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Protein

Supervillin

Gene

SVIL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420).2 Publications
Isoform 2: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: UniProtKB

GO - Biological processi

  • cytoskeleton organization Source: InterPro
  • positive regulation of cytokinesis Source: UniProtKB
  • skeletal muscle tissue development Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Supervillin1 Publication
Alternative name(s):
Archvillin1 Publication
p205/p2502 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SVIL1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000197321.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11480 SVIL

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604126 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95425

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2176L → K: Strongly increased affinity for F-actin. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6840

Open Targets

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OpenTargetsi
ENSG00000197321

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36265

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SVIL

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002187401 – 2214SupervillinAdd BLAST2214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50PhosphoserineCombined sources1
Modified residuei221PhosphoserineCombined sources1
Modified residuei238PhosphoserineBy similarity1
Modified residuei240PhosphothreonineCombined sources1
Modified residuei245PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1
Modified residuei259PhosphoserineBy similarity1
Modified residuei270PhosphoserineCombined sources1
Modified residuei319PhosphoserineBy similarity1
Modified residuei673PhosphoserineBy similarity1
Modified residuei707PhosphoserineCombined sources1
Modified residuei769PhosphoserineCombined sources1
Modified residuei850PhosphotyrosineBy similarity1
Modified residuei852PhosphothreonineCombined sources1
Modified residuei914PhosphoserineCombined sources1
Modified residuei920PhosphoserineCombined sources1
Modified residuei924PhosphoserineCombined sources1
Modified residuei968PhosphoserineCombined sources1
Modified residuei1000PhosphoserineBy similarity1
Modified residuei1052PhosphoserineBy similarity1
Modified residuei1111PhosphothreonineCombined sources1
Modified residuei1120PhosphoserineCombined sources1
Modified residuei1203Omega-N-methylarginineCombined sources1
Modified residuei1225PhosphoserineCombined sources1
Modified residuei1230PhosphothreonineCombined sources1
Modified residuei1234PhosphoserineBy similarity1
Modified residuei1322PhosphoserineCombined sources1
Modified residuei1405PhosphoserineBy similarity1
Isoform 2 (identifier: O95425-2)
Modified residuei261PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Isoform SV3 (identifier: O95425-3)
Modified residuei261PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95425

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95425

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95425

PeptideAtlas

More...
PeptideAtlasi
O95425

PRoteomics IDEntifications database

More...
PRIDEi
O95425

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50866
50867 [O95425-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95425

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95425

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 1 (archvillin) is muscle specific.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197321 Expressed in 224 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis

CleanEx database of gene expression profiles

More...
CleanExi
HS_SVIL

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95425 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95425 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010878
HPA020095
HPA020138

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with F-actin (By similarity). Interacts with NEB (By similarity). Interacts with MYH9 (By similarity). Interacts with MYLK (By similarity). Isoform 2: Interacts with TRIP6 (By similarity). Isoform 2: Interacts with DYNLT1 (By similarity). Isoform 2: Interacts with KIF14; at midbody during cytokinesis (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NEBP209294EBI-487145,EBI-1049657

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112707, 127 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O95425

Protein interaction database and analysis system

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IntActi
O95425, 63 interactors

Molecular INTeraction database

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MINTi
O95425

STRING: functional protein association networks

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STRINGi
9606.ENSP00000348128

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O95425

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95425

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O95425

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1441 – 1540Gelsolin-like 1Add BLAST100
Repeati1560 – 1682Gelsolin-like 2Add BLAST123
Repeati1752 – 1862Gelsolin-like 3Add BLAST111
Repeati1881 – 1982Gelsolin-like 4Add BLAST102
Repeati2015 – 2122Gelsolin-like 5Add BLAST108
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2151 – 2214HPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 174Interaction with MYLKBy similarityAdd BLAST174
Regioni1419 – 1687Interaction with NEB1 PublicationAdd BLAST269

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

As opposed to other villin-type headpiece domains, supervillin HP (SVHP) doesn't bind F-actin due to the absence of a conformationally flexible region (V-loop).1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0445 Eukaryota
ENOG410XPWY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154653

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052980

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95425

KEGG Orthology (KO)

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KOi
K10369

Identification of Orthologs from Complete Genome Data

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OMAi
SRTSMIV

Database of Orthologous Groups

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OrthoDBi
EOG091G00HK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95425

