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UniProtKB - O95405 (ZFYV9_HUMAN)

Entry version 188 (07 Apr 2021)
Sequence version 2 (14 Aug 2001)
Previous versions | rss
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Protein

Zinc finger FYVE domain-containing protein 9

Gene

ZFYVE9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri699 – 758FYVE-typePROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • endocytosis Source: UniProtKB
  • endosomal transport Source: GO_Central
  • transforming growth factor beta receptor signaling pathway Source: UniProtKB
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95405

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2173788, Downregulation of TGF-beta receptor signaling [O95405-1]
R-HSA-2173789, TGF-beta receptor signaling activates SMADs [O95405-1]
R-HSA-3304356, SMAD2/3 Phosphorylation Motif Mutants in Cancer [O95405-1]
R-HSA-3656532, TGFBR1 KD Mutants in Cancer [O95405-1]

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O95405

SIGNOR Signaling Network Open Resource

More...SIGNORi		O95405

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger FYVE domain-containing protein 9
Alternative name(s):
Mothers against decapentaplegic homolog-interacting protein
Short name:
Madh-interacting protein
Novel serine protease
Short name:
NSP
Receptor activation anchor
Short name:
hSARA
Smad anchor for receptor activation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFYVE9
Synonyms:MADHIP, SARA, SMADIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6775, ZFYVE9

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603755, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95405

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000157077.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi782Y → A: Diminishes complex formation with SMAD2. 1 Publication1
Mutagenesisi782Y → E: Diminishes complex formation with SMAD2. 1 Publication1
Mutagenesisi783C → A: Diminishes complex formation with SMAD2. 1 Publication1
Mutagenesisi783C → E: Diminishes complex formation with SMAD2. 1 Publication1
Mutagenesisi788P → A: Diminishes complex formation with SMAD2. 1 Publication1
Mutagenesisi788P → E: Diminishes complex formation with SMAD2. 1 Publication1
Mutagenesisi790Q → A: No effect on complex formation with SMAD2. 1 Publication1
Mutagenesisi793Q → A: No effect on complex formation with SMAD2. 1 Publication1
Mutagenesisi805V → A: Diminishes complex formation with SMAD2. 1 Publication1
Mutagenesisi805V → E: Diminishes complex formation with SMAD2. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		9372

Open Targets

More...OpenTargetsi		ENSG00000157077

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30532

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95405, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZFYVE9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000987151 – 1425Zinc finger FYVE domain-containing protein 9Add BLAST1425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei306PhosphoserineCombined sources1
Modified residuei668PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95405

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95405

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95405

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95405

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95405

PeptideAtlas

More...PeptideAtlasi		O95405

PRoteomics IDEntifications database

More...PRIDEi		O95405

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50856 [O95405-1]
50857 [O95405-2]
50858 [O95405-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95405

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95405

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000157077, Expressed in frontal cortex and 204 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95405, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000157077, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the SBD region) with SMAD2; the interaction recruits SMAD2 to the TGF-beta receptor and is disrupted by phosphorylation of SMAD2 upon TGF-beta receptor activation.

Interacts with SMAD3.

Interacts with TGFBR1 and TGFBR2; the interaction recruits SMAD2 to the TGF-beta receptor.

Interacts with PML.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114773, 51 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O95405

Protein interaction database and analysis system

More...IntActi		O95405, 42 interactors

Molecular INTeraction database

More...MINTi		O95405

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000287727

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95405, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11425
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95405

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O95405

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni767 – 823SBDAdd BLAST57

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SMAD binding domain (SBD) interacts with the MH2 domains of SMAD2 or SMAD3.
The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri699 – 758FYVE-typePROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1841, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154290

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004326_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95405

Identification of Orthologs from Complete Genome Data

More...OMAi		HIQWVED

Database of Orthologous Groups

More...OrthoDBi		278124at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95405

TreeFam database of animal gene trees

More...TreeFami		TF324904

Family and domain databases

Database of protein disorder

More...DisProti		DP00141

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit
4.10.720.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00112

