Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 150 (02 Jun 2021)
Sequence version 4 (07 Jul 2009)
Previous versions | rss
Add a publicationFeedback
Protein

Papilin

Gene

PAPLN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O95428

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I02.972

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Papilin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PAPLN
ORF Names:UNQ2420/PRO4977
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19262, PAPLN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617785, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95428

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000100767.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
89932

Open Targets

More...
OpenTargetsi
ENSG00000100767

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134914395

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O95428, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PAPLN

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032455019 – 1278PapilinAdd BLAST1260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi38 ↔ 74By similarity
Disulfide bondi42 ↔ 79By similarity
Disulfide bondi53 ↔ 64By similarity
Disulfide bondi316 ↔ 355By similarity
Disulfide bondi320 ↔ 360By similarity
Disulfide bondi331 ↔ 343By similarity
Disulfide bondi754 ↔ 804By similarity
Disulfide bondi763 ↔ 787By similarity
Disulfide bondi779 ↔ 800By similarity
Disulfide bondi931 ↔ 978By similarity
Disulfide bondi1065 ↔ 1112By similarity
Disulfide bondi1154 ↔ 1202By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95428

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O95428

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95428

PeptideAtlas

More...
PeptideAtlasi
O95428

PRoteomics IDEntifications database

More...
PRIDEi
O95428

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50869 [O95428-1]
50870 [O95428-2]
50871 [O95428-3]
50872 [O95428-4]
50873 [O95428-5]
50874 [O95428-6]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O95428, 11 sites, 3 O-linked glycans (11 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95428

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95428

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100767, Expressed in tendon and 194 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95428, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95428, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000100767, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124645, 12 interactors

Protein interaction database and analysis system

More...
IntActi
O95428, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345395

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O95428, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95428

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 80TSP type-1 1PROSITE-ProRule annotationAdd BLAST55
Domaini304 – 361TSP type-1 2PROSITE-ProRule annotationAdd BLAST58
Domaini362 – 421TSP type-1 3PROSITE-ProRule annotationAdd BLAST60
Domaini423 – 481TSP type-1 4PROSITE-ProRule annotationAdd BLAST59
Domaini484 – 539TSP type-1 5PROSITE-ProRule annotationAdd BLAST56
Domaini754 – 804BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST51
Domaini900 – 995Ig-like C2-type 1Add BLAST96
Domaini1033 – 1128Ig-like C2-type 2Add BLAST96
Domaini1133 – 1218Ig-like C2-type 3Add BLAST86
Domaini1231 – 1270PLACPROSITE-ProRule annotationAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni544 – 632DisorderedSequence analysisAdd BLAST89
Regioni805 – 901DisorderedSequence analysisAdd BLAST97
Regioni1014 – 1042DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi582 – 598Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi606 – 621Polar residuesSequence analysisAdd BLAST16
Compositional biasi818 – 843Polar residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the papilin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3510, Eukaryota
KOG4597, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156891

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000660_7_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95428

Identification of Orthologs from Complete Genome Data

More...
OMAi
EECMSSC

Database of Orthologous Groups

More...
OrthoDBi
56186at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95428

