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Protein

Bone morphogenetic protein 10

Gene

BMP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.3 Publications

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB-KW
  • hormone activity Source: BHF-UCL
  • receptor serine/threonine kinase binding Source: UniProtKB
  • telethonin binding Source: BHF-UCL
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-201451 Signaling by BMP
R-HSA-2129379 Molecules associated with elastic fibres
SIGNORiO95393

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 10
Short name:
BMP-10
Gene namesi
Name:BMP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163217.1
HGNCiHGNC:20869 BMP10
MIMi608748 gene
neXtProtiNX_O95393

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi27302
OpenTargetsiENSG00000163217
PharmGKBiPA134953092

Chemistry databases

ChEMBLiCHEMBL3713453

Polymorphism and mutation databases

BioMutaiBMP10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000003388822 – 316Sequence analysisAdd BLAST295
ChainiPRO_0000033889317 – 424Bone morphogenetic protein 10Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi323 ↔ 389By similarity
Disulfide bondi352 ↔ 421By similarity
Disulfide bondi356 ↔ 423By similarity
Disulfide bondi388InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO95393
PaxDbiO95393
PeptideAtlasiO95393
PRIDEiO95393
ProteomicsDBi50844

PTM databases

iPTMnetiO95393
PhosphoSitePlusiO95393

Expressioni

Tissue specificityi

Detected in mammary epithelia (at protein level).1 Publication

Inductioni

Down-regulated in some breast cancer subtypes and breast cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000163217 Expressed in 46 organ(s), highest expression level in right atrium auricular region
CleanExiHS_BMP10
GenevisibleiO95393 HS

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631). Interacts with ENG (PubMed:21737454).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118125, 4 interactors
IntActiO95393, 48 interactors
STRINGi9606.ENSP00000295379

Structurei

3D structure databases

ProteinModelPortaliO95393
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00760000118883
HOGENOMiHOG000249477
HOVERGENiHBG106648
InParanoidiO95393
KOiK22670
OMAiMSLEQSP
OrthoDBiEOG091G075U
PhylomeDBiO95393
TreeFamiTF316134

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95393-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSLVLTLCA LFCLAAYLVS GSPIMNLEQS PLEEDMSLFG DVFSEQDGVD
60 70 80 90 100
FNTLLQSMKD EFLKTLNLSD IPTQDSAKVD PPEYMLELYN KFATDRTSMP
110 120 130 140 150
SANIIRSFKN EDLFSQPVSF NGLRKYPLLF NVSIPHHEEV IMAELRLYTL
160 170 180 190 200
VQRDRMIYDG VDRKITIFEV LESKGDNEGE RNMLVLVSGE IYGTNSEWET
210 220 230 240 250
FDVTDAIRRW QKSGSSTHQL EVHIESKHDE AEDASSGRLE IDTSAQNKHN
260 270 280 290 300
PLLIVFSDDQ SSDKERKEEL NEMISHEQLP ELDNLGLDSF SSGPGEEALL
310 320 330 340 350
QMRSNIIYDS TARIRRNAKG NYCKRTPLYI DFKEIGWDSW IIAPPGYEAY
360 370 380 390 400
ECRGVCNYPL AEHLTPTKHA IIQALVHLKN SQKASKACCV PTKLEPISIL
410 420
YLDKGVVTYK FKYEGMAVSE CGCR
Length:424
Mass (Da):48,047
Last modified:May 1, 1999 - v1
Checksum:i3FDB3B7221BB2254
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143A → T in AAH69080 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052572200T → S. Corresponds to variant dbSNP:rs2231342Ensembl.1
Natural variantiVAR_052573250N → K. Corresponds to variant dbSNP:rs2231345Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101441 mRNA Translation: AAC77462.1
AC097495 Genomic DNA Translation: AAY15075.1
BC069080 mRNA Translation: AAH69080.1
BC101734 mRNA Translation: AAI01735.1
BC105063 mRNA Translation: AAI05064.1
CCDSiCCDS1890.1
RefSeqiNP_055297.1, NM_014482.2
UniGeneiHs.158317

Genome annotation databases

EnsembliENST00000295379; ENSP00000295379; ENSG00000163217
GeneIDi27302
KEGGihsa:27302
UCSCiuc002sez.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 10 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101441 mRNA Translation: AAC77462.1
AC097495 Genomic DNA Translation: AAY15075.1
BC069080 mRNA Translation: AAH69080.1
BC101734 mRNA Translation: AAI01735.1
BC105063 mRNA Translation: AAI05064.1
CCDSiCCDS1890.1
RefSeqiNP_055297.1, NM_014482.2
UniGeneiHs.158317

3D structure databases

ProteinModelPortaliO95393
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118125, 4 interactors
IntActiO95393, 48 interactors
STRINGi9606.ENSP00000295379

Chemistry databases

ChEMBLiCHEMBL3713453

PTM databases

iPTMnetiO95393
PhosphoSitePlusiO95393

Polymorphism and mutation databases

BioMutaiBMP10

Proteomic databases

MaxQBiO95393
PaxDbiO95393
PeptideAtlasiO95393
PRIDEiO95393
ProteomicsDBi50844

Protocols and materials databases

DNASUi27302
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295379; ENSP00000295379; ENSG00000163217
GeneIDi27302
KEGGihsa:27302
UCSCiuc002sez.1 human

Organism-specific databases

CTDi27302
DisGeNETi27302
EuPathDBiHostDB:ENSG00000163217.1
GeneCardsiBMP10
HGNCiHGNC:20869 BMP10
MIMi608748 gene
neXtProtiNX_O95393
OpenTargetsiENSG00000163217
PharmGKBiPA134953092
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00760000118883
HOGENOMiHOG000249477
HOVERGENiHBG106648
InParanoidiO95393
KOiK22670
OMAiMSLEQSP
OrthoDBiEOG091G075U
PhylomeDBiO95393
TreeFamiTF316134

Enzyme and pathway databases

ReactomeiR-HSA-201451 Signaling by BMP
R-HSA-2129379 Molecules associated with elastic fibres
SIGNORiO95393

Miscellaneous databases

GeneWikiiBone_morphogenetic_protein_10
GenomeRNAii27302
PROiPR:O95393
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163217 Expressed in 46 organ(s), highest expression level in right atrium auricular region
CleanExiHS_BMP10
GenevisibleiO95393 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBMP10_HUMAN
AccessioniPrimary (citable) accession number: O95393
Secondary accession number(s): Q53R17, Q6NTE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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