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022557, DUF3480
IPR035438, SARA/endofin
IPR024608, SARA_Smad-bd
IPR037145, SARA_Smad-bd_sf
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11979, DUF3480, 1 hit
PF01363, FYVE, 1 hit
PF11409, SARA, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037289, SARA/endofin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00064, FYVE, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50178, ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O95405-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENYFQAEAY NLDKVLDEFE QNEDETVSST LLDTKWNKIL DPPSHRLSFN 
        60         70         80         90        100
PTLASVNESA VSNESQPQLK VFSLAHSAPL TTEEEDHCAN GQDCNLNPEI 
       110        120        130        140        150
ATMWIDENAV AEDQLIKRNY SWDDQCSAVE VGEKKCGNLA CLPDEKNVLV 
       160        170        180        190        200
VAVMHNCDKR TLQNDLQDCN NYNSQSLMDA FSCSLDNENR QTDQFSFSIN 
       210        220        230        240        250
ESTEKDMNSE KQMDPLNRPK TEGRSVNHLC PTSSDSLASV CSPSQLKDDG 
       260        270        280        290        300
SIGRDPSMSA ITSLTVDSVI SSQGTDGCPA VKKQENYIPD EDLTGKISSP 
       310        320        330        340        350
RTDLGSPNSF SHMSEGILMK KEPAEESTTE ESLRSGLPLL LKPDMPNGSG 
       360        370        380        390        400
RNNDCERCSD CLVPNEVRAD ENEGYEHEET LGTTEFLNMT EHFSESQDMT 
       410        420        430        440        450
NWKLTKLNEM NDSQVNEEKE KFLQISQPED TNGDSGGQCV GLADAGLDLK 
       460        470        480        490        500
GTCISESEEC DFSTVIDTPA ANYLSNGCDS YGMQDPGVSF VPKTLPSKED 
       510        520        530        540        550
SVTEEKEIEE SKSECYSNIY EQRGNEATEG SGLLLNSTGD LMKKNYLHNF 
       560        570        580        590        600
CSQVPSVLGQ SSPKVVASLP SISVPFGGAR PKQPSNLKLQ IPKPLSDHLQ 
       610        620        630        640        650
NDFPANSGNN TKNKNDILGK AKLGENSATN VCSPSLGNIS NVDTNGEHLE 
       660        670        680        690        700
SYEAEISTRP CLALAPDSPD NDLRAGQFGI SARKPFTTLG EVAPVWVPDS 
       710        720        730        740        750
QAPNCMKCEA RFTFTKRRHH CRACGKVFCA SCCSLKCKLL YMDRKEARVC 
       760        770        780        790        800
VICHSVLMNA QAWENMMSAS SQSPNPNNPA EYCSTIPPLQ QAQASGALSS 
       810        820        830        840        850
PPPTVMVPVG VLKHPGAEVA QPREQRRVWF ADGILPNGEV ADAAKLTMNG 
       860        870        880        890        900
TSSAGTLAVS HDPVKPVTTS PLPAETDICL FSGSITQVGS PVGSAMNLIP 
       910        920        930        940        950
EDGLPPILIS TGVKGDYAVE EKPSQISVMQ QLEDGGPDPL VFVLNANLLS 
       960        970        980        990       1000
MVKIVNYVNR KCWCFTTKGM HAVGQSEIVI LLQCLPDEKC LPKDIFNHFV 
      1010       1020       1030       1040       1050
QLYRDALAGN VVSNLGHSFF SQSFLGSKEH GGFLYVTSTY QSLQDLVLPT 
      1060       1070       1080       1090       1100
PPYLFGILIQ KWETPWAKVF PIRLMLRLGA EYRLYPCPLF SVRFRKPLFG 
      1110       1120       1130       1140       1150
ETGHTIMNLL ADFRNYQYTL PVVQGLVVDM EVRKTSIKIP SNRYNEMMKA 
      1160       1170       1180       1190       1200
MNKSNEHVLA GGACFNEKAD SHLVCVQNDD GNYQTQAISI HNQPRKVTGA 
      1210       1220       1230       1240       1250
SFFVFSGALK SSSGYLAKSS IVEDGVMVQI TAENMDSLRQ ALREMKDFTI 
      1260       1270       1280       1290       1300
TCGKADAEEP QEHIHIQWVD DDKNVSKGVV SPIDGKSMET ITNVKIFHGS 
      1310       1320       1330       1340       1350
EYKANGKVIR WTEVFFLEND DQHNCLSDPA DHSRLTEHVA KAFCLALCPH 
      1360       1370       1380       1390       1400
LKLLKEDGMT KLGLRVTLDS DQVGYQAGSN GQPLPSQYMN DLDSALVPVI 
      1410       1420 
HGGACQLSEG PVVMELIFYI LENIV
Length:1,425
Mass (Da):156,403
Last modified:August 14, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADE5CB530C1272C6
GO
Isoform 2 (identifier: O95405-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     760-818: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:1,366
Mass (Da):150,348
Checksum:iC7779D54E2435CC9
GO
Isoform 3 (identifier: O95405-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     760-762: AQA → GKY
     763-1425: Missing.

Show »
Length:762
Mass (Da):83,721
Checksum:iB96C60B807CFF367
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC99462 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAD31694 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052985287Y → C. Corresponds to variant dbSNP:rs9803965Ensembl.1
Natural variantiVAR_052986414Q → P. Corresponds to variant dbSNP:rs3790525Ensembl.1
Natural variantiVAR_052987639I → V. Corresponds to variant dbSNP:rs11809887Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004315760 – 818Missing in isoform 2. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_004316760 – 762AQA → GKY in isoform 3. 1 Publication3
Alternative sequenceiVSP_004317763 – 1425Missing in isoform 3. 1 PublicationAdd BLAST663