TreeFam database of animal gene trees

More...
TreeFami
TF316874

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00109, KU, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 5 hits
2.60.40.10, 3 hits
4.10.410.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010294, ADAM_spacer1
IPR013273, ADAMTS/ADAMTS-like
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR010909, PLAC
IPR020901, Prtase_inh_Kunz-CS
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05986, ADAM_spacer1, 1 hit
PF07679, I-set, 3 hits
PF00014, Kunitz_BPTI, 1 hit
PF08686, PLAC, 1 hit
PF00090, TSP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857, ADAMTSFAMILY
PR00759, BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 3 hits
SM00408, IGc2, 3 hits
SM00406, IGv, 3 hits
SM00131, KU, 1 hit
SM00209, TSP1, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 3 hits
SSF57362, SSF57362, 1 hit
SSF82895, SSF82895, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00280, BPTI_KUNITZ_1, 1 hit
PS50279, BPTI_KUNITZ_2, 1 hit
PS50835, IG_LIKE, 3 hits
PS50900, PLAC, 1 hit
PS50092, TSP1, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95428-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLLLLVPLL LAPAPGSSAP KVRRQSDTWG PWSQWSPCSR TCGGGVSFRE
60 70 80 90 100
RPCYSQRRDG GSSCVGPARS HRSCRTESCP DGARDFRAEQ CAEFDGAEFQ
110 120 130 140 150
GRRYRWLPYY SAPNKCELNC IPKGENFYYK HREAVVDGTP CEPGKRDVCV
160 170 180 190 200
DGSCRVVGCD HELDSSKQED KCLRCGGDGT TCYPVAGTFD ANDLSRGYNQ
210 220 230 240 250
ILIVPMGATS ILIDEAAASR NFLAVKNVRG EYYLNGHWTI EAARALPAAS
260 270 280 290 300
TILHYERGAE GDLAPERLHA RGPTSEPLVI ELISQEPNPG VHYEYHLPLR
310 320 330 340 350
RPSPGFSWSH GSWSDCSAEC GGGHQSRLVF CTIDHEAYPD HMCQRQPRPA
360 370 380 390 400
DRRSCNLHPC PETKRWKAGP WAPCSASCGG GSQSRSVYCI SSDGAGIQEA
410 420 430 440 450
VEEAECAGLP GKPPAIQACN LQRCAAWSPE PWGECSVSCG VGVRKRSVTC
460 470 480 490 500
RGERGSLLHT AACSLEDRPP LTEPCVHEDC PLLSDQAWHV GTWGLCSKSC
510 520 530 540 550
SSGTRRRQVI CAIGPPSHCG SLQHSKPVDV EPCNTQPCHL PQEVPSMQDV
560 570 580 590 600
HTPASNPWMP LGPQESPASD SRGQWWAAQE HPSARGDHRG ERGDPRGDQG
610 620 630 640 650
THLSALGPAP SLQQPPYQQP LRSGSGPHDC RHSPHGCCPD GHTASLGPQW
660 670 680 690 700
QGCPGAPCQQ SRYGCCPDRV SVAEGPHHAG CTKSYGGDST GGMPRSRAVA
710 720 730 740 750
STVHNTHQPQ AQQNEPSECR GSQFGCCYDN VATAAGPLGE GCVGQPSHAY
760 770 780 790 800
PVRCLLPSAH GSCADWAARW YFVASVGQCN RFWYGGCHGN ANNFASEQEC
810 820 830 840 850
MSSCQGSLHG PRRPQPGASG RSTHTDGGGS SPAGEQEPSQ HRTGAAVQRK
860 870 880 890 900
PWPSGGLWRQ DQQPGPGEAP HTQAFGEWPW GQELGSRAPG LGGDAGSPAP
910 920 930 940 950
PFHSSSYRIS LAGVEPSLVQ AALGQLVRLS CSDDTAPESQ AAWQKDGQPI
960 970 980 990 1000
SSDRHRLQFD GSLIIHPLQA EDAGTYSCGS TRPGRDSQKI QLRIIGGDMA
1010 1020 1030 1040 1050
VLSEAELSRF PQPRDPAQDF GQAGAAGPLG AIPSSHPQPA NRLRLDQNQP
1060 1070 1080 1090 1100
RVVDASPGQR IRMTCRAEGF PPPAIEWQRD GQPVSSPRHQ LQPDGSLVIS
1110 1120 1130 1140 1150
RVAVEDGGFY TCVAFNGQDR DQRWVQLRVL GELTISGLPP TVTVPEGDTA
1160 1170 1180 1190 1200
RLLCVVAGES VNIRWSRNGL PVQADGHRVH QSPDGTLLIY NLRARDEGSY
1210 1220 1230 1240 1250
TCSAYQGSQA VSRSTEVKVV SPAPTAQPRD PGRDCVDQPE LANCDLILQA
1260 1270
QLCGNEYYSS FCCASCSRFQ PHAQPIWQ
Length:1,278
Mass (Da):137,700
Last modified:July 7, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8DED3CADB0D70C1
GO
Isoform 2 (identifier: O95428-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-801: Missing.
     802-907: SSCQGSLHGP...PAPPFHSSSY → MGPVVPSLGL...PPTDLTSHLS

Show »
Length:477
Mass (Da):51,082
Checksum:i1979A1F2428DE816
GO
Isoform 5 (identifier: O95428-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     749-764: Missing.

Show »
Length:1,262
Mass (Da):136,073
Checksum:i3D334E4C30CDE94F
GO
Isoform 6 (identifier: O95428-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-223: Missing.

Show »
Length:1,251
Mass (Da):134,840
Checksum:i149C41975845C4E9
GO
Isoform 3 (identifier: O95428-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-129: GENFYY → VLGLQA
     130-1278: Missing.

Show »
Length:129
Mass (Da):14,368
Checksum:iD51144A494C12B3B
GO
Isoform 4 (identifier: O95428-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1088-1109: RHQLQPDGSLVISRVAVEDGGF → STHRPAQGPWQGLRRPARAGQL
     1110-1278: Missing.