TreeFam database of animal gene trees

More...
TreeFami
TF316081

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.950.10, 1 hit
3.40.20.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR015628 SV/p205
IPR007122 Villin/Gelsolin
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR11977 PTHR11977, 1 hit
PTHR11977:SF45 PTHR11977:SF45, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00626 Gelsolin, 1 hit
PF02209 VHP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00597 GELSOLIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00262 GEL, 4 hits
SM00153 VHP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47050 SSF47050, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51089 HP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O95425-1) [UniParc]FASTAAdd to basket
Also known as: Archvillin1 Publication, p2501 Publication, SV2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRKERIARR LEGIENDTQP ILLQSCTGLV THRLLEEDTP RYMRASDPAS
60 70 80 90 100
PHIGRSNEEE ETSDSSLEKQ TRSKYCTETS GVHGDSPYGS GTMDTHSLES
110 120 130 140 150
KAERIARYKA ERRRQLAEKY GLTLDPEADS EYLSRYTKSR KEPDAVEKRG
160 170 180 190 200
GKSDKQEESS RDASSLYPGT ETMGLRTCAG ESKDYALHVG DGSSDPEVLL
210 220 230 240 250
NIENQRRGQE LSATRQAHDL SPAAESSSTF SFSGRDSSFT EVPRSPKHAH
260 270 280 290 300
SSSLQQAASR SPSFGDPQLS PEARPSTGKP KHEWFLQKDS EGDTPSLINW
310 320 330 340 350
PSRVKVREKL VKEESARNSP ELASESVTQR RHQPAPVHYV SFQSEHSAFD
360 370 380 390 400
RVPSKAAGST RQPIRGYVQP ADTGHTAKLV TPETPENASE CSWVASATQN
410 420 430 440 450
VPKPPSLTVL EGDGRDSPVL HVCESKAEEE EGEGEGEEKE EDVCFTEALE
460 470 480 490 500
QSKKTLLALE GDGLVRSPED PSRNEDFGKP AVSTVTLEHQ KELENVAQPP
510 520 530 540 550
QAPHQPTERT GRSEMVLYIQ SEPVSQDAKP TGHNREASKK RKVRTRSLSD
560 570 580 590 600
FTGPPQLQAL KYKDPASRRE LELPSSKTEG PYGEISMLDT KVSVAQLRSA
610 620 630 640 650
FLASANACRR PELKSRVERS AEGPGLPTGV ERERGSRKPR RYFSPGESRK
660 670 680 690 700
TSERFRTQPI TSAERKESDR CTSHSETPTV DDEEKVDERA KLSVAAKRLL
710 720 730 740 750
FREMEKSFDE QNVPKRRSRN TAVEQRLRRL QDRSLTQPIT TEEVVIAATE
760 770 780 790 800
PIPASCSGGT HPVMARLPSP TVARSAVQPA RLQASAHQKA LAKDQTNEGK
810 820 830 840 850
ELAEQGEPDS STLSLAEKLA LFNKLSQPVS KAISTRNRID TRQRRMNARY
860 870 880 890 900
QTQPVTLGEV EQVQSGKLIP FSPAVNTSVS TVASTVAPMY AGDLRTKPPL
910 920 930 940 950
DHNASATDYK FSSSIENSDS PVRSILKSQA WQPLVEGSEN KGMLREYGET
960 970 980 990 1000
ESKRALTGRD SGMEKYGSFE EAEASYPILN RAREGDSHKE SKYAVPRRGS
1010 1020 1030 1040 1050
LERANPPITH LGDEPKEFSM AKMNAQGNLD LRDRLPFEEK VEVENVMKRK
1060 1070 1080 1090 1100
FSLRAAEFGE PTSEQTGTAA GKTIAQTTAP VSWKPQDSSE QPQEKLCKNP
1110 1120 1130 1140 1150
CAMFAAGEIK TPTGEGLLDS PSKTMSIKER LALLKKSGEE DWRNRLSRRQ
1160 1170 1180 1190 1200
EGGKAPASSL HTQEAGRSLI KKRVTESRES QMTIEERKQL ITVREEAWKT
1210 1220 1230 1240 1250
RGRGAANDST QFTVAGRMVK KGLASPTAIT PVASPICGKT RGTTPVSKPL
1260 1270 1280 1290 1300
EDIEARPDMQ LESDLKLDRL ETFLRRLNNK VGGMHETVLT VTGKSVKEVM
1310 1320 1330 1340 1350
KPDDDETFAK FYRSVDYNMP RSPVEMDEDF DVIFDPYAPK LTSSVAEHKR
1360 1370 1380 1390 1400
AVRPKRRVQA SKNPLKMLAA REDLLQEYTE QRLNVAFMES KRMKVEKMSS
1410 1420 1430 1440 1450
NSNFSEVTLA GLASKENFSN VSLRSVNLTE QNSNNSAVPY KRLMLLQIKG
1460 1470 1480 1490 1500
RRHVQTRLVE PRASALNSGD CFLLLSPHCC FLWVGEFANV IEKAKASELA
1510 1520 1530 1540 1550
TLIQTKRELG CRATYIQTIE EGINTHTHAA KDFWKLLGGQ TSYQSAGDPK
1560 1570 1580 1590 1600
EDELYEAAII ETNCIYRLMD DKLVPDDDYW GKIPKCSLLQ PKEVLVFDFG
1610 1620 1630 1640 1650
SEVYVWHGKE VTLAQRKIAF QLAKHLWNGT FDYENCDINP LDPGECNPLI
1660 1670 1680 1690 1700
PRKGQGRPDW AIFGRLTEHN ETILFKEKFL DWTELKRSNE KNPGELAQHK
1710 1720 1730 1740 1750
EDPRTDVKAY DVTRMVSMPQ TTAGTILDGV NVGRGYGLVE GHDRRQFEIT
1760 1770 1780 1790 1800
SVSVDVWHIL EFDYSRLPKQ SIGQFHEGDA YVVKWKFMVS TAVGSRQKGE
1810 1820 1830 1840 1850
HSVRAAGKEK CVYFFWQGRH STVSEKGTSA LMTVELDEER GAQVQVLQGK
1860 1870 1880 1890 1900
EPPCFLQCFQ GGMVVHSGRR EEEEENVQSE WRLYCVRGEV PVEGNLLEVA
1910 1920 1930 1940 1950
CHCSSLRSRT SMVVLNVNKA LIYLWHGCKA QAHTKEVGRT AANKIKEQCP
1960 1970 1980 1990 2000
LEAGLHSSSK VTIHECDEGS EPLGFWDALG RRDRKAYDCM LQDPGSFNFA
2010 2020 2030 2040 2050
PRLFILSSSS GDFAATEFVY PARAPSVVSS MPFLQEDLYS APQPALFLVD
2060 2070 2080 2090 2100
NHHEVYLWQG WWPIENKITG SARIRWASDR KSAMETVLQY CKGKNLKKPA
2110 2120 2130 2140 2150
PKSYLIHAGL EPLTFTNMFP SWEHREDIAE ITEMDTEVSN QITLVEDVLA
2160 2170 2180 2190 2200
KLCKTIYPLA DLLARPLPEG VDPLKLEIYL TDEDFEFALD MTRDEYNALP
2210
AWKQVNLKKA KGLF
Length:2,214
Mass (Da):247,746
Last modified:July 7, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C4793D31FCBDF7C
GO
Isoform 2 (identifier: O95425-2) [UniParc]FASTAAdd to basket
Also known as: Supervillin1 Publication, p2051 Publication, SV1

