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Protein

Brain protein I3

Gene

BRI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in tumor necrosis factor-alpha (TNF)-induced cell death (PubMed:14592447). May be a target of Wnt/beta-catenin signaling in the liver (PubMed:20538055).2 Publications

GO - Molecular functioni

  • identical protein binding Source: MGI

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Brain protein I3
Alternative name(s):
pRGR2
Gene namesi
Name:BRI3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164713.9
HGNCiHGNC:1109 BRI3
MIMi615628 gene
neXtProtiNX_O95415

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei67 – 86HelicalSequence analysisAdd BLAST20
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25798
OpenTargetsiENSG00000164713
PharmGKBiPA25422

Polymorphism and mutation databases

BioMutaiBRI3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649231 – 125Brain protein I3Add BLAST125

Proteomic databases

EPDiO95415
MaxQBiO95415
PaxDbiO95415
PeptideAtlasiO95415
PRIDEiO95415
ProteomicsDBi50863

PTM databases

iPTMnetiO95415
PhosphoSitePlusiO95415

Expressioni

Inductioni

Up-regulated during TNF-mediated inflammation and immunity (By similarity). Up-regulated by beta-catenin and TCF4 (PubMed:20538055).By similarity1 Publication

Gene expression databases

BgeeiENSG00000164713 Expressed in 201 organ(s), highest expression level in skeletal muscle tissue
CleanExiHS_BRI3
ExpressionAtlasiO95415 baseline and differential
GenevisibleiO95415 HS

Organism-specific databases

HPAiHPA042215

Interactioni

Subunit structurei

Interacts with BRI3BP.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117330, 2 interactors
IntActiO95415, 3 interactors
STRINGi9606.ENSP00000297290

Structurei

3D structure databases

ProteinModelPortaliO95415
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 43Poly-Pro7

Sequence similaritiesi

Belongs to the BRI3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4517 Eukaryota
ENOG41121JM LUCA
GeneTreeiENSGT00510000048486
HOGENOMiHOG000035090
HOVERGENiHBG104957
InParanoidiO95415
OMAiGTYAIIQ
OrthoDBiEOG091G18Q7
PhylomeDBiO95415
TreeFamiTF329242

Family and domain databases

InterProiView protein in InterPro
IPR019317 Brain_I3
PANTHERiPTHR13551 PTHR13551, 1 hit
PfamiView protein in Pfam
PF10164 DUF2367, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O95415-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDHKPLLQER PPAYNLEAGQ GDYACGPHGY GAIPAAPPPP PYPYLVTGIP
60 70 80 90 100
THHPRVYNIH SRTVTRYPAN SIVVVGGCPV CRVGVLEDCF TFLGIFLAII
110 120
LFPFGFICCF ALRKRRCPNC GATFA
Length:125
Mass (Da):13,645
Last modified:May 1, 1999 - v1
Checksum:iABBFADD00E91C52C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GXW6F5GXW6_HUMAN
Brain protein I3
BRI3
98Annotation score:
I3L1V6I3L1V6_HUMAN
Brain protein I3
BRI3
47Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53H → Y in AAH18737 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033516123T → A. Corresponds to variant dbSNP:rs12865Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106966 mRNA Translation: AAD05167.1
AB055977 mRNA Translation: BAB32785.1
AF041430 mRNA Translation: AAF18565.2
AC091654 Genomic DNA No translation available.
AC093169 Genomic DNA No translation available.
CH471091 Genomic DNA Translation: EAW76713.1
CH471091 Genomic DNA Translation: EAW76714.1
CH471091 Genomic DNA Translation: EAW76715.1
BC018737 mRNA Translation: AAH18737.1
BC062370 mRNA Translation: AAH62370.1
CCDSiCCDS5656.1
RefSeqiNP_056194.1, NM_015379.4
UniGeneiHs.567438

Genome annotation databases

EnsembliENST00000297290; ENSP00000297290; ENSG00000164713
GeneIDi25798
KEGGihsa:25798
UCSCiuc003upi.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106966 mRNA Translation: AAD05167.1
AB055977 mRNA Translation: BAB32785.1
AF041430 mRNA Translation: AAF18565.2
AC091654 Genomic DNA No translation available.
AC093169 Genomic DNA No translation available.
CH471091 Genomic DNA Translation: EAW76713.1
CH471091 Genomic DNA Translation: EAW76714.1
CH471091 Genomic DNA Translation: EAW76715.1
BC018737 mRNA Translation: AAH18737.1
BC062370 mRNA Translation: AAH62370.1
CCDSiCCDS5656.1
RefSeqiNP_056194.1, NM_015379.4
UniGeneiHs.567438

3D structure databases

ProteinModelPortaliO95415
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117330, 2 interactors
IntActiO95415, 3 interactors
STRINGi9606.ENSP00000297290

PTM databases

iPTMnetiO95415
PhosphoSitePlusiO95415

Polymorphism and mutation databases

BioMutaiBRI3

Proteomic databases

EPDiO95415
MaxQBiO95415
PaxDbiO95415
PeptideAtlasiO95415
PRIDEiO95415
ProteomicsDBi50863

Protocols and materials databases

DNASUi25798
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297290; ENSP00000297290; ENSG00000164713
GeneIDi25798
KEGGihsa:25798
UCSCiuc003upi.3 human

Organism-specific databases

CTDi25798
DisGeNETi25798
EuPathDBiHostDB:ENSG00000164713.9
GeneCardsiBRI3
HGNCiHGNC:1109 BRI3
HPAiHPA042215
MIMi615628 gene
neXtProtiNX_O95415
OpenTargetsiENSG00000164713
PharmGKBiPA25422
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4517 Eukaryota
ENOG41121JM LUCA
GeneTreeiENSGT00510000048486
HOGENOMiHOG000035090
HOVERGENiHBG104957
InParanoidiO95415
OMAiGTYAIIQ
OrthoDBiEOG091G18Q7
PhylomeDBiO95415
TreeFamiTF329242

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiBRI3 human
GenomeRNAii25798
PROiPR:O95415
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164713 Expressed in 201 organ(s), highest expression level in skeletal muscle tissue
CleanExiHS_BRI3
ExpressionAtlasiO95415 baseline and differential
GenevisibleiO95415 HS

Family and domain databases

InterProiView protein in InterPro
IPR019317 Brain_I3
PANTHERiPTHR13551 PTHR13551, 1 hit
PfamiView protein in Pfam
PF10164 DUF2367, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBRI3_HUMAN
AccessioniPrimary (citable) accession number: O95415
Secondary accession number(s): D6W5R8, Q8WV52, Q9UIC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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