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UniProtKB - O95402 (MED26_HUMAN)

Entry version 173 (29 Sep 2021)
Sequence version 2 (02 Oct 2007)
Previous versions | rss
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Protein

Mediator of RNA polymerase II transcription subunit 26

Gene

MED26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transcription coactivator activity Source: ProtInc
  • transcription coregulator activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95402

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1989781, PPARA activates gene expression
R-HSA-212436, Generic Transcription Pathway
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 26
Alternative name(s):
Activator-recruited cofactor 70 kDa component
Short name:
ARC70
Cofactor required for Sp1 transcriptional activation subunit 7
Short name:
CRSP complex subunit 7
Mediator complex subunit 26
Transcriptional coactivator CRSP70
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MED26
Synonyms:ARC70, CRSP7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2376, MED26

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605043, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95402

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000105085

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9441

Open Targets

More...OpenTargetsi		ENSG00000105085

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162395623

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95402, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MED26

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000793601 – 600Mediator of RNA polymerase II transcription subunit 26Add BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei447PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
Modified residuei535PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95402

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95402

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95402

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95402

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95402

PeptideAtlas

More...PeptideAtlasi		O95402

PRoteomics IDEntifications database

More...PRIDEi		O95402

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50854 [O95402-1]
50855 [O95402-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O95402-1 [O95402-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95402

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95402

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105085, Expressed in sperm and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95402, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95402, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105085, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

Interacts with CEBPB (when not methylated)(PubMed:20111005).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114831, 99 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3227, Core mediator complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O95402

Database of interacting proteins

More...DIPi		DIP-31464N

Protein interaction database and analysis system

More...IntActi		O95402, 96 interactors

Molecular INTeraction database

More...MINTi		O95402

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263390

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95402, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1600
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95402

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 87TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni99 – 330DisorderedSequence analysisAdd BLAST232
Regioni348 – 402DisorderedSequence analysisAdd BLAST55
Regioni431 – 461DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi125 – 157Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi171 – 195Polar residuesSequence analysisAdd BLAST25
Compositional biasi204 – 222Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi276 – 295Polar residuesSequence analysisAdd BLAST20
Compositional biasi387 – 402Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi445 – 461Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 26 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1105, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000259

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_478915_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95402

Identification of Orthologs from Complete Genome Data

More...OMAi		QTDWKEL

Database of Orthologous Groups

More...OrthoDBi		459216at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95402

TreeFam database of animal gene trees

More...TreeFami		TF328436

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR042376, MED26
IPR031416, Med26_C
IPR031417, Med26_Mid
IPR003617, TFIIS/CRSP70_N_sub
IPR035441, TFIIS/LEDGF_dom_sf
IPR017923, TFIIS_N

The PANTHER Classification System

More...PANTHERi		PTHR15201, PTHR15201, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08711, Med26, 1 hit
PF15693, Med26_C, 1 hit
PF15694, Med26_M, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00509, TFS2N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47676, SSF47676, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51319, TFIIS_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95402-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAAPASPQQ IRDRLLQAID PQSNIRNMVA VLEVISSLEK YPITKEALEE 
        60         70         80         90        100
TRLGKLINDV RKKTKNEELA KRAKKLLRSW QKLIEPAHQH EAALRGLAGA 
       110        120        130        140        150
TGSANGGAHN CRPEVGAAGP PRSIHDLKSR NDLQRLPGQR LDRLGSRKRR 
       160        170        180        190        200
GDQRDLGHPG PPPKVSKASH DPLVPNSSPL PTNGISGSPE SFASSLDGSG 
       210        220        230        240        250
HAGPEGSRLE RDENDKHSGK IPVNAVRPHT SSPGLGKPPG PCLQPKASVL 
       260        270        280        290        300
QQLDRVDETP GPPHPKGPPR CSFSPRNSRH EGSFARQQSL YAPKGSVPSP 
       310        320        330        340        350
SPRPQALDAT QVPSPLPLAQ PSTPPVRRLE LLPSAESPVC WLEQPESHQR 
       360        370        380        390        400
LAGPGCKAGL SPAEPLLSRA GFSPDSSKAD SDAASSGGSD SKKKKRYRPR 
       410        420        430        440        450
DYTVNLDGQV AEAGVKPVRL KERKLTFDPM TRQIKPLTQK EPVRADSPVH 
       460        470        480        490        500
MEQQSRTELD KQEAKASLQS PFEQTNWKEL SRNEIIQSYL SRQSSLLSSS 
       510        520        530        540        550
GAQTPGAHHF MSEYLKQEES TRQGARQLHV LVPQSPPTDL PGLTREVTQD 
       560        570        580        590        600
DLDRIQASQW PGVNGCQDTQ GNWYDWTQCI SLDPHGDDGR LNILPYVCLD
Length:600
Mass (Da):65,446
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BEA264A3EB5A407
GO
Isoform 2 (identifier: O95402-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-92: LLRSWQKLIEPAHQHEA → LPGWQWACRPRGQPPGA
     93-600: Missing.