The sequence of this isoform differs from the canonical sequence as follows:
     276-669: Missing.
     750-781: Missing.

Show »
Length:1,788
Mass (Da):200,847
Checksum:i03BDF48043A3CC8C
GO
Isoform SV3 (identifier: O95425-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-302: Missing.

Show »
Length:2,187
Mass (Da):244,679
Checksum:i112D7378B67AEED1
GO
Isoform SV4 (identifier: O95425-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-781: Missing.

Show »
Length:2,182
Mass (Da):244,523
Checksum:iD0DB0FB611E25EB4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YWY6A0A0J9YWY6_HUMAN
Supervillin
SVIL
963Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020791189V → A2 PublicationsCorresponds to variant dbSNP:rs10160013Ensembl.1
Natural variantiVAR_058308422V → I2 PublicationsCorresponds to variant dbSNP:rs1247696Ensembl.1
Natural variantiVAR_0574671041V → L. Corresponds to variant dbSNP:rs7070135Ensembl.1
Natural variantiVAR_0207921235P → ACombined sources2 PublicationsCorresponds to variant dbSNP:rs2368406Ensembl.1
Natural variantiVAR_0246911688S → P. Corresponds to variant dbSNP:rs11007612Ensembl.1
Natural variantiVAR_0574682005I → V. Corresponds to variant dbSNP:rs7921306Ensembl.1
Natural variantiVAR_0574692041A → V. Corresponds to variant dbSNP:rs17694739Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012425276 – 669Missing in isoform 2. 1 PublicationAdd BLAST394
Alternative sequenceiVSP_053768276 – 302Missing in isoform SV3. CuratedAdd BLAST27
Alternative sequenceiVSP_012426750 – 781Missing in isoform 2 and isoform SV4. 2 PublicationsAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF051850 mRNA Translation: AAC64695.1
AF051851 mRNA Translation: AAC64696.1
AF109135 mRNA Translation: AAD14682.1
JX467682 mRNA Translation: AGE81989.1
AL158167 Genomic DNA No translation available.
AL160060 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86018.1
CH471072 Genomic DNA Translation: EAW86019.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7163.1 [O95425-2]
CCDS7164.1 [O95425-1]

