UniProtKB - O95402 (MED26_HUMAN)

BLAST

>sp|O95402|MED26_HUMAN Mediator of RNA polymerase II transcription subunit 26 OS=Homo sapiens OX=9606 GN=MED26 PE=1 SV=2
MTAAPASPQQIRDRLLQAIDPQSNIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDV
RKKTKNEELAKRAKKLLRSWQKLIEPAHQHEAALRGLAGATGSANGGAHNCRPEVGAAGP
PRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPL
PTNGISGSPESFASSLDGSGHAGPEGSRLERDENDKHSGKIPVNAVRPHTSSPGLGKPPG
PCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQSLYAPKGSVPSP
SPRPQALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVCWLEQPESHQRLAGPGCKAGL
SPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRL
KERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQQSRTELDKQEAKASLQSPFEQTNWKEL
SRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRQGARQLHVLVPQSPPTDL
PGLTREVTQDDLDRIQASQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD

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History
Entry version 157 (07 Nov 2018)
Sequence version 2 (02 Oct 2007)
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Protein

Mediator of RNA polymerase II transcription subunit 26

Gene

MED26

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functionⁱ

transcription coactivator activity
Source: ProtInc
Traceable author statementⁱ
- 9989412
transcription coregulator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15989967

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of gene expression
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 15989967
transcription initiation from RNA polymerase II promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-212436 Generic Transcription Pathway R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Reactomeⁱ

R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mediator of RNA polymerase II transcription subunit 26 Alternative name(s): Activator-recruited cofactor 70 kDa component Short name: ARC70 Cofactor required for Sp1 transcriptional activation subunit 7 Short name: CRSP complex subunit 7 Mediator complex subunit 26 Transcriptional coactivator CRSP70
Gene namesⁱ	Name:MED26 Synonyms:ARC70, CRSP7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105085.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2376 MED26
MIMⁱ	605043 gene
neXtProtⁱ	NX_O95402

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000105085
PharmGKBⁱ	PA162395623

Polymorphism and mutation databases

BioMutaⁱ	MED26

BioMutaⁱ

MED26

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000079360	1 – 600	Mediator of RNA polymerase II transcription subunit 26Add BLAST		600

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	447	PhosphoserineCombined sources	1
Modified residueⁱ	470	PhosphoserineCombined sources	1
Modified residueⁱ	535	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O95402
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95402
PaxDbⁱ	O95402
PeptideAtlas More...PeptideAtlasⁱ	O95402
PRIDEⁱ	O95402
ProteomicsDBⁱ	50854 50855 [O95402-2]
TopDownProteomicsⁱ	O95402-1 [O95402-1]

PTM databases

iPTMnetⁱ	O95402
PhosphoSitePlusⁱ	O95402

Miscellaneous databases

PMAP-CutDBⁱ	O95402

PMAP-CutDBⁱ

O95402

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000105085 Expressed in 209 organ(s), highest expression level in sperm
CleanExⁱ	HS_MED26
ExpressionAtlasⁱ	O95402 baseline and differential
Genevisibleⁱ	O95402 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA057997 HPA071835

HPAⁱ

HPA057997
HPA071835

Interactionⁱ

Subunit structureⁱ

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB (when not methylated)(PubMed:20111005).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
EAF1	Q96JC9	5	EBI-394392,EBI-769261
Med19	Q8C1S0	2	EBI-394392,EBI-398761	From Mus musculus.
MED4	Q9NPJ6	9	EBI-394392,EBI-394607
MED7	O43513	6	EBI-394392,EBI-394632

Protein-protein interaction databases

BioGridⁱ	114831, 87 interactors
ComplexPortalⁱ	CPX-3227 Core mediator complex
CORUMⁱ	O95402
Database of interacting proteins More...DIPⁱ	DIP-31464N
IntActⁱ	O95402, 95 interactors
STRINGⁱ	9606.ENSP00000263390

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	8 – 18	Combined sources	11
Helixⁱ	28 – 40	Combined sources	13
Helixⁱ	45 – 50	Combined sources	6
Turnⁱ	51 – 53	Combined sources	3
Helixⁱ	54 – 63	Combined sources	10
Helixⁱ	67 – 81	Combined sources	15
Turnⁱ	82 – 84	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	O95402
SMRⁱ	O95402
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	10 – 87	TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST		78

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	228 – 325	Pro-richAdd BLAST		98

Sequence similaritiesⁱ

Belongs to the Mediator complex subunit 26 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1105 Eukaryota COG1594 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000259
HOGENOMⁱ	HOG000113539
HOVERGENⁱ	HBG051124
InParanoidⁱ	O95402
KEGG Orthology (KO) More...KOⁱ	K15169
OMAⁱ	IQAHQWP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H00
PhylomeDBⁱ	O95402
TreeFamⁱ	TF328436