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF104304 mRNA Translation: AAC99462.1 Different initiation.
AF130419 mRNA Translation: AAD31694.1 Frameshift.
AF130420 mRNA Translation: AAD31695.1
AC105754 Genomic DNA No translation available.
AL513218 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06790.1
CH471059 Genomic DNA Translation: EAX06791.1
BC032680 mRNA Translation: AAH32680.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS563.1 [O95405-1]
CCDS564.1 [O95405-2]

NCBI Reference Sequences

More...RefSeqi		NP_004790.2, NM_004799.3 [O95405-1]
NP_015563.2, NM_007324.3 [O95405-2]
XP_011540739.1, XM_011542437.2 [O95405-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000287727; ENSP00000287727; ENSG00000157077 [O95405-1]
ENST00000357206; ENSP00000349737; ENSG00000157077 [O95405-2]
ENST00000371591; ENSP00000360647; ENSG00000157077 [O95405-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9372

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9372

UCSC genome browser

More...UCSCi		uc001cto.5, human [O95405-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104304 mRNA Translation: AAC99462.1 Different initiation.
AF130419 mRNA Translation: AAD31694.1 Frameshift.
AF130420 mRNA Translation: AAD31695.1
AC105754 Genomic DNA No translation available.
AL513218 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06790.1
CH471059 Genomic DNA Translation: EAX06791.1
BC032680 mRNA Translation: AAH32680.1
CCDSiCCDS563.1 [O95405-1]
CCDS564.1 [O95405-2]
RefSeqiNP_004790.2, NM_004799.3 [O95405-1]
NP_015563.2, NM_007324.3 [O95405-2]
XP_011540739.1, XM_011542437.2 [O95405-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DEVX-ray2.20B/D771-811[»]
1MK2X-ray2.74B773-810[»]
4BKWX-ray2.53A895-1425[»]
5MJYX-ray2.25E/F1-22[»]
SMRiO95405
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114773, 51 interactors
CORUMiO95405
IntActiO95405, 42 interactors
MINTiO95405
STRINGi9606.ENSP00000287727

PTM databases

iPTMnetiO95405
PhosphoSitePlusiO95405

Genetic variation databases

BioMutaiZFYVE9

Proteomic databases

EPDiO95405
jPOSTiO95405
MassIVEiO95405
MaxQBiO95405
PaxDbiO95405
PeptideAtlasiO95405
PRIDEiO95405
ProteomicsDBi50856 [O95405-1]
50857 [O95405-2]
50858 [O95405-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32995, 109 antibodies

The DNASU plasmid repository

More...DNASUi		9372

Genome annotation databases

EnsembliENST00000287727; ENSP00000287727; ENSG00000157077 [O95405-1]
ENST00000357206; ENSP00000349737; ENSG00000157077 [O95405-2]
ENST00000371591; ENSP00000360647; ENSG00000157077 [O95405-1]
GeneIDi9372
KEGGihsa:9372
UCSCiuc001cto.5, human [O95405-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9372
DisGeNETi9372

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZFYVE9
HGNCiHGNC:6775, ZFYVE9
HPAiENSG00000157077, Low tissue specificity
MIMi603755, gene
neXtProtiNX_O95405
OpenTargetsiENSG00000157077
PharmGKBiPA30532
VEuPathDBiHostDB:ENSG00000157077.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1841, Eukaryota
GeneTreeiENSGT00940000154290
HOGENOMiCLU_004326_1_0_1
InParanoidiO95405
OMAiHIQWVED
OrthoDBi278124at2759
PhylomeDBiO95405
TreeFamiTF324904

Enzyme and pathway databases

PathwayCommonsiO95405
ReactomeiR-HSA-2173788, Downregulation of TGF-beta receptor signaling [O95405-1]
R-HSA-2173789, TGF-beta receptor signaling activates SMADs [O95405-1]
R-HSA-3304356, SMAD2/3 Phosphorylation Motif Mutants in Cancer [O95405-1]
R-HSA-3656532, TGFBR1 KD Mutants in Cancer [O95405-1]
SignaLinkiO95405
SIGNORiO95405

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9372, 8 hits in 1001 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZFYVE9, human
EvolutionaryTraceiO95405

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Zinc_finger_FYVE_domain-containing_protein_9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9372
PharosiO95405, Tbio

Protein Ontology

More...PROi		PR:O95405
RNActiO95405, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000157077, Expressed in frontal cortex and 204 other tissues
GenevisibleiO95405, HS

Family and domain databases

DisProtiDP00141
Gene3Di3.30.40.10, 1 hit
4.10.720.10, 1 hit
IDEALiIID00112
InterProiView protein in InterPro
IPR022557, DUF3480
IPR035438, SARA/endofin
IPR024608, SARA_Smad-bd
IPR037145, SARA_Smad-bd_sf
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF11979, DUF3480, 1 hit
PF01363, FYVE, 1 hit
PF11409, SARA, 1 hit
PIRSFiPIRSF037289, SARA/endofin, 1 hit
SMARTiView protein in SMART
SM00064, FYVE, 1 hit
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50178, ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFYV9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95405
Secondary accession number(s): Q5T0F6
, Q5T0F7, Q9UNE1, Q9Y5R7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: April 7, 2021
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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