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Protein

Zinc finger FYVE domain-containing protein 9

Gene

ZFYVE9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri699 – 758FYVE-typePROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 1-phosphatidylinositol binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein domain specific binding Source: CAFA
  • serine-type peptidase activity Source: UniProtKB

GO - Biological processi

  • endocytosis Source: UniProtKB
  • endosomal transport Source: GO_Central
  • transforming growth factor beta receptor signaling pathway Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-2173789 TGF-beta receptor signaling activates SMADs
R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer
R-HSA-3315487 SMAD2/3 MH2 Domain Mutants in Cancer
R-HSA-3656532 TGFBR1 KD Mutants in Cancer

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
O95405

SIGNOR Signaling Network Open Resource

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SIGNORi
O95405

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger FYVE domain-containing protein 9
Alternative name(s):
Mothers against decapentaplegic homolog-interacting protein
Short name:
Madh-interacting protein
Novel serine protease
Short name:
NSP
Receptor activation anchor
Short name:
hSARA
Smad anchor for receptor activation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFYVE9
Synonyms:MADHIP, SARA, SMADIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000157077.14

Human Gene Nomenclature Database

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HGNCi
HGNC:6775 ZFYVE9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603755 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95405

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi782Y → A: Diminishes complex formation with SMAD2. 1 Publication1
Mutagenesisi782Y → E: Diminishes complex formation with SMAD2. 1 Publication1
Mutagenesisi783C → A: Diminishes complex formation with SMAD2. 1 Publication1
Mutagenesisi783C → E: Diminishes complex formation with SMAD2. 1 Publication1
Mutagenesisi788P → A: Diminishes complex formation with SMAD2. 1 Publication1
Mutagenesisi788P → E: Diminishes complex formation with SMAD2. 1 Publication1
Mutagenesisi790Q → A: No effect on complex formation with SMAD2. 1 Publication1
Mutagenesisi793Q → A: No effect on complex formation with SMAD2. 1 Publication1
Mutagenesisi805V → A: Diminishes complex formation with SMAD2. 1 Publication1
Mutagenesisi805V → E: Diminishes complex formation with SMAD2. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9372

Open Targets

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OpenTargetsi
ENSG00000157077

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30532

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ZFYVE9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000987151 – 1425Zinc finger FYVE domain-containing protein 9Add BLAST1425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei306PhosphoserineCombined sources1
Modified residuei668PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O95405

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O95405

MaxQB - The MaxQuant DataBase

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MaxQBi
O95405

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O95405

PeptideAtlas

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PeptideAtlasi
O95405

PRoteomics IDEntifications database

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PRIDEi
O95405

ProteomicsDB human proteome resource

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ProteomicsDBi
50856
50857 [O95405-2]
50858 [O95405-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O95405

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O95405

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000157077 Expressed in 188 organ(s), highest expression level in kidney

CleanEx database of gene expression profiles

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CleanExi
HS_ZFYVE9

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O95405 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB017702
HPA065852
HPA065862

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the SBD region) with SMAD2; the interaction recruits SMAD2 to the TGF-beta receptor and is disrupted by phosphorylation of SMAD2 upon TGF-beta receptor activation. Interacts with SMAD3. Interacts with TGFBR1 and TGFBR2; the interaction recruits SMAD2 to the TGF-beta receptor. Interacts with PML.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114773, 44 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O95405

Protein interaction database and analysis system

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IntActi
O95405, 40 interactors

Molecular INTeraction database

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MINTi
O95405

STRING: functional protein association networks

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STRINGi
9606.ENSP00000287727

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11425
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DEVX-ray2.20B/D771-811[»]
1MK2X-ray2.74B773-810[»]
4BKWX-ray2.53A895-1425[»]
5MJYX-ray2.25E/F1-22[»]

Database of protein disorder

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DisProti
DP00141

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O95405

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95405

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O95405

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni767 – 823SBDAdd BLAST57

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SMAD binding domain (SBD) interacts with the MH2 domains of SMAD2 or SMAD3.
The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri699 – 758FYVE-typePROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1841 Eukaryota
ENOG410XSEQ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154290

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231131

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG079085

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O95405

KEGG Orthology (KO)

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KOi
K04679

Identification of Orthologs from Complete Genome Data

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OMAi
SQEMTNW

Database of Orthologous Groups

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OrthoDBi
278124at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O95405