Family and domain databases

Gene3Dⁱ	1.20.930.10, 1 hit
InterProⁱ	View protein in InterPro IPR031416 Med26_C IPR031417 Med26_Mid IPR003617 TFIIS/CRSP70_N_sub IPR035441 TFIIS/LEDGF_dom_sf IPR017923 TFIIS_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08711 Med26, 1 hit PF15693 Med26_C, 1 hit PF15694 Med26_M, 1 hit
SMARTⁱ	View protein in SMART SM00509 TFS2N, 1 hit
SUPFAMⁱ	SSF47676 SSF47676, 1 hit
PROSITEⁱ	View protein in PROSITE PS51319 TFIIS_N, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O95402-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAAPASPQQ IRDRLLQAID PQSNIRNMVA VLEVISSLEK YPITKEALEE 
        60         70         80         90        100
TRLGKLINDV RKKTKNEELA KRAKKLLRSW QKLIEPAHQH EAALRGLAGA 
       110        120        130        140        150
TGSANGGAHN CRPEVGAAGP PRSIHDLKSR NDLQRLPGQR LDRLGSRKRR 
       160        170        180        190        200
GDQRDLGHPG PPPKVSKASH DPLVPNSSPL PTNGISGSPE SFASSLDGSG 
       210        220        230        240        250
HAGPEGSRLE RDENDKHSGK IPVNAVRPHT SSPGLGKPPG PCLQPKASVL 
       260        270        280        290        300
QQLDRVDETP GPPHPKGPPR CSFSPRNSRH EGSFARQQSL YAPKGSVPSP 
       310        320        330        340        350
SPRPQALDAT QVPSPLPLAQ PSTPPVRRLE LLPSAESPVC WLEQPESHQR 
       360        370        380        390        400
LAGPGCKAGL SPAEPLLSRA GFSPDSSKAD SDAASSGGSD SKKKKRYRPR 
       410        420        430        440        450
DYTVNLDGQV AEAGVKPVRL KERKLTFDPM TRQIKPLTQK EPVRADSPVH 
       460        470        480        490        500
MEQQSRTELD KQEAKASLQS PFEQTNWKEL SRNEIIQSYL SRQSSLLSSS 
       510        520        530        540        550
GAQTPGAHHF MSEYLKQEES TRQGARQLHV LVPQSPPTDL PGLTREVTQD 
       560        570        580        590        600
DLDRIQASQW PGVNGCQDTQ GNWYDWTQCI SLDPHGDDGR LNILPYVCLD

Length:600

Mass (Da):65,446

Last modified:October 2, 2007 - v2

Checksum:ⁱ4BEA264A3EB5A407

Isoform 2 (identifier: O95402-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
76-92: LLRSWQKLIEPAHQHEA → LPGWQWACRPRGQPPGA
93-600: Missing.

« Hide

        10         20         30         40         50
MTAAPASPQQ IRDRLLQAID PQSNIRNMVA VLEVISSLEK YPITKEALEE 
        60         70         80         90 
TRLGKLINDV RKKTKNEELA KRAKKLPGWQ WACRPRGQPP GA

Note: No experimental confirmation available.

Show »

Length:92

Mass (Da):10,359

Checksum:ⁱ6837BD299DE56B5A

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

M0R064	M0R064_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 26	MED26	213	Annotation score:
M0QXW8	M0QXW8_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 26	MED26	110	Annotation score:
M0R2P1	M0R2P1_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 26	MED26	54	Annotation score:
M0R2Y4	M0R2Y4_HUMAN	Mediator of RNA polymerase II trans... Mediator of RNA polymerase II transcription subunit 26	MED26	82	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	156	L → F in AAD12722 (PubMed:9989412).Curated	1
Sequence conflictⁱ	241	P → A in AAI27216 (PubMed:15489334).Curated	1
Sequence conflictⁱ	369	R → L in AAI10431 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_028151	76 – 92	LLRSW…HQHEA → LPGWQWACRPRGQPPGA in isoform 2. 1 PublicationAdd BLAST		17
Alternative sequenceⁱVSP_028152	93 – 600	Missing in isoform 2. 1 PublicationAdd BLAST		508

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF104253 mRNA Translation: AAD12722.1 BC110430 mRNA Translation: AAI10431.1 BC127215 mRNA Translation: AAI27216.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12347.1 [O95402-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_004822.2, NM_004831.3 [O95402-1]
UniGeneⁱ	Hs.715040

Genome annotation databases

Ensemblⁱ	ENST00000263390; ENSP00000263390; ENSG00000105085 [O95402-1] ENST00000611692; ENSP00000484490; ENSG00000105085 [O95402-2]
GeneIDⁱ	9441
KEGGⁱ	hsa:9441
UCSC genome browser More...UCSCⁱ	uc002nen.2 human [O95402-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95402	Uncharacterized protein		PANPA		607	UniRef90_O95402
Uncharacterized protein		MANLE		605
Mediator complex subunit 26 (Fragment)		MACMU		577
Uncharacterized protein		PAPAN		600
Uncharacterized protein		RHIRO		600
+43
O95402-2	Uncharacterized protein		COLAP		93	UniRef90_O95402-2
Uncharacterized protein		PROCO		89

