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Entry version 117 (08 May 2019)
Sequence version 2 (14 Aug 2001)
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Protein

Dexamethasone-induced protein

Gene

DEXI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dexamethasone-induced protein
Alternative name(s):
Protein MYLE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DEXI
Synonyms:MYLE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13267 DEXI

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617901 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95424

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
28955

Open Targets

More...
OpenTargetsi
ENSG00000182108

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165449964

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DEXI

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000966691 – 95Dexamethasone-induced proteinAdd BLAST95

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95424

PeptideAtlas

More...
PeptideAtlasi
O95424

PRoteomics IDEntifications database

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PRIDEi
O95424

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50865

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in heart. Also expressed in brain, liver, pancreas, placenta and lung. Up-regulated in emphysematous lung compared to normal lung.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By dexamethasone.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182108 Expressed in 225 organ(s), highest expression level in apex of heart

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95424 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041511

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
O95424, 6 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000330509

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95424

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DEXI family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J0RE Eukaryota
ENOG4111YRS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013271

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112199

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95424

Identification of Orthologs from Complete Genome Data

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OMAi
SVPYDTD

Database of Orthologous Groups

More...
OrthoDBi
1373211at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95424

TreeFam database of animal gene trees

More...
TreeFami
TF338557

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023259 Dexamethasone-induced

The PANTHER Classification System

More...
PANTHERi
PTHR17070 PTHR17070, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15198 Dexa_ind, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR02032 DEXMETHSNEIP

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD195637 Dexamethasone-induced, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O95424-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGARVAAHL DALGPLVPYV PPPLLPSMFY VGLFFVNVLI LYYAFLMEYI
60 70 80 90
VLNVGLVFLP EDMDQALVDL GVLSDPGSGL YDADSELDVF DAYLE
Length:95
Mass (Da):10,429
Last modified:August 14, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9F98DE2572D3F83
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF108145 mRNA Translation: AAC83382.2
AK314111 mRNA Translation: BAG36804.1
CH471112 Genomic DNA Translation: EAW85167.1
BC001083 mRNA Translation: AAH01083.2
BC037569 mRNA Translation: AAH37569.1
BC052989 mRNA Translation: AAH52989.1
BC071683 mRNA Translation: AAH71683.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10545.1

NCBI Reference Sequences

More...
RefSeqi
NP_054734.2, NM_014015.3
XP_016878660.1, XM_017023171.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331808; ENSP00000330509; ENSG00000182108
ENST00000469379; ENSP00000482265; ENSG00000182108
ENST00000570440; ENSP00000493467; ENSG00000182108

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
28955

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:28955

UCSC genome browser

More...
UCSCi
uc002dal.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108145 mRNA Translation: AAC83382.2
AK314111 mRNA Translation: BAG36804.1
CH471112 Genomic DNA Translation: EAW85167.1
BC001083 mRNA Translation: AAH01083.2
BC037569 mRNA Translation: AAH37569.1
BC052989 mRNA Translation: AAH52989.1
BC071683 mRNA Translation: AAH71683.1
CCDSiCCDS10545.1
RefSeqiNP_054734.2, NM_014015.3
XP_016878660.1, XM_017023171.1

3D structure databases

SMRiO95424
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO95424, 6 interactors
STRINGi9606.ENSP00000330509

Polymorphism and mutation databases

BioMutaiDEXI

Proteomic databases

PaxDbiO95424
PeptideAtlasiO95424
PRIDEiO95424
ProteomicsDBi50865

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
28955
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331808; ENSP00000330509; ENSG00000182108
ENST00000469379; ENSP00000482265; ENSG00000182108
ENST00000570440; ENSP00000493467; ENSG00000182108
GeneIDi28955
KEGGihsa:28955
UCSCiuc002dal.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
28955
DisGeNETi28955

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DEXI

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0019242
HIX0172763
HGNCiHGNC:13267 DEXI
HPAiHPA041511
MIMi617901 gene
neXtProtiNX_O95424
OpenTargetsiENSG00000182108
PharmGKBiPA165449964

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J0RE Eukaryota
ENOG4111YRS LUCA
GeneTreeiENSGT00390000013271
HOGENOMiHOG000112199
InParanoidiO95424
OMAiSVPYDTD
OrthoDBi1373211at2759
PhylomeDBiO95424
TreeFamiTF338557

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DEXI human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
28955

Protein Ontology

More...
PROi
PR:O95424

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000182108 Expressed in 225 organ(s), highest expression level in apex of heart
GenevisibleiO95424 HS

Family and domain databases

InterProiView protein in InterPro
IPR023259 Dexamethasone-induced
PANTHERiPTHR17070 PTHR17070, 1 hit
PfamiView protein in Pfam
PF15198 Dexa_ind, 1 hit
PRINTSiPR02032 DEXMETHSNEIP
ProDomiView protein in ProDom or Entries sharing at least one domain
PD195637 Dexamethasone-induced, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEXI_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95424
Secondary accession number(s): B2RAA7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 14, 2001
Last modified: May 8, 2019
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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