UniProtKB - O95393 (BMP10_HUMAN)
Bone morphogenetic protein 10
BMP10
Functioni
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
3 PublicationsGO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- hormone activity Source: BHF-UCL
- receptor serine/threonine kinase binding Source: UniProtKB
- telethonin binding Source: BHF-UCL
GO - Biological processi
- activin receptor signaling pathway Source: BHF-UCL
- adult heart development Source: BHF-UCL
- atrial cardiac muscle tissue morphogenesis Source: BHF-UCL
- BMP signaling pathway Source: BHF-UCL
- cardiac muscle cell proliferation Source: UniProtKB
- cell adhesion Source: UniProtKB-KW
- heart trabecula formation Source: BHF-UCL
- kidney development Source: Ensembl
- negative regulation of cardiac muscle hypertrophy Source: BHF-UCL
- negative regulation of cell growth Source: UniProtKB
- negative regulation of cell migration Source: UniProtKB
- negative regulation of endothelial cell migration Source: BHF-UCL
- pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
- positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
- positive regulation of cartilage development Source: Ensembl
- positive regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
- positive regulation of gene expression Source: Ensembl
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- positive regulation of sarcomere organization Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: BHF-UCL
- regulation of cardiac muscle contraction Source: BHF-UCL
- regulation of cardiac muscle hypertrophy in response to stress Source: BHF-UCL
- sarcomere organization Source: BHF-UCL
- SMAD protein signal transduction Source: GO_Central
- ventricular cardiac muscle cell development Source: BHF-UCL
- ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
Keywordsi
Molecular function | Cytokine, Developmental protein, Growth factor |
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | O95393 |
Reactomei | R-HSA-201451, Signaling by BMP R-HSA-2129379, Molecules associated with elastic fibres |
SignaLinki | O95393 |
SIGNORi | O95393 |
Names & Taxonomyi
Protein namesi | Recommended name: Bone morphogenetic protein 10Short name: BMP-10 |
Gene namesi | Name:BMP10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20869, BMP10 |
MIMi | 608748, gene |
neXtProti | NX_O95393 |
VEuPathDBi | HostDB:ENSG00000163217 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Other locations
- cell surface Source: BHF-UCL
- cytoplasm Source: BHF-UCL
- Z disc Source: BHF-UCL
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 27302 |
OpenTargetsi | ENSG00000163217 |
PharmGKBi | PA134953092 |
Miscellaneous databases
Pharosi | O95393, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3713453 |
Genetic variation databases
BioMutai | BMP10 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
PropeptideiPRO_0000033888 | 22 – 316 | Sequence analysisAdd BLAST | 295 | |
ChainiPRO_0000033889 | 317 – 424 | Bone morphogenetic protein 10Add BLAST | 108 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 67 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 131 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 323 ↔ 389 | By similarity | ||
Disulfide bondi | 352 ↔ 421 | By similarity | ||
Disulfide bondi | 356 ↔ 423 | By similarity | ||
Disulfide bondi | 388 | InterchainBy similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
MassIVEi | O95393 |
MaxQBi | O95393 |
PaxDbi | O95393 |
PeptideAtlasi | O95393 |
PRIDEi | O95393 |
ProteomicsDBi | 50844 |
PTM databases
GlyGeni | O95393, 2 sites |
iPTMneti | O95393 |
PhosphoSitePlusi | O95393 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000163217, Expressed in right atrium auricular region and 60 other tissues |
Genevisiblei | O95393, HS |
Organism-specific databases
HPAi | ENSG00000163217, Tissue enriched (heart) |
Interactioni
Subunit structurei
Binary interactionsi
O95393
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- hormone activity Source: BHF-UCL
- receptor serine/threonine kinase binding Source: UniProtKB
- telethonin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 118125, 59 interactors |
IntActi | O95393, 55 interactors |
STRINGi | 9606.ENSP00000295379 |
Miscellaneous databases
RNActi | O95393, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | O95393 |
SMRi | O95393 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000156279 |