Protein	Similar proteins		Species	Score	Length	Source
O95402	Mediator of RNA polymerase II transcription subunit 26		BOVIN		599	UniRef50_O95402
Uncharacterized protein		PANPA		607
Uncharacterized protein		MANLE		605
Mediator complex subunit 26 (Fragment)		MACMU		577
cDNA, FLJ94385, highly similar to Homo sapiens cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa (CRSP7), mRNA		HUMAN		600
+237
O95402-2	Uncharacterized protein		COLAP		93	UniRef50_O95402-2
Uncharacterized protein		PROCO		89
Mediator of RNA polymerase II transcription subunit 26 (Fragment)		MACMU		92
Mediator of RNA polymerase II transcription subunit 26 (Fragment)		HUMAN		82

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF104253 mRNA Translation: AAD12722.1 BC110430 mRNA Translation: AAI10431.1 BC127215 mRNA Translation: AAI27216.1
CCDSⁱ	CCDS12347.1 [O95402-1]
RefSeqⁱ	NP_004822.2, NM_004831.3 [O95402-1]
UniGeneⁱ	Hs.715040

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5ODD	NMR	-	A	1-92	[»]
ProteinModelPortalⁱ	O95402
SMRⁱ	O95402
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114831, 87 interactors
ComplexPortalⁱ	CPX-3227 Core mediator complex
CORUMⁱ	O95402
DIPⁱ	DIP-31464N
IntActⁱ	O95402, 95 interactors
STRINGⁱ	9606.ENSP00000263390

PTM databases

iPTMnetⁱ	O95402
PhosphoSitePlusⁱ	O95402

Polymorphism and mutation databases

BioMutaⁱ	MED26

BioMutaⁱ

MED26

Proteomic databases

EPDⁱ	O95402
MaxQBⁱ	O95402
PaxDbⁱ	O95402
PeptideAtlasⁱ	O95402
PRIDEⁱ	O95402
ProteomicsDBⁱ	50854 50855 [O95402-2]
TopDownProteomicsⁱ	O95402-1 [O95402-1]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000263390; ENSP00000263390; ENSG00000105085 [O95402-1] ENST00000611692; ENSP00000484490; ENSG00000105085 [O95402-2]
GeneIDⁱ	9441
KEGGⁱ	hsa:9441
UCSCⁱ	uc002nen.2 human [O95402-1]

Organism-specific databases

CTDⁱ	9441
EuPathDBⁱ	HostDB:ENSG00000105085.10
GeneCardsⁱ	MED26
H-InvDBⁱ	HIX0202876
HGNCⁱ	HGNC:2376 MED26
HPAⁱ	HPA057997 HPA071835
MIMⁱ	605043 gene
neXtProtⁱ	NX_O95402
OpenTargetsⁱ	ENSG00000105085
PharmGKBⁱ	PA162395623
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1105 Eukaryota COG1594 LUCA
GeneTreeⁱ	ENSGT00390000000259
HOGENOMⁱ	HOG000113539
HOVERGENⁱ	HBG051124
InParanoidⁱ	O95402
KOⁱ	K15169
OMAⁱ	IQAHQWP
OrthoDBⁱ	EOG091G0H00
PhylomeDBⁱ	O95402
TreeFamⁱ	TF328436

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-212436 Generic Transcription Pathway R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Reactomeⁱ

R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

ChiTaRSⁱ	MED26 human
GeneWikiⁱ	MED26
GenomeRNAiⁱ	9441
PMAP-CutDBⁱ	O95402
Protein Ontology More...PROⁱ	PR:O95402
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000105085 Expressed in 209 organ(s), highest expression level in sperm
CleanExⁱ	HS_MED26
ExpressionAtlasⁱ	O95402 baseline and differential
Genevisibleⁱ	O95402 HS

Family and domain databases

Gene3Dⁱ	1.20.930.10, 1 hit
InterProⁱ	View protein in InterPro IPR031416 Med26_C IPR031417 Med26_Mid IPR003617 TFIIS/CRSP70_N_sub IPR035441 TFIIS/LEDGF_dom_sf IPR017923 TFIIS_N
Pfamⁱ	View protein in Pfam PF08711 Med26, 1 hit PF15693 Med26_C, 1 hit PF15694 Med26_M, 1 hit
SMARTⁱ	View protein in SMART SM00509 TFS2N, 1 hit
SUPFAMⁱ	SSF47676 SSF47676, 1 hit
PROSITEⁱ	View protein in PROSITE PS51319 TFIIS_N, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MED26_HUMAN
Accessionⁱ	O95402Primary (citable) accession number: O95402 Secondary accession number(s): A1A4S3, Q0VGB6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
	Last sequence update:	October 2, 2007
	Last modified:	November 7, 2018
	This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O95402 (MED26_HUMAN)

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Mediator of RNA polymerase II transcription subunit 26

MED26

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