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UniProtKB - O95393 (BMP10_HUMAN)

Entry version 163 (07 Apr 2021)
Sequence version 1 (01 May 1999)
Previous versions | rss
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Protein

Bone morphogenetic protein 10

Gene

BMP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor
Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95393

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-201451, Signaling by BMP
R-HSA-2129379, Molecules associated with elastic fibres

SIGNOR Signaling Network Open Resource

More...SIGNORi		O95393

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bone morphogenetic protein 10
Short name:
BMP-10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BMP10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20869, BMP10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608748, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95393

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163217.1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		27302

Open Targets

More...OpenTargetsi		ENSG00000163217

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134953092

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95393, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3713453

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BMP10

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000003388822 – 316Sequence analysisAdd BLAST295
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000033889317 – 424Bone morphogenetic protein 10Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi323 ↔ 389By similarity
Disulfide bondi352 ↔ 421By similarity
Disulfide bondi356 ↔ 423By similarity
Disulfide bondi388InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95393

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95393

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95393

PeptideAtlas

More...PeptideAtlasi		O95393

PRoteomics IDEntifications database

More...PRIDEi		O95393

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50844

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O95393, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95393

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95393

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in mammary epithelia (at protein level).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in some breast cancer subtypes and breast cancer cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163217, Expressed in right atrium auricular region and 60 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95393, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163217, Tissue enriched (heart)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked (By similarity).

Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631).

Interacts with ENG (PubMed:21737454).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O95393
With#Exp.IntAct
APOA5 [Q6Q788]3EBI-3922513,EBI-3936819
AQP6 [Q13520]3EBI-3922513,EBI-13059134
ARL13B [Q3SXY8]3EBI-3922513,EBI-11343438
BIK [Q13323]3EBI-3922513,EBI-700794
BSCL2 [J3KQ12]3EBI-3922513,EBI-11532900
BSND [Q8WZ55]3EBI-3922513,EBI-7996695
CCDC70 [Q6NSX1]3EBI-3922513,EBI-6873045
CD33 [P20138]3EBI-3922513,EBI-3906571
CISD2 [Q8N5K1]3EBI-3922513,EBI-1045797
CLDN7 [O95471]3EBI-3922513,EBI-740744
COQ9 [O75208]3EBI-3922513,EBI-724524
CREB3L1 [Q96BA8]3EBI-3922513,EBI-6942903
DEXI [O95424]3EBI-3922513,EBI-724515
EBP [Q15125]3EBI-3922513,EBI-3915253
ERP29 [P30040]3EBI-3922513,EBI-946830
FAM209A [Q5JX71]3EBI-3922513,EBI-18304435
FCGR1A [P12314]3EBI-3922513,EBI-2869867
FCRL4 [Q96PJ5]3EBI-3922513,EBI-4314687
FFAR2 [O15552]3EBI-3922513,EBI-2833872
FKBP7 [Q9Y680]3EBI-3922513,EBI-3918971
FNDC9 [Q8TBE3]3EBI-3922513,EBI-12142257
GGT6 [Q6P531]3EBI-3922513,EBI-2868927
GJB1 [P08034]3EBI-3922513,EBI-17565645
GPR152 [Q8TDT2]3EBI-3922513,EBI-13345167
GPX8 [Q8TED1]3EBI-3922513,EBI-11721746
IL3RA [P26951]3EBI-3922513,EBI-1757512
JAGN1 [Q8N5M9]3EBI-3922513,EBI-10266796
KIR2DL3 [P43628]3EBI-3922513,EBI-8632435
KIR3DL1 [P43629]3EBI-3922513,EBI-3910993
KLRC1 [P26715]3EBI-3922513,EBI-9018187
LRRC25 [Q8N386]3EBI-3922513,EBI-11304917
LRRC4C [Q9HCJ2]3EBI-3922513,EBI-3925442
MGST3 [O14880]3EBI-3922513,EBI-724754
MRPS18B [Q9Y676]3EBI-3922513,EBI-750085
MS4A3 [Q96HJ5]3EBI-3922513,EBI-12806656
MTIF3 [Q9H2K0]3EBI-3922513,EBI-3923617
PLPP4 [Q5VZY2]3EBI-3922513,EBI-10485931
REEP4 [Q9H6H4]3EBI-3922513,EBI-7545592
SIT1 [Q9Y3P8]3EBI-3922513,EBI-6977215
SLC10A1 [Q14973]3EBI-3922513,EBI-3923031
SLC10A6 [Q3KNW5]3EBI-3922513,EBI-18159983
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-3922513,EBI-17295964
SLC38A1 [Q9H2H9]3EBI-3922513,EBI-9978441
SLC4A1 [P02730]3EBI-3922513,EBI-7576138
SPAG4 [Q9NPE6]3EBI-3922513,EBI-10819434
TCTA [P57738]3EBI-3922513,EBI-6447595
TMEM14B [Q9NUH8]3EBI-3922513,EBI-8638294
TMEM45B [Q96B21]3EBI-3922513,EBI-3923061
TMEM86B [Q8N661]3EBI-3922513,EBI-2548832
TMPRSS2 - isoform 2 [O15393-2]3EBI-3922513,EBI-12345267
TNFSF14 [O43557]3EBI-3922513,EBI-524131
TNFSF8 [P32971]3EBI-3922513,EBI-13076860
TSPAN31 [Q12999]3EBI-3922513,EBI-17678331
VSIR [Q9H7M9]3EBI-3922513,EBI-744988

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118125, 59 interactors

Protein interaction database and analysis system

More...IntActi		O95393, 55 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295379

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95393, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1424
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95393

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3900, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156279

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020515_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95393

