AHSA1

Functionⁱ

Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155).2 Publications

GO - Molecular functionⁱ

ATPase activator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 27353360
- 29127155
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
chaperone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 27353360
Hsp90 protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 29127155

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of ATPase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 29127155

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Biological process	Stress response

Enzyme and pathway databases

SIGNORⁱ	O95433

SIGNORⁱ

O95433

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Activator of 90 kDa heat shock protein ATPase homolog 1 Short name: AHA1 Alternative name(s): p38
Gene namesⁱ	Name:AHSA1 Synonyms:C14orf3 ORF Names:HSPC322
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100591.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1189 AHSA1
MIMⁱ	608466 gene
neXtProtⁱ	NX_O95433

Keywords - Cellular componentⁱ

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	223	Y → E: Phosphomimetic mutant. Increases the binding to HSP90AA1 resulting in TSC1 dissociation from HSP90AA1. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10598
Open Targets More...OpenTargetsⁱ	ENSG00000100591
PharmGKBⁱ	PA25515

Chemistry databases

ChEMBLⁱ	CHEMBL3309113

ChEMBLⁱ

CHEMBL3309113

Polymorphism and mutation databases

BioMutaⁱ	AHSA1

BioMutaⁱ

AHSA1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000215820	1 – 338	Activator of 90 kDa heat shock protein ATPase homolog 1Add BLAST		338

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	3	N6-acetyllysineCombined sources	1
Cross-linkⁱ	182	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residueⁱ	193	PhosphoserineCombined sources	1
Cross-linkⁱ	203	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	212	N6-acetyllysineCombined sources	1
Modified residueⁱ	223	Phosphotyrosine; by ABL1 Publication	1
Modified residueⁱ	258	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O95433
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95433
PaxDbⁱ	O95433
PeptideAtlas More...PeptideAtlasⁱ	O95433
PRIDEⁱ	O95433
ProteomicsDBⁱ	50878

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00030706

REPRODUCTION-2DPAGEⁱ

IPI00030706

PTM databases

iPTMnetⁱ	O95433
PhosphoSitePlusⁱ	O95433
SwissPalmⁱ	O95433

Expressionⁱ

Tissue specificityⁱ

Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.1 Publication

Inductionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000100591 Expressed in 233 organ(s), highest expression level in right testis
CleanExⁱ	HS_AHSA1
ExpressionAtlasⁱ	O95433 baseline and differential
Genevisibleⁱ	O95433 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB006244 HPA000903

HPAⁱ

CAB006244
HPA000903

Interactionⁱ

Subunit structureⁱ

Interacts with HSPCA/HSP90 (PubMed:12504007, PubMed:12604615). Interacts (phosphorylated on Tyr-223) with HSP90AA1; the interaction activates HSP90AA1 ATPase activity (PubMed:27353360, PubMed:29127155). Interacts with HSP90AB1 (By similarity). Interacts with GCH1 (PubMed:16696853). Interacts with SRPK1 (PubMed:19240134). Interacts with FLCN (PubMed:27353360).By similarity6 Publications

(Microbial infection) Interacts with vesicular stomatitis virus glycoprotein (VSV G) (via cytoplasmic tail).1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
GCH1	P30793	3	EBI-448610,EBI-958183
HSP90AA1	P07900	4	EBI-448610,EBI-296047
HSP90AB1	P08238	3	EBI-448610,EBI-352572

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
chaperone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 27353360
Hsp90 protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 29127155

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115846, 178 interactors
IntActⁱ	O95433, 31 interactors
Molecular INTeraction database More...MINTⁱ	O95433
STRINGⁱ	9606.ENSP00000216479

