Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor SOX-14

Gene

SOX14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of transcription.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi8 – 76HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-14
Alternative name(s):
Protein SOX-28
Gene namesi
Name:SOX14
Synonyms:SOX28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000168875.2
HGNCiHGNC:11193 SOX14
MIMi604747 gene
neXtProtiNX_O95416

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8403
OpenTargetsiENSG00000168875
PharmGKBiPA36030

Polymorphism and mutation databases

BioMutaiSOX14

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487581 – 240Transcription factor SOX-14Add BLAST240

Proteomic databases

EPDiO95416
MaxQBiO95416
PaxDbiO95416
PeptideAtlasiO95416
PRIDEiO95416
ProteomicsDBi50864

PTM databases

iPTMnetiO95416
PhosphoSitePlusiO95416

Expressioni

Gene expression databases

BgeeiENSG00000168875 Expressed in 6 organ(s), highest expression level in substantia nigra
CleanExiHS_SOX14
GenevisibleiO95416 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NAIF1Q69YI73EBI-9087806,EBI-10249231

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113991, 3 interactors
IntActiO95416, 8 interactors
STRINGi9606.ENSP00000305343

Structurei

3D structure databases

ProteinModelPortaliO95416
SMRiO95416
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IPZF Eukaryota
ENOG41115Y8 LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000231647
HOVERGENiHBG105618
InParanoidiO95416
KOiK09267
OMAiTLGCPSQ
OrthoDBiEOG091G0F15
PhylomeDBiO95416
TreeFamiTF351735

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR022097 SOX_fam
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12336 SOXp, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O95416-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKPSDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS
60 70 80 90 100
EAEKRPYIDE AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG
110 120 130 140 150
DTDPLKAAGL PVGASDGLLS APEKARAFLP PASAPYSLLD PAQFSSSAIQ
160 170 180 190 200
KMGEVPHTLA TGALPYASTL GYQNGAFGSL SCPSQHTHTH PSPTNPGYVV
210 220 230 240
PCNCTAWSAS TLQPPVAYIL FPGMTKTGID PYSSAHATAM
Length:240
Mass (Da):26,485
Last modified:May 1, 1999 - v1
Checksum:i7F574AFDA571D903
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107043 Genomic DNA Translation: AAC95380.1
AJ006230 Genomic DNA Translation: CAB43111.1
AF193436 Genomic DNA Translation: AAF76294.1
AK314127 mRNA Translation: BAG36817.1
CH471052 Genomic DNA Translation: EAW79097.1
BC106729 mRNA Translation: AAI06730.1
BC106730 mRNA Translation: AAI06731.1
AF032451 Genomic DNA Translation: AAC94971.1
CCDSiCCDS3094.1
RefSeqiNP_004180.1, NM_004189.3
UniGeneiHs.248184

Genome annotation databases

EnsembliENST00000306087; ENSP00000305343; ENSG00000168875
GeneIDi8403
KEGGihsa:8403
UCSCiuc003erm.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107043 Genomic DNA Translation: AAC95380.1
AJ006230 Genomic DNA Translation: CAB43111.1
AF193436 Genomic DNA Translation: AAF76294.1
AK314127 mRNA Translation: BAG36817.1
CH471052 Genomic DNA Translation: EAW79097.1
BC106729 mRNA Translation: AAI06730.1
BC106730 mRNA Translation: AAI06731.1
AF032451 Genomic DNA Translation: AAC94971.1
CCDSiCCDS3094.1
RefSeqiNP_004180.1, NM_004189.3
UniGeneiHs.248184

3D structure databases

ProteinModelPortaliO95416
SMRiO95416
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113991, 3 interactors
IntActiO95416, 8 interactors
STRINGi9606.ENSP00000305343

PTM databases

iPTMnetiO95416
PhosphoSitePlusiO95416

Polymorphism and mutation databases

BioMutaiSOX14

Proteomic databases

EPDiO95416
MaxQBiO95416
PaxDbiO95416
PeptideAtlasiO95416
PRIDEiO95416
ProteomicsDBi50864

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306087; ENSP00000305343; ENSG00000168875
GeneIDi8403
KEGGihsa:8403
UCSCiuc003erm.3 human

Organism-specific databases

CTDi8403
DisGeNETi8403
EuPathDBiHostDB:ENSG00000168875.2
GeneCardsiSOX14
HGNCiHGNC:11193 SOX14
MIMi604747 gene
neXtProtiNX_O95416
OpenTargetsiENSG00000168875
PharmGKBiPA36030
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPZF Eukaryota
ENOG41115Y8 LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000231647
HOVERGENiHBG105618
InParanoidiO95416
KOiK09267
OMAiTLGCPSQ
OrthoDBiEOG091G0F15
PhylomeDBiO95416
TreeFamiTF351735

Miscellaneous databases

GeneWikiiSOX14
GenomeRNAii8403
PROiPR:O95416
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168875 Expressed in 6 organ(s), highest expression level in substantia nigra
CleanExiHS_SOX14
GenevisibleiO95416 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR022097 SOX_fam
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12336 SOXp, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOX14_HUMAN
AccessioniPrimary (citable) accession number: O95416
Secondary accession number(s): B2RAC0, Q3KPH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again