Identification of Orthologs from Complete Genome Data

More...OMAi		MIAHEQL

Database of Orthologous Groups

More...OrthoDBi		749511at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95393

TreeFam database of animal gene trees

More...TreeFami		TF316134

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029034, Cystine-knot_cytokine
IPR001839, TGF-b_C
IPR001111, TGF-b_propeptide
IPR015615, TGF-beta-rel
IPR017948, TGFb_CS

The PANTHER Classification System

More...PANTHERi		PTHR11848, PTHR11848, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00019, TGF_beta, 1 hit
PF00688, TGFb_propeptide, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00204, TGFB, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57501, SSF57501, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00250, TGF_BETA_1, 1 hit
PS51362, TGF_BETA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O95393-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSLVLTLCA LFCLAAYLVS GSPIMNLEQS PLEEDMSLFG DVFSEQDGVD 
        60         70         80         90        100
FNTLLQSMKD EFLKTLNLSD IPTQDSAKVD PPEYMLELYN KFATDRTSMP 
       110        120        130        140        150
SANIIRSFKN EDLFSQPVSF NGLRKYPLLF NVSIPHHEEV IMAELRLYTL 
       160        170        180        190        200
VQRDRMIYDG VDRKITIFEV LESKGDNEGE RNMLVLVSGE IYGTNSEWET 
       210        220        230        240        250
FDVTDAIRRW QKSGSSTHQL EVHIESKHDE AEDASSGRLE IDTSAQNKHN 
       260        270        280        290        300
PLLIVFSDDQ SSDKERKEEL NEMISHEQLP ELDNLGLDSF SSGPGEEALL 
       310        320        330        340        350
QMRSNIIYDS TARIRRNAKG NYCKRTPLYI DFKEIGWDSW IIAPPGYEAY 
       360        370        380        390        400
ECRGVCNYPL AEHLTPTKHA IIQALVHLKN SQKASKACCV PTKLEPISIL 
       410        420 
YLDKGVVTYK FKYEGMAVSE CGCR
Length:424
Mass (Da):48,047
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3FDB3B7221BB2254
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti143A → T in AAH69080 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052572200T → S. Corresponds to variant dbSNP:rs2231342Ensembl.1
Natural variantiVAR_052573250N → K. Corresponds to variant dbSNP:rs2231345EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF101441 mRNA Translation: AAC77462.1
AC097495 Genomic DNA Translation: AAY15075.1
BC069080 mRNA Translation: AAH69080.1
BC101734 mRNA Translation: AAI01735.1
BC105063 mRNA Translation: AAI05064.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1890.1

NCBI Reference Sequences

More...RefSeqi		NP_055297.1, NM_014482.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295379; ENSP00000295379; ENSG00000163217

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27302

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27302

UCSC genome browser

More...UCSCi		uc002sez.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Bone morphogenetic protein 10 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101441 mRNA Translation: AAC77462.1
AC097495 Genomic DNA Translation: AAY15075.1
BC069080 mRNA Translation: AAH69080.1
BC101734 mRNA Translation: AAI01735.1
BC105063 mRNA Translation: AAI05064.1
CCDSiCCDS1890.1
RefSeqiNP_055297.1, NM_014482.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6SF1X-ray2.80B317-424[»]
6SF3X-ray2.30B317-424[»]
SMRiO95393
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118125, 59 interactors
IntActiO95393, 55 interactors
STRINGi9606.ENSP00000295379

Chemistry databases

ChEMBLiCHEMBL3713453

PTM databases

GlyGeniO95393, 2 sites
iPTMnetiO95393
PhosphoSitePlusiO95393

Genetic variation databases

BioMutaiBMP10

Proteomic databases

MassIVEiO95393
MaxQBiO95393
PaxDbiO95393
PeptideAtlasiO95393
PRIDEiO95393
ProteomicsDBi50844

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16182, 395 antibodies

The DNASU plasmid repository

More...DNASUi		27302

Genome annotation databases

EnsembliENST00000295379; ENSP00000295379; ENSG00000163217
GeneIDi27302
KEGGihsa:27302
UCSCiuc002sez.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27302
DisGeNETi27302

GeneCards: human genes, protein and diseases

More...GeneCardsi		BMP10
HGNCiHGNC:20869, BMP10
HPAiENSG00000163217, Tissue enriched (heart)
MIMi608748, gene
neXtProtiNX_O95393
OpenTargetsiENSG00000163217
PharmGKBiPA134953092
VEuPathDBiHostDB:ENSG00000163217.1

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3900, Eukaryota
GeneTreeiENSGT00940000156279
HOGENOMiCLU_020515_2_0_1
InParanoidiO95393
OMAiMIAHEQL
OrthoDBi749511at2759
PhylomeDBiO95393
TreeFamiTF316134

Enzyme and pathway databases

PathwayCommonsiO95393
ReactomeiR-HSA-201451, Signaling by BMP
R-HSA-2129379, Molecules associated with elastic fibres
SIGNORiO95393

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27302, 7 hits in 977 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Bone_morphogenetic_protein_10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27302
PharosiO95393, Tbio

Protein Ontology

More...PROi		PR:O95393
RNActiO95393, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163217, Expressed in right atrium auricular region and 60 other tissues
GenevisibleiO95393, HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034, Cystine-knot_cytokine
IPR001839, TGF-b_C
IPR001111, TGF-b_propeptide
IPR015615, TGF-beta-rel
IPR017948, TGFb_CS
PANTHERiPTHR11848, PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019, TGF_beta, 1 hit
PF00688, TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204, TGFB, 1 hit
SUPFAMiSSF57501, SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250, TGF_BETA_1, 1 hit
PS51362, TGF_BETA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBMP10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95393
Secondary accession number(s): Q53R17, Q6NTE0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: April 7, 2021
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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