NCBI Reference Sequences

More...
RefSeqi
NP_003165.2, NM_003174.3 [O95425-2]
NP_068506.2, NM_021738.2 [O95425-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.499209
Hs.684405

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355867; ENSP00000348128; ENSG00000197321 [O95425-1]
ENST00000375398; ENSP00000364547; ENSG00000197321 [O95425-4]
ENST00000375400; ENSP00000364549; ENSG00000197321 [O95425-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6840

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6840

UCSC genome browser

More...
UCSCi
uc001iut.2 human [O95425-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051850 mRNA Translation: AAC64695.1
AF051851 mRNA Translation: AAC64696.1
AF109135 mRNA Translation: AAD14682.1
JX467682 mRNA Translation: AGE81989.1
AL158167 Genomic DNA No translation available.
AL160060 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86018.1
CH471072 Genomic DNA Translation: EAW86019.1
CCDSiCCDS7163.1 [O95425-2]
CCDS7164.1 [O95425-1]
RefSeqiNP_003165.2, NM_003174.3 [O95425-2]
NP_068506.2, NM_021738.2 [O95425-1]
UniGeneiHs.499209
Hs.684405

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K6MNMR-S2149-2214[»]
2K6NNMR-A2149-2214[»]
ProteinModelPortaliO95425
SMRiO95425
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112707, 127 interactors
CORUMiO95425
IntActiO95425, 63 interactors
MINTiO95425
STRINGi9606.ENSP00000348128

PTM databases

iPTMnetiO95425
PhosphoSitePlusiO95425

Polymorphism and mutation databases

BioMutaiSVIL

Proteomic databases

EPDiO95425
MaxQBiO95425
PaxDbiO95425
PeptideAtlasiO95425
PRIDEiO95425
ProteomicsDBi50866
50867 [O95425-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6840
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355867; ENSP00000348128; ENSG00000197321 [O95425-1]
ENST00000375398; ENSP00000364547; ENSG00000197321 [O95425-4]
ENST00000375400; ENSP00000364549; ENSG00000197321 [O95425-2]
GeneIDi6840
KEGGihsa:6840
UCSCiuc001iut.2 human [O95425-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6840
DisGeNETi6840
EuPathDBiHostDB:ENSG00000197321.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SVIL

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0008738
HGNCiHGNC:11480 SVIL
HPAiCAB010878
HPA020095
HPA020138
MIMi604126 gene
neXtProtiNX_O95425
OpenTargetsiENSG00000197321
PharmGKBiPA36265

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0445 Eukaryota
ENOG410XPWY LUCA
GeneTreeiENSGT00940000154653
HOVERGENiHBG052980
InParanoidiO95425
KOiK10369
OMAiSRTSMIV
OrthoDBiEOG091G00HK
PhylomeDBiO95425
TreeFamiTF316081

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SVIL human
EvolutionaryTraceiO95425

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SVIL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6840

Protein Ontology

More...
PROi
PR:O95425

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197321 Expressed in 224 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_SVIL
ExpressionAtlasiO95425 baseline and differential
GenevisibleiO95425 HS

Family and domain databases

Gene3Di1.10.950.10, 1 hit
3.40.20.10, 5 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR015628 SV/p205
IPR007122 Villin/Gelsolin
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF45 PTHR11977:SF45, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF02209 VHP, 1 hit
PRINTSiPR00597 GELSOLIN
SMARTiView protein in SMART
SM00262 GEL, 4 hits
SM00153 VHP, 1 hit
SUPFAMiSSF47050 SSF47050, 1 hit
PROSITEiView protein in PROSITE
PS51089 HP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSVIL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95425
Secondary accession number(s): D3DRW9
, M1J557, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 7, 2009
Last modified: December 5, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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