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Protein

Tumor necrosis factor receptor superfamily member 6B

Gene

TNFRSF6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • signaling receptor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5669034 TNFs bind their physiological receptors

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O95407

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 6B
Alternative name(s):
Decoy receptor 3
Short name:
DcR3
Decoy receptor for Fas ligand
M68
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFRSF6B
Synonyms:DCR3, TR6
ORF Names:UNQ186/PRO212
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000243509.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11921 TNFRSF6B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603361 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95407

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8771

Open Targets

More...
OpenTargetsi
ENSG00000243509

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36614

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNFRSF6B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 291 PublicationAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003457030 – 300Tumor necrosis factor receptor superfamily member 6BAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 62PROSITE-ProRule annotation1 Publication
Disulfide bondi52 ↔ 70PROSITE-ProRule annotation1 Publication
Disulfide bondi73 ↔ 88PROSITE-ProRule annotation1 Publication
Disulfide bondi91 ↔ 105PROSITE-ProRule annotation1 Publication
Disulfide bondi95 ↔ 113PROSITE-ProRule annotation1 Publication
Disulfide bondi115 ↔ 126PROSITE-ProRule annotation1 Publication
Disulfide bondi132 ↔ 150PROSITE-ProRule annotation1 Publication
Disulfide bondi153 ↔ 168PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi174 ↔ 193PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95407

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95407

PeptideAtlas

More...
PeptideAtlasi
O95407

PRoteomics IDEntifications database

More...
PRIDEi
O95407

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50860

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95407

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95407

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000243509 Expressed in 80 organ(s), highest expression level in substantia nigra

CleanEx database of gene expression profiles

More...
CleanExi
HS_TNFRSF6B

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95407 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047154

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114301, 6 interactors

Protein interaction database and analysis system

More...
IntActi
O95407, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359013

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1300
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95407

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95407

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O95407

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati31 – 70TNFR-Cys 1Add BLAST40
Repeati72 – 113TNFR-Cys 2Add BLAST42
Repeati115 – 150TNFR-Cys 3Add BLAST36
Repeati152 – 193TNFR-Cys 4Add BLAST42

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH0F Eukaryota
ENOG410YF4X LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162635

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154657

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95407

KEGG Orthology (KO)

More...
KOi
K05143

Identification of Orthologs from Complete Genome Data

More...
OMAi
NVICGER

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03XW

TreeFam database of animal gene trees

More...
TreeFami
TF331157

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10575 TNFRSF6B, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR034023 TNFRSF6B_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00020 TNFR_c6, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00208 TNFR, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O95407-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRALEGPGLS LLCLVLALPA LLPVPAVRGV AETPTYPWRD AETGERLVCA
60 70 80 90 100
QCPPGTFVQR PCRRDSPTTC GPCPPRHYTQ FWNYLERCRY CNVLCGEREE
110 120 130 140 150
EARACHATHN RACRCRTGFF AHAGFCLEHA SCPPGAGVIA PGTPSQNTQC
160 170 180 190 200
QPCPPGTFSA SSSSSEQCQP HRNCTALGLA LNVPGSSSHD TLCTSCTGFP
210 220 230 240 250
LSTRVPGAEE CERAVIDFVA FQDISIKRLQ RLLQALEAPE GWGPTPRAGR
260 270 280 290 300
AALQLKLRRR LTELLGAQDG ALLVRLLQAL RVARMPGLER SVRERFLPVH
Length:300
Mass (Da):32,680
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF90AEE33718449AF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF104419 mRNA Translation: AAD03056.1
AF134240 mRNA Translation: AAD29688.1
AF217796 Genomic DNA Translation: AAF35244.1
AF217793 mRNA Translation: AAF33685.1
AF217794 mRNA Translation: AAF33686.1
AY358279 mRNA Translation: AAQ88646.1
AL121845 Genomic DNA No translation available.
BC017065 mRNA Translation: AAH17065.1
BC034349 mRNA Translation: AAH34349.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13532.1

NCBI Reference Sequences

More...
RefSeqi
NP_003814.1, NM_003823.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.434878

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369996; ENSP00000359013; ENSG00000243509

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8771

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8771

UCSC genome browser

More...
UCSCi
uc002yfz.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104419 mRNA Translation: AAD03056.1
AF134240 mRNA Translation: AAD29688.1
AF217796 Genomic DNA Translation: AAF35244.1
AF217793 mRNA Translation: AAF33685.1
AF217794 mRNA Translation: AAF33686.1
AY358279 mRNA Translation: AAQ88646.1
AL121845 Genomic DNA No translation available.
BC017065 mRNA Translation: AAH17065.1
BC034349 mRNA Translation: AAH34349.1
CCDSiCCDS13532.1
RefSeqiNP_003814.1, NM_003823.3
UniGeneiHs.434878

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3K51X-ray2.45B30-195[»]
3MHDX-ray2.90D30-195[»]
3MI8X-ray2.95D30-195[»]
4J6GX-ray2.40C/D30-195[»]
4KGGX-ray2.78C/D30-195[»]
4KGQX-ray2.27C/D30-195[»]
4MSVX-ray2.50B30-195[»]
5L36X-ray3.10B30-195[»]
ProteinModelPortaliO95407
SMRiO95407
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114301, 6 interactors
IntActiO95407, 5 interactors
STRINGi9606.ENSP00000359013

PTM databases

iPTMnetiO95407
PhosphoSitePlusiO95407

Polymorphism and mutation databases

BioMutaiTNFRSF6B

Proteomic databases

EPDiO95407
PaxDbiO95407
PeptideAtlasiO95407
PRIDEiO95407
ProteomicsDBi50860

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369996; ENSP00000359013; ENSG00000243509
GeneIDi8771
KEGGihsa:8771
UCSCiuc002yfz.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8771
DisGeNETi8771
EuPathDBiHostDB:ENSG00000243509.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNFRSF6B
HGNCiHGNC:11921 TNFRSF6B
HPAiHPA047154
MIMi603361 gene
neXtProtiNX_O95407
OpenTargetsiENSG00000243509
PharmGKBiPA36614

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH0F Eukaryota
ENOG410YF4X LUCA
GeneTreeiENSGT00940000162635
HOGENOMiHOG000154657
InParanoidiO95407
KOiK05143
OMAiNVICGER
OrthoDBiEOG091G03XW
TreeFamiTF331157

Enzyme and pathway databases

ReactomeiR-HSA-5669034 TNFs bind their physiological receptors
SIGNORiO95407

Miscellaneous databases

EvolutionaryTraceiO95407

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TNFRSF6B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8771

Protein Ontology

More...
PROi
PR:O95407

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000243509 Expressed in 80 organ(s), highest expression level in substantia nigra
CleanExiHS_TNFRSF6B
GenevisibleiO95407 HS

Family and domain databases

CDDicd10575 TNFRSF6B, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR034023 TNFRSF6B_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 3 hits
SMARTiView protein in SMART
SM00208 TNFR, 4 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNF6B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95407
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 1999
Last modified: December 5, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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