Show »
Length:1,109
Mass (Da):119,209
Checksum:iFB23C426C3F47E83
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V5P6G3V5P6_HUMAN
Papilin
PAPLN
929Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MDP7B5MDP7_HUMAN
Papilin
PAPLN
808Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJA1H0YJA1_HUMAN
Papilin
PAPLN
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMM2H0YMM2_HUMAN
Papilin
PAPLN
311Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC97963 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAC86235 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG57189 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAG57189 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAG57757 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAH56406 differs from that shown. Partially unspliced mRNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti326S → P in BAG57757 (PubMed:14702039).Curated1
Sequence conflicti693M → R in BAG57757 (PubMed:14702039).Curated1
Sequence conflicti693M → R in CAD97826 (PubMed:17974005).Curated1
Sequence conflicti693M → R in BAC85123 (Ref. 6) Curated1
Sequence conflicti1162N → D in BAG57189 (PubMed:14702039).Curated1
Sequence conflicti1229R → K in CAD97826 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03981533S → G. Corresponds to variant dbSNP:rs2280792Ensembl.1
Natural variantiVAR_039816191A → T. Corresponds to variant dbSNP:rs741842Ensembl.1
Natural variantiVAR_039817356N → H. Corresponds to variant dbSNP:rs17126331Ensembl.1
Natural variantiVAR_039818443V → I. Corresponds to variant dbSNP:rs17126352Ensembl.1
Natural variantiVAR_039819461A → V. Corresponds to variant dbSNP:rs17126354Ensembl.1
Natural variantiVAR_039820628H → R. Corresponds to variant dbSNP:rs17182244Ensembl.1
Natural variantiVAR_039821723Q → H. Corresponds to variant dbSNP:rs2242616Ensembl.1
Natural variantiVAR_039822896G → R1 PublicationCorresponds to variant dbSNP:rs177386Ensembl.1
Natural variantiVAR_0398231192L → V. Corresponds to variant dbSNP:rs2107731Ensembl.1
Natural variantiVAR_0398241201T → M1 PublicationCorresponds to variant dbSNP:rs4903104Ensembl.1
Natural variantiVAR_0398251260S → T. Corresponds to variant dbSNP:rs11626824Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0322691 – 801Missing in isoform 2. 1 PublicationAdd BLAST801
Alternative sequenceiVSP_032270124 – 129GENFYY → VLGLQA in isoform 3. 1 Publication6
Alternative sequenceiVSP_032271130 – 1278Missing in isoform 3. 1 PublicationAdd BLAST1149
Alternative sequenceiVSP_037595197 – 223Missing in isoform 6. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_037596749 – 764Missing in isoform 5. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_032272802 – 907SSCQG…HSSSY → MGPVVPSLGLLEGAPTRMVA AAVLQASRNPASTGQGPRCR ESPGLLVVSGGKTNSLGQGR PPTPRPLENGHGGRSLGPGP LDWVEMPDHQRHPSTAPPTD LTSHLS in isoform 2. 1 PublicationAdd BLAST106
Alternative sequenceiVSP_0322731088 – 1109RHQLQ…EDGGF → STHRPAQGPWQGLRRPARAG QL in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0322741110 – 1278Missing in isoform 4. 1 PublicationAdd BLAST169

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358330 mRNA Translation: AAQ88696.1
AK125658 mRNA Translation: BAC86235.1 Different initiation.
AK294560 mRNA Translation: BAG57757.1 Different initiation.
AK293773 mRNA Translation: BAG57189.1 Sequence problems.
AC004846 Genomic DNA No translation available.
AF109907 Genomic DNA Translation: AAC97963.1 Sequence problems.
BC042057 mRNA Translation: AAH42057.1
AL110280 mRNA Translation: CAH56406.1 Sequence problems.
BX470414 mRNA No translation available.
BX537757 mRNA Translation: CAD97826.1
AK131073 mRNA Translation: BAC85123.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32114.1 [O95428-6]

NCBI Reference Sequences

More...
RefSeqi
NP_775733.3, NM_173462.3 [O95428-6]
XP_011535592.1, XM_011537290.2
XP_011535593.1, XM_011537291.2 [O95428-1]
XP_011535594.1, XM_011537292.2 [O95428-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340738; ENSP00000345395; ENSG00000100767 [O95428-6]
ENST00000554301; ENSP00000451803; ENSG00000100767 [O95428-1]
ENST00000555445; ENSP00000451729; ENSG00000100767 [O95428-5]
ENST00000644200; ENSP00000495882; ENSG00000100767 [O95428-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
89932