HOGENOMi | CLU_020515_2_0_1 |
InParanoidi | O95393 |
OMAi | MIAHEQL |
OrthoDBi | 749511at2759 |
PhylomeDBi | O95393 |
TreeFami | TF316134 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MGSLVLTLCA LFCLAAYLVS GSPIMNLEQS PLEEDMSLFG DVFSEQDGVD
60 70 80 90 100
FNTLLQSMKD EFLKTLNLSD IPTQDSAKVD PPEYMLELYN KFATDRTSMP
110 120 130 140 150
SANIIRSFKN EDLFSQPVSF NGLRKYPLLF NVSIPHHEEV IMAELRLYTL
160 170 180 190 200
VQRDRMIYDG VDRKITIFEV LESKGDNEGE RNMLVLVSGE IYGTNSEWET
210 220 230 240 250
FDVTDAIRRW QKSGSSTHQL EVHIESKHDE AEDASSGRLE IDTSAQNKHN
260 270 280 290 300
PLLIVFSDDQ SSDKERKEEL NEMISHEQLP ELDNLGLDSF SSGPGEEALL
310 320 330 340 350
QMRSNIIYDS TARIRRNAKG NYCKRTPLYI DFKEIGWDSW IIAPPGYEAY
360 370 380 390 400
ECRGVCNYPL AEHLTPTKHA IIQALVHLKN SQKASKACCV PTKLEPISIL
410 420
YLDKGVVTYK FKYEGMAVSE CGCR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 143 | A → T in AAH69080 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052572 | 200 | T → S. Corresponds to variant dbSNP:rs2231342Ensembl. | 1 | |
Natural variantiVAR_052573 | 250 | N → K. Corresponds to variant dbSNP:rs2231345EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF101441 mRNA Translation: AAC77462.1 AC097495 Genomic DNA Translation: AAY15075.1 BC069080 mRNA Translation: AAH69080.1 BC101734 mRNA Translation: AAI01735.1 BC105063 mRNA Translation: AAI05064.1 |
CCDSi | CCDS1890.1 |
RefSeqi | NP_055297.1, NM_014482.2 |
Genome annotation databases
Ensembli | ENST00000295379.2; ENSP00000295379.1; ENSG00000163217.2 |
GeneIDi | 27302 |
KEGGi | hsa:27302 |
MANE-Selecti | ENST00000295379.2; ENSP00000295379.1; NM_014482.3; NP_055297.1 |
UCSCi | uc002sez.1, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Bone morphogenetic protein 10 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF101441 mRNA Translation: AAC77462.1 AC097495 Genomic DNA Translation: AAY15075.1 BC069080 mRNA Translation: AAH69080.1 BC101734 mRNA Translation: AAI01735.1 BC105063 mRNA Translation: AAI05064.1 |
CCDSi | CCDS1890.1 |
RefSeqi | NP_055297.1, NM_014482.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6SF1 | X-ray | 2.80 | B | 317-424 | [»] | |
6SF3 | X-ray | 2.30 | B | 317-424 | [»] | |
AlphaFoldDBi | O95393 | |||||
SMRi | O95393 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118125, 59 interactors |
IntActi | O95393, 55 interactors |
STRINGi | 9606.ENSP00000295379 |
Chemistry databases
ChEMBLi | CHEMBL3713453 |
PTM databases
GlyGeni | O95393, 2 sites |
iPTMneti | O95393 |
PhosphoSitePlusi | O95393 |
Genetic variation databases
BioMutai | BMP10 |
Proteomic databases
MassIVEi | O95393 |
MaxQBi | O95393 |
PaxDbi | O95393 |
PeptideAtlasi | O95393 |
PRIDEi | O95393 |
ProteomicsDBi | 50844 |
Protocols and materials databases
Antibodypediai | 16182, 404 antibodies from 37 providers |
DNASUi | 27302 |
Genome annotation databases
Ensembli | ENST00000295379.2; ENSP00000295379.1; ENSG00000163217.2 |
GeneIDi | 27302 |
KEGGi | hsa:27302 |
MANE-Selecti | ENST00000295379.2; ENSP00000295379.1; NM_014482.3; NP_055297.1 |
UCSCi | uc002sez.1, human |
Organism-specific databases
CTDi | 27302 |
DisGeNETi | 27302 |
GeneCardsi | BMP10 |
HGNCi | HGNC:20869, BMP10 |
HPAi | ENSG00000163217, Tissue enriched (heart) |
MIMi | 608748, gene |
neXtProti | NX_O95393 |
OpenTargetsi | ENSG00000163217 |
PharmGKBi | PA134953092 |
VEuPathDBi | HostDB:ENSG00000163217 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000156279 |
HOGENOMi | CLU_020515_2_0_1 |
InParanoidi | O95393 |
OMAi | MIAHEQL |
OrthoDBi | 749511at2759 |
PhylomeDBi | O95393 |
TreeFami | TF316134 |
Enzyme and pathway databases
PathwayCommonsi | O95393 |
Reactomei | R-HSA-201451, Signaling by BMP R-HSA-2129379, Molecules associated with elastic fibres |
SignaLinki | O95393 |
SIGNORi | O95393 |
Miscellaneous databases
BioGRID-ORCSi | 27302, 9 hits in 1058 CRISPR screens |
GeneWikii | Bone_morphogenetic_protein_10 |
GenomeRNAii | 27302 |
Pharosi | O95393, Tbio |
PROi | PR:O95393 |
RNActi | O95393, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163217, Expressed in right atrium auricular region and 60 other tissues |
Genevisiblei | O95393, HS |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BMP10_HUMAN | |
Accessioni | O95393Primary (citable) accession number: O95393 Secondary accession number(s): Q53R17, Q6NTE0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | May 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families