Show »
Length:92
Mass (Da):10,359
Checksum:i6837BD299DE56B5A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R064M0R064_HUMAN
Mediator complex subunit 26
MED26
213Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXW8M0QXW8_HUMAN
Mediator complex subunit 26
MED26
110Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2P1M0R2P1_HUMAN
Mediator complex subunit 26
MED26
54Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2Y4M0R2Y4_HUMAN
Mediator of RNA polymerase II trans...
MED26
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti156L → F in AAD12722 (PubMed:9989412).Curated1
Sequence conflicti241P → A in AAI27216 (PubMed:15489334).Curated1
Sequence conflicti369R → L in AAI10431 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02815176 – 92LLRSW…HQHEA → LPGWQWACRPRGQPPGA in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_02815293 – 600Missing in isoform 2. 1 PublicationAdd BLAST508

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF104253 mRNA Translation: AAD12722.1
BC110430 mRNA Translation: AAI10431.1
BC127215 mRNA Translation: AAI27216.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12347.1 [O95402-1]

NCBI Reference Sequences

More...RefSeqi		NP_004822.2, NM_004831.3 [O95402-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263390; ENSP00000263390; ENSG00000105085 [O95402-1]
ENST00000611692; ENSP00000484490; ENSG00000105085 [O95402-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9441

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9441

UCSC genome browser

More...UCSCi		uc002nen.2, human [O95402-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104253 mRNA Translation: AAD12722.1
BC110430 mRNA Translation: AAI10431.1
BC127215 mRNA Translation: AAI27216.1
CCDSiCCDS12347.1 [O95402-1]
RefSeqiNP_004822.2, NM_004831.3 [O95402-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ODDNMR-A1-92[»]
7EMFelectron microscopy3.50Z1-600[»]
7ENAelectron microscopy4.07z1-600[»]
7ENCelectron microscopy4.13z1-600[»]
7ENJelectron microscopy4.40Z1-600[»]
SMRiO95402
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114831, 99 interactors
ComplexPortaliCPX-3227, Core mediator complex
CORUMiO95402
DIPiDIP-31464N
IntActiO95402, 96 interactors
MINTiO95402
STRINGi9606.ENSP00000263390

PTM databases

iPTMnetiO95402
PhosphoSitePlusiO95402

Genetic variation databases

BioMutaiMED26

Proteomic databases

EPDiO95402
jPOSTiO95402
MassIVEiO95402
MaxQBiO95402
PaxDbiO95402
PeptideAtlasiO95402
PRIDEiO95402
ProteomicsDBi50854 [O95402-1]
50855 [O95402-2]
TopDownProteomicsiO95402-1 [O95402-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14206, 284 antibodies

The DNASU plasmid repository

More...DNASUi		9441

Genome annotation databases

EnsembliENST00000263390; ENSP00000263390; ENSG00000105085 [O95402-1]
ENST00000611692; ENSP00000484490; ENSG00000105085 [O95402-2]
GeneIDi9441
KEGGihsa:9441
UCSCiuc002nen.2, human [O95402-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9441
DisGeNETi9441

GeneCards: human genes, protein and diseases

More...GeneCardsi		MED26
HGNCiHGNC:2376, MED26
HPAiENSG00000105085, Tissue enhanced (testis)
MIMi605043, gene
neXtProtiNX_O95402
OpenTargetsiENSG00000105085
PharmGKBiPA162395623
VEuPathDBiHostDB:ENSG00000105085

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1105, Eukaryota
GeneTreeiENSGT00390000000259
HOGENOMiCLU_478915_0_0_1
InParanoidiO95402
OMAiQTDWKEL
OrthoDBi459216at2759
PhylomeDBiO95402
TreeFamiTF328436

Enzyme and pathway databases

PathwayCommonsiO95402
ReactomeiR-HSA-1989781, PPARA activates gene expression
R-HSA-212436, Generic Transcription Pathway
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9441, 590 hits in 1014 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MED26, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MED26

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9441
PharosiO95402, Tbio

Protein Ontology

More...PROi		PR:O95402
RNActiO95402, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105085, Expressed in sperm and 226 other tissues
ExpressionAtlasiO95402, baseline and differential
GenevisibleiO95402, HS

Family and domain databases

Gene3Di1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR042376, MED26
IPR031416, Med26_C
IPR031417, Med26_Mid
IPR003617, TFIIS/CRSP70_N_sub
IPR035441, TFIIS/LEDGF_dom_sf
IPR017923, TFIIS_N
PANTHERiPTHR15201, PTHR15201, 1 hit
PfamiView protein in Pfam
PF08711, Med26, 1 hit
PF15693, Med26_C, 1 hit
PF15694, Med26_M, 1 hit
SMARTiView protein in SMART
SM00509, TFS2N, 1 hit
SUPFAMiSSF47676, SSF47676, 1 hit
PROSITEiView protein in PROSITE
PS51319, TFIIS_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED26_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95402
Secondary accession number(s): A1A4S3, Q0VGB6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: October 2, 2007
Last modified: September 29, 2021
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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