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:89932

UCSC genome browser

More...
UCSCi
uc001xnw.5, human [O95428-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358330 mRNA Translation: AAQ88696.1
AK125658 mRNA Translation: BAC86235.1 Different initiation.
AK294560 mRNA Translation: BAG57757.1 Different initiation.
AK293773 mRNA Translation: BAG57189.1 Sequence problems.
AC004846 Genomic DNA No translation available.
AF109907 Genomic DNA Translation: AAC97963.1 Sequence problems.
BC042057 mRNA Translation: AAH42057.1
AL110280 mRNA Translation: CAH56406.1 Sequence problems.
BX470414 mRNA No translation available.
BX537757 mRNA Translation: CAD97826.1
AK131073 mRNA Translation: BAC85123.1
CCDSiCCDS32114.1 [O95428-6]
RefSeqiNP_775733.3, NM_173462.3 [O95428-6]
XP_011535592.1, XM_011537290.2
XP_011535593.1, XM_011537291.2 [O95428-1]
XP_011535594.1, XM_011537292.2 [O95428-1]

3D structure databases

SMRiO95428
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124645, 12 interactors
IntActiO95428, 9 interactors
STRINGi9606.ENSP00000345395

Protein family/group databases

MEROPSiI02.972

PTM databases

GlyGeniO95428, 11 sites, 3 O-linked glycans (11 sites)
iPTMnetiO95428
PhosphoSitePlusiO95428

Genetic variation databases

BioMutaiPAPLN

Proteomic databases

jPOSTiO95428
MassIVEiO95428
PaxDbiO95428
PeptideAtlasiO95428
PRIDEiO95428
ProteomicsDBi50869 [O95428-1]
50870 [O95428-2]
50871 [O95428-3]
50872 [O95428-4]
50873 [O95428-5]
50874 [O95428-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
63258, 117 antibodies

The DNASU plasmid repository

More...
DNASUi
89932

Genome annotation databases

EnsembliENST00000340738; ENSP00000345395; ENSG00000100767 [O95428-6]
ENST00000554301; ENSP00000451803; ENSG00000100767 [O95428-1]
ENST00000555445; ENSP00000451729; ENSG00000100767 [O95428-5]
ENST00000644200; ENSP00000495882; ENSG00000100767 [O95428-1]
GeneIDi89932
KEGGihsa:89932
UCSCiuc001xnw.5, human [O95428-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
89932
DisGeNETi89932

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PAPLN
HGNCiHGNC:19262, PAPLN
HPAiENSG00000100767, Low tissue specificity
MIMi617785, gene
neXtProtiNX_O95428
OpenTargetsiENSG00000100767
PharmGKBiPA134914395
VEuPathDBiHostDB:ENSG00000100767.15

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3510, Eukaryota
KOG4597, Eukaryota
GeneTreeiENSGT00940000156891
HOGENOMiCLU_000660_7_0_1
InParanoidiO95428
OMAiEECMSSC
OrthoDBi56186at2759
PhylomeDBiO95428
TreeFamiTF316874

Enzyme and pathway databases

PathwayCommonsiO95428

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
89932, 4 hits in 990 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PAPLN, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PAPLN

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
89932
PharosiO95428, Tbio

Protein Ontology

More...
PROi
PR:O95428
RNActiO95428, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100767, Expressed in tendon and 194 other tissues
ExpressionAtlasiO95428, baseline and differential
GenevisibleiO95428, HS

Family and domain databases

CDDicd00109, KU, 1 hit
Gene3Di2.20.100.10, 5 hits
2.60.40.10, 3 hits
4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR010294, ADAM_spacer1
IPR013273, ADAMTS/ADAMTS-like
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR010909, PLAC
IPR020901, Prtase_inh_Kunz-CS
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF05986, ADAM_spacer1, 1 hit
PF07679, I-set, 3 hits
PF00014, Kunitz_BPTI, 1 hit
PF08686, PLAC, 1 hit
PF00090, TSP_1, 1 hit
PRINTSiPR01857, ADAMTSFAMILY
PR00759, BASICPTASE
SMARTiView protein in SMART
SM00409, IG, 3 hits
SM00408, IGc2, 3 hits
SM00406, IGv, 3 hits
SM00131, KU, 1 hit
SM00209, TSP1, 5 hits
SUPFAMiSSF48726, SSF48726, 3 hits
SSF57362, SSF57362, 1 hit
SSF82895, SSF82895, 5 hits
PROSITEiView protein in PROSITE
PS00280, BPTI_KUNITZ_1, 1 hit
PS50279, BPTI_KUNITZ_2, 1 hit
PS50835, IG_LIKE, 3 hits
PS50900, PLAC, 1 hit
PS50092, TSP1, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95428
Secondary accession number(s): B4DES8
, B4DGE6, Q659F2, Q6UXJ4, Q6ZNM1, Q6ZUJ0, Q7Z681, Q8IVU0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 7, 2009
Last modified: June 2, 2021
This is version 150 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again