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	206 – 217	Combined sources	12
Helixⁱ	219 – 225	Combined sources	7
Helixⁱ	229 – 235	Combined sources	7
Turnⁱ	253 – 256	Combined sources	4
Beta strandⁱ	261 – 265	Combined sources	5
Turnⁱ	266 – 268	Combined sources	3
Beta strandⁱ	269 – 276	Combined sources	8
Beta strandⁱ	285 – 290	Combined sources	6
Beta strandⁱ	298 – 308	Combined sources	11
Helixⁱ	309 – 317	Combined sources	9
Turnⁱ	318 – 323	Combined sources	6
Helixⁱ	324 – 330	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	O95433
SMRⁱ	O95433
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O95433

EvolutionaryTraceⁱ

O95433

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the AHA1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2936 Eukaryota COG5580 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006429
HOGENOMⁱ	HOG000242852
HOVERGENⁱ	HBG065806
InParanoidⁱ	O95433
OMAⁱ	WVDKNCI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BRP
PhylomeDBⁱ	O95433
TreeFamⁱ	TF313680

Family and domain databases

Gene3Dⁱ	3.15.10.20, 1 hit 3.30.530.20, 1 hit
InterProⁱ	View protein in InterPro IPR013538 Activator_of_Hsp90_ATPase IPR036338 Aha1 IPR039981 AHSA-like IPR015310 AHSA1_N IPR023393 START-like_dom_sf
PANTHERⁱ	PTHR13009 PTHR13009, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09229 Aha1_N, 1 hit PF08327 AHSA1, 1 hit
SMARTⁱ	View protein in SMART SM01000 Aha1_N, 1 hit
SUPFAMⁱ	SSF103111 SSF103111, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O95433-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKWGEGDPR WIVEERADAT NVNNWHWTER DASNWSTDKL KTLFLAVQVQ 
        60         70         80         90        100
NEEGKCEVTE VSKLDGEASI NNRKGKLIFF YEWSVKLNWT GTSKSGVQYK 
       110        120        130        140        150
GHVEIPNLSD ENSVDEVEIS VSLAKDEPDT NLVALMKEEG VKLLREAMGI 
       160        170        180        190        200
YISTLKTEFT QGMILPTMNG ESVDPVGQPA LKTEERKAKP APSKTQARPV 
       210        220        230        240        250
GVKIPTCKIT LKETFLTSPE ELYRVFTTQE LVQAFTHAPA TLEADRGGKF 
       260        270        280        290        300
HMVDGNVSGE FTDLVPEKHI VMKWRFKSWP EGHFATITLT FIDKNGETEL 
       310        320        330 
CMEGRGIPAP EEERTRQGWQ RYYFEGIKQT FGYGARLF

Length:338

Mass (Da):38,274

Last modified:May 1, 1999 - v1

Checksum:ⁱE6B686DDD8D7D729

GO

Isoform 2 (identifier: O95433-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
283-338: HFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYGARLF → SHCHSG

« Hide

        10         20         30         40         50
MAKWGEGDPR WIVEERADAT NVNNWHWTER DASNWSTDKL KTLFLAVQVQ 
        60         70         80         90        100
NEEGKCEVTE VSKLDGEASI NNRKGKLIFF YEWSVKLNWT GTSKSGVQYK 
       110        120        130        140        150
GHVEIPNLSD ENSVDEVEIS VSLAKDEPDT NLVALMKEEG VKLLREAMGI 
       160        170        180        190        200
YISTLKTEFT QGMILPTMNG ESVDPVGQPA LKTEERKAKP APSKTQARPV 
       210        220        230        240        250
GVKIPTCKIT LKETFLTSPE ELYRVFTTQE LVQAFTHAPA TLEADRGGKF 
       260        270        280 
HMVDGNVSGE FTDLVPEKHI VMKWRFKSWP EGSHCHSG

Note: No experimental confirmation available.