TreeFam database of animal gene trees

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TreeFami
TF324904

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit
4.10.720.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR022557 DUF3480
IPR035438 SARA/endofin
IPR024608 SARA_Smad-bd
IPR037145 SARA_Smad-bd_sf
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11979 DUF3480, 1 hit
PF01363 FYVE, 1 hit
PF11409 SARA, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF037289 SARA/endofin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00064 FYVE, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50178 ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O95405-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENYFQAEAY NLDKVLDEFE QNEDETVSST LLDTKWNKIL DPPSHRLSFN
60 70 80 90 100
PTLASVNESA VSNESQPQLK VFSLAHSAPL TTEEEDHCAN GQDCNLNPEI
110 120 130 140 150
ATMWIDENAV AEDQLIKRNY SWDDQCSAVE VGEKKCGNLA CLPDEKNVLV
160 170 180 190 200
VAVMHNCDKR TLQNDLQDCN NYNSQSLMDA FSCSLDNENR QTDQFSFSIN
210 220 230 240 250
ESTEKDMNSE KQMDPLNRPK TEGRSVNHLC PTSSDSLASV CSPSQLKDDG
260 270 280 290 300
SIGRDPSMSA ITSLTVDSVI SSQGTDGCPA VKKQENYIPD EDLTGKISSP
310 320 330 340 350
RTDLGSPNSF SHMSEGILMK KEPAEESTTE ESLRSGLPLL LKPDMPNGSG
360 370 380 390 400
RNNDCERCSD CLVPNEVRAD ENEGYEHEET LGTTEFLNMT EHFSESQDMT
410 420 430 440 450
NWKLTKLNEM NDSQVNEEKE KFLQISQPED TNGDSGGQCV GLADAGLDLK
460 470 480 490 500
GTCISESEEC DFSTVIDTPA ANYLSNGCDS YGMQDPGVSF VPKTLPSKED
510 520 530 540 550
SVTEEKEIEE SKSECYSNIY EQRGNEATEG SGLLLNSTGD LMKKNYLHNF
560 570 580 590 600
CSQVPSVLGQ SSPKVVASLP SISVPFGGAR PKQPSNLKLQ IPKPLSDHLQ
610 620 630 640 650
NDFPANSGNN TKNKNDILGK AKLGENSATN VCSPSLGNIS NVDTNGEHLE
660 670 680 690 700
SYEAEISTRP CLALAPDSPD NDLRAGQFGI SARKPFTTLG EVAPVWVPDS
710 720 730 740 750
QAPNCMKCEA RFTFTKRRHH CRACGKVFCA SCCSLKCKLL YMDRKEARVC
760 770 780 790 800
VICHSVLMNA QAWENMMSAS SQSPNPNNPA EYCSTIPPLQ QAQASGALSS
810 820 830 840 850
PPPTVMVPVG VLKHPGAEVA QPREQRRVWF ADGILPNGEV ADAAKLTMNG
860 870 880 890 900
TSSAGTLAVS HDPVKPVTTS PLPAETDICL FSGSITQVGS PVGSAMNLIP
910 920 930 940 950
EDGLPPILIS TGVKGDYAVE EKPSQISVMQ QLEDGGPDPL VFVLNANLLS
960 970 980 990 1000
MVKIVNYVNR KCWCFTTKGM HAVGQSEIVI LLQCLPDEKC LPKDIFNHFV
1010 1020 1030 1040 1050
QLYRDALAGN VVSNLGHSFF SQSFLGSKEH GGFLYVTSTY QSLQDLVLPT
1060 1070 1080 1090 1100
PPYLFGILIQ KWETPWAKVF PIRLMLRLGA EYRLYPCPLF SVRFRKPLFG
1110 1120 1130 1140 1150
ETGHTIMNLL ADFRNYQYTL PVVQGLVVDM EVRKTSIKIP SNRYNEMMKA
1160 1170 1180 1190 1200
MNKSNEHVLA GGACFNEKAD SHLVCVQNDD GNYQTQAISI HNQPRKVTGA
1210 1220 1230 1240 1250
SFFVFSGALK SSSGYLAKSS IVEDGVMVQI TAENMDSLRQ ALREMKDFTI
1260 1270 1280 1290 1300
TCGKADAEEP QEHIHIQWVD DDKNVSKGVV SPIDGKSMET ITNVKIFHGS
1310 1320 1330 1340 1350
EYKANGKVIR WTEVFFLEND DQHNCLSDPA DHSRLTEHVA KAFCLALCPH
1360 1370 1380 1390 1400
LKLLKEDGMT KLGLRVTLDS DQVGYQAGSN GQPLPSQYMN DLDSALVPVI
1410 1420
HGGACQLSEG PVVMELIFYI LENIV
Length:1,425
Mass (Da):156,403
Last modified:August 14, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADE5CB530C1272C6
GO
Isoform 2 (identifier: O95405-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     760-818: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:1,366
Mass (Da):150,348
Checksum:iC7779D54E2435CC9
GO
Isoform 3 (identifier: O95405-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     760-762: AQA → GKY
     763-1425: Missing.

