP_001171469.1, NM_001177998.1 [O95436-2]
NP_001171470.1, NM_001177999.1
NP_006415.2, NM_006424.2 [O95436-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000382051; ENSP00000371483; ENSG00000157765 [O95436-1]
ENST00000503434; ENSP00000423021; ENSG00000157765 [O95436-2]
ENST00000504570; ENSP00000425501; ENSG00000157765 [O95436-2]
ENST00000645788; ENSP00000494094; ENSG00000157765 [O95436-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10568

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10568

UCSC genome browser

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UCSCi
uc003grr.4 human [O95436-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111856 mRNA Translation: AAC98695.1
AF146796 mRNA Translation: AAF31328.1
AC092436 Genomic DNA No translation available.
BC142704 mRNA Translation: AAI42705.1
BC146666 mRNA Translation: AAI46667.1
AH011306 Genomic DNA Translation: AAL55657.1
AK075015 mRNA Translation: BAC11354.1 Different initiation.
CCDSiCCDS3435.1 [O95436-1]
CCDS54750.1 [O95436-2]
RefSeqiNP_001171469.1, NM_001177998.1 [O95436-2]
NP_001171470.1, NM_001177999.1
NP_006415.2, NM_006424.2 [O95436-1]

3D structure databases

SMRiO95436
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115819, 15 interactors
IntActiO95436, 29 interactors
STRINGi9606.ENSP00000371483

Chemistry databases

DrugBankiDB11348 Calcium Phosphate
DB14481 Calcium phosphate dihydrate
DB14502 Sodium phosphate, dibasic
DB09449 Sodium phosphate, monobasic
DB14503 Sodium phosphate, monobasic, unspecified form

Protein family/group databases

TCDBi2.A.58.1.4 the phosphate:na(+) symporter (pnas) family

PTM databases

iPTMnetiO95436
PhosphoSitePlusiO95436

Polymorphism and mutation databases

BioMutaiSLC34A2

Proteomic databases

MassIVEiO95436
MaxQBiO95436
PaxDbiO95436
PeptideAtlasiO95436
PRIDEiO95436
ProteomicsDBi50879 [O95436-1]
50880 [O95436-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
O95436

Genome annotation databases

EnsembliENST00000382051; ENSP00000371483; ENSG00000157765 [O95436-1]
ENST00000503434; ENSP00000423021; ENSG00000157765 [O95436-2]
ENST00000504570; ENSP00000425501; ENSG00000157765 [O95436-2]
ENST00000645788; ENSP00000494094; ENSG00000157765 [O95436-2]
GeneIDi10568
KEGGihsa:10568
UCSCiuc003grr.4 human [O95436-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10568
DisGeNETi10568

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC34A2
HGNCiHGNC:11020 SLC34A2
HPAiHPA037989
MalaCardsiSLC34A2
MIMi265100 phenotype
604217 gene
neXtProtiNX_O95436
OpenTargetsiENSG00000157765
Orphaneti60025 Pulmonary alveolar microlithiasis
PharmGKBiPA35888

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE8P Eukaryota
COG1283 LUCA
GeneTreeiENSGT00950000183177
HOGENOMiHOG000006550
InParanoidiO95436
KOiK14683
OMAiSKCCEDL
OrthoDBi976094at2759
PhylomeDBiO95436
TreeFamiTF313981

Enzyme and pathway databases

ReactomeiR-HSA-427589 Type II Na+/Pi cotransporters
R-HSA-5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
R-HSA-5683826 Surfactant metabolism
R-HSA-5687583 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
SIGNORiO95436

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC34A2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC34A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10568
PharosiO95436

Protein Ontology

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PROi
PR:O95436

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000157765 Expressed in 116 organ(s), highest expression level in right lung
ExpressionAtlasiO95436 baseline and differential
GenevisibleiO95436 HS

Family and domain databases

InterProiView protein in InterPro
IPR003841 Na/Pi_transpt
IPR029852 Na/Pi_transpt_2B
PANTHERiPTHR10010 PTHR10010, 1 hit
PTHR10010:SF23 PTHR10010:SF23, 1 hit
PfamiView protein in Pfam
PF02690 Na_Pi_cotrans, 2 hits
TIGRFAMsiTIGR01013 2a58, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNPT2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95436
Secondary accession number(s): A5PL17
, Q8N2K2, Q8WYA9, Q9P0V7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 30, 2010
Last modified: November 13, 2019
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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