Show »

Length:288

Mass (Da):32,340

Checksum:ⁱ4ACB777F0ED29F4E

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3V438	G3V438_HUMAN	Activator of 90 kDa heat shock prot... Activator of 90 kDa heat shock protein ATPase homolog 1	AHSA1	203	Annotation score:
H0YJU2	H0YJU2_HUMAN	Activator of 90 kDa heat shock prot... Activator of 90 kDa heat shock protein ATPase homolog 1	AHSA1	133	Annotation score:
H0YJG7	H0YJG7_HUMAN	Activator of 90 kDa heat shock prot... Activator of 90 kDa heat shock protein ATPase homolog 1	AHSA1	216	Annotation score:
G3V3W9	G3V3W9_HUMAN	Activator of 90 kDa heat shock prot... Activator of 90 kDa heat shock protein ATPase homolog 1	AHSA1	100	Annotation score:
H0YJ63	H0YJ63_HUMAN	Activator of 90 kDa heat shock prot... Activator of 90 kDa heat shock protein ATPase homolog 1	AHSA1	90	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	67 – 68	EA → CL in AAF29000 (PubMed:11042152).Curated		2

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055797	283 – 338	HFATI…GARLF → SHCHSG in isoform 2. 1 PublicationAdd BLAST		56

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ243310 mRNA Translation: CAB45684.1 AF164791 mRNA Translation: AAF80755.1 AK300766 mRNA Translation: BAG62431.1 AK313824 mRNA Translation: BAG36559.1 AF111168 Genomic DNA Translation: AAD09623.1 CH471061 Genomic DNA Translation: EAW81291.1 BC000321 mRNA Translation: AAH00321.1 BC007398 mRNA Translation: AAH07398.2 AF161440 mRNA Translation: AAF29000.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9863.1 [O95433-1]
PIRⁱ	JC7769
NCBI Reference Sequences More...RefSeqⁱ	NP_001308370.1, NM_001321441.1 NP_036243.1, NM_012111.2 [O95433-1]
UniGeneⁱ	Hs.204041

Genome annotation databases

Ensemblⁱ	ENST00000216479; ENSP00000216479; ENSG00000100591 [O95433-1] ENST00000535854; ENSP00000440108; ENSG00000100591 [O95433-2]
GeneIDⁱ	10598
KEGGⁱ	hsa:10598
UCSC genome browser More...UCSCⁱ	uc001xtw.4 human [O95433-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95433	Activator of HSP90 ATPase activity 1		GORGO		338	UniRef100_O95433
Activator of 90 kDa heat shock protein ATPase homolog 1 (Fragment)		HUMAN		203

Protein	Similar proteins		Species	Score	Length	Source
O95433	Activator of 90 kDa heat shock protein ATPase homolog 1		MOUSE		338	UniRef90_O95433
Activator of HSP90 ATPase activity 1		GORGO		338
Activator of 90 kDa heat shock protein ATPase homolog 1 (Fragment)		HUMAN		203
Uncharacterized protein		OTOGA		339
activator of 90 kDa heat shock protein ATPase homolog 1 isoform X1		Florida manatee		339
+107

Protein	Similar proteins		Species	Score	Length	Source
O95433	Activator of 90 kDa heat shock protein ATPase homolog 1		MOUSE		338	UniRef50_O95433
Activator of HSP90 ATPase activity 1		GORGO		338
Activator of 90 kDa heat shock protein ATPase homolog 1 (Fragment)		HUMAN		203
activator of 90 kDa heat shock protein ATPase homolog 1 isoform X1		Florida manatee		339
Uncharacterized protein		LOXAF		339
+486

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ243310 mRNA Translation: CAB45684.1 AF164791 mRNA Translation: AAF80755.1 AK300766 mRNA Translation: BAG62431.1 AK313824 mRNA Translation: BAG36559.1 AF111168 Genomic DNA Translation: AAD09623.1 CH471061 Genomic DNA Translation: EAW81291.1 BC000321 mRNA Translation: AAH00321.1 BC007398 mRNA Translation: AAH07398.2 AF161440 mRNA Translation: AAF29000.1
CCDSⁱ	CCDS9863.1 [O95433-1]
PIRⁱ	JC7769
RefSeqⁱ	NP_001308370.1, NM_001321441.1 NP_036243.1, NM_012111.2 [O95433-1]
UniGeneⁱ	Hs.204041

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1X53	NMR	-	A	204-335	[»]
ProteinModelPortalⁱ	O95433
SMRⁱ	O95433
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115846, 178 interactors
IntActⁱ	O95433, 31 interactors
MINTⁱ	O95433
STRINGⁱ	9606.ENSP00000216479

Chemistry databases

ChEMBLⁱ	CHEMBL3309113

ChEMBLⁱ

CHEMBL3309113

PTM databases

iPTMnetⁱ	O95433
PhosphoSitePlusⁱ	O95433
SwissPalmⁱ	O95433

Polymorphism and mutation databases

BioMutaⁱ	AHSA1

BioMutaⁱ

AHSA1

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00030706

REPRODUCTION-2DPAGEⁱ

IPI00030706

Proteomic databases

EPDⁱ	O95433
MaxQBⁱ	O95433
PaxDbⁱ	O95433
PeptideAtlasⁱ	O95433
PRIDEⁱ	O95433
ProteomicsDBⁱ	50878

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000216479; ENSP00000216479; ENSG00000100591 [O95433-1] ENST00000535854; ENSP00000440108; ENSG00000100591 [O95433-2]
GeneIDⁱ	10598
KEGGⁱ	hsa:10598
UCSCⁱ	uc001xtw.4 human [O95433-1]

Organism-specific databases

CTDⁱ	10598
DisGeNETⁱ	10598
EuPathDBⁱ	HostDB:ENSG00000100591.7
GeneCardsⁱ	AHSA1
HGNCⁱ	HGNC:1189 AHSA1
HPAⁱ	CAB006244 HPA000903
MIMⁱ	608466 gene
neXtProtⁱ	NX_O95433
OpenTargetsⁱ	ENSG00000100591
PharmGKBⁱ	PA25515
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2936 Eukaryota COG5580 LUCA
GeneTreeⁱ	ENSGT00390000006429
HOGENOMⁱ	HOG000242852
HOVERGENⁱ	HBG065806
InParanoidⁱ	O95433
OMAⁱ	WVDKNCI
OrthoDBⁱ	EOG091G0BRP
PhylomeDBⁱ	O95433
TreeFamⁱ	TF313680

Enzyme and pathway databases

SIGNORⁱ	O95433

SIGNORⁱ

O95433

Miscellaneous databases

ChiTaRSⁱ	AHSA1 human
EvolutionaryTraceⁱ	O95433
GeneWikiⁱ	AHSA1
GenomeRNAiⁱ	10598
Protein Ontology More...PROⁱ	PR:O95433
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100591 Expressed in 233 organ(s), highest expression level in right testis
CleanExⁱ	HS_AHSA1
ExpressionAtlasⁱ	O95433 baseline and differential
Genevisibleⁱ	O95433 HS

Family and domain databases

Gene3Dⁱ	3.15.10.20, 1 hit 3.30.530.20, 1 hit
InterProⁱ	View protein in InterPro IPR013538 Activator_of_Hsp90_ATPase IPR036338 Aha1 IPR039981 AHSA-like IPR015310 AHSA1_N IPR023393 START-like_dom_sf
PANTHERⁱ	PTHR13009 PTHR13009, 1 hit
Pfamⁱ	View protein in Pfam PF09229 Aha1_N, 1 hit PF08327 AHSA1, 1 hit
SMARTⁱ	View protein in SMART SM01000 Aha1_N, 1 hit
SUPFAMⁱ	SSF103111 SSF103111, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AHSA1_HUMAN
Accessionⁱ	O95433Primary (citable) accession number: O95433 Secondary accession number(s): B2R9L2 , B4DUR9, Q96IL6, Q9P060
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - O95433 (AHSA1_HUMAN)

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Activator of 90 kDa heat shock protein ATPase homolog 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Cytosol

Cytosol

Endoplasmic reticulum

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