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Protein

BAG family molecular chaperone regulator 4

Gene

BAG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-75893 TNF signaling
R-HSA-8853336 Signaling by plasma membrane FGFR1 fusions
SIGNORiO95429

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 4
Short name:
BAG-4
Alternative name(s):
Bcl-2-associated athanogene 4
Silencer of death domains
Gene namesi
Name:BAG4
Synonyms:SODD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000156735.10
HGNCiHGNC:940 BAG4
MIMi603884 gene
neXtProtiNX_O95429

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi414E → A: Reduces interaction with HSP70. 1 Publication1
Mutagenesisi424D → A: Abolishes interaction with HSP70. 1 Publication1
Mutagenesisi438 – 439RK → AA: Reduces interaction with HSP70. 1 Publication2
Mutagenesisi446Q → A: Abolishes interaction with HSP70. 1 Publication1

Organism-specific databases

DisGeNETi9530
OpenTargetsiENSG00000156735
PharmGKBiPA25240

Polymorphism and mutation databases

BioMutaiBAG4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000888701 – 457BAG family molecular chaperone regulator 4Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1
Modified residuei40Omega-N-methylarginineCombined sources1
Modified residuei53Omega-N-methylarginineCombined sources1
Modified residuei108Omega-N-methylarginineCombined sources1
Modified residuei185Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO95429
MaxQBiO95429
PaxDbiO95429
PeptideAtlasiO95429
PRIDEiO95429
ProteomicsDBi50875
50876 [O95429-2]

PTM databases

iPTMnetiO95429
PhosphoSitePlusiO95429

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000156735 Expressed in 215 organ(s), highest expression level in frontal cortex
CleanExiHS_BAG4
ExpressionAtlasiO95429 baseline and differential
GenevisibleiO95429 HS

Organism-specific databases

HPAiCAB013716
HPA018951

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Binds to the death domain of TNFRSF12. Interacts with PRKN.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114906, 89 interactors
IntActiO95429, 137 interactors
MINTiO95429
STRINGi9606.ENSP00000287322

Structurei

Secondary structure

1457
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95429
SMRiO95429
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95429

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini379 – 456BAGPROSITE-ProRule annotationAdd BLAST78

Phylogenomic databases

eggNOGiKOG4361 Eukaryota
ENOG4111WNH LUCA
GeneTreeiENSGT00530000063256
HOGENOMiHOG000290673
HOVERGENiHBG004809
InParanoidiO95429
KOiK09558
OMAiPAETTWP
OrthoDBiEOG091G08LY
PhylomeDBiO95429
TreeFamiTF102013

Family and domain databases

Gene3Di1.20.58.120, 1 hit
InterProiView protein in InterPro
IPR036533 BAG_dom_sf
IPR003103 BAG_domain
PfamiView protein in Pfam
PF02179 BAG, 1 hit
SMARTiView protein in SMART
SM00264 BAG, 1 hit
SUPFAMiSSF63491 SSF63491, 1 hit
PROSITEiView protein in PROSITE
PS51035 BAG, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: O95429-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSALRRSGYG PSDGPSYGRY YGPGGGDVPV HPPPPLYPLR PEPPQPPISW
60 70 80 90 100
RVRGGGPAET TWLGEGGGGD GYYPSGGAWP EPGRAGGSHQ EQPPYPSYNS
110 120 130 140 150
NYWNSTARSR APYPSTYPVR PELQGQSLNS YTNGAYGPTY PPGPGANTAS
160 170 180 190 200
YSGAYYAPGY TQTSYSTEVP STYRSSGNSP TPVSRWIYPQ QDCQTEAPPL
210 220 230 240 250
RGQVPGYPPS QNPGMTLPHY PYGDGNRSVP QSGPTVRPQE DAWASPGAYG
260 270 280 290 300
MGGRYPWPSS APSAPPGNLY MTESTSPWPS SGSPQSPPSP PVQQPKDSSY
310 320 330 340 350
PYSQSDQSMN RHNFPCSVHQ YESSGTVNND DSDLLDSQVQ YSAEPQLYGN
360 370 380 390 400
ATSDHPNNQD QSSSLPEECV PSDESTPPSI KKIIHVLEKV QYLEQEVEEF
410 420 430 440 450
VGKKTDKAYW LLEEMLTKEL LELDSVETGG QDSVRQARKE AVCKIQAILE

KLEKKGL
Length:457
Mass (Da):49,594
Last modified:May 1, 1999 - v1
Checksum:iB89D59E8118684A3
GO
Isoform 2 (identifier: O95429-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-125: Missing.

Note: No experimental confirmation available.
Show »
Length:421
Mass (Da):45,410
Checksum:i3E39EF28E280E94A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBT1H0YBT1_HUMAN
BAG family molecular chaperone regu...
BAG4
155Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04274190 – 125Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095194 mRNA Translation: AAD16123.2
AF111116 mRNA Translation: AAD05226.1
AK304072 mRNA Translation: BAG64979.1
AC084024 Genomic DNA No translation available.
BC038505 mRNA Translation: AAH38505.2
CCDSiCCDS56533.1 [O95429-2]
CCDS6104.1 [O95429-1]
RefSeqiNP_001191807.1, NM_001204878.1 [O95429-2]
NP_004865.1, NM_004874.3 [O95429-1]
UniGeneiHs.194726

Genome annotation databases

EnsembliENST00000287322; ENSP00000287322; ENSG00000156735 [O95429-1]
ENST00000432471; ENSP00000393298; ENSG00000156735 [O95429-2]
GeneIDi9530
KEGGihsa:9530
UCSCiuc003xky.3 human [O95429-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBAG4_HUMAN
AccessioniPrimary (citable) accession number: O95429
Secondary accession number(s): B4E217, O95818
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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