Show »
Length:762
Mass (Da):83,721
Checksum:iB96C60B807CFF367
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC99462 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAD31694 differs from that shown. Reason: Frameshift at position 1243.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052985287Y → C. Corresponds to variant dbSNP:rs9803965Ensembl.1
Natural variantiVAR_052986414Q → P. Corresponds to variant dbSNP:rs3790525Ensembl.1
Natural variantiVAR_052987639I → V. Corresponds to variant dbSNP:rs11809887Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004315760 – 818Missing in isoform 2. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_004316760 – 762AQA → GKY in isoform 3. 1 Publication3
Alternative sequenceiVSP_004317763 – 1425Missing in isoform 3. 1 PublicationAdd BLAST663

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF104304 mRNA Translation: AAC99462.1 Different initiation.
AF130419 mRNA Translation: AAD31694.1 Frameshift.
AF130420 mRNA Translation: AAD31695.1
AC105754 Genomic DNA No translation available.
AL513218 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06790.1
CH471059 Genomic DNA Translation: EAX06791.1
BC032680 mRNA Translation: AAH32680.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS563.1 [O95405-1]
CCDS564.1 [O95405-2]

NCBI Reference Sequences

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RefSeqi
NP_004790.2, NM_004799.3 [O95405-1]
NP_015563.2, NM_007324.3 [O95405-2]
XP_011540739.1, XM_011542437.2 [O95405-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.532345

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000287727; ENSP00000287727; ENSG00000157077 [O95405-1]
ENST00000357206; ENSP00000349737; ENSG00000157077 [O95405-2]
ENST00000371591; ENSP00000360647; ENSG00000157077 [O95405-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9372

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9372

UCSC genome browser

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UCSCi
uc001cto.5 human [O95405-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104304 mRNA Translation: AAC99462.1 Different initiation.
AF130419 mRNA Translation: AAD31694.1 Frameshift.
AF130420 mRNA Translation: AAD31695.1
AC105754 Genomic DNA No translation available.
AL513218 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06790.1
CH471059 Genomic DNA Translation: EAX06791.1
BC032680 mRNA Translation: AAH32680.1
CCDSiCCDS563.1 [O95405-1]
CCDS564.1 [O95405-2]
RefSeqiNP_004790.2, NM_004799.3 [O95405-1]
NP_015563.2, NM_007324.3 [O95405-2]
XP_011540739.1, XM_011542437.2 [O95405-1]
UniGeneiHs.532345

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DEVX-ray2.20B/D771-811[»]
1MK2X-ray2.74B773-810[»]
4BKWX-ray2.53A895-1425[»]
5MJYX-ray2.25E/F1-22[»]
DisProtiDP00141
ProteinModelPortaliO95405
SMRiO95405
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114773, 44 interactors
CORUMiO95405
IntActiO95405, 40 interactors
MINTiO95405
STRINGi9606.ENSP00000287727

PTM databases

iPTMnetiO95405
PhosphoSitePlusiO95405

Polymorphism and mutation databases

BioMutaiZFYVE9

Proteomic databases

EPDiO95405
jPOSTiO95405
MaxQBiO95405
PaxDbiO95405
PeptideAtlasiO95405
PRIDEiO95405
ProteomicsDBi50856
50857 [O95405-2]
50858 [O95405-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9372
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287727; ENSP00000287727; ENSG00000157077 [O95405-1]
ENST00000357206; ENSP00000349737; ENSG00000157077 [O95405-2]
ENST00000371591; ENSP00000360647; ENSG00000157077 [O95405-1]
GeneIDi9372
KEGGihsa:9372
UCSCiuc001cto.5 human [O95405-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9372
DisGeNETi9372
EuPathDBiHostDB:ENSG00000157077.14

GeneCards: human genes, protein and diseases

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GeneCardsi
ZFYVE9

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0000582
HGNCiHGNC:6775 ZFYVE9
HPAiCAB017702
HPA065852
HPA065862
MIMi603755 gene
neXtProtiNX_O95405
OpenTargetsiENSG00000157077
PharmGKBiPA30532

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1841 Eukaryota
ENOG410XSEQ LUCA
GeneTreeiENSGT00940000154290
HOGENOMiHOG000231131
HOVERGENiHBG079085
InParanoidiO95405
KOiK04679
OMAiSQEMTNW
OrthoDBi278124at2759
PhylomeDBiO95405
TreeFamiTF324904

Enzyme and pathway databases

ReactomeiR-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-2173789 TGF-beta receptor signaling activates SMADs
R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer
R-HSA-3315487 SMAD2/3 MH2 Domain Mutants in Cancer
R-HSA-3656532 TGFBR1 KD Mutants in Cancer
SignaLinkiO95405
SIGNORiO95405

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZFYVE9 human
EvolutionaryTraceiO95405

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Zinc_finger_FYVE_domain-containing_protein_9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9372

Protein Ontology

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PROi
PR:O95405

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000157077 Expressed in 188 organ(s), highest expression level in kidney
CleanExiHS_ZFYVE9
GenevisibleiO95405 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
4.10.720.10, 1 hit
InterProiView protein in InterPro
IPR022557 DUF3480
IPR035438 SARA/endofin
IPR024608 SARA_Smad-bd
IPR037145 SARA_Smad-bd_sf
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF11979 DUF3480, 1 hit
PF01363 FYVE, 1 hit
PF11409 SARA, 1 hit
PIRSFiPIRSF037289 SARA/endofin, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50178 ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFYV9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95405
Secondary accession number(s): Q5T0F6
, Q5T0F7, Q9UNE1, Q9Y5R7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: January 16